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The map label for this gene is cca

Identifier: 45358512

GI number: 45358512

Start: 936440

End: 937774

Strand: Direct

Name: cca

Synonym: MMP0949

Alternate gene names: 45358512

Gene position: 936440-937774 (Clockwise)

Preceding gene: 45358511

Following gene: 45358513

Centisome position: 56.37

GC content: 27.72

Gene sequence:

>1335_bases
TTGAAAAAATTAAATGCTGATGATTATATTGATATTTTAAACGATGTTTTAAAGGATATCTGTCCAACAGACTCGGAAAA
AGAAGAATTAAAAATATTTTCGGATAAAATAATCTCTAAAATCAAAGATATTTCAAAATATCCTGTGTTAGATATAATTC
AGGTTGGATCAACTGCAAGAGATGCAAATTTAAAAAATGATCACGATATTGACATATTTTTAAGGTTTGAAAAAGAAACC
GATAGGGATATGCTAAAAGAATTGGGCTTAAAACTTGGAAAAGATGTAATTAATTATTTCAATGGAAAATCATGGATAGA
ATATGCAGAACACCCGTATGTTTCTGGAGAAATTGGGAAATTTAACTTAGATATCGTTCCTTGCTATGATATTGAAAATT
GCGAAAAAATAATTTCTGCCGTTGATAGGACTCCACTTCATAACGAATTTTTGTTGAATGCATACGAAAATAATGATTTA
TCAAATGATATCCGTCTTTTAAAAAAATTTTTAAAAGGTCTTGGAATATATGGATCAGACCTAAAAACTGCGGGATTTTC
AGGATATCTCTGCGAACTTTTAATATTAAAGTACAGGGGATTTTTAAACCTTTTATCTGCCGTACAAACGTGGAAACCAA
AACATTCAATAGTTTTAGATGAAATTTACGAAATGTATGATTTAAAAAAAGATCATGATTTTTTAAAATTTAATGATTCT
CTGGTGGTTTACGACCCTGTTGATCTAAATAGAAACGTTGCCGCAGCATTAAATAAAGAAAACCTATGTAAATTTATATT
TTATTCAAAAATGTTTTTGAAAAAACCTTCAAAAGAGTTTTTTTACGGATTTTATAAAAAAACTACTGATTTATTAAATC
AGCGAAAAAGGGGCTATTTAATAACATTAGAAATTTTAAGGCCTGAAAATATTGTTGAAGATGTAATATATCCTCAAATG
GAAAAAATACAAAAAAGTATTAATAAATTAGTTAAAGAGCATGATTTTGAATATTTACAGTACCAAAATTTTGCAGATGA
TAATACCTGTTATTTATCTTGGGAATTTTTAATTCATGAGCTTCCAGATGTAAAATTAAGAATTGGGCCCCCAGTATACA
GTGAACAGGGAGTATTAAATTTTATAACGCATAACGAACATTATTTTGTTAAAGAATGCAATGTTTGCGCATACAAAACC
AGAAAATATAAAAACATACAAATACTATTCGAAGATATTGTTAATGGGAAATTAAAGAACATTATAACCTATCCTAAGTA
CGTATGTCCAGAAAATGCGAAAATACGATTAGGTACTTTTATAGAACGGAAATAA

Upstream 100 bases:

>100_bases
TGATGTTCAATGTAAACACGAAAACGTAAAAAACACGGTTTAATCTGTTTTTAAATATATTACATAGTTATTTTTTAAAT
TTTATTTTCAGGTGGATATT

Downstream 100 bases:

>100_bases
TTTCGGGAGAATATGGATAGTAGCGTCTTGATTAAAGAATGCAATGATTTTTTAGATTGTTTATCAAATTTTGGGAAGAA
ATTAAAAGATTTTGACTCCA

Product: tRNA CCA-pyrophosphorylase

Products: NA

Alternate protein names: tRNA CCA-pyrophosphorylase; tRNA adenylyl-/cytidylyl- transferase; tRNA nucleotidyltransferase; tRNA-NT

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKKLNADDYIDILNDVLKDICPTDSEKEELKIFSDKIISKIKDISKYPVLDIIQVGSTARDANLKNDHDIDIFLRFEKET
DRDMLKELGLKLGKDVINYFNGKSWIEYAEHPYVSGEIGKFNLDIVPCYDIENCEKIISAVDRTPLHNEFLLNAYENNDL
SNDIRLLKKFLKGLGIYGSDLKTAGFSGYLCELLILKYRGFLNLLSAVQTWKPKHSIVLDEIYEMYDLKKDHDFLKFNDS
LVVYDPVDLNRNVAAALNKENLCKFIFYSKMFLKKPSKEFFYGFYKKTTDLLNQRKRGYLITLEILRPENIVEDVIYPQM
EKIQKSINKLVKEHDFEYLQYQNFADDNTCYLSWEFLIHELPDVKLRIGPPVYSEQGVLNFITHNEHYFVKECNVCAYKT
RKYKNIQILFEDIVNGKLKNIITYPKYVCPENAKIRLGTFIERK

Sequences:

>Translated_444_residues
MKKLNADDYIDILNDVLKDICPTDSEKEELKIFSDKIISKIKDISKYPVLDIIQVGSTARDANLKNDHDIDIFLRFEKET
DRDMLKELGLKLGKDVINYFNGKSWIEYAEHPYVSGEIGKFNLDIVPCYDIENCEKIISAVDRTPLHNEFLLNAYENNDL
SNDIRLLKKFLKGLGIYGSDLKTAGFSGYLCELLILKYRGFLNLLSAVQTWKPKHSIVLDEIYEMYDLKKDHDFLKFNDS
LVVYDPVDLNRNVAAALNKENLCKFIFYSKMFLKKPSKEFFYGFYKKTTDLLNQRKRGYLITLEILRPENIVEDVIYPQM
EKIQKSINKLVKEHDFEYLQYQNFADDNTCYLSWEFLIHELPDVKLRIGPPVYSEQGVLNFITHNEHYFVKECNVCAYKT
RKYKNIQILFEDIVNGKLKNIITYPKYVCPENAKIRLGTFIERK
>Mature_444_residues
MKKLNADDYIDILNDVLKDICPTDSEKEELKIFSDKIISKIKDISKYPVLDIIQVGSTARDANLKNDHDIDIFLRFEKET
DRDMLKELGLKLGKDVINYFNGKSWIEYAEHPYVSGEIGKFNLDIVPCYDIENCEKIISAVDRTPLHNEFLLNAYENNDL
SNDIRLLKKFLKGLGIYGSDLKTAGFSGYLCELLILKYRGFLNLLSAVQTWKPKHSIVLDEIYEMYDLKKDHDFLKFNDS
LVVYDPVDLNRNVAAALNKENLCKFIFYSKMFLKKPSKEFFYGFYKKTTDLLNQRKRGYLITLEILRPENIVEDVIYPQM
EKIQKSINKLVKEHDFEYLQYQNFADDNTCYLSWEFLIHELPDVKLRIGPPVYSEQGVLNFITHNEHYFVKECNVCAYKT
RKYKNIQILFEDIVNGKLKNIITYPKYVCPENAKIRLGTFIERK

Specific function: Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing

COG id: COG1746

COG function: function code J; tRNA nucleotidyltransferase (CCA-adding enzyme)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCA_METMP (Q6LYP1)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988069.1
- ProteinModelPortal:   Q6LYP1
- SMR:   Q6LYP1
- GeneID:   2761506
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0949
- NMPDR:   fig|267377.1.peg.949
- HOGENOM:   HBG645243
- OMA:   CEKIISA
- ProtClustDB:   PRK13300
- BioCyc:   MMAR267377:MMP0949-MONOMER
- BRENDA:   2.7.7.21
- BRENDA:   2.7.7.25
- HAMAP:   MF_01264
- InterPro:   IPR008229
- InterPro:   IPR002934
- InterPro:   IPR011068
- InterPro:   IPR015329
- PIRSF:   PIRSF005335
- TIGRFAMs:   TIGR03671

Pfam domain/function: PF01909 NTP_transf_2; PF09249 tRNA_NucTransf2; SSF55003 PAP_C

EC number: =2.7.7.21; =2.7.7.25

Molecular weight: Translated: 52134; Mature: 52134

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: BINDING 57-57 BINDING 60-60 BINDING 147-147 BINDING 168-168 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLNADDYIDILNDVLKDICPTDSEKEELKIFSDKIISKIKDISKYPVLDIIQVGSTAR
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
DANLKNDHDIDIFLRFEKETDRDMLKELGLKLGKDVINYFNGKSWIEYAEHPYVSGEIGK
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCE
FNLDIVPCYDIENCEKIISAVDRTPLHNEFLLNAYENNDLSNDIRLLKKFLKGLGIYGSD
EEEEEEECCCHHHHHHHHHHHHCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCC
LKTAGFSGYLCELLILKYRGFLNLLSAVQTWKPKHSIVLDEIYEMYDLKKDHDFLKFNDS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCC
LVVYDPVDLNRNVAAALNKENLCKFIFYSKMFLKKPSKEFFYGFYKKTTDLLNQRKRGYL
EEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEE
ITLEILRPENIVEDVIYPQMEKIQKSINKLVKEHDFEYLQYQNFADDNTCYLSWEFLIHE
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHHC
LPDVKLRIGPPVYSEQGVLNFITHNEHYFVKECNVCAYKTRKYKNIQILFEDIVNGKLKN
CCCCEEEECCCCCCCCCCEEEEECCCEEEEEECCEEEEHHCCCCHHHHHHHHHHCCHHHH
IITYPKYVCPENAKIRLGTFIERK
HHCCCCEECCCCCEEEECCCCCCC
>Mature Secondary Structure
MKKLNADDYIDILNDVLKDICPTDSEKEELKIFSDKIISKIKDISKYPVLDIIQVGSTAR
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
DANLKNDHDIDIFLRFEKETDRDMLKELGLKLGKDVINYFNGKSWIEYAEHPYVSGEIGK
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCE
FNLDIVPCYDIENCEKIISAVDRTPLHNEFLLNAYENNDLSNDIRLLKKFLKGLGIYGSD
EEEEEEECCCHHHHHHHHHHHHCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCC
LKTAGFSGYLCELLILKYRGFLNLLSAVQTWKPKHSIVLDEIYEMYDLKKDHDFLKFNDS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCC
LVVYDPVDLNRNVAAALNKENLCKFIFYSKMFLKKPSKEFFYGFYKKTTDLLNQRKRGYL
EEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEE
ITLEILRPENIVEDVIYPQMEKIQKSINKLVKEHDFEYLQYQNFADDNTCYLSWEFLIHE
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHHC
LPDVKLRIGPPVYSEQGVLNFITHNEHYFVKECNVCAYKTRKYKNIQILFEDIVNGKLKN
CCCCEEEECCCCCCCCCCEEEEECCCEEEEEECCEEEEHHCCCCHHHHHHHHHHCCHHHH
IITYPKYVCPENAKIRLGTFIERK
HHCCCCEECCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA