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The map label for this gene is pyrC

Identifier: 45656472

GI number: 45656472

Start: 699396

End: 700670

Strand: Direct

Name: pyrC

Synonym: LIC10574

Alternate gene names: 45656472

Gene position: 699396-700670 (Clockwise)

Preceding gene: 45656471

Following gene: 45656475

Centisome position: 16.35

GC content: 36.86

Gene sequence:

>1275_bases
ATGATTAAAAAAATATCCGGTAGGATTGTTACTCATGAGAAAGATTTTTTAGGAACTGTGGAATGGGATTCTAAAACAGG
ATTGATTTTAACCGTTTTAGAACAAAAAGAATCTATTCCTATTTTGAATTCACAACACCAGGAAAATGAAATTCAATTCA
ATTCTTTAGAGACTGTAATTTTTCCGGGGTTCGGAGACATTCATATTCATGCGAGAGAAGACGAAAGTGGCAAACATACT
TACAAGGAAGATTTTGTTTCTGCAAGTGCCGCCGCCGTGAATGGTGGAGTAATTCATGTGGCAGACATGCCAAATAATCC
GATTCCTCCGATCGATGAAAATTCATATTCAAAAAAACGCAAGTTAGCTGATCGATCAAATATACACATAACGTTATATG
CAGGAATTGGACCGGATACGAAGCCATTGAAAAAATCAGTGCCTTATAAAGTTTTTATGGGACCGAGTATTGGAGAACTT
TTTTTTCATAATAATCAAACCTTGGAAGATACGATTTCCAGTTATGTGGGCGAAAATGTAAGTTTTCACTGCGAAGATCC
GGAAATTTTAGAAAAACATCAGAATGAAACGTTTCACGAAGATAGAAGGCCAGCTGAAGCGGAAACGACGGCGACTGATT
TTGCATTATATCTGATTGAAAAATACAATCTCAGAGGTAAACTTTGCCATTATTCTACCGGAGAAGGTCTGAACAAGATC
AAATTTGCAAAACAAAAAGGAGTAAAAGTAACGTGTGAAGTTACCCCTACTCATTTGTTTTTTGATAGGTCTATGTTGAC
TCCGGAAAATCGTCATTGGTTCCAAATGAATCCTCCTCTGAGGAGTAAGGAAGATCGTGAAAGAATGTTGGAAGGAGTCA
AACAAGGTTGGATCGATTATCTTGCTACGGATCACGCTCCTCATAGTATCGAAGAAAAACGTAAAGGTACGAGCGGTATT
TCTCAATTAGATACATATTCACTTTTTGTAACGTGGTTGGTTTTGAAAGCGGGTGTAGAATTAAAAACGGTCGCAAGAAT
CTGCGCAAAAAATCCAGGTGATTTTGTGAACGAATATCTTCCTGAAAAATTCGGAAAGGGTTTTGGAAGGATCGAACCGG
GTTACTCTGCCAATTTTACTGTGTTAAATCTAAAAAAACCAAAGAAGTTTTTAAAAGAAGAAATTAAAAGTAAATCTGGT
TGGTCTCCTTTTGAAAATTTCGAATTTCCAGGTTCGATCGAAGCTGTGTTTTTTCTTGGGAAACAGATGAAGTGA

Upstream 100 bases:

>100_bases
ATGAGGTTCAGATCAAAAAATTCATCAATAAACTAAAAACAGAATGGAACGAAATTCATTGTTGTTACGATCTTCCAAGT
TTATTCAAAAAGGAGTTTAG

Downstream 100 bases:

>100_bases
AATCGATGTTGTTTGTGGGAACTCCTCTGTATGATTTAACAACAAAATCTCTGTTTAGAAATCCGTAAATTGACTGTAGA
GTCTGATTTTTTGTGGGAAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIKKISGRIVTHEKDFLGTVEWDSKTGLILTVLEQKESIPILNSQHQENEIQFNSLETVIFPGFGDIHIHAREDESGKHT
YKEDFVSASAAAVNGGVIHVADMPNNPIPPIDENSYSKKRKLADRSNIHITLYAGIGPDTKPLKKSVPYKVFMGPSIGEL
FFHNNQTLEDTISSYVGENVSFHCEDPEILEKHQNETFHEDRRPAEAETTATDFALYLIEKYNLRGKLCHYSTGEGLNKI
KFAKQKGVKVTCEVTPTHLFFDRSMLTPENRHWFQMNPPLRSKEDRERMLEGVKQGWIDYLATDHAPHSIEEKRKGTSGI
SQLDTYSLFVTWLVLKAGVELKTVARICAKNPGDFVNEYLPEKFGKGFGRIEPGYSANFTVLNLKKPKKFLKEEIKSKSG
WSPFENFEFPGSIEAVFFLGKQMK

Sequences:

>Translated_424_residues
MIKKISGRIVTHEKDFLGTVEWDSKTGLILTVLEQKESIPILNSQHQENEIQFNSLETVIFPGFGDIHIHAREDESGKHT
YKEDFVSASAAAVNGGVIHVADMPNNPIPPIDENSYSKKRKLADRSNIHITLYAGIGPDTKPLKKSVPYKVFMGPSIGEL
FFHNNQTLEDTISSYVGENVSFHCEDPEILEKHQNETFHEDRRPAEAETTATDFALYLIEKYNLRGKLCHYSTGEGLNKI
KFAKQKGVKVTCEVTPTHLFFDRSMLTPENRHWFQMNPPLRSKEDRERMLEGVKQGWIDYLATDHAPHSIEEKRKGTSGI
SQLDTYSLFVTWLVLKAGVELKTVARICAKNPGDFVNEYLPEKFGKGFGRIEPGYSANFTVLNLKKPKKFLKEEIKSKSG
WSPFENFEFPGSIEAVFFLGKQMK
>Mature_424_residues
MIKKISGRIVTHEKDFLGTVEWDSKTGLILTVLEQKESIPILNSQHQENEIQFNSLETVIFPGFGDIHIHAREDESGKHT
YKEDFVSASAAAVNGGVIHVADMPNNPIPPIDENSYSKKRKLADRSNIHITLYAGIGPDTKPLKKSVPYKVFMGPSIGEL
FFHNNQTLEDTISSYVGENVSFHCEDPEILEKHQNETFHEDRRPAEAETTATDFALYLIEKYNLRGKLCHYSTGEGLNKI
KFAKQKGVKVTCEVTPTHLFFDRSMLTPENRHWFQMNPPLRSKEDRERMLEGVKQGWIDYLATDHAPHSIEEKRKGTSGI
SQLDTYSLFVTWLVLKAGVELKTVARICAKNPGDFVNEYLPEKFGKGFGRIEPGYSANFTVLNLKKPKKFLKEEIKSKSG
WSPFENFEFPGSIEAVFFLGKQMK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=373, Percent_Identity=27.6139410187668, Blast_Score=109, Evalue=6e-24,
Organism=Escherichia coli, GI1786722, Length=391, Percent_Identity=25.3196930946292, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082175, Length=398, Percent_Identity=20.8542713567839, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=370, Percent_Identity=26.7567567567568, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322218, Length=453, Percent_Identity=22.9580573951435, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642586, Length=377, Percent_Identity=27.5862068965517, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48159; Mature: 48159

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKISGRIVTHEKDFLGTVEWDSKTGLILTVLEQKESIPILNSQHQENEIQFNSLETVI
CCCCCCCEEEEECHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCEEE
FPGFGDIHIHAREDESGKHTYKEDFVSASAAAVNGGVIHVADMPNNPIPPIDENSYSKKR
ECCCCEEEEEECCCCCCCCHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCHHHHH
KLADRSNIHITLYAGIGPDTKPLKKSVPYKVFMGPSIGELFFHNNQTLEDTISSYVGENV
HHHCCCCEEEEEEECCCCCCCHHHHCCCEEEEECCCHHHEEECCCCCHHHHHHHHHCCCC
SFHCEDPEILEKHQNETFHEDRRPAEAETTATDFALYLIEKYNLRGKLCHYSTGEGLNKI
EEECCCHHHHHHHCCCCHHHHCCCCCCHHHHHHHHEEEEHHCCCCCEEEECCCCCCCHHH
KFAKQKGVKVTCEVTPTHLFFDRSMLTPENRHWFQMNPPLRSKEDRERMLEGVKQGWIDY
HHHHHCCCEEEEEECCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
LATDHAPHSIEEKRKGTSGISQLDTYSLFVTWLVLKAGVELKTVARICAKNPGDFVNEYL
HHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHH
PEKFGKGFGRIEPGYSANFTVLNLKKPKKFLKEEIKSKSGWSPFENFEFPGSIEAVFFLG
HHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEC
KQMK
CCCC
>Mature Secondary Structure
MIKKISGRIVTHEKDFLGTVEWDSKTGLILTVLEQKESIPILNSQHQENEIQFNSLETVI
CCCCCCCEEEEECHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCEEE
FPGFGDIHIHAREDESGKHTYKEDFVSASAAAVNGGVIHVADMPNNPIPPIDENSYSKKR
ECCCCEEEEEECCCCCCCCHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCHHHHH
KLADRSNIHITLYAGIGPDTKPLKKSVPYKVFMGPSIGELFFHNNQTLEDTISSYVGENV
HHHCCCCEEEEEEECCCCCCCHHHHCCCEEEEECCCHHHEEECCCCCHHHHHHHHHCCCC
SFHCEDPEILEKHQNETFHEDRRPAEAETTATDFALYLIEKYNLRGKLCHYSTGEGLNKI
EEECCCHHHHHHHCCCCHHHHCCCCCCHHHHHHHHEEEEHHCCCCCEEEECCCCCCCHHH
KFAKQKGVKVTCEVTPTHLFFDRSMLTPENRHWFQMNPPLRSKEDRERMLEGVKQGWIDY
HHHHHCCCEEEEEECCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
LATDHAPHSIEEKRKGTSGISQLDTYSLFVTWLVLKAGVELKTVARICAKNPGDFVNEYL
HHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHH
PEKFGKGFGRIEPGYSANFTVLNLKKPKKFLKEEIKSKSGWSPFENFEFPGSIEAVFFLG
HHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEC
KQMK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]