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The map label for this gene is aer

Identifier: 45655957

GI number: 45655957

Start: 52070

End: 53767

Strand: Direct

Name: aer

Synonym: LIC10043

Alternate gene names: 45655957

Gene position: 52070-53767 (Clockwise)

Preceding gene: 45655952

Following gene: 45655958

Centisome position: 1.22

GC content: 35.81

Gene sequence:

>1698_bases
ATGAGAAAAAATCTCCCGATTACAAGTCAAGAAATAACAATACCTATCAATTCAGTTCTAATCTCACGTACGGATATGAA
AGGAAGAATATCGTATGTAAGTCAGGATTTTGCTAATATCAGCGGGTTTTCCGAAGAGGAAATGTTAGGCGAGCCTCATA
ATCTAATTCGTCATCCGGATGTTCCTTCCGAAATTTTTCGAGAGATGTGGGAAACGATACAAGATGGAAATCCTTGGAGT
GGAATCATAAAAAACCGTGCTAAGTCAGGTGATTATTATTGGGTAGATGCTACGGTTACTCCGGTAATGAACGAAGGTGT
GATTTCCGGTTATATGTCCGTTCGTAAAAAAGCGACTGAAGATCAGATCAGAAGGGCGGAAATTTTATTCTCTCAACTAA
AAAATACAAAATCATTTCTTTGGAAATTAAAAGAAGGTATTCAGATATTATTCAAAAAACTGGGGCTTTCCGGAAAGATT
ATAGTATATGCCTTACTTGTTTTCGTTCCCTTATTGTTCGCAAATTTCGAATGGATTCGAAATGGTATGATCGTATTACC
TATATTAGGAGTTTCTTGCGGAAGTGTAGGAATTCTTTTTTTGATCAATACAATTCTAAATTATCGAAAAGAGATTCGAG
AAATTATTTCAATTCAAAAAGAAATTGTATCTGGTAATTTCCTCATGGAAATTCCAGAAAAAAAAGGGAATTCCGAAATA
TTTGAAATTCGTTCTAGTCTTAGAGTTTTTGTAATCAGTATTTGGGGATTGTTGGTTCAAATTAAAGAAAACTTTGAAAA
GAATCAGGAACTTTATCAATATCTTTCTCAGTCGAGTGAACAATTTCAATCTAAAACACAAAATCAGGCCGCTTCCGTGG
AACAAACAGCGTCTGCTTCTCACGAACTATCTTCAACGTTAGATGAAATTGTAAAATCAATTCATTTACAATCTACAGGT
CTGACCGCAATTAACGACGGAATCGGAAAAGTAAACGAGTCGATTCAAAACGTATCTAAATCTATGGATAATCTTTCTTC
TCAAACTTCTTCCGTAAAAGAAAAGGCTTCTCAAAGTGAAAAAACTTTTGAAAAAGCAATTCTAGCAATGAACGAAATCA
AAGAATATTCGAACGGAATTTCAAATATTATAGGAATTATTACTTCGATCTCCGAAAAAACAAATCTACTATCGTTAAAC
GCTTCCATCGAGTCTGCGAGAGCGGGAGAAGCTGGGAAAGGTTTTAGTGTGGTGGCTGAAGAAATTTCAAAATTAGCTTC
TCAGACTAGAGAATCTATCAAAGACATAGTCAATCTAATAGATAACACTACAAAGGCGGTTAATTTAGGCGCGGAGAAAT
TTCAAGAATCCTTATCCATCGTTAAACAACTTACGGATTATATAGGCGAAGTAAATTCTTCCGCTACGATTGTGAGAGCA
TCTTTATTTGCTCAGGCGGAAAAGTTGGGAGAAATCAGAAAGAATACGGATCAAGTCAATCAACTCGGTGAAACCGTAAG
CGAATCTTCCGGGTTTCAAAAAACGGCTTCCGATGAAATTTCTTTATCCATGCAAAACATCGCGGAAAGTTCGGAATTGA
TCGCAAGAACATCCGGAGAAATCAAACAACTCGTGGACGAATCCATTCGTAAAGCGGCTAAGTTGTACGAAATCTTAAAA
CATTTTAAGACTTCTTAA

Upstream 100 bases:

>100_bases
TTCGATTTGACGAGACGGTCATCTTATATTTTTTTCTTTTGAAACATTATTTGAATTTCTTGTTTTAAATACTCGAGGTT
CATTTTTAATGTAACGGATC

Downstream 100 bases:

>100_bases
AGGCCGTCCCAAAACTTAAACACCTACCATAGAAGGTGTTTGCTGAGTTTCACAAAAAATGTGGGAACTACCACAAATCT
ATAATTTACGGTAGAACTTT

Product: Aer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MRKNLPITSQEITIPINSVLISRTDMKGRISYVSQDFANISGFSEEEMLGEPHNLIRHPDVPSEIFREMWETIQDGNPWS
GIIKNRAKSGDYYWVDATVTPVMNEGVISGYMSVRKKATEDQIRRAEILFSQLKNTKSFLWKLKEGIQILFKKLGLSGKI
IVYALLVFVPLLFANFEWIRNGMIVLPILGVSCGSVGILFLINTILNYRKEIREIISIQKEIVSGNFLMEIPEKKGNSEI
FEIRSSLRVFVISIWGLLVQIKENFEKNQELYQYLSQSSEQFQSKTQNQAASVEQTASASHELSSTLDEIVKSIHLQSTG
LTAINDGIGKVNESIQNVSKSMDNLSSQTSSVKEKASQSEKTFEKAILAMNEIKEYSNGISNIIGIITSISEKTNLLSLN
ASIESARAGEAGKGFSVVAEEISKLASQTRESIKDIVNLIDNTTKAVNLGAEKFQESLSIVKQLTDYIGEVNSSATIVRA
SLFAQAEKLGEIRKNTDQVNQLGETVSESSGFQKTASDEISLSMQNIAESSELIARTSGEIKQLVDESIRKAAKLYEILK
HFKTS

Sequences:

>Translated_565_residues
MRKNLPITSQEITIPINSVLISRTDMKGRISYVSQDFANISGFSEEEMLGEPHNLIRHPDVPSEIFREMWETIQDGNPWS
GIIKNRAKSGDYYWVDATVTPVMNEGVISGYMSVRKKATEDQIRRAEILFSQLKNTKSFLWKLKEGIQILFKKLGLSGKI
IVYALLVFVPLLFANFEWIRNGMIVLPILGVSCGSVGILFLINTILNYRKEIREIISIQKEIVSGNFLMEIPEKKGNSEI
FEIRSSLRVFVISIWGLLVQIKENFEKNQELYQYLSQSSEQFQSKTQNQAASVEQTASASHELSSTLDEIVKSIHLQSTG
LTAINDGIGKVNESIQNVSKSMDNLSSQTSSVKEKASQSEKTFEKAILAMNEIKEYSNGISNIIGIITSISEKTNLLSLN
ASIESARAGEAGKGFSVVAEEISKLASQTRESIKDIVNLIDNTTKAVNLGAEKFQESLSIVKQLTDYIGEVNSSATIVRA
SLFAQAEKLGEIRKNTDQVNQLGETVSESSGFQKTASDEISLSMQNIAESSELIARTSGEIKQLVDESIRKAAKLYEILK
HFKTS
>Mature_565_residues
MRKNLPITSQEITIPINSVLISRTDMKGRISYVSQDFANISGFSEEEMLGEPHNLIRHPDVPSEIFREMWETIQDGNPWS
GIIKNRAKSGDYYWVDATVTPVMNEGVISGYMSVRKKATEDQIRRAEILFSQLKNTKSFLWKLKEGIQILFKKLGLSGKI
IVYALLVFVPLLFANFEWIRNGMIVLPILGVSCGSVGILFLINTILNYRKEIREIISIQKEIVSGNFLMEIPEKKGNSEI
FEIRSSLRVFVISIWGLLVQIKENFEKNQELYQYLSQSSEQFQSKTQNQAASVEQTASASHELSSTLDEIVKSIHLQSTG
LTAINDGIGKVNESIQNVSKSMDNLSSQTSSVKEKASQSEKTFEKAILAMNEIKEYSNGISNIIGIITSISEKTNLLSLN
ASIESARAGEAGKGFSVVAEEISKLASQTRESIKDIVNLIDNTTKAVNLGAEKFQESLSIVKQLTDYIGEVNSSATIVRA
SLFAQAEKLGEIRKNTDQVNQLGETVSESSGFQKTASDEISLSMQNIAESSELIARTSGEIKQLVDESIRKAAKLYEILK
HFKTS

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=536, Percent_Identity=26.3059701492537, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI1787690, Length=255, Percent_Identity=28.6274509803922, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788195, Length=271, Percent_Identity=26.5682656826568, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI2367378, Length=260, Percent_Identity=26.5384615384615, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788194, Length=263, Percent_Identity=28.1368821292776, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 62869; Mature: 62869

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50112 PAS ; PS00120 LIPASE_SER ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKNLPITSQEITIPINSVLISRTDMKGRISYVSQDFANISGFSEEEMLGEPHNLIRHPD
CCCCCCCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCC
VPSEIFREMWETIQDGNPWSGIIKNRAKSGDYYWVDATVTPVMNEGVISGYMSVRKKATE
CCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECEECCHHHHHHHHHHHHHHHHHHH
DQIRRAEILFSQLKNTKSFLWKLKEGIQILFKKLGLSGKIIVYALLVFVPLLFANFEWIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
NGMIVLPILGVSCGSVGILFLINTILNYRKEIREIISIQKEIVSGNFLMEIPEKKGNSEI
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHH
FEIRSSLRVFVISIWGLLVQIKENFEKNQELYQYLSQSSEQFQSKTQNQAASVEQTASAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELSSTLDEIVKSIHLQSTGLTAINDGIGKVNESIQNVSKSMDNLSSQTSSVKEKASQSE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTFEKAILAMNEIKEYSNGISNIIGIITSISEKTNLLSLNASIESARAGEAGKGFSVVAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHCCCCCCCCHHHHHH
EISKLASQTRESIKDIVNLIDNTTKAVNLGAEKFQESLSIVKQLTDYIGEVNSSATIVRA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SLFAQAEKLGEIRKNTDQVNQLGETVSESSGFQKTASDEISLSMQNIAESSELIARTSGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
IKQLVDESIRKAAKLYEILKHFKTS
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRKNLPITSQEITIPINSVLISRTDMKGRISYVSQDFANISGFSEEEMLGEPHNLIRHPD
CCCCCCCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCC
VPSEIFREMWETIQDGNPWSGIIKNRAKSGDYYWVDATVTPVMNEGVISGYMSVRKKATE
CCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECEECCHHHHHHHHHHHHHHHHHHH
DQIRRAEILFSQLKNTKSFLWKLKEGIQILFKKLGLSGKIIVYALLVFVPLLFANFEWIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
NGMIVLPILGVSCGSVGILFLINTILNYRKEIREIISIQKEIVSGNFLMEIPEKKGNSEI
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHH
FEIRSSLRVFVISIWGLLVQIKENFEKNQELYQYLSQSSEQFQSKTQNQAASVEQTASAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELSSTLDEIVKSIHLQSTGLTAINDGIGKVNESIQNVSKSMDNLSSQTSSVKEKASQSE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTFEKAILAMNEIKEYSNGISNIIGIITSISEKTNLLSLNASIESARAGEAGKGFSVVAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHCCCCCCCCHHHHHH
EISKLASQTRESIKDIVNLIDNTTKAVNLGAEKFQESLSIVKQLTDYIGEVNSSATIVRA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SLFAQAEKLGEIRKNTDQVNQLGETVSESSGFQKTASDEISLSMQNIAESSELIARTSGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
IKQLVDESIRKAAKLYEILKHFKTS
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]