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The map label for this gene is lig [H]

Identifier: 45358533

GI number: 45358533

Start: 956353

End: 958074

Strand: Direct

Name: lig [H]

Synonym: MMP0970

Alternate gene names: 45358533

Gene position: 956353-958074 (Clockwise)

Preceding gene: 45358532

Following gene: 45358534

Centisome position: 57.57

GC content: 31.94

Gene sequence:

>1722_bases
ATGCTTTTTAGTGATTTTTGTAAAATTCTTGATAAAATTGAAAAAACTACGAAAAGACTTGAAAAAACAGACTATTTTGT
AGAATTAATCGATTTTATCAAAACTAGTGAAAAACCTGAAAATTTAAAACAAGTGTCACAAATCACGATTGGAAGGGTTT
TTGCAGAATTTGAAAACAAAGAAATTGGGATTGGGCCAAACTTGTTGCTTGAAGCAGTGAAAACCACAGGGATACCTGAA
AAAGATTTGAAATCAAAAATTAAAGAAACCGGAGACATTGGAACTGCTGTTGAAAATTTAAGTTCAAATATAAAACAGGT
TTCATTGTTCAGCCAAGCACTTACGCTTGAAGAAGTGTATTCCACATTAAAAAAACTTTCAGAAATTGAAGGAAATTCCT
CACAAAAAAAGAAAACAAGAATAATTTCAAATTTACTAATTTTAGCAGACCCTGTTGAATCAAGATACATTTCAAGGCTT
ATTTTAGAAGATATGCGGATTGGAATGAACATTCCAACAATTTTAGCCTCATTTTCAAATTATTTTAATGTTAATAAGGA
ATCTGTCGAAAAAATATATGCCGTTACAAATGATATTGGACTTTTGGGCGAAAAGTTAATTTCTGGCTCAGACATTGAAA
ACGATCCCGAATTAAAATTAAAAGTATTCAGGCCGATAAAACCTATGCTTGCACAGCTAACTCCATCAATTGAAGATGCG
ATGATTGAGACTAAAATGCCCCAATTTGAAACTAAATACGATGGTGCAAGAGTTCAAGTGCATAAATCGAATGGAGACGT
AAAGATATACAGCAGAAGGCTTGAAAATATTACAAATTCGGTTCCAGAACTCGTTGAAGAAATCAAAAAACTAGATATTG
ATAATATCATATTAGAAGGGGAATGCGTTGCAATGGATTTAGATTCGGGAAAACCAAGACCTTTCCAGGATATTTTAAGA
AGGTTCAGGCGAAAATATAATATTGATAAAATGGCCGAAAAAATAGCTTTAAGAATATATTTCTTCGATGTTTTATACTA
CAACCGAGGTTTAATCGATACTCCACTAAAAACCAGAAGGGAAATTTTAGAAAAACTATTTGGAACAAATAACTGGGATA
GTGAATTAGAAAAAATTAAAAAAGAGATATTTTCTAGCAAAATGCTATTTTCATCGTTTAAATTAAATAGTGGTGATCCA
AATCTTGTAAAAGAATTTTTTAACTGGAGTTTAAGTATCGGTCATGAAGGAATCATGATTAAAAACCCTGATGCACCATA
CACCCCTGGAAGCCGTGTTAAAACTATGTATAAAGTTAAACCAACGTTAGAAAATCTTGATGTTGTTGTAACCCGTGCAA
AAATTGGAATGGGAAAAAGAAAAGACTGGTACGGTTCATATGAACTCTCCGTGAAAGATAATGATGGCAACTTACACGTT
ATCGGAAACGTTGGAAGCGGACTCACTGAAGACGACCTTGAAAAACTCACAAAAATAGTTAATGAAATAAAAATCGAAGA
TTTGGGTGAAGAAGTAATTTTAGAACCTAAAATCGTACTTGAAGTAACTTACGAAGAAATTCAGACTTCTGAAAAATATG
AAATGGGTTATGCCTTACGTTTTCCAAGAGTTGTCCAGATAAGGGAAGACAAATCTATAAATGACATTAATACCTTAGAT
GATGTGAAGAAAATATACGAAATAGAACGAAACAGAAAATAA

Upstream 100 bases:

>100_bases
ACGGAAAATTCACAAGAAACAGAACCTTTAGAATCTGAAGATGGGATAATTATTGAAGTTGATTTAAAATAATTTACTTT
TTTATTTTTAAGGTGTAATA

Downstream 100 bases:

>100_bases
TTTTTTATAAAAGGTGATTACATGGCAATTCACCCTATCGACTTTAGATACGGAACTCCTGAAATGAAAAAAGTATGGGG
AGAAGAAACAAAACTTCAAA

Product: DNA ligase I, ATP-dependent Dnl1

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MLFSDFCKILDKIEKTTKRLEKTDYFVELIDFIKTSEKPENLKQVSQITIGRVFAEFENKEIGIGPNLLLEAVKTTGIPE
KDLKSKIKETGDIGTAVENLSSNIKQVSLFSQALTLEEVYSTLKKLSEIEGNSSQKKKTRIISNLLILADPVESRYISRL
ILEDMRIGMNIPTILASFSNYFNVNKESVEKIYAVTNDIGLLGEKLISGSDIENDPELKLKVFRPIKPMLAQLTPSIEDA
MIETKMPQFETKYDGARVQVHKSNGDVKIYSRRLENITNSVPELVEEIKKLDIDNIILEGECVAMDLDSGKPRPFQDILR
RFRRKYNIDKMAEKIALRIYFFDVLYYNRGLIDTPLKTRREILEKLFGTNNWDSELEKIKKEIFSSKMLFSSFKLNSGDP
NLVKEFFNWSLSIGHEGIMIKNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYELSVKDNDGNLHV
IGNVGSGLTEDDLEKLTKIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALRFPRVVQIREDKSINDINTLD
DVKKIYEIERNRK

Sequences:

>Translated_573_residues
MLFSDFCKILDKIEKTTKRLEKTDYFVELIDFIKTSEKPENLKQVSQITIGRVFAEFENKEIGIGPNLLLEAVKTTGIPE
KDLKSKIKETGDIGTAVENLSSNIKQVSLFSQALTLEEVYSTLKKLSEIEGNSSQKKKTRIISNLLILADPVESRYISRL
ILEDMRIGMNIPTILASFSNYFNVNKESVEKIYAVTNDIGLLGEKLISGSDIENDPELKLKVFRPIKPMLAQLTPSIEDA
MIETKMPQFETKYDGARVQVHKSNGDVKIYSRRLENITNSVPELVEEIKKLDIDNIILEGECVAMDLDSGKPRPFQDILR
RFRRKYNIDKMAEKIALRIYFFDVLYYNRGLIDTPLKTRREILEKLFGTNNWDSELEKIKKEIFSSKMLFSSFKLNSGDP
NLVKEFFNWSLSIGHEGIMIKNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYELSVKDNDGNLHV
IGNVGSGLTEDDLEKLTKIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALRFPRVVQIREDKSINDINTLD
DVKKIYEIERNRK
>Mature_573_residues
MLFSDFCKILDKIEKTTKRLEKTDYFVELIDFIKTSEKPENLKQVSQITIGRVFAEFENKEIGIGPNLLLEAVKTTGIPE
KDLKSKIKETGDIGTAVENLSSNIKQVSLFSQALTLEEVYSTLKKLSEIEGNSSQKKKTRIISNLLILADPVESRYISRL
ILEDMRIGMNIPTILASFSNYFNVNKESVEKIYAVTNDIGLLGEKLISGSDIENDPELKLKVFRPIKPMLAQLTPSIEDA
MIETKMPQFETKYDGARVQVHKSNGDVKIYSRRLENITNSVPELVEEIKKLDIDNIILEGECVAMDLDSGKPRPFQDILR
RFRRKYNIDKMAEKIALRIYFFDVLYYNRGLIDTPLKTRREILEKLFGTNNWDSELEKIKKEIFSSKMLFSSFKLNSGDP
NLVKEFFNWSLSIGHEGIMIKNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYELSVKDNDGNLHV
IGNVGSGLTEDDLEKLTKIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALRFPRVVQIREDKSINDINTLD
DVKKIYEIERNRK

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=625, Percent_Identity=26.72, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI46255052, Length=629, Percent_Identity=26.550079491256, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI23199993, Length=629, Percent_Identity=26.550079491256, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148539894, Length=629, Percent_Identity=26.550079491256, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI73747829, Length=534, Percent_Identity=24.3445692883895, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI73747844, Length=534, Percent_Identity=24.3445692883895, Blast_Score=110, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71985269, Length=622, Percent_Identity=28.2958199356913, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71985278, Length=188, Percent_Identity=28.7234042553192, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320038, Length=624, Percent_Identity=27.2435897435897, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24762424, Length=613, Percent_Identity=25.1223491027732, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI85815841, Length=524, Percent_Identity=25.1908396946565, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24641829, Length=506, Percent_Identity=22.3320158102767, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 65753; Mature: 65753

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSDFCKILDKIEKTTKRLEKTDYFVELIDFIKTSEKPENLKQVSQITIGRVFAEFENK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
EIGIGPNLLLEAVKTTGIPEKDLKSKIKETGDIGTAVENLSSNIKQVSLFSQALTLEEVY
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STLKKLSEIEGNSSQKKKTRIISNLLILADPVESRYISRLILEDMRIGMNIPTILASFSN
HHHHHHHHCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YFNVNKESVEKIYAVTNDIGLLGEKLISGSDIENDPELKLKVFRPIKPMLAQLTPSIEDA
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHCCCHHHH
MIETKMPQFETKYDGARVQVHKSNGDVKIYSRRLENITNSVPELVEEIKKLDIDNIILEG
HHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
ECVAMDLDSGKPRPFQDILRRFRRKYNIDKMAEKIALRIYFFDVLYYNRGLIDTPLKTRR
CEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EILEKLFGTNNWDSELEKIKKEIFSSKMLFSSFKLNSGDPNLVKEFFNWSLSIGHEGIMI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEECCCCEEE
KNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYELSVKDNDGNLHV
ECCCCCCCCCHHHEEEEEECCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCEEE
IGNVGSGLTEDDLEKLTKIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALR
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEEEEHHHHCCCHHHHCCEEEC
FPRVVQIREDKSINDINTLDDVKKIYEIERNRK
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLFSDFCKILDKIEKTTKRLEKTDYFVELIDFIKTSEKPENLKQVSQITIGRVFAEFENK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
EIGIGPNLLLEAVKTTGIPEKDLKSKIKETGDIGTAVENLSSNIKQVSLFSQALTLEEVY
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STLKKLSEIEGNSSQKKKTRIISNLLILADPVESRYISRLILEDMRIGMNIPTILASFSN
HHHHHHHHCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YFNVNKESVEKIYAVTNDIGLLGEKLISGSDIENDPELKLKVFRPIKPMLAQLTPSIEDA
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHCCCHHHH
MIETKMPQFETKYDGARVQVHKSNGDVKIYSRRLENITNSVPELVEEIKKLDIDNIILEG
HHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
ECVAMDLDSGKPRPFQDILRRFRRKYNIDKMAEKIALRIYFFDVLYYNRGLIDTPLKTRR
CEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EILEKLFGTNNWDSELEKIKKEIFSSKMLFSSFKLNSGDPNLVKEFFNWSLSIGHEGIMI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEECCCCEEE
KNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYELSVKDNDGNLHV
ECCCCCCCCCHHHEEEEEECCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCEEE
IGNVGSGLTEDDLEKLTKIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALR
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEEEEHHHHCCCHHHHCCEEEC
FPRVVQIREDKSINDINTLDDVKKIYEIERNRK
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA