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The map label for this gene is serA

Identifier: 304570495

GI number: 304570495

Start: 2401441

End: 2402664

Strand: Direct

Name: serA

Synonym: NA

Alternate gene names: 304570495

Gene position: 2401441-2402664 (Clockwise)

Preceding gene: 45657843

Following gene: 45657846

Centisome position: 56.15

GC content: 37.66

Gene sequence:

>1224_bases
ATGATTTCATTTCCAAAAGATAAAATTCAAGTTCTCCTTTTAGAAAACGTCCACCAAGACGCATTTGATATGTTCCAAAA
AGATGGATTTAATGTACGCCTTCTTCCCGCTGCCTTTTCGGAAAAAGAACTTTTAGACGAAATCGAAAACATTCATGTTT
TAGGAATTAGAAGTAAAACCAACGTCACTTCCGCCGTTTTAGAAAAAGCCAAAAGACTTTTGACAATTGGTTGTTTTTGT
ATCGGAACCAATCAAGTGGATTTAGTTGGAGCAGAAAAAAAAGGAATCCCTGTTTTTAATGCCCCCTATTCTAATACTCG
TTCCGTAGCGGAATTAGTAATTTCAGAAATCATCATGTTGGCCAGAAGAGTTCCGGATCATATTCGAAATACTCACTCTG
GTATTTGGAATAAAATTTCCAAAAATTGTTTTGAGGTTCGAGGTAAGACGATTGGAATCGTGGGTTATGGTCATATTGGA
AGTCAGGTTTCAGTACTTGCAGAAGCGATGGGAATGAAAGTGATCTACTACGATATTCAAACGGTTCTTCCTCTTGGAAA
TGCAACTCCAGTTTCTAGTTACGAAGAACTTTTAAAAAATTCGGACTTTATTTCTTTTCACGTTCCCGAAACTCCACAAA
CGATGAATCTTTATGGAAAAAAAGAAATCGAAGTTACTAAAAAAGGCGCTTATATGATCAACCTTTCCAGAGGGAAGGTT
GTGGATCTGGAAGCTCTTGCAAAAGCAATCCAATCGGGTCATATTGCTGGAGCGGGAATAGACGTTTTTCCGGAAGAACC
CGAATCCAACAACGATCCATTTCTAACTCCTATGCAAAATCTGCCGAATGTAATTTTGACTCCTCATATAGGCGGTAGTA
CCGAAGAAGCTCAAAGAAACATCGGTTCCGAAGTAGCCAGTAAACTTTTGAAATTCATAAACAACGGTTCCACTACATTT
TCCGTAAATTTTCCTAATTTGGAAATTACTCCGTTACCCGCAGGTCAATATAGAATTTTGAACGTCCATAAAAACCAACC
AGGGTTTTTAAAAGACATCAACTCTATGGTATCCGCAATCGGCGCCAATATCAGTTCCCAACATTTAGGAACCAGTGCAG
AAATCGGTTATCTTTCCATGGTAATCGATAAATCTGTAGGAGACGAATTGAAAGAAAAAATCGAAAAACATCCTTTTTCG
ATCAAAACTAGGATTCTTTACTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:
NA

Sequences:

>Translated_407_residues
MISFPKDKIQVLLLENVHQDAFDMFQKDGFNVRLLPAAFSEKELLDEIENIHVLGIRSKTNVTSAVLEKAKRLLTIGCFC
IGTNQVDLVGAEKKGIPVFNAPYSNTRSVAELVISEIIMLARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIG
SQVSVLAEAMGMKVIYYDIQTVLPLGNATPVSSYEELLKNSDFISFHVPETPQTMNLYGKKEIEVTKKGAYMINLSRGKV
VDLEALAKAIQSGHIAGAGIDVFPEEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQRNIGSEVASKLLKFINNGSTTF
SVNFPNLEITPLPAGQYRILNVHKNQPGFLKDINSMVSAIGANISSQHLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFS
IKTRILY
>Mature_407_residues
MISFPKDKIQVLLLENVHQDAFDMFQKDGFNVRLLPAAFSEKELLDEIENIHVLGIRSKTNVTSAVLEKAKRLLTIGCFC
IGTNQVDLVGAEKKGIPVFNAPYSNTRSVAELVISEIIMLARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIG
SQVSVLAEAMGMKVIYYDIQTVLPLGNATPVSSYEELLKNSDFISFHVPETPQTMNLYGKKEIEVTKKGAYMINLSRGKV
VDLEALAKAIQSGHIAGAGIDVFPEEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQRNIGSEVASKLLKFINNGSTTF
SVNFPNLEITPLPAGQYRILNVHKNQPGFLKDINSMVSAIGANISSQHLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFS
IKTRILY

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=321, Percent_Identity=35.202492211838, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4557497, Length=291, Percent_Identity=28.8659793814433, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI61743967, Length=291, Percent_Identity=28.8659793814433, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI145580578, Length=290, Percent_Identity=30, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4557499, Length=290, Percent_Identity=30, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI145580575, Length=291, Percent_Identity=29.8969072164948, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI6912396, Length=276, Percent_Identity=31.8840579710145, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=50.3667481662592, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=30.8880308880309, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=29.6, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788660, Length=274, Percent_Identity=30.2919708029197, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081824, Length=195, Percent_Identity=28.7179487179487, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=311, Percent_Identity=33.1189710610932, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=30.1158301158301, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=418, Percent_Identity=49.0430622009569, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322116, Length=418, Percent_Identity=48.3253588516746, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=30.859375, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=227, Percent_Identity=28.1938325991189, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324980, Length=197, Percent_Identity=31.9796954314721, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=29.5454545454545, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=30.3225806451613, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=30.2180685358255, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI28574286, Length=278, Percent_Identity=30.2158273381295, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=272, Percent_Identity=30.8823529411765, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646448, Length=272, Percent_Identity=30.8823529411765, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646452, Length=272, Percent_Identity=30.8823529411765, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646450, Length=272, Percent_Identity=30.8823529411765, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI62472511, Length=272, Percent_Identity=30.8823529411765, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=25.4019292604502, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=25.4019292604502, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24585514, Length=311, Percent_Identity=25.4019292604502, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574282, Length=311, Percent_Identity=25.4019292604502, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=25.4019292604502, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=25.7142857142857, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571528, Length=258, Percent_Identity=27.5193798449612, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44789; Mature: 44789

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFPKDKIQVLLLENVHQDAFDMFQKDGFNVRLLPAAFSEKELLDEIENIHVLGIRSKT
CCCCCCHHHEEEEHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCEEEEEECCCC
NVTSAVLEKAKRLLTIGCFCIGTNQVDLVGAEKKGIPVFNAPYSNTRSVAELVISEIIML
HHHHHHHHHHHHHHEEEEEEEECCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIGSQVSVLAEAMGMKVIYYDIQ
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEEE
TVLPLGNATPVSSYEELLKNSDFISFHVPETPQTMNLYGKKEIEVTKKGAYMINLSRGKV
HHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCEECCCCEEEEEEECCEEEEEECCCCE
VDLEALAKAIQSGHIAGAGIDVFPEEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQRN
ECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCHHHCCCEEEECCCCCCHHHHHHH
IGSEVASKLLKFINNGSTTFSVNFPNLEITPLPAGQYRILNVHKNQPGFLKDINSMVSAI
HHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
GANISSQHLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFSIKTRILY
CCCCCHHHCCCCCCCCHHEEEHHHHCCHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure
MISFPKDKIQVLLLENVHQDAFDMFQKDGFNVRLLPAAFSEKELLDEIENIHVLGIRSKT
CCCCCCHHHEEEEHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCEEEEEECCCC
NVTSAVLEKAKRLLTIGCFCIGTNQVDLVGAEKKGIPVFNAPYSNTRSVAELVISEIIML
HHHHHHHHHHHHHHEEEEEEEECCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIGSQVSVLAEAMGMKVIYYDIQ
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEEE
TVLPLGNATPVSSYEELLKNSDFISFHVPETPQTMNLYGKKEIEVTKKGAYMINLSRGKV
HHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCEECCCCEEEEEEECCEEEEEECCCCE
VDLEALAKAIQSGHIAGAGIDVFPEEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQRN
ECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCHHHCCCEEEECCCCCCHHHHHHH
IGSEVASKLLKFINNGSTTFSVNFPNLEITPLPAGQYRILNVHKNQPGFLKDINSMVSAI
HHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
GANISSQHLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFSIKTRILY
CCCCCHHHCCCCCCCCHHEEEHHHHCCHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]