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The map label for this gene is prs

Identifier: 45656328

GI number: 45656328

Start: 489767

End: 490705

Strand: Direct

Name: prs

Synonym: LIC10429

Alternate gene names: 45656328

Gene position: 489767-490705 (Clockwise)

Preceding gene: 45656327

Following gene: 45656329

Centisome position: 11.45

GC content: 39.3

Gene sequence:

>939_bases
ATGAACGGAGACATTGCTGTATTTGCAGGAAATTCTAACAAACAAATCGCCGAAGAAATTTGTACTCATTTAGGAATTCA
GTCTGGTAAAATTAATCTAAAGAAATTTTCTGATGGAGAAATTTCAGTTAAAATCGAAGATAACGTTCGTGGAAAAGAAG
TTTTTATCGTTCAATCCACTTCGGCCCCAGCTAACGATCATTTGATGGAATTAATTTTAATTATGGACGCTCTTCGTAGA
GCCTCCGTGTCCAGCATCAGTGTGGTGATCCCATATTATGGTTATGGTCGCCAAGATCGTAAGGTAGAACCCCGTGTTCC
CATTTCTGCGAGAGTTGTTGCGGATCTGATAGAAGTAGTAGGACTAGATCGGATTTTGACTATGGATTTACACGCAGATC
AGATTCAAGGGTTCTTTCGTGTTCCGGTGGACAATCTGCATTTTGCTCCTGTGTTAGCCGAGTATGTAAATACTAAGAAA
ATTGATGATTTAGTAATCGTTTCTCCAGATTCGGGCGGTGCGGAAAGAGCTAGAGCTTTCGGTAAAAAGGTAAACGGTTC
ATTAGCAATCATTGATAAACGTAGACCTAAAGCGAACGTTTCCGAAGTGATGAATGTGATCGGAGAAATAGAAGGAAAAA
ATTGTATTCTTCTAGATGATATGATAGACACCGCAGGTACAATTTGTAAGGCTGCGGACGTACTTTTAAAACACGGAGCT
AAATCCGTTTATTGCGCAGCGACTCATGGAGTTCTTTCCGGAGAAGCAGTGGATCGGATCAACTCTACTCAATTCTCTGA
AGTTGTTCTTGCGAATACGATTGCAATTCCTGAGTCTAAGAAAATTAATAAATTGAAGTCATTATCCGTAGCTCCTTTGT
TTGCAAATGCAATTCAAAGGATTCATACAAATCAATCCGTAAGCACTTTATTCGATTAA

Upstream 100 bases:

>100_bases
GCGCTATGAAACTTAAAAATCATCTTGAAAGTCATGGCGTAAATTCCCCTGAAGATCTACAGATGCTTTCCGCTTTAATT
AAAGGGGAGGCGGTCCATCC

Downstream 100 bases:

>100_bases
GGTTAGGTAATATAAGAATGAGCCAGAACACGATTCACAAAATTGCAGTTAAAAAAAGAACAACAACCGGTAAAAACGAA
AACAATCGTCTTCGTTCATC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNGDIAVFAGNSNKQIAEEICTHLGIQSGKINLKKFSDGEISVKIEDNVRGKEVFIVQSTSAPANDHLMELILIMDALRR
ASVSSISVVIPYYGYGRQDRKVEPRVPISARVVADLIEVVGLDRILTMDLHADQIQGFFRVPVDNLHFAPVLAEYVNTKK
IDDLVIVSPDSGGAERARAFGKKVNGSLAIIDKRRPKANVSEVMNVIGEIEGKNCILLDDMIDTAGTICKAADVLLKHGA
KSVYCAATHGVLSGEAVDRINSTQFSEVVLANTIAIPESKKINKLKSLSVAPLFANAIQRIHTNQSVSTLFD

Sequences:

>Translated_312_residues
MNGDIAVFAGNSNKQIAEEICTHLGIQSGKINLKKFSDGEISVKIEDNVRGKEVFIVQSTSAPANDHLMELILIMDALRR
ASVSSISVVIPYYGYGRQDRKVEPRVPISARVVADLIEVVGLDRILTMDLHADQIQGFFRVPVDNLHFAPVLAEYVNTKK
IDDLVIVSPDSGGAERARAFGKKVNGSLAIIDKRRPKANVSEVMNVIGEIEGKNCILLDDMIDTAGTICKAADVLLKHGA
KSVYCAATHGVLSGEAVDRINSTQFSEVVLANTIAIPESKKINKLKSLSVAPLFANAIQRIHTNQSVSTLFD
>Mature_312_residues
MNGDIAVFAGNSNKQIAEEICTHLGIQSGKINLKKFSDGEISVKIEDNVRGKEVFIVQSTSAPANDHLMELILIMDALRR
ASVSSISVVIPYYGYGRQDRKVEPRVPISARVVADLIEVVGLDRILTMDLHADQIQGFFRVPVDNLHFAPVLAEYVNTKK
IDDLVIVSPDSGGAERARAFGKKVNGSLAIIDKRRPKANVSEVMNVIGEIEGKNCILLDDMIDTAGTICKAADVLLKHGA
KSVYCAATHGVLSGEAVDRINSTQFSEVVLANTIAIPESKKINKLKSLSVAPLFANAIQRIHTNQSVSTLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506129, Length=313, Percent_Identity=44.0894568690096, Blast_Score=278, Evalue=3e-75,
Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=44.408945686901, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=43.9873417721519, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=43.7299035369775, Blast_Score=274, Evalue=8e-74,
Organism=Homo sapiens, GI4506133, Length=348, Percent_Identity=32.7586206896552, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=32.4561403508772, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=31.9444444444444, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=31.9444444444444, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=31.9444444444444, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=31.9444444444444, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=50.3205128205128, Blast_Score=328, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=44.6945337620579, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=44.6945337620579, Blast_Score=280, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=44.8051948051948, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=44.6945337620579, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=30.8605341246291, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319403, Length=311, Percent_Identity=41.8006430868167, Blast_Score=264, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6320946, Length=310, Percent_Identity=41.6129032258065, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=41.1575562700965, Blast_Score=250, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322667, Length=195, Percent_Identity=40, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=108, Percent_Identity=37.037037037037, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=45.3674121405751, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=42.2619047619048, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=31.3559322033898, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=31.3559322033898, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=31.3559322033898, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=31.3559322033898, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651462, Length=202, Percent_Identity=35.6435643564356, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24651464, Length=202, Percent_Identity=35.6435643564356, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45552010, Length=202, Percent_Identity=35.6435643564356, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_LEPIC (Q72V73)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000414.1
- ProteinModelPortal:   Q72V73
- SMR:   Q72V73
- GeneID:   2771013
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10429
- NMPDR:   fig|267671.1.peg.414
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK01259
- BioCyc:   LINT267671:LIC_10429-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 33847; Mature: 33847

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGDIAVFAGNSNKQIAEEICTHLGIQSGKINLKKFSDGEISVKIEDNVRGKEVFIVQST
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEECC
SAPANDHLMELILIMDALRRASVSSISVVIPYYGYGRQDRKVEPRVPISARVVADLIEVV
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GLDRILTMDLHADQIQGFFRVPVDNLHFAPVLAEYVNTKKIDDLVIVSPDSGGAERARAF
CCCCEEEEECCHHHHCCEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHH
GKKVNGSLAIIDKRRPKANVSEVMNVIGEIEGKNCILLDDMIDTAGTICKAADVLLKHGA
HHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC
KSVYCAATHGVLSGEAVDRINSTQFSEVVLANTIAIPESKKINKLKSLSVAPLFANAIQR
CEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHEEECCCCHHHHHHHCCCHHHHHHHHHHH
IHTNQSVSTLFD
HHCCCCHHHHCC
>Mature Secondary Structure
MNGDIAVFAGNSNKQIAEEICTHLGIQSGKINLKKFSDGEISVKIEDNVRGKEVFIVQST
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEECC
SAPANDHLMELILIMDALRRASVSSISVVIPYYGYGRQDRKVEPRVPISARVVADLIEVV
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GLDRILTMDLHADQIQGFFRVPVDNLHFAPVLAEYVNTKKIDDLVIVSPDSGGAERARAF
CCCCEEEEECCHHHHCCEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHH
GKKVNGSLAIIDKRRPKANVSEVMNVIGEIEGKNCILLDDMIDTAGTICKAADVLLKHGA
HHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC
KSVYCAATHGVLSGEAVDRINSTQFSEVVLANTIAIPESKKINKLKSLSVAPLFANAIQR
CEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHEEECCCCHHHHHHHCCCHHHHHHHHHHH
IHTNQSVSTLFD
HHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA