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The map label for this gene is fabH [C]

Identifier: 45358774

GI number: 45358774

Start: 1198055

End: 1199104

Strand: Direct

Name: fabH [C]

Synonym: MMP1211

Alternate gene names: 45358774

Gene position: 1198055-1199104 (Clockwise)

Preceding gene: 45358773

Following gene: 45358775

Centisome position: 72.12

GC content: 39.33

Gene sequence:

>1050_bases
ATGAAAGAAGTAGGTATTGTAGGATATGGAAGTGACCTTCCAAAATACAGAATAAAAGCTGAAGATATCGCTGGTGCTTG
GGGTAAAGACGCTCAAGCAATCAAAAGAGGTCTTGTTGTAAACGAAAAAAGCGTTCCAGGACCTGACGAAGACACTGCAA
CAATTGCAGTACAATCTGCAAGAAGAGCATTATCAAGAGCAGGAATTAATCCAAAAGATATTGGTGCTGTTTACGTAGGA
AGTGAAAGCCACCCTTACGCAGTAAAACCAACATCTGGAATTGTTGCTGAGGCATGTGGTGTATCACCAGATTTTACCGC
TGCAGATTTAGAATTTGCATGTAAAGCAGGAACTGCAGGAATCCAGATGTGTATGGGTTTAGTTGGAAGCGAAATGATGG
AATATGCTATGGCAGTTGGTGCAGATACTGCTCAAGGTGCTCCAGGTGATGCCCTTGAATACACTGCTGCAGCAGGTGGT
GCAGCATTTATTATCGGTGCAAAAAAAGAAGAATTTATCGCTAAATTTAACGGAACTTACTCTTACACCACAGACACTCC
CGATTTCTGGAGAAGAGAACATGAACACTACCCAAAACACGGTGGTAGATTTACAGGTGAACCTGCATACTTTAAACACG
TTTTAAACGGTGCAAAAGGTATGATGGAAAAAATGGGTACAACATCAAAAGATTACGATTACTGTGTATTCCACCAGCCT
AATGGAAAATTCTACCTAACTGCGGCTAAAAAATTAGGATTTACAGAAGAACAGTACAAATATGGACTTTTAACACCATA
TTTAGGAAACACATACTCAGGAGCCGTTCCACTTGGACTTTCGAACATTTTAGACCATGCAAAAGCAGACGACAGAATAT
TCGTTGTTTCATACGGTAGTGGTGCAGGAAGTGACGCATTTGACATTACTGTAACTGACAGGATTTCAGAAGTAGTTGAC
AAAGAAATAACAACTGAAAAACTTTTAGAACAGAAAAAATACGTTGATTATGCAGTTTACTTGAAATACAGAGGAAAAAT
TAGAATGTAA

Upstream 100 bases:

>100_bases
CCGATGAGCTTTTAAAACGATTAAAAGAAATGAAATAATTTTTTTTGTTTATATTGTTATGAATTTAACAATTGTTCATT
AACAAAAAAATGGTGAGCAA

Downstream 100 bases:

>100_bases
CTTCATCAGGTGGATAAAATGAAGGATGTAGCAATTATAGGATACGGACAGACCAAATTTGGTGAACTCTGGGAAGAATC
ATTCAGAAGTTTAATTGTGG

Product: hypothetical protein

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKEVGIVGYGSDLPKYRIKAEDIAGAWGKDAQAIKRGLVVNEKSVPGPDEDTATIAVQSARRALSRAGINPKDIGAVYVG
SESHPYAVKPTSGIVAEACGVSPDFTAADLEFACKAGTAGIQMCMGLVGSEMMEYAMAVGADTAQGAPGDALEYTAAAGG
AAFIIGAKKEEFIAKFNGTYSYTTDTPDFWRREHEHYPKHGGRFTGEPAYFKHVLNGAKGMMEKMGTTSKDYDYCVFHQP
NGKFYLTAAKKLGFTEEQYKYGLLTPYLGNTYSGAVPLGLSNILDHAKADDRIFVVSYGSGAGSDAFDITVTDRISEVVD
KEITTEKLLEQKKYVDYAVYLKYRGKIRM

Sequences:

>Translated_349_residues
MKEVGIVGYGSDLPKYRIKAEDIAGAWGKDAQAIKRGLVVNEKSVPGPDEDTATIAVQSARRALSRAGINPKDIGAVYVG
SESHPYAVKPTSGIVAEACGVSPDFTAADLEFACKAGTAGIQMCMGLVGSEMMEYAMAVGADTAQGAPGDALEYTAAAGG
AAFIIGAKKEEFIAKFNGTYSYTTDTPDFWRREHEHYPKHGGRFTGEPAYFKHVLNGAKGMMEKMGTTSKDYDYCVFHQP
NGKFYLTAAKKLGFTEEQYKYGLLTPYLGNTYSGAVPLGLSNILDHAKADDRIFVVSYGSGAGSDAFDITVTDRISEVVD
KEITTEKLLEQKKYVDYAVYLKYRGKIRM
>Mature_349_residues
MKEVGIVGYGSDLPKYRIKAEDIAGAWGKDAQAIKRGLVVNEKSVPGPDEDTATIAVQSARRALSRAGINPKDIGAVYVG
SESHPYAVKPTSGIVAEACGVSPDFTAADLEFACKAGTAGIQMCMGLVGSEMMEYAMAVGADTAQGAPGDALEYTAAAGG
AAFIIGAKKEEFIAKFNGTYSYTTDTPDFWRREHEHYPKHGGRFTGEPAYFKHVLNGAKGMMEKMGTTSKDYDYCVFHQP
NGKFYLTAAKKLGFTEEQYKYGLLTPYLGNTYSGAVPLGLSNILDHAKADDRIFVVSYGSGAGSDAFDITVTDRISEVVD
KEITTEKLLEQKKYVDYAVYLKYRGKIRM

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Catalyzes The First Condensation Reaction Which Initiates Fatty Acid Synthesis And May Therefore Play A Role In Governing The

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0219 family

Homologues:

Organism=Escherichia coli, GI1787333, Length=304, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1211_METMP (Q6LXY3)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988331.1
- ProteinModelPortal:   Q6LXY3
- SMR:   Q6LXY3
- GeneID:   2762287
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP1211
- NMPDR:   fig|267377.1.peg.1211
- HOGENOM:   HBG297330
- OMA:   ESKPYAV
- ProtClustDB:   PRK04262
- BioCyc:   MMAR267377:MMP1211-MONOMER
- HAMAP:   MF_01409
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004656
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00748

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: 2.3.1.41

Molecular weight: Translated: 37738; Mature: 37738

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVGIVGYGSDLPKYRIKAEDIAGAWGKDAQAIKRGLVVNEKSVPGPDEDTATIAVQSA
CCCCEEEECCCCCCCEEEEHHHHCCCCCCCHHHHHHCCEECCCCCCCCCCCCCEEEHHHH
RRALSRAGINPKDIGAVYVGSESHPYAVKPTSGIVAEACGVSPDFTAADLEFACKAGTAG
HHHHHHCCCCHHHCCEEEECCCCCCEEECCCCCHHHHHCCCCCCCCHHCHHHHCCCCCHH
IQMCMGLVGSEMMEYAMAVGADTAQGAPGDALEYTAAAGGAAFIIGAKKEEFIAKFNGTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHCCCCEEEEEECCHHHHHHHCCCEE
SYTTDTPDFWRREHEHYPKHGGRFTGEPAYFKHVLNGAKGMMEKMGTTSKDYDYCVFHQP
EECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
NGKFYLTAAKKLGFTEEQYKYGLLTPYLGNTYSGAVPLGLSNILDHAKADDRIFVVSYGS
CCCEEEEEHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECC
GAGSDAFDITVTDRISEVVDKEITTEKLLEQKKYVDYAVYLKYRGKIRM
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEECC
>Mature Secondary Structure
MKEVGIVGYGSDLPKYRIKAEDIAGAWGKDAQAIKRGLVVNEKSVPGPDEDTATIAVQSA
CCCCEEEECCCCCCCEEEEHHHHCCCCCCCHHHHHHCCEECCCCCCCCCCCCCEEEHHHH
RRALSRAGINPKDIGAVYVGSESHPYAVKPTSGIVAEACGVSPDFTAADLEFACKAGTAG
HHHHHHCCCCHHHCCEEEECCCCCCEEECCCCCHHHHHCCCCCCCCHHCHHHHCCCCCHH
IQMCMGLVGSEMMEYAMAVGADTAQGAPGDALEYTAAAGGAAFIIGAKKEEFIAKFNGTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHCCCCEEEEEECCHHHHHHHCCCEE
SYTTDTPDFWRREHEHYPKHGGRFTGEPAYFKHVLNGAKGMMEKMGTTSKDYDYCVFHQP
EECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
NGKFYLTAAKKLGFTEEQYKYGLLTPYLGNTYSGAVPLGLSNILDHAKADDRIFVVSYGS
CCCEEEEEHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECC
GAGSDAFDITVTDRISEVVDKEITTEKLLEQKKYVDYAVYLKYRGKIRM
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; DTT; EDTA [C]

Metal ions: Phosphate [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl -ACP-decarboxyl ation, [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA