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The map label for this gene is hisD

Identifier: 45358531

GI number: 45358531

Start: 954600

End: 955874

Strand: Direct

Name: hisD

Synonym: MMP0968

Alternate gene names: 45358531

Gene position: 954600-955874 (Clockwise)

Preceding gene: 45358530

Following gene: 45358532

Centisome position: 57.47

GC content: 34.67

Gene sequence:

>1275_bases
ATGATTGTCAAAAAAATATCAAAATTAAACGAAAAAGAACTTGATATTATACTTAACAGGAATAAAACAAACATTTCTGG
AATTTTACCAACAGTAAGCGAAATTTTAGAAAATGTTCAAAAAAATGGAGATAATGCCTTAAAAGAATATACTAAAAAAT
TCGATGGCGTTGACATTGATAATTTTAAAGTATCTACTGAAGAAATTGATAAAGCATACGACAAAATTGATTCAAAAGTA
GTTGAATCTCTTGAAAAAGCTTATGAAAACATTAGGGAGTTTCACGAAATCCAGTTTAAAAATTTAAACGAATGGGAAAT
TGATAAAAAAGGAATTAAAGCGGGACAAATTATAAGACCTGTTGAAAAAGCTGGATGTTACGTTCCAGGAGGACGGGCAT
TTTACCCTTCAACAGTTTTAATGACTGTAACTCCTGCAAAAGTAGCGGGTGTAAAAGAGGTAATTGTAACCTCCCCTCCA
AACGGAACCGAAGGAAACCCTGCAACACTTGTTGCTTCAGACATTGCAAAAGCTGATGGAATATACAAAATCGGAGGAGC
TCAAGCAATTGGAGCTCTTGCATACGGTACTAAATCTATTCCAAAAGTCGATATTATTGTAGGGCCTGGAAATATCTTTG
TAACTGCCGCTAAAAAGTTAGTTTACGGTGAAGTTTCAATTGATTTTCCAGCAGGGCCTTCCGAAGTTCTTATTATGTGT
GATGAATCATCAAATGAAGAATACGTTGCAATGGACTTTTTAGCACAGGCTGAGCACGACCCTAACGCTTCATGTATAAT
TACAGTCACTTCCGAAAAAAAAGCGGAAAAAATTAAAGAAAGAATTTTGATGGAAATAAAAACTGCTAAAAGAACCGAAA
TTATTGAAAAATCGATTTTAAATTCTGCAATCGTTATCGGCTCAATTGATGAATGTATTGAACTTTCAAACAGCTACGCA
CCAGAACACTTGGAAATAATGACAAAAAATCCAAGGGAAGTTTTAAAATCCATTGAAAATGCAGGCAGCATCTTTTTAGG
AAATTACGCACCTGTTCCTGTTGGAGACTATGCAAGCGGTACTAACCACGTTCTTCCAACATCCGCCTGTGCAAAAATGT
ATTCTGGACTCAGCGTTGAAACATTTATTAAAAAGCCAACAGTCCAAGAATTGACAAAAGAAGGACTTTTAGGAATTAGT
GACATTGTAACCACACTTGCAGAAGCTGAAGGATTATTCAACCATTCTGAAGCAGTTAAAAGAAGATTAAATTAA

Upstream 100 bases:

>100_bases
AAGGGAAGTTTTTGAAATTAACCTTCACGGAAACCTAATTGAAAGAGTTTGTGAAAAAATTGCTCTTATCGAGGTTCTAT
GATTTGGTTTGGTGTGGATT

Downstream 100 bases:

>100_bases
AAAATATTAAAAATCAGTACTGTCGTGAAAAACATGATGCAGCAGCTGAAATTACTTATATCGCTTTTTGTGGTCTTGAT
GATTTTGATGGTCGGAATGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIVKKISKLNEKELDIILNRNKTNISGILPTVSEILENVQKNGDNALKEYTKKFDGVDIDNFKVSTEEIDKAYDKIDSKV
VESLEKAYENIREFHEIQFKNLNEWEIDKKGIKAGQIIRPVEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVKEVIVTSPP
NGTEGNPATLVASDIAKADGIYKIGGAQAIGALAYGTKSIPKVDIIVGPGNIFVTAAKKLVYGEVSIDFPAGPSEVLIMC
DESSNEEYVAMDFLAQAEHDPNASCIITVTSEKKAEKIKERILMEIKTAKRTEIIEKSILNSAIVIGSIDECIELSNSYA
PEHLEIMTKNPREVLKSIENAGSIFLGNYAPVPVGDYASGTNHVLPTSACAKMYSGLSVETFIKKPTVQELTKEGLLGIS
DIVTTLAEAEGLFNHSEAVKRRLN

Sequences:

>Translated_424_residues
MIVKKISKLNEKELDIILNRNKTNISGILPTVSEILENVQKNGDNALKEYTKKFDGVDIDNFKVSTEEIDKAYDKIDSKV
VESLEKAYENIREFHEIQFKNLNEWEIDKKGIKAGQIIRPVEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVKEVIVTSPP
NGTEGNPATLVASDIAKADGIYKIGGAQAIGALAYGTKSIPKVDIIVGPGNIFVTAAKKLVYGEVSIDFPAGPSEVLIMC
DESSNEEYVAMDFLAQAEHDPNASCIITVTSEKKAEKIKERILMEIKTAKRTEIIEKSILNSAIVIGSIDECIELSNSYA
PEHLEIMTKNPREVLKSIENAGSIFLGNYAPVPVGDYASGTNHVLPTSACAKMYSGLSVETFIKKPTVQELTKEGLLGIS
DIVTTLAEAEGLFNHSEAVKRRLN
>Mature_424_residues
MIVKKISKLNEKELDIILNRNKTNISGILPTVSEILENVQKNGDNALKEYTKKFDGVDIDNFKVSTEEIDKAYDKIDSKV
VESLEKAYENIREFHEIQFKNLNEWEIDKKGIKAGQIIRPVEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVKEVIVTSPP
NGTEGNPATLVASDIAKADGIYKIGGAQAIGALAYGTKSIPKVDIIVGPGNIFVTAAKKLVYGEVSIDFPAGPSEVLIMC
DESSNEEYVAMDFLAQAEHDPNASCIITVTSEKKAEKIKERILMEIKTAKRTEIIEKSILNSAIVIGSIDECIELSNSYA
PEHLEIMTKNPREVLKSIENAGSIFLGNYAPVPVGDYASGTNHVLPTSACAKMYSGLSVETFIKKPTVQELTKEGLLGIS
DIVTTLAEAEGLFNHSEAVKRRLN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=420, Percent_Identity=41.4285714285714, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=41.9664268585132, Blast_Score=314, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_METMP (P60862)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988088.1
- ProteinModelPortal:   P60862
- SMR:   P60862
- GeneID:   2762510
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0968
- NMPDR:   fig|267377.1.peg.968
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   MMAR267377:MMP0968-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46184; Mature: 46184

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 322-322 ACT_SITE 323-323 BINDING 127-127 BINDING 188-188 BINDING 211-211 BINDING 234-234 BINDING 256-256 BINDING 259-259 BINDING 323-323 BINDING 356-356 BINDING 410-410 BINDING 415-415

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVKKISKLNEKELDIILNRNKTNISGILPTVSEILENVQKNGDNALKEYTKKFDGVDID
CCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
NFKVSTEEIDKAYDKIDSKVVESLEKAYENIREFHEIQFKNLNEWEIDKKGIKAGQIIRP
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCH
VEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVKEVIVTSPPNGTEGNPATLVASDIAKADG
HHHCCCCCCCCCEECCCEEEEEECCHHHCCCEEEEEECCCCCCCCCCCEEEEHHHHHCCC
IYKIGGAQAIGALAYGTKSIPKVDIIVGPGNIFVTAAKKLVYGEVSIDFPAGPSEVLIMC
EEEECCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEHEEEEEEEEEECCCCCCEEEEEE
DESSNEEYVAMDFLAQAEHDPNASCIITVTSEKKAEKIKERILMEIKTAKRTEIIEKSIL
CCCCCCCEEEHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSAIVIGSIDECIELSNSYAPEHLEIMTKNPREVLKSIENAGSIFLGNYAPVPVGDYASG
CCEEEECCHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
TNHVLPTSACAKMYSGLSVETFIKKPTVQELTKEGLLGISDIVTTLAEAEGLFNHSEAVK
CCCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
RRLN
HHCC
>Mature Secondary Structure
MIVKKISKLNEKELDIILNRNKTNISGILPTVSEILENVQKNGDNALKEYTKKFDGVDID
CCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
NFKVSTEEIDKAYDKIDSKVVESLEKAYENIREFHEIQFKNLNEWEIDKKGIKAGQIIRP
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCH
VEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVKEVIVTSPPNGTEGNPATLVASDIAKADG
HHHCCCCCCCCCEECCCEEEEEECCHHHCCCEEEEEECCCCCCCCCCCEEEEHHHHHCCC
IYKIGGAQAIGALAYGTKSIPKVDIIVGPGNIFVTAAKKLVYGEVSIDFPAGPSEVLIMC
EEEECCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEHEEEEEEEEEECCCCCCEEEEEE
DESSNEEYVAMDFLAQAEHDPNASCIITVTSEKKAEKIKERILMEIKTAKRTEIIEKSIL
CCCCCCCEEEHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSAIVIGSIDECIELSNSYAPEHLEIMTKNPREVLKSIENAGSIFLGNYAPVPVGDYASG
CCEEEECCHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
TNHVLPTSACAKMYSGLSVETFIKKPTVQELTKEGLLGISDIVTTLAEAEGLFNHSEAVK
CCCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
RRLN
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA