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The map label for this gene is fadA [C]

Identifier: 45358775

GI number: 45358775

Start: 1199123

End: 1200301

Strand: Direct

Name: fadA [C]

Synonym: MMP1212

Alternate gene names: 45358775

Gene position: 1199123-1200301 (Clockwise)

Preceding gene: 45358774

Following gene: 45358776

Centisome position: 72.19

GC content: 41.14

Gene sequence:

>1179_bases
ATGAAGGATGTAGCAATTATAGGATACGGACAGACCAAATTTGGTGAACTCTGGGAAGAATCATTCAGAAGTTTAATTGT
GGAAGCAGGAGTTAAAGCAATTAGTGATGCAAACGTTGATGGAGACGACATTGATGCAATGTACGTCGGTACCATGAGTG
GAGGTCTTTTCGTAGGACAGGAACACTCTGCATCATTAATTGCAGACTATGCAGGATTAAACCCTGTTCCATGTACCAGA
GTTGAAGCTGCATGTGCTTCTGGAAGTTTAGCATTGAGAAGTGCATGTTTATCTATTGCAAGTGGTGCACACGATGTTGT
TTTAGTAGGCGGTGTTGAAAAAATGACTGATGTTGCAGACGCAACTTCAGCAATCGCAACAGCATCAGACCAGGAATGGG
AAGCTTTCGTTGGTGCAACATTCCCATCACTCTATGCAATGATGGCAAAAAGATACATGCATGAATACGGGCTAACCATT
GAACAGCTTTCAAGCTGGAGTGCTATTGCTCACGAAAATGCAGTTCATAACAAATACGCACAGTTCAGATCAAAAGTAAC
GATTGATCAGGTTATGAGAGCTTCGCCAGTTGCAGACCCATTAACATTATTACACTGCTCACCGGTTTCAGATGGTGCTT
CAGCACTTATCATCTGTGATGCAGAAAAAGCAACAGAATATGCTCCAAAAGATGAAATCATTTACATAAAAGCGTCTACT
CAGGCATCTGACACTATTGCACTGCACGACAGAAAAGATATGACTACATTGAATGCTGCAAAAGTTGCATCAGACAAAGC
ATACAAAATTGCAGGAATTGATGCTAAAAAAGTTGACGTTGCAGAAGTTCACGATTGTTTTGCAATTAATGGATTGGTAT
TAACTGAAGACCTCGGATTCTGTAAAAAAGGAGATGCGGGAAAAGTTGTAGAATCTGGAAAAACTAGAATCGACGACGAA
AGCTTCGTTACAGTAAACCCAAGTGGTGGATTAAAAGCTGCTGGCCACGCATTAGGTGCTACAGGTATCAGACAGGTCGG
TGAACTTTACTGGCAGTTAAAACAGGATAAAGAATGTAAAGATAGACAGGCTGCAATTAAAAACGGATACGCTATTGCAG
CAAATGTCGGTGGAACAGGCGGTACAGTCTGTACTCACGTTTTATCAAACAAAAGATAA

Upstream 100 bases:

>100_bases
AACAACTGAAAAACTTTTAGAACAGAAAAAATACGTTGATTATGCAGTTTACTTGAAATACAGAGGAAAAATTAGAATGT
AACTTCATCAGGTGGATAAA

Downstream 100 bases:

>100_bases
TTAATAATTTAAGCTAAAAAATGATTTCCGGTGAGATTATGGTAGTAAGAACCTGGAGAAGCATGCAAGAAAGGTACAAC
CTTATTGGATCAAAATGTAA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKDVAIIGYGQTKFGELWEESFRSLIVEAGVKAISDANVDGDDIDAMYVGTMSGGLFVGQEHSASLIADYAGLNPVPCTR
VEAACASGSLALRSACLSIASGAHDVVLVGGVEKMTDVADATSAIATASDQEWEAFVGATFPSLYAMMAKRYMHEYGLTI
EQLSSWSAIAHENAVHNKYAQFRSKVTIDQVMRASPVADPLTLLHCSPVSDGASALIICDAEKATEYAPKDEIIYIKAST
QASDTIALHDRKDMTTLNAAKVASDKAYKIAGIDAKKVDVAEVHDCFAINGLVLTEDLGFCKKGDAGKVVESGKTRIDDE
SFVTVNPSGGLKAAGHALGATGIRQVGELYWQLKQDKECKDRQAAIKNGYAIAANVGGTGGTVCTHVLSNKR

Sequences:

>Translated_392_residues
MKDVAIIGYGQTKFGELWEESFRSLIVEAGVKAISDANVDGDDIDAMYVGTMSGGLFVGQEHSASLIADYAGLNPVPCTR
VEAACASGSLALRSACLSIASGAHDVVLVGGVEKMTDVADATSAIATASDQEWEAFVGATFPSLYAMMAKRYMHEYGLTI
EQLSSWSAIAHENAVHNKYAQFRSKVTIDQVMRASPVADPLTLLHCSPVSDGASALIICDAEKATEYAPKDEIIYIKAST
QASDTIALHDRKDMTTLNAAKVASDKAYKIAGIDAKKVDVAEVHDCFAINGLVLTEDLGFCKKGDAGKVVESGKTRIDDE
SFVTVNPSGGLKAAGHALGATGIRQVGELYWQLKQDKECKDRQAAIKNGYAIAANVGGTGGTVCTHVLSNKR
>Mature_392_residues
MKDVAIIGYGQTKFGELWEESFRSLIVEAGVKAISDANVDGDDIDAMYVGTMSGGLFVGQEHSASLIADYAGLNPVPCTR
VEAACASGSLALRSACLSIASGAHDVVLVGGVEKMTDVADATSAIATASDQEWEAFVGATFPSLYAMMAKRYMHEYGLTI
EQLSSWSAIAHENAVHNKYAQFRSKVTIDQVMRASPVADPLTLLHCSPVSDGASALIICDAEKATEYAPKDEIIYIKAST
QASDTIALHDRKDMTTLNAAKVASDKAYKIAGIDAKKVDVAEVHDCFAINGLVLTEDLGFCKKGDAGKVVESGKTRIDDE
SFVTVNPSGGLKAAGHALGATGIRQVGELYWQLKQDKECKDRQAAIKNGYAIAANVGGTGGTVCTHVLSNKR

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=400, Percent_Identity=31.75, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI302344760, Length=326, Percent_Identity=31.9018404907975, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI302344767, Length=322, Percent_Identity=31.9875776397516, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI302344762, Length=307, Percent_Identity=31.2703583061889, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI55956775, Length=264, Percent_Identity=30.6818181818182, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17537653, Length=384, Percent_Identity=31.5104166666667, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19921506, Length=393, Percent_Identity=29.7709923664122, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24585051, Length=393, Percent_Identity=29.7709923664122, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41453; Mature: 41453

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVAIIGYGQTKFGELWEESFRSLIVEAGVKAISDANVDGDDIDAMYVGTMSGGLFVGQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEC
EHSASLIADYAGLNPVPCTRVEAACASGSLALRSACLSIASGAHDVVLVGGVEKMTDVAD
CCCHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHH
ATSAIATASDQEWEAFVGATFPSLYAMMAKRYMHEYGLTIEQLSSWSAIAHENAVHNKYA
HHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHH
QFRSKVTIDQVMRASPVADPLTLLHCSPVSDGASALIICDAEKATEYAPKDEIIYIKAST
HHHHCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEECHHHHCCCCCCCEEEEEECC
QASDTIALHDRKDMTTLNAAKVASDKAYKIAGIDAKKVDVAEVHDCFAINGLVLTEDLGF
CCCCEEEEECCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHEECCEEEECCCCC
CKKGDAGKVVESGKTRIDDESFVTVNPSGGLKAAGHALGATGIRQVGELYWQLKQDKECK
CCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCCHH
DRQAAIKNGYAIAANVGGTGGTVCTHVLSNKR
HHHHHHHCCEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKDVAIIGYGQTKFGELWEESFRSLIVEAGVKAISDANVDGDDIDAMYVGTMSGGLFVGQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEC
EHSASLIADYAGLNPVPCTRVEAACASGSLALRSACLSIASGAHDVVLVGGVEKMTDVAD
CCCHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHH
ATSAIATASDQEWEAFVGATFPSLYAMMAKRYMHEYGLTIEQLSSWSAIAHENAVHNKYA
HHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHH
QFRSKVTIDQVMRASPVADPLTLLHCSPVSDGASALIICDAEKATEYAPKDEIIYIKAST
HHHHCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEECHHHHCCCCCCCEEEEEECC
QASDTIALHDRKDMTTLNAAKVASDKAYKIAGIDAKKVDVAEVHDCFAINGLVLTEDLGF
CCCCEEEEECCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHEECCEEEECCCCC
CKKGDAGKVVESGKTRIDDESFVTVNPSGGLKAAGHALGATGIRQVGELYWQLKQDKECK
CCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCCHH
DRQAAIKNGYAIAANVGGTGGTVCTHVLSNKR
HHHHHHHCCEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]