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The map label for this gene is dnaA

Identifier: 45655915

GI number: 45655915

Start: 292

End: 1623

Strand: Direct

Name: dnaA

Synonym: LIC10001

Alternate gene names: 45655915

Gene position: 292-1623 (Clockwise)

Preceding gene: NA

Following gene: 45655916

Centisome position: 0.01

GC content: 31.61

Gene sequence:

>1332_bases
TTGTTTTTGGAGGAAAAATTGAACCTAGTTTGGAATAAAATTTTGGAAGAAGTATCCAAAAAAATATCTCCGCAATATTA
TGAACGGTTCATTGATACACTAAAGTTAGAGACCATTAACTCTGAAAAATGTACAATCATAGCTCCATCTGCCACAATCA
AAACGCACGTAGAAAGAAAATATCAAAGTATTATTGAAAATGCAATTTTAGAAACTTGTGGCGATAAGATTCCAGTGGAA
ATCTTAATCGAAACAAAAGCAGCTTCTCCTCTTCAGTCTATTCTTGAAAAATCTTTTGATCAAAAAGATTTTCAATTTAA
CCCAGATTATACATTTGAAACTTTTATTGTAGGGGATTGTAATCGTTTGGCATATACAGCTGCAAAAGAATGCGTTCGAA
AACCTGCAGAAATCAATCCTCTATATATATTTGGAAGTGTAGGAGTAGGAAAGACACATTTACTTCACGCAATTGGATCA
GAACTTACTAAAAAAGATCCATGGAAAACAGTATGTTATGTAGATATTTCTTCTTTTATGAATGAGTTTCGTTTTGCACT
TCAATCCAGGGAACTTATCGAAAGTTTTAAGATTAAATATCAATCCTATAACTGTCTTATCGTAGATGATATTCAGCTTC
TCTCTACGAATGCTGAAAAAACTCAAGATGAGTTTTTTGCATTGTTTAACTTTTTATTTGAAAGAAAAAGACAAATCGTA
ATCGCTTCGGATCGTCCTAGCTCTGAACTTGCAATTCATGAAAGACTAAAATCTAGATTTGTTACAGGTGTTCAAGCAGA
CATTCAATACCCAGACAGGGAAATTAGAAAAGGAATAGTAACTCATCATTCTAAAATTATGGATCTGGGTTTAAGCGAAG
ATATATTAGATTTTTTAGCAGATCAAATCGAAGAAGATACAAGACTTCTTTTAGGTGCGCTTAACGACATTTATCTATAT
AAAAAATCGTATTCTCTTCTTTTTTTAAATTTAGATAAAGTGAAAGAAATCGTAAAAAACAGACTTTATCGTAAAAAAAA
TATAGAATTTTCTCATGATCGGATTATAGAAGCCGTTGCGAAGGAATTTAATTTAAACACTGCCGAAATTATGGGAAAAA
GTAGAAAGAAAGAATTAATCATTCCGCGTCATATATGTTTTTATTTACTCCACAATGTATTTAACGTGAACAAGTCCCAA
GTTGGAAGACTTTTTCAAACTCAACACACCACAGTAATCCACGGAGTTAGAAAAACCGAGGAACTTCTTTCCAACAATAA
GGAAATGCGTTTTTTAGTAGAACGAATTAGTTCCAAATATAAACTACAATAA

Upstream 100 bases:

>100_bases
AAAATTTTGGAATGCTATAAATGAAAGATCAGTAAACTCAATCGAATTGAGAAAATTTTTTTAATTCGAACTTATATAAA
TTTCTTTAAGAGAGAGTTAA

Downstream 100 bases:

>100_bases
GATTCATTCTACATTTGTAGAGATTGATATTCAAATTTACTCTTATAAAATTTTAGATACGTTTTATTATATAATTTTTA
ACGTGAGTTCGTGGAGAAAT

Product: chromosomal replication initiator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLEEKLNLVWNKILEEVSKKISPQYYERFIDTLKLETINSEKCTIIAPSATIKTHVERKYQSIIENAILETCGDKIPVE
ILIETKAASPLQSILEKSFDQKDFQFNPDYTFETFIVGDCNRLAYTAAKECVRKPAEINPLYIFGSVGVGKTHLLHAIGS
ELTKKDPWKTVCYVDISSFMNEFRFALQSRELIESFKIKYQSYNCLIVDDIQLLSTNAEKTQDEFFALFNFLFERKRQIV
IASDRPSSELAIHERLKSRFVTGVQADIQYPDREIRKGIVTHHSKIMDLGLSEDILDFLADQIEEDTRLLLGALNDIYLY
KKSYSLLFLNLDKVKEIVKNRLYRKKNIEFSHDRIIEAVAKEFNLNTAEIMGKSRKKELIIPRHICFYLLHNVFNVNKSQ
VGRLFQTQHTTVIHGVRKTEELLSNNKEMRFLVERISSKYKLQ

Sequences:

>Translated_443_residues
MFLEEKLNLVWNKILEEVSKKISPQYYERFIDTLKLETINSEKCTIIAPSATIKTHVERKYQSIIENAILETCGDKIPVE
ILIETKAASPLQSILEKSFDQKDFQFNPDYTFETFIVGDCNRLAYTAAKECVRKPAEINPLYIFGSVGVGKTHLLHAIGS
ELTKKDPWKTVCYVDISSFMNEFRFALQSRELIESFKIKYQSYNCLIVDDIQLLSTNAEKTQDEFFALFNFLFERKRQIV
IASDRPSSELAIHERLKSRFVTGVQADIQYPDREIRKGIVTHHSKIMDLGLSEDILDFLADQIEEDTRLLLGALNDIYLY
KKSYSLLFLNLDKVKEIVKNRLYRKKNIEFSHDRIIEAVAKEFNLNTAEIMGKSRKKELIIPRHICFYLLHNVFNVNKSQ
VGRLFQTQHTTVIHGVRKTEELLSNNKEMRFLVERISSKYKLQ
>Mature_443_residues
MFLEEKLNLVWNKILEEVSKKISPQYYERFIDTLKLETINSEKCTIIAPSATIKTHVERKYQSIIENAILETCGDKIPVE
ILIETKAASPLQSILEKSFDQKDFQFNPDYTFETFIVGDCNRLAYTAAKECVRKPAEINPLYIFGSVGVGKTHLLHAIGS
ELTKKDPWKTVCYVDISSFMNEFRFALQSRELIESFKIKYQSYNCLIVDDIQLLSTNAEKTQDEFFALFNFLFERKRQIV
IASDRPSSELAIHERLKSRFVTGVQADIQYPDREIRKGIVTHHSKIMDLGLSEDILDFLADQIEEDTRLLLGALNDIYLY
KKSYSLLFLNLDKVKEIVKNRLYRKKNIEFSHDRIIEAVAKEFNLNTAEIMGKSRKKELIIPRHICFYLLHNVFNVNKSQ
VGRLFQTQHTTVIHGVRKTEELLSNNKEMRFLVERISSKYKLQ

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=448, Percent_Identity=28.125, Blast_Score=189, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_LEPIC (Q72WD6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000001.1
- ProteinModelPortal:   Q72WD6
- SMR:   Q72WD6
- GeneID:   2771345
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10001
- HOGENOM:   HBG695666
- OMA:   DEVAFLI
- ProtClustDB:   PRK00149
- BioCyc:   LINT267671:LIC_10001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51622; Mature: 51622

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLEEKLNLVWNKILEEVSKKISPQYYERFIDTLKLETINSEKCTIIAPSATIKTHVERK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCEEEECCCCHHHHHHHHH
YQSIIENAILETCGDKIPVEILIETKAASPLQSILEKSFDQKDFQFNPDYTFETFIVGDC
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
NRLAYTAAKECVRKPAEINPLYIFGSVGVGKTHLLHAIGSELTKKDPWKTVCYVDISSFM
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHHH
NEFRFALQSRELIESFKIKYQSYNCLIVDDIQLLSTNAEKTQDEFFALFNFLFERKRQIV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCHHHHHHHHHHHHHHHHCCCEEE
IASDRPSSELAIHERLKSRFVTGVQADIQYPDREIRKGIVTHHSKIMDLGLSEDILDFLA
EECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DQIEEDTRLLLGALNDIYLYKKSYSLLFLNLDKVKEIVKNRLYRKKNIEFSHDRIIEAVA
HHHHHHHHHHHHHHHHHEEEEECCEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
KEFNLNTAEIMGKSRKKELIIPRHICFYLLHNVFNVNKSQVGRLFQTQHTTVIHGVRKTE
HHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
ELLSNNKEMRFLVERISSKYKLQ
HHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFLEEKLNLVWNKILEEVSKKISPQYYERFIDTLKLETINSEKCTIIAPSATIKTHVERK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCEEEECCCCHHHHHHHHH
YQSIIENAILETCGDKIPVEILIETKAASPLQSILEKSFDQKDFQFNPDYTFETFIVGDC
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
NRLAYTAAKECVRKPAEINPLYIFGSVGVGKTHLLHAIGSELTKKDPWKTVCYVDISSFM
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHHH
NEFRFALQSRELIESFKIKYQSYNCLIVDDIQLLSTNAEKTQDEFFALFNFLFERKRQIV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCHHHHHHHHHHHHHHHHCCCEEE
IASDRPSSELAIHERLKSRFVTGVQADIQYPDREIRKGIVTHHSKIMDLGLSEDILDFLA
EECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DQIEEDTRLLLGALNDIYLYKKSYSLLFLNLDKVKEIVKNRLYRKKNIEFSHDRIIEAVA
HHHHHHHHHHHHHHHHHEEEEECCEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
KEFNLNTAEIMGKSRKKELIIPRHICFYLLHNVFNVNKSQVGRLFQTQHTTVIHGVRKTE
HHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
ELLSNNKEMRFLVERISSKYKLQ
HHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA