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The map label for this gene is opuE [H]

Identifier: 45359263

GI number: 45359263

Start: 1640720

End: 1642321

Strand: Direct

Name: opuE [H]

Synonym: MMP1700

Alternate gene names: 45359263

Gene position: 1640720-1642321 (Clockwise)

Preceding gene: 45359262

Following gene: 45359264

Centisome position: 98.77

GC content: 37.77

Gene sequence:

>1602_bases
ATGAATATCCTTCTTCTAAACGTGATTGTTTTAATATATTTGTTAGTTATTGGATACCTTGGATACAAAGGTTGGAAAGG
AACTTCAAGTGCTGAAGACTACATGGTCGGAGGTAGAAAAATCCACCCATTCGTTATGGCAATGAGCTACGGTGCTACAT
TTATCAGTACTGCTGCAATTGTTGGTTTTGGTGGATTCTCAGGACTATTTGGTATGAGTTTGCTCTGGCTGACGTTTCTA
AATATATTTTTAGGTATCTTTATAGCATTTGTATTTTTTGGGAAAAGAACTAGAAAAATGGGGCATAACTTAAATGCACT
GACATTTCCTGAGCTACTGGCAAAAAGATTCGAAAGTAAATTTATACAGTGGTTTTCAGGGCTTTTAATATTTTGTGCAA
TGCCAATTTATGCAGCAGCAGTTTTGATTGGTGCTGCAAGATTTATAGAAACTACACTTAATATTTCATTTGACGTTGCA
CTGCTTGTATTTTCCATAATTATCGCAGTATATGTCGTAATGGGTGGATTAAAAGGTGTTATGTACACGGATGCGTTCCA
AGGAACAATTATGTTTTTTGGAATGTTGTTTTTGCTATACATGACTTATGATATCCTCGGTGGAGTTACCACAGCCCACC
AGGCAATTTCAAATATGTCAGGGTTAGTTCCAGCAAACCTTGCAAGTGTCGGACATGCAGGGTGGACTTCGATGCCGACT
TTTGGTTCTCCGATGTGGTGGACAATTGTTTCGAGCATAATTTTAGGTGTTGGAATCGGAGTTTTAGCACAACCTCAACT
TATTGTTAGATTCATGACTGTAAAAAGTAACAGGGAATTAAACAGGGCTGTTTTGATTGGTGCAGTCTTTATTTTAATTG
CAACAGGTACTGCATACGTTGTAGGAACCCTTTCAAACGTTTATTTCATGAATACTGAAGGTGTTCTTTCAATTGGTGCA
ACAGTGTCTGAAGCATTCCCTACAGGAAACAGCGACAGTATCATGCCGTTATATATCAACAAAGCAATGCCAGAATGGTT
TATTTACATATTCTTGGTTTCACTGCTTGCAGCTGCAATGTCAACAATTTCAAGCCAGTTCCACGCTCAAGGAACATCTA
TTGGAAGGGATGTTTATGAAACCATTTGTGGTAAAAAAGGATTAAATTCAGTAATTATAACGAGATTAGGAATTATTGTT
GCAATTGTAATTGCTGCAATTCTTGGATACATTCTTCCAGGAGGAATAGTTGCAAGAGGAACTGCATTATTCTTTGGACT
CTGCAGTGCTGCGTTTTTACCAGCATACGCGTTAGGACTATTCTGGAAAAGAACCACAAAAGAAGGAGCAATTGCAGGTC
TTTTAACAGGTACTTTTGTAAGTCTGTTCTGCTTAGTATTCATTCATCAAGCAGAATCAGCAGCACTTGGAATTTCAAAA
ATGCTGATTGGTAGAGATGTTTTGATTTCCGCGATGCCCTGGCCTTATGTAGACCCAATGGTAATCTCCCTACCGCTTGC
ATTTATTGCAACCGTAATAGTAAGTCTTTTAACTAAAGCGCCGTCAAAAGAACATTTGAAAAAGTGCTTTAAAGGAATTT
AA

Upstream 100 bases:

>100_bases
GAATAAAGGTTCAGAAACCGAAAAAGAAGAAATTGAAGAACAGTTGGACTGGGAAAAAGAAGAAGAAAAGATGGAAGATG
AAATCGGAACGGTGGTCTAA

Downstream 100 bases:

>100_bases
TTCTTTTTTCGTTTTTTATTTTTCAGCTATCAATTTTTTAATAATCTCGAGCGCGTCCGATCGTTCAAATCTAACTTTTA
AGGGGCTTTGGTCTAATATT

Product: SSS sodium solute transporter superfamily

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MNILLLNVIVLIYLLVIGYLGYKGWKGTSSAEDYMVGGRKIHPFVMAMSYGATFISTAAIVGFGGFSGLFGMSLLWLTFL
NIFLGIFIAFVFFGKRTRKMGHNLNALTFPELLAKRFESKFIQWFSGLLIFCAMPIYAAAVLIGAARFIETTLNISFDVA
LLVFSIIIAVYVVMGGLKGVMYTDAFQGTIMFFGMLFLLYMTYDILGGVTTAHQAISNMSGLVPANLASVGHAGWTSMPT
FGSPMWWTIVSSIILGVGIGVLAQPQLIVRFMTVKSNRELNRAVLIGAVFILIATGTAYVVGTLSNVYFMNTEGVLSIGA
TVSEAFPTGNSDSIMPLYINKAMPEWFIYIFLVSLLAAAMSTISSQFHAQGTSIGRDVYETICGKKGLNSVIITRLGIIV
AIVIAAILGYILPGGIVARGTALFFGLCSAAFLPAYALGLFWKRTTKEGAIAGLLTGTFVSLFCLVFIHQAESAALGISK
MLIGRDVLISAMPWPYVDPMVISLPLAFIATVIVSLLTKAPSKEHLKKCFKGI

Sequences:

>Translated_533_residues
MNILLLNVIVLIYLLVIGYLGYKGWKGTSSAEDYMVGGRKIHPFVMAMSYGATFISTAAIVGFGGFSGLFGMSLLWLTFL
NIFLGIFIAFVFFGKRTRKMGHNLNALTFPELLAKRFESKFIQWFSGLLIFCAMPIYAAAVLIGAARFIETTLNISFDVA
LLVFSIIIAVYVVMGGLKGVMYTDAFQGTIMFFGMLFLLYMTYDILGGVTTAHQAISNMSGLVPANLASVGHAGWTSMPT
FGSPMWWTIVSSIILGVGIGVLAQPQLIVRFMTVKSNRELNRAVLIGAVFILIATGTAYVVGTLSNVYFMNTEGVLSIGA
TVSEAFPTGNSDSIMPLYINKAMPEWFIYIFLVSLLAAAMSTISSQFHAQGTSIGRDVYETICGKKGLNSVIITRLGIIV
AIVIAAILGYILPGGIVARGTALFFGLCSAAFLPAYALGLFWKRTTKEGAIAGLLTGTFVSLFCLVFIHQAESAALGISK
MLIGRDVLISAMPWPYVDPMVISLPLAFIATVIVSLLTKAPSKEHLKKCFKGI
>Mature_533_residues
MNILLLNVIVLIYLLVIGYLGYKGWKGTSSAEDYMVGGRKIHPFVMAMSYGATFISTAAIVGFGGFSGLFGMSLLWLTFL
NIFLGIFIAFVFFGKRTRKMGHNLNALTFPELLAKRFESKFIQWFSGLLIFCAMPIYAAAVLIGAARFIETTLNISFDVA
LLVFSIIIAVYVVMGGLKGVMYTDAFQGTIMFFGMLFLLYMTYDILGGVTTAHQAISNMSGLVPANLASVGHAGWTSMPT
FGSPMWWTIVSSIILGVGIGVLAQPQLIVRFMTVKSNRELNRAVLIGAVFILIATGTAYVVGTLSNVYFMNTEGVLSIGA
TVSEAFPTGNSDSIMPLYINKAMPEWFIYIFLVSLLAAAMSTISSQFHAQGTSIGRDVYETICGKKGLNSVIITRLGIIV
AIVIAAILGYILPGGIVARGTALFFGLCSAAFLPAYALGLFWKRTTKEGAIAGLLTGTFVSLFCLVFIHQAESAALGISK
MLIGRDVLISAMPWPYVDPMVISLPLAFIATVIVSLLTKAPSKEHLKKCFKGI

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=535, Percent_Identity=26.5420560747664, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4507035, Length=429, Percent_Identity=21.4452214452214, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI14140236, Length=469, Percent_Identity=21.9616204690832, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI109659836, Length=390, Percent_Identity=23.5897435897436, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI110835708, Length=558, Percent_Identity=23.1182795698925, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI17941285, Length=431, Percent_Identity=26.6821345707657, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI109659839, Length=400, Percent_Identity=23, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87082237, Length=428, Percent_Identity=25.7009345794392, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1787251, Length=534, Percent_Identity=25.8426966292135, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790503, Length=546, Percent_Identity=21.0622710622711, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533094, Length=456, Percent_Identity=23.9035087719298, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24645928, Length=398, Percent_Identity=25.1256281407035, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221459584, Length=462, Percent_Identity=24.8917748917749, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 57530; Mature: 57530

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLLNVIVLIYLLVIGYLGYKGWKGTSSAEDYMVGGRKIHPFVMAMSYGATFISTAAI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEECHHHHHHHHCHHHHHHHHH
VGFGGFSGLFGMSLLWLTFLNIFLGIFIAFVFFGKRTRKMGHNLNALTFPELLAKRFESK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FIQWFSGLLIFCAMPIYAAAVLIGAARFIETTLNISFDVALLVFSIIIAVYVVMGGLKGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHH
MYTDAFQGTIMFFGMLFLLYMTYDILGGVTTAHQAISNMSGLVPANLASVGHAGWTSMPT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC
FGSPMWWTIVSSIILGVGIGVLAQPQLIVRFMTVKSNRELNRAVLIGAVFILIATGTAYV
CCCCHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHH
VGTLSNVYFMNTEGVLSIGATVSEAFPTGNSDSIMPLYINKAMPEWFIYIFLVSLLAAAM
HHHHCCEEEECCCCCCEECCHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
STISSQFHAQGTSIGRDVYETICGKKGLNSVIITRLGIIVAIVIAAILGYILPGGIVARG
HHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TALFFGLCSAAFLPAYALGLFWKRTTKEGAIAGLLTGTFVSLFCLVFIHQAESAALGISK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLIGRDVLISAMPWPYVDPMVISLPLAFIATVIVSLLTKAPSKEHLKKCFKGI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNILLLNVIVLIYLLVIGYLGYKGWKGTSSAEDYMVGGRKIHPFVMAMSYGATFISTAAI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEECHHHHHHHHCHHHHHHHHH
VGFGGFSGLFGMSLLWLTFLNIFLGIFIAFVFFGKRTRKMGHNLNALTFPELLAKRFESK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FIQWFSGLLIFCAMPIYAAAVLIGAARFIETTLNISFDVALLVFSIIIAVYVVMGGLKGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHH
MYTDAFQGTIMFFGMLFLLYMTYDILGGVTTAHQAISNMSGLVPANLASVGHAGWTSMPT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC
FGSPMWWTIVSSIILGVGIGVLAQPQLIVRFMTVKSNRELNRAVLIGAVFILIATGTAYV
CCCCHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHH
VGTLSNVYFMNTEGVLSIGATVSEAFPTGNSDSIMPLYINKAMPEWFIYIFLVSLLAAAM
HHHHCCEEEECCCCCCEECCHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
STISSQFHAQGTSIGRDVYETICGKKGLNSVIITRLGIIVAIVIAAILGYILPGGIVARG
HHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TALFFGLCSAAFLPAYALGLFWKRTTKEGAIAGLLTGTFVSLFCLVFIHQAESAALGISK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLIGRDVLISAMPWPYVDPMVISLPLAFIATVIVSLLTKAPSKEHLKKCFKGI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]