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The map label for this gene is add

Identifier: 45656357

GI number: 45656357

Start: 523243

End: 524571

Strand: Direct

Name: add

Synonym: LIC10459

Alternate gene names: 45656357

Gene position: 523243-524571 (Clockwise)

Preceding gene: 45656353

Following gene: 45656358

Centisome position: 12.23

GC content: 39.73

Gene sequence:

>1329_bases
GTGGCTTTAACTTTTCAAGAGATTTTAGATAGAATTCGGATCATCGATCGAGACGTGACCGAACTGAACCGTTTGAAGTC
TAGACTTCCTGCGGACCGACCTTATTCTTCTTCTTTACAAATTTCTTTTGATAAACAAATCAACGAACTCTTAAACGAAA
GAGTCGGTCTCATGGAACTTGAGGTCCTAGATCCGCCTTCTTGGATCTTAGGAGTTCCTACAACTGGGATTTCTCAGGAA
ACTCCGGTTCCACTCAAAGGCCTTTTTCCGTCCGGAGATCTTTCTAAGGAAAAACCGGACGATCAAGACGTAATTAATTT
CCTACGAGAACTTCCTAAAACGGAAATTCATCTCCACCTTGAGGCGTGTGTTAATAAGGACACGATGAAAAGATTGATGG
CTAAAAATGGAATTAATGTAACGGATGAAGAGTTTGAAGCTAAATTCAATTTTAAGGATTTAAACAGTTTCATTCAGGTA
TTCTTTTTTATTCAGTCGCTTGTTAAAGAACCTTCTGATTTCTCATTTTTTATAGAAAGTCTCGCGGAATACATGAGAGC
GAATAACATCCTTTATACGGAAGTTTTTTTTGCACCTTCTAAGTTTATTCAGAACGGTCTCGATTTTGAAGAAATGATCG
ATTTTTTAGTCAATCGAATTCGAGAAGAAAAAGAAAACGACGGTATCGTCATACGTCTATTAGTTGATGTTTCCAGATCC
TTTGGGCCAGAAAATGCGATGAAAAATCTAGATCGGGTTCTAAAACTGAGACATCCGGAAGTGATTGGAATTGGTCTTGG
AGGCGCGGAACTTATGGGACCCGCCAGGGATTATCAAGGGGTTTTTCAAAAAGCGAGGGAAGCGGGGCTCAGAGTGGTGG
CGCATTCCGGAGAAGACGATGGTCCTTGGGCAATTTGGGAGGCGGTGGAACTTCTCAAAGCGGAGAGGATTGGACACGGA
ACTTCTGCGATCCAAGATCCCGAGTTAGTAAAATATCTTAGGGAGAATCATATTCCAATCGAGATTTGTGTGACGTCTAA
CGTATTTACTGGTAAATACGTTAGAAAAGAACAAAACCATCCAGTTCGTTATTATTACGATCAGGGTCTTCCTCTTAGTA
TCAATACGGACGATCCTGAGATATTCAATGTAAATCTTACATACGAATATTATAAACTTTGGAGATTCTTAGATTTCTCT
TTGGATGAGATCGTAGATTTGATCCGTCAAGGTGTTTTTGCTTCCTTCCATCCCAATAAAGAATCTCTCTGGGCCGAAAT
GGAAAAAAACATTCATCTCGTAAAAACAAGATACGGTCTAAAAAGATAA

Upstream 100 bases:

>100_bases
CAAAGTGGAAAGGTTAGGGGTCATTTGGTTCTTAGGTCATTCAAACTTTGATACTTGAATCAGAATTGAAATCTTTTCCT
GGAAAATATATATTGCCTTA

Downstream 100 bases:

>100_bases
AAATTGTTTTGAAAATAATTTGAACGTTCTCGTTTCCTTTAAATTACCGTTTGGAAAACTTAGAATTTAACTCAAAAATA
CTTTATCTTTGTTTAAAATG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MALTFQEILDRIRIIDRDVTELNRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMELEVLDPPSWILGVPTTGISQE
TPVPLKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGINVTDEEFEAKFNFKDLNSFIQV
FFFIQSLVKEPSDFSFFIESLAEYMRANNILYTEVFFAPSKFIQNGLDFEEMIDFLVNRIREEKENDGIVIRLLVDVSRS
FGPENAMKNLDRVLKLRHPEVIGIGLGGAELMGPARDYQGVFQKAREAGLRVVAHSGEDDGPWAIWEAVELLKAERIGHG
TSAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFS
LDEIVDLIRQGVFASFHPNKESLWAEMEKNIHLVKTRYGLKR

Sequences:

>Translated_442_residues
MALTFQEILDRIRIIDRDVTELNRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMELEVLDPPSWILGVPTTGISQE
TPVPLKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGINVTDEEFEAKFNFKDLNSFIQV
FFFIQSLVKEPSDFSFFIESLAEYMRANNILYTEVFFAPSKFIQNGLDFEEMIDFLVNRIREEKENDGIVIRLLVDVSRS
FGPENAMKNLDRVLKLRHPEVIGIGLGGAELMGPARDYQGVFQKAREAGLRVVAHSGEDDGPWAIWEAVELLKAERIGHG
TSAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFS
LDEIVDLIRQGVFASFHPNKESLWAEMEKNIHLVKTRYGLKR
>Mature_441_residues
ALTFQEILDRIRIIDRDVTELNRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMELEVLDPPSWILGVPTTGISQET
PVPLKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGINVTDEEFEAKFNFKDLNSFIQVF
FFIQSLVKEPSDFSFFIESLAEYMRANNILYTEVFFAPSKFIQNGLDFEEMIDFLVNRIREEKENDGIVIRLLVDVSRSF
GPENAMKNLDRVLKLRHPEVIGIGLGGAELMGPARDYQGVFQKAREAGLRVVAHSGEDDGPWAIWEAVELLKAERIGHGT
SAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSL
DEIVDLIRQGVFASFHPNKESLWAEMEKNIHLVKTRYGLKR

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=339, Percent_Identity=24.4837758112094, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI61175224, Length=245, Percent_Identity=26.530612244898, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787910, Length=289, Percent_Identity=30.7958477508651, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI115537133, Length=324, Percent_Identity=25.9259259259259, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI32565969, Length=341, Percent_Identity=25.2199413489736, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538512, Length=341, Percent_Identity=25.2199413489736, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324188, Length=289, Percent_Identity=26.2975778546713, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645260, Length=326, Percent_Identity=25.7668711656442, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 51053; Mature: 50922

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00485 A_DEAMINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTFQEILDRIRIIDRDVTELNRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMEL
CCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEE
EVLDPPSWILGVPTTGISQETPVPLKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHL
EEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEH
EACVNKDTMKRLMAKNGINVTDEEFEAKFNFKDLNSFIQVFFFIQSLVKEPSDFSFFIES
HHHCCHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAEYMRANNILYTEVFFAPSKFIQNGLDFEEMIDFLVNRIREEKENDGIVIRLLVDVSRS
HHHHHHHCCEEEEEEHHCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHC
FGPENAMKNLDRVLKLRHPEVIGIGLGGAELMGPARDYQGVFQKAREAGLRVVAHSGEDD
CCHHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCC
GPWAIWEAVELLKAERIGHGTSAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNH
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCC
PVRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIVDLIRQGVFASFHPNK
CEEEEECCCEEEEECCCCCEEEEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCH
ESLWAEMEKNIHLVKTRYGLKR
HHHHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
ALTFQEILDRIRIIDRDVTELNRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMEL
CCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEE
EVLDPPSWILGVPTTGISQETPVPLKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHL
EEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEH
EACVNKDTMKRLMAKNGINVTDEEFEAKFNFKDLNSFIQVFFFIQSLVKEPSDFSFFIES
HHHCCHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAEYMRANNILYTEVFFAPSKFIQNGLDFEEMIDFLVNRIREEKENDGIVIRLLVDVSRS
HHHHHHHCCEEEEEEHHCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHC
FGPENAMKNLDRVLKLRHPEVIGIGLGGAELMGPARDYQGVFQKAREAGLRVVAHSGEDD
CCHHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCC
GPWAIWEAVELLKAERIGHGTSAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNH
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCC
PVRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIVDLIRQGVFASFHPNK
CEEEEECCCEEEEECCCCCEEEEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCH
ESLWAEMEKNIHLVKTRYGLKR
HHHHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA