Click here to switch to the map view.

The map label for this gene is comC [H]

Identifier: 45358696

GI number: 45358696

Start: 1122832

End: 1123875

Strand: Direct

Name: comC [H]

Synonym: MMP1133

Alternate gene names: 45358696

Gene position: 1122832-1123875 (Clockwise)

Preceding gene: 45358695

Following gene: 45358697

Centisome position: 67.59

GC content: 33.81

Gene sequence:

>1044_bases
ATGGCACACATAATTACGCCTGAAGGAGAAAAAAAACTACTTTCTGATATTTTAATGGCATTTGGTGTTAAGGAAGAACA
TGCAAAAATTACTGCAGAAATTTACACAGAAGCTGATTTGAAAGGATTTACTTCACACGGTATTGGAAGATTTCCACAAA
CAATAATCGGTCTTGAAACTGAAAATATAAAAACTGACCCCGAAATAAAAATAATAAAAGAAAGTCCTGCAATTGCAACA
ATAAACGGAGATTTAGCATTGGGTTATGTTACAGCTGCAATGGCAATGGATTTAGCAGTTGAAAAAGCAAAAAATGTAGG
AATTGGTGCAGTTGCTACATATAACTCAAATCACTTTGGAATTACAGGACACTATTCCGAAAGAGCTTCGAAAAAAGGAA
TGATTGGAATTGCAATTACAAATACTGAGCCTGCAATGGCACCATACGGCGGAAAAGATAAAATTTTGGGTACAAACCCG
ATTGCAATTGCGGTTTCTGGAAAAAAACACAAATATTCATTGGATATGGCAACAGCATCTGTTGCAAGGGGAAAAATCTT
TGAAGCAAAACGTCTTGGAAAAATACTTCCTGAAAATGCAGCAGTAGATATCAATGGAAATATCACAACTGACCCAGATA
AAGCTCTTGCAGGCAGTATTTTACCATTTGGTGGAATTAAAGGATACGGAATTGCAATGGCTGTTGAAATTCTTTCTGCA
ATCGGCGGTGCAGAAATTGGAACAAATGTAAAAGGAACTGCAAGAGCTGACGAAAAATGTACAAAAGGAGATTTGTTTAT
CGCGATAAATCCTGAATTTTTCGGTGAAAAAAGCGAATTTTTGGATAAAACTGACTTTTTAGTCGATGAAATAAAAAATT
CAAAACTCTCTGAAGGCTCTTCTGAAATTTTAATTCCGGGTGATGTTGAAGCTAGAACTTCTGAAAATAAGAAAAATGGT
TTTGAAATTGATGAAATACTATATAAAAAATTAAAAAATATCTGCGATAAAAAAGGAATTACTATTGAAAACTACTTAAA
ATAA

Upstream 100 bases:

>100_bases
CTGTTAGAAAAGAATTAATTATTGCAATAGTTGATGCTGACGGGAGCGTCGTTTACTACAACATGGGATATTTAAAGCTT
TAATTATTGGAGGAATCAAT

Downstream 100 bases:

>100_bases
TTCTTAATTTTACCTCTTTTGATGAAATAGTATTTCTAAATATAAAATTATATAAATAGATTCTTTTTATAAATTATAAT
ATCAATAACTCAATTCTTAT

Product: L-sulfolactate dehydrogenase/(S)-hydroxyglutaric acid dehydrogenase

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase; (R)-sulfolactate dehydrogenase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MAHIITPEGEKKLLSDILMAFGVKEEHAKITAEIYTEADLKGFTSHGIGRFPQTIIGLETENIKTDPEIKIIKESPAIAT
INGDLALGYVTAAMAMDLAVEKAKNVGIGAVATYNSNHFGITGHYSERASKKGMIGIAITNTEPAMAPYGGKDKILGTNP
IAIAVSGKKHKYSLDMATASVARGKIFEAKRLGKILPENAAVDINGNITTDPDKALAGSILPFGGIKGYGIAMAVEILSA
IGGAEIGTNVKGTARADEKCTKGDLFIAINPEFFGEKSEFLDKTDFLVDEIKNSKLSEGSSEILIPGDVEARTSENKKNG
FEIDEILYKKLKNICDKKGITIENYLK

Sequences:

>Translated_347_residues
MAHIITPEGEKKLLSDILMAFGVKEEHAKITAEIYTEADLKGFTSHGIGRFPQTIIGLETENIKTDPEIKIIKESPAIAT
INGDLALGYVTAAMAMDLAVEKAKNVGIGAVATYNSNHFGITGHYSERASKKGMIGIAITNTEPAMAPYGGKDKILGTNP
IAIAVSGKKHKYSLDMATASVARGKIFEAKRLGKILPENAAVDINGNITTDPDKALAGSILPFGGIKGYGIAMAVEILSA
IGGAEIGTNVKGTARADEKCTKGDLFIAINPEFFGEKSEFLDKTDFLVDEIKNSKLSEGSSEILIPGDVEARTSENKKNG
FEIDEILYKKLKNICDKKGITIENYLK
>Mature_346_residues
AHIITPEGEKKLLSDILMAFGVKEEHAKITAEIYTEADLKGFTSHGIGRFPQTIIGLETENIKTDPEIKIIKESPAIATI
NGDLALGYVTAAMAMDLAVEKAKNVGIGAVATYNSNHFGITGHYSERASKKGMIGIAITNTEPAMAPYGGKDKILGTNPI
AIAVSGKKHKYSLDMATASVARGKIFEAKRLGKILPENAAVDINGNITTDPDKALAGSILPFGGIKGYGIAMAVEILSAI
GGAEIGTNVKGTARADEKCTKGDLFIAINPEFFGEKSEFLDKTDFLVDEIKNSKLSEGSSEILIPGDVEARTSENKKNGF
EIDEILYKKLKNICDKKGITIENYLK

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynth

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=332, Percent_Identity=31.0240963855422, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787020, Length=336, Percent_Identity=32.4404761904762, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1790000, Length=333, Percent_Identity=30.03003003003, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17507179, Length=355, Percent_Identity=34.3661971830986, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17536633, Length=318, Percent_Identity=35.2201257861635, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24667904, Length=312, Percent_Identity=35.5769230769231, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45553211, Length=314, Percent_Identity=35.3503184713376, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24667912, Length=314, Percent_Identity=35.3503184713376, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24667908, Length=314, Percent_Identity=35.3503184713376, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24658010, Length=302, Percent_Identity=31.4569536423841, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24648360, Length=308, Percent_Identity=32.1428571428571, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272 [H]

Molecular weight: Translated: 37095; Mature: 36964

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHIITPEGEKKLLSDILMAFGVKEEHAKITAEIYTEADLKGFTSHGIGRFPQTIIGLET
CCEEECCCCHHHHHHHHHHHHCCCHHHHEEEEEEEECCCCCCCHHCCCCCCCHHHEECCC
ENIKTDPEIKIIKESPAIATINGDLALGYVTAAMAMDLAVEKAKNVGIGAVATYNSNHFG
CCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCE
ITGHYSERASKKGMIGIAITNTEPAMAPYGGKDKILGTNPIAIAVSGKKHKYSLDMATAS
EECCHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEECCCCEEEEECCCCEEEEEHHHHHH
VARGKIFEAKRLGKILPENAAVDINGNITTDPDKALAGSILPFGGIKGYGIAMAVEILSA
HHHCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHH
IGGAEIGTNVKGTARADEKCTKGDLFIAINPEFFGEKSEFLDKTDFLVDEIKNSKLSEGS
HCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
SEILIPGDVEARTSENKKNGFEIDEILYKKLKNICDKKGITIENYLK
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
AHIITPEGEKKLLSDILMAFGVKEEHAKITAEIYTEADLKGFTSHGIGRFPQTIIGLET
CEEECCCCHHHHHHHHHHHHCCCHHHHEEEEEEEECCCCCCCHHCCCCCCCHHHEECCC
ENIKTDPEIKIIKESPAIATINGDLALGYVTAAMAMDLAVEKAKNVGIGAVATYNSNHFG
CCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCE
ITGHYSERASKKGMIGIAITNTEPAMAPYGGKDKILGTNPIAIAVSGKKHKYSLDMATAS
EECCHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEECCCCEEEEECCCCEEEEEHHHHHH
VARGKIFEAKRLGKILPENAAVDINGNITTDPDKALAGSILPFGGIKGYGIAMAVEILSA
HHHCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHH
IGGAEIGTNVKGTARADEKCTKGDLFIAINPEFFGEKSEFLDKTDFLVDEIKNSKLSEGS
HCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
SEILIPGDVEARTSENKKNGFEIDEILYKKLKNICDKKGITIENYLK
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10850983 [H]