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The map label for this gene is glmU

Identifier: 45656327

GI number: 45656327

Start: 489012

End: 489770

Strand: Direct

Name: glmU

Synonym: LIC10428

Alternate gene names: 45656327

Gene position: 489012-489770 (Clockwise)

Preceding gene: 45656326

Following gene: 45656328

Centisome position: 11.43

GC content: 40.45

Gene sequence:

>759_bases
ATGAAACCTACTCAGGATAAGGTCGCTGTGGTATTAGCCGCAGGGAAGGGCACCCGTATGAAAACGGATCAGCCTAAGGT
TGCGGTAGAACTCAATGGCAAACCGCTGCTTTTACATGTACTCGATCATCTAAAAGGTTCTGGTGTAGAACGGATCGTAG
TAGTAGTAGGTTACAAAAAAGAATTGGTTCAGTCTCTTTGCTCCAAAATTCCAGGTGTTACTTTTGCCGAACAAAAAGAA
CAACTTGGAACTGCTCATGCTCTTCTTTGCGCCGAAACGGAACTGAAAAATTTCCAAGGTTCTGTGATCGTTGCCTGTGG
AGACGTTCCAATGATTACTTCCGAAACGTTTTCTAATATAGTAAAACAACACAAAGAGAATGAATTTTCTGCAACGATCC
TTTCTGCAGTCGTAGAAAAACCTACAGGATATGGAAGAATTATCCGCAACTCCTCCGGTGAAGTAACAGCTATCGTAGAA
GAAAAAGATTCTTCTACCGAAGAAAAATTGATCAACGAAATTAACACTGGAACCTATGTATTCGACGGAGAAGGTCTTTT
TGATTCTCTGAGAAAAATTGGAAATCAAAACGCTCAGGGAGAATATTATCTTCCTGATCTAGTGAAATTATATAGAAACT
CCGGAAAAAAACTAGGCGCTATGAAACTTAAAAATCATCTTGAAAGTCATGGCGTAAATTCCCCTGAAGATCTACAGATG
CTTTCCGCTTTAATTAAAGGGGAGGCGGTCCATCCATGA

Upstream 100 bases:

>100_bases
GGGCTGTCGCCAAGTGGTAAGGCAGCGGTTTTTGGTATCGCCATTTCCTAGGTTCGAATCCTAGCAGCCCAGCCAATGAA
ATTACTAACATAGATTAAAG

Downstream 100 bases:

>100_bases
ACGGAGACATTGCTGTATTTGCAGGAAATTCTAACAAACAAATCGCCGAAGAAATTTGTACTCATTTAGGAATTCAGTCT
GGTAAAATTAATCTAAAGAA

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKPTQDKVAVVLAAGKGTRMKTDQPKVAVELNGKPLLLHVLDHLKGSGVERIVVVVGYKKELVQSLCSKIPGVTFAEQKE
QLGTAHALLCAETELKNFQGSVIVACGDVPMITSETFSNIVKQHKENEFSATILSAVVEKPTGYGRIIRNSSGEVTAIVE
EKDSSTEEKLINEINTGTYVFDGEGLFDSLRKIGNQNAQGEYYLPDLVKLYRNSGKKLGAMKLKNHLESHGVNSPEDLQM
LSALIKGEAVHP

Sequences:

>Translated_252_residues
MKPTQDKVAVVLAAGKGTRMKTDQPKVAVELNGKPLLLHVLDHLKGSGVERIVVVVGYKKELVQSLCSKIPGVTFAEQKE
QLGTAHALLCAETELKNFQGSVIVACGDVPMITSETFSNIVKQHKENEFSATILSAVVEKPTGYGRIIRNSSGEVTAIVE
EKDSSTEEKLINEINTGTYVFDGEGLFDSLRKIGNQNAQGEYYLPDLVKLYRNSGKKLGAMKLKNHLESHGVNSPEDLQM
LSALIKGEAVHP
>Mature_252_residues
MKPTQDKVAVVLAAGKGTRMKTDQPKVAVELNGKPLLLHVLDHLKGSGVERIVVVVGYKKELVQSLCSKIPGVTFAEQKE
QLGTAHALLCAETELKNFQGSVIVACGDVPMITSETFSNIVKQHKENEFSATILSAVVEKPTGYGRIIRNSSGEVTAIVE
EKDSSTEEKLINEINTGTYVFDGEGLFDSLRKIGNQNAQGEYYLPDLVKLYRNSGKKLGAMKLKNHLESHGVNSPEDLQM
LSALIKGEAVHP

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=185, Percent_Identity=28.1081081081081, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI11761619, Length=185, Percent_Identity=28.1081081081081, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790168, Length=239, Percent_Identity=36.4016736401674, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI133931050, Length=182, Percent_Identity=31.8681318681319, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=184, Percent_Identity=29.3478260869565, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355443, Length=224, Percent_Identity=29.4642857142857, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24644084, Length=224, Percent_Identity=29.4642857142857, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 27400; Mature: 27400

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTQDKVAVVLAAGKGTRMKTDQPKVAVELNGKPLLLHVLDHLKGSGVERIVVVVGYKK
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCEEHHHHHHHHCCCCCEEEEEEECCHH
ELVQSLCSKIPGVTFAEQKEQLGTAHALLCAETELKNFQGSVIVACGDVPMITSETFSNI
HHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
VKQHKENEFSATILSAVVEKPTGYGRIIRNSSGEVTAIVEEKDSSTEEKLINEINTGTYV
HHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCEEE
FDGEGLFDSLRKIGNQNAQGEYYLPDLVKLYRNSGKKLGAMKLKNHLESHGVNSPEDLQM
ECCCCHHHHHHHHCCCCCCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
LSALIKGEAVHP
HHHHHCCCCCCC
>Mature Secondary Structure
MKPTQDKVAVVLAAGKGTRMKTDQPKVAVELNGKPLLLHVLDHLKGSGVERIVVVVGYKK
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCEEHHHHHHHHCCCCCEEEEEEECCHH
ELVQSLCSKIPGVTFAEQKEQLGTAHALLCAETELKNFQGSVIVACGDVPMITSETFSNI
HHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
VKQHKENEFSATILSAVVEKPTGYGRIIRNSSGEVTAIVEEKDSSTEEKLINEINTGTYV
HHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCEEE
FDGEGLFDSLRKIGNQNAQGEYYLPDLVKLYRNSGKKLGAMKLKNHLESHGVNSPEDLQM
ECCCCHHHHHHHHCCCCCCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
LSALIKGEAVHP
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]