Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 45359265

GI number: 45359265

Start: 1642986

End: 1643999

Strand: Direct

Name: hom [H]

Synonym: MMP1702

Alternate gene names: 45359265

Gene position: 1642986-1643999 (Clockwise)

Preceding gene: 45359264

Following gene: 45359266

Centisome position: 98.91

GC content: 34.32

Gene sequence:

>1014_bases
ATGAAGATAATACTTGTAGGATTTGGAATAATTGGTAAGGGTGTTTTAAAGGCCATTAATCTCAAATCAGAACATTTAAA
GAAAAAATATGGATTAGATTTAAAAGTTGCTGCGATTTGTGACCGCAGTGGTGCTGCAATTGATGAAGAAGGCCTTGATT
TAGAACTAGCCTTAAAAGTTAAAGAAGAAACAAGAAAAATATCAAATTATCCCGAAAAAGGATGTAAAATGGATATTTTA
GAAGTTATAGAATCTGTAAATGCAGATGTGGTTGTAGAAGTAAGCCCCACAAACATTGAAACTGGCGAACCTGCAAAATC
ATACATGTTAAAAGCATTTGAAACCAAAAAACACGTCGTGAGTGCAAACAAAGGCCCTCTTGCAGTTTCATTTAAAGAAT
TAGTAACTGCAGCAGAAAAAAATAAATTATGTTTTAGATATGAAGCTTCAGTCGGTGGCGCAATGCCGATAATCAATCTT
GCAAAGGAAACATTGGCAGGAAACGATGTTAAATTAATAAAAGGAATTTTAAACGGGACTACAAACTACATTTTAACCAA
AATGGAAAAAGAACAGCTTGATTTTGATACAGTATTAAAAGAAGCTCAAGAACTTGGAATTGCGGAAACAAATCCCCACC
AAGACATCAGCGGACTTGATACTGCTGCAAAAATTGTAATTTTAGCAAATTCAATATTTGGACGAGATGTAACAATTAAA
GACGTAAATTTAGAAGGAATAACAAGAATTACGCCTGAAGCACTCGTTATGGCAAATAAAAGTGGCCATACAATAAAATT
AATAGGCGAAGTTACTGACAAAAAACTCGAAGTTTGCCCAAAACTTGTGCCTGTTGACAGCCCCTTGAATGTTATGGGCT
GTTTAAATGTTGCAATGTTTGATACAGATCTTGCAAACGATATCGTGGTTGTAGGAACCGGTGCAGGAGATATTGAAACT
GCATCTGCCATATTAAGCGATTTAATAAATATTCACCAGACTATTAAAAATTAA

Upstream 100 bases:

>100_bases
CGATAGATAACGAAAAATTAAAAGAACTTTATGACGAATTTGATAAGATAGCCAAAGAAAAAGGTTTGTTATTTATTAAA
TCATGCTAAGGGGATAATTT

Downstream 100 bases:

>100_bases
TAACTCTTTTTTTAAAACGTTTTTTAATAAAGTTTAAAAGGAACGTAAACAAAAAGACTTATATATCTTTAAAAAGAGTT
TATATCTTGGCTTCGTGGCA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKIILVGFGIIGKGVLKAINLKSEHLKKKYGLDLKVAAICDRSGAAIDEEGLDLELALKVKEETRKISNYPEKGCKMDIL
EVIESVNADVVVEVSPTNIETGEPAKSYMLKAFETKKHVVSANKGPLAVSFKELVTAAEKNKLCFRYEASVGGAMPIINL
AKETLAGNDVKLIKGILNGTTNYILTKMEKEQLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSIFGRDVTIK
DVNLEGITRITPEALVMANKSGHTIKLIGEVTDKKLEVCPKLVPVDSPLNVMGCLNVAMFDTDLANDIVVVGTGAGDIET
ASAILSDLINIHQTIKN

Sequences:

>Translated_337_residues
MKIILVGFGIIGKGVLKAINLKSEHLKKKYGLDLKVAAICDRSGAAIDEEGLDLELALKVKEETRKISNYPEKGCKMDIL
EVIESVNADVVVEVSPTNIETGEPAKSYMLKAFETKKHVVSANKGPLAVSFKELVTAAEKNKLCFRYEASVGGAMPIINL
AKETLAGNDVKLIKGILNGTTNYILTKMEKEQLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSIFGRDVTIK
DVNLEGITRITPEALVMANKSGHTIKLIGEVTDKKLEVCPKLVPVDSPLNVMGCLNVAMFDTDLANDIVVVGTGAGDIET
ASAILSDLINIHQTIKN
>Mature_337_residues
MKIILVGFGIIGKGVLKAINLKSEHLKKKYGLDLKVAAICDRSGAAIDEEGLDLELALKVKEETRKISNYPEKGCKMDIL
EVIESVNADVVVEVSPTNIETGEPAKSYMLKAFETKKHVVSANKGPLAVSFKELVTAAEKNKLCFRYEASVGGAMPIINL
AKETLAGNDVKLIKGILNGTTNYILTKMEKEQLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSIFGRDVTIK
DVNLEGITRITPEALVMANKSGHTIKLIGEVTDKKLEVCPKLVPVDSPLNVMGCLNVAMFDTDLANDIVVVGTGAGDIET
ASAILSDLINIHQTIKN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=348, Percent_Identity=27.0114942528736, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790376, Length=361, Percent_Identity=22.7146814404432, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 36295; Mature: 36295

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIILVGFGIIGKGVLKAINLKSEHLKKKYGLDLKVAAICDRSGAAIDEEGLDLELALKV
CEEEEEECCHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
KEETRKISNYPEKGCKMDILEVIESVNADVVVEVSPTNIETGEPAKSYMLKAFETKKHVV
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
SANKGPLAVSFKELVTAAEKNKLCFRYEASVGGAMPIINLAKETLAGNDVKLIKGILNGT
CCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCC
TNYILTKMEKEQLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSIFGRDVTIK
CHHEEEECHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCEEEE
DVNLEGITRITPEALVMANKSGHTIKLIGEVTDKKLEVCPKLVPVDSPLNVMGCLNVAMF
ECCCCCCEECCCCCEEEECCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHEE
DTDLANDIVVVGTGAGDIETASAILSDLINIHQTIKN
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIILVGFGIIGKGVLKAINLKSEHLKKKYGLDLKVAAICDRSGAAIDEEGLDLELALKV
CEEEEEECCHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
KEETRKISNYPEKGCKMDILEVIESVNADVVVEVSPTNIETGEPAKSYMLKAFETKKHVV
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
SANKGPLAVSFKELVTAAEKNKLCFRYEASVGGAMPIINLAKETLAGNDVKLIKGILNGT
CCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCC
TNYILTKMEKEQLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSIFGRDVTIK
CHHEEEECHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCEEEE
DVNLEGITRITPEALVMANKSGHTIKLIGEVTDKKLEVCPKLVPVDSPLNVMGCLNVAMF
ECCCCCCEECCCCCEEEECCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHEE
DTDLANDIVVVGTGAGDIETASAILSDLINIHQTIKN
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]