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The map label for this gene is lhr [C]

Identifier: 45358453

GI number: 45358453

Start: 881791

End: 884034

Strand: Direct

Name: lhr [C]

Synonym: MMP0890

Alternate gene names: 45358453

Gene position: 881791-884034 (Clockwise)

Preceding gene: 45358445

Following gene: 45358454

Centisome position: 53.08

GC content: 31.51

Gene sequence:

>2244_bases
ATGCACGTATTAGATATTCTTAAAGAAAACAAAATTACTGAATTAAGGCCTCCGCAAAAAAAAGTGATTGATGAAGGATT
ATTTGATAAAACAAAGAATTTTTTAATATGTATTCCAACCGCGAGTGGAAAAACGCTTATTGGAGAAATGGCTTTATTAA
ACCATATTTTAGATGAAAATAAAAATTTAACTGGAAAAAAAGGGTTATTTATCGTCCCACTAAAAGCGCTTGCAAATGAA
AAATTTGACGAATTTAAGGAAAAATATGAAAAATATGGAATAAAAGTGGGACTATCAATTGGGGATTTTGATACTAAAGA
GAATCTTTCAAAGTTTCATATCATTATAACTACTTCTGAAAAGCTCGATTCATTAATGAGGCACGAAGTTGAATGGATAA
ATGACGTATCCTTAGCAGTTATTGATGAAATCCATTTAATAGGGGATAATGACAGGGGCGGAACTTTAGAAGTAATTTTA
ACAAAACTGAAAAATTTAAACGCCCAGATTGTCGGCCTTTCTGCAACTATTGGAAACCCCGAAGAACTCTCAAACTGGCT
AAACGCGAAATTAATCGTTGATGAATGGAGGCCAGTTGAATTAAAAAAAGGAATTTACTTTGAAAATGAACTTGAGTTTG
TAAAAAGCCCTGCAAAAAAAATAAAGCAGGTTTCTAAAAATAATATAACTGATTTAATAGTTGACAGTGTCGAAGAAAAA
GGTTCTTGCCTGATATTTTGCAATTCAAAAAGAAATGCAGTTGGCGAAGCAAAAAAACACAATTTAACTAAGTATTTAAC
AAGAACTGAACAGCATGAATTGAATAAATTAAGTGAAGAAATTTTATCAATTCTTGATACGCCAACTGAAACCTGTAAGG
CCCTTTCAGAATGTATTAAAAAAGGAATAGCATTTCACCATGCAGGACTCACTTATCAGCATAGAAAAATTGTTGAAGAT
GGATTTAGAAATAGATTAATAAAAGTAATCTGCTGTACACCAACACTTTCGGCAGGCTTGAATTTACCGTGCAGGCGAGC
AATCGTGCGCGATATAAAAAGATATTCACAAAACGGCCTTGTAGATATTCCAAGAATGGAAATTCAGCAGTGTATTGGAA
GAGCTGGAAGACCTGGATTGGATCCTTACGGTGAAGGGATAATTTATATTAAAAATGAAAAAGAGATTGAAAAAGCTTAT
GAAATTCTTACTGGAAGCGTTGAAAACATATATTCAAAATTGGCAAACCAGAAAGTTTTGAGAATCCATATTTTGGGTTT
AATTTCAACAGGAGAAATTAAAGACGGACAGAATCTTGTTAATTTCATGAAAAATACATTTTACGCATACCAGTTTGGAA
ATATCGGTGCAGTTTTATTAAATGTATCAGAAGTTGTAAAATTTTTAGAAAAAAATAAATTTTTAGAAACATCCGTTCTT
AAAAAAACAGAAAACACGGTTAGGGAGCTTTCTTTCGACTCTTCAAACAATTTAGTTTTGGATTCAAAAGAAACTTCATT
CGATCTTGCAAATCCGGATTCAAAAGTTGAATTTAGATCAACGAAGCTTGGAAAAAGAATATCTGAACTTTATATCGACC
CGATGAGTTCTGAAATCATAATTGAAGAATTGTATGAATTGAAGAAAAAATGTGCTCAATTGGATAGATCAAAAATTGAT
CAGTCTTTATTCTATTTAATTTCAAAAACTAACGAAATGAGGCCACTTTTAAGAGTTAGGGCAAATGAAGAACTTGATTT
AATTCTCAAAATGGATAAAATGGGGCTGAAAGATTATTCTGCGGAAAATATTGAAGCTTTTAAAAATTCAAAAATGTTCT
GCGACTGGGTAAGTGAAATACCTGAAGAAATAATTTTGGAAAAGTACGGTGTTGAACCCGGAATCTTAAGATACAAAGTA
GAACAGGCCAAATGGATGATTTATTCAACAAAAGAGATTGCAAAACTAATTAATTTGGACAGCAGTGCAATATACAGAGC
CCTTATGGAAATGGAATTAAGAATTGAATATGGTGCAAAAGAAGAATTAATTGAATTATTAAAAGTCAAAAATATCGGTC
GTTCAAGGTCGAGAAAACTCTATAATGCAGGAATCAGGTCTAAAATTGAAATAAATAATAATCCTGAAAAAATCTTTGAA
CTTTTCGGCGAAAAAATCGGTAAAAAAATCCTTGGAGAACTTGGAATGAAATATGGCCAACAAACTCTCCTAAATTTTAA
TTAA

Upstream 100 bases:

>100_bases
ATGTAACAATACTATGTAATTATTATTACTCATATGGGCAAAATTATATTATAAATGGAATACAATTAAAAAGAAAAGAA
TTAACAAAAATGTTGAAAAA

Downstream 100 bases:

>100_bases
AATTGAAATATAAATTTTTTAAAAAAGTTATGCTCAGCTGTCCCCGTTGTCTTCATCGGAAAAGGATCCTCAGTGAAGTC
GGCACTCATCATTGCATAAT

Product: superfamily II helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MHVLDILKENKITELRPPQKKVIDEGLFDKTKNFLICIPTASGKTLIGEMALLNHILDENKNLTGKKGLFIVPLKALANE
KFDEFKEKYEKYGIKVGLSIGDFDTKENLSKFHIIITTSEKLDSLMRHEVEWINDVSLAVIDEIHLIGDNDRGGTLEVIL
TKLKNLNAQIVGLSATIGNPEELSNWLNAKLIVDEWRPVELKKGIYFENELEFVKSPAKKIKQVSKNNITDLIVDSVEEK
GSCLIFCNSKRNAVGEAKKHNLTKYLTRTEQHELNKLSEEILSILDTPTETCKALSECIKKGIAFHHAGLTYQHRKIVED
GFRNRLIKVICCTPTLSAGLNLPCRRAIVRDIKRYSQNGLVDIPRMEIQQCIGRAGRPGLDPYGEGIIYIKNEKEIEKAY
EILTGSVENIYSKLANQKVLRIHILGLISTGEIKDGQNLVNFMKNTFYAYQFGNIGAVLLNVSEVVKFLEKNKFLETSVL
KKTENTVRELSFDSSNNLVLDSKETSFDLANPDSKVEFRSTKLGKRISELYIDPMSSEIIIEELYELKKKCAQLDRSKID
QSLFYLISKTNEMRPLLRVRANEELDLILKMDKMGLKDYSAENIEAFKNSKMFCDWVSEIPEEIILEKYGVEPGILRYKV
EQAKWMIYSTKEIAKLINLDSSAIYRALMEMELRIEYGAKEELIELLKVKNIGRSRSRKLYNAGIRSKIEINNNPEKIFE
LFGEKIGKKILGELGMKYGQQTLLNFN

Sequences:

>Translated_747_residues
MHVLDILKENKITELRPPQKKVIDEGLFDKTKNFLICIPTASGKTLIGEMALLNHILDENKNLTGKKGLFIVPLKALANE
KFDEFKEKYEKYGIKVGLSIGDFDTKENLSKFHIIITTSEKLDSLMRHEVEWINDVSLAVIDEIHLIGDNDRGGTLEVIL
TKLKNLNAQIVGLSATIGNPEELSNWLNAKLIVDEWRPVELKKGIYFENELEFVKSPAKKIKQVSKNNITDLIVDSVEEK
GSCLIFCNSKRNAVGEAKKHNLTKYLTRTEQHELNKLSEEILSILDTPTETCKALSECIKKGIAFHHAGLTYQHRKIVED
GFRNRLIKVICCTPTLSAGLNLPCRRAIVRDIKRYSQNGLVDIPRMEIQQCIGRAGRPGLDPYGEGIIYIKNEKEIEKAY
EILTGSVENIYSKLANQKVLRIHILGLISTGEIKDGQNLVNFMKNTFYAYQFGNIGAVLLNVSEVVKFLEKNKFLETSVL
KKTENTVRELSFDSSNNLVLDSKETSFDLANPDSKVEFRSTKLGKRISELYIDPMSSEIIIEELYELKKKCAQLDRSKID
QSLFYLISKTNEMRPLLRVRANEELDLILKMDKMGLKDYSAENIEAFKNSKMFCDWVSEIPEEIILEKYGVEPGILRYKV
EQAKWMIYSTKEIAKLINLDSSAIYRALMEMELRIEYGAKEELIELLKVKNIGRSRSRKLYNAGIRSKIEINNNPEKIFE
LFGEKIGKKILGELGMKYGQQTLLNFN
>Mature_747_residues
MHVLDILKENKITELRPPQKKVIDEGLFDKTKNFLICIPTASGKTLIGEMALLNHILDENKNLTGKKGLFIVPLKALANE
KFDEFKEKYEKYGIKVGLSIGDFDTKENLSKFHIIITTSEKLDSLMRHEVEWINDVSLAVIDEIHLIGDNDRGGTLEVIL
TKLKNLNAQIVGLSATIGNPEELSNWLNAKLIVDEWRPVELKKGIYFENELEFVKSPAKKIKQVSKNNITDLIVDSVEEK
GSCLIFCNSKRNAVGEAKKHNLTKYLTRTEQHELNKLSEEILSILDTPTETCKALSECIKKGIAFHHAGLTYQHRKIVED
GFRNRLIKVICCTPTLSAGLNLPCRRAIVRDIKRYSQNGLVDIPRMEIQQCIGRAGRPGLDPYGEGIIYIKNEKEIEKAY
EILTGSVENIYSKLANQKVLRIHILGLISTGEIKDGQNLVNFMKNTFYAYQFGNIGAVLLNVSEVVKFLEKNKFLETSVL
KKTENTVRELSFDSSNNLVLDSKETSFDLANPDSKVEFRSTKLGKRISELYIDPMSSEIIIEELYELKKKCAQLDRSKID
QSLFYLISKTNEMRPLLRVRANEELDLILKMDKMGLKDYSAENIEAFKNSKMFCDWVSEIPEEIILEKYGVEPGILRYKV
EQAKWMIYSTKEIAKLINLDSSAIYRALMEMELRIEYGAKEELIELLKVKNIGRSRSRKLYNAGIRSKIEINNNPEKIFE
LFGEKIGKKILGELGMKYGQQTLLNFN

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI110556640, Length=739, Percent_Identity=27.7401894451962, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI139394648, Length=745, Percent_Identity=27.5167785234899, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI130484567, Length=407, Percent_Identity=29.97542997543, Blast_Score=174, Evalue=4e-43,
Organism=Homo sapiens, GI76880486, Length=447, Percent_Identity=30.4250559284116, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI169218225, Length=536, Percent_Identity=28.544776119403, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI40217847, Length=536, Percent_Identity=28.3582089552239, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI193211480, Length=467, Percent_Identity=24.8394004282655, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI67782311, Length=474, Percent_Identity=24.0506329113924, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1787942, Length=430, Percent_Identity=23.7209302325581, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71995032, Length=745, Percent_Identity=26.4429530201342, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17537519, Length=466, Percent_Identity=29.6137339055794, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17537127, Length=414, Percent_Identity=30.9178743961353, Blast_Score=155, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI86563272, Length=413, Percent_Identity=28.5714285714286, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17542826, Length=473, Percent_Identity=22.6215644820296, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71995036, Length=450, Percent_Identity=26.4444444444444, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI133930973, Length=185, Percent_Identity=30.2702702702703, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17552356, Length=194, Percent_Identity=25.7731958762887, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI9755332, Length=596, Percent_Identity=27.8523489932886, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321020, Length=616, Percent_Identity=28.5714285714286, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321710, Length=457, Percent_Identity=28.6652078774617, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322411, Length=450, Percent_Identity=25.1111111111111, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323430, Length=204, Percent_Identity=30.3921568627451, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24660651, Length=782, Percent_Identity=26.2148337595908, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17933644, Length=449, Percent_Identity=29.6213808463252, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24647182, Length=468, Percent_Identity=29.9145299145299, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28574898, Length=451, Percent_Identity=28.159645232816, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17864608, Length=486, Percent_Identity=25.9259259259259, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17933658, Length=178, Percent_Identity=28.6516853932584, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR003583 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: 3.6.1.-

Molecular weight: Translated: 85282; Mature: 85282

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVLDILKENKITELRPPQKKVIDEGLFDKTKNFLICIPTASGKTLIGEMALLNHILDEN
CCHHHHHHCCCCCCCCCCHHHHHHCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
KNLTGKKGLFIVPLKALANEKFDEFKEKYEKYGIKVGLSIGDFDTKENLSKFHIIITTSE
CCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEECHH
KLDSLMRHEVEWINDVSLAVIDEIHLIGDNDRGGTLEVILTKLKNLNAQIVGLSATIGNP
HHHHHHHHHHHHHCCCHHHEEHEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCH
EELSNWLNAKLIVDEWRPVELKKGIYFENELEFVKSPAKKIKQVSKNNITDLIVDSVEEK
HHHHHHHCCEEEEECCCCEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GSCLIFCNSKRNAVGEAKKHNLTKYLTRTEQHELNKLSEEILSILDTPTETCKALSECIK
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGIAFHHAGLTYQHRKIVEDGFRNRLIKVICCTPTLSAGLNLPCRRAIVRDIKRYSQNGL
HCHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
VDIPRMEIQQCIGRAGRPGLDPYGEGIIYIKNEKEIEKAYEILTGSVENIYSKLANQKVL
EECCHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCCEE
RIHILGLISTGEIKDGQNLVNFMKNTFYAYQFGNIGAVLLNVSEVVKFLEKNKFLETSVL
EEEEEEEEECCCCCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHH
KKTENTVRELSFDSSNNLVLDSKETSFDLANPDSKVEFRSTKLGKRISELYIDPMSSEII
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHH
IEELYELKKKCAQLDRSKIDQSLFYLISKTNEMRPLLRVRANEELDLILKMDKMGLKDYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCC
AENIEAFKNSKMFCDWVSEIPEEIILEKYGVEPGILRYKVEQAKWMIYSTKEIAKLINLD
CHHHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCEEEEEEHHHHHHHHCCC
SSAIYRALMEMELRIEYGAKEELIELLKVKNIGRSRSRKLYNAGIRSKIEINNNPEKIFE
HHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCHHHHHH
LFGEKIGKKILGELGMKYGQQTLLNFN
HHHHHHHHHHHHHHHHHHCCHHHCCCC
>Mature Secondary Structure
MHVLDILKENKITELRPPQKKVIDEGLFDKTKNFLICIPTASGKTLIGEMALLNHILDEN
CCHHHHHHCCCCCCCCCCHHHHHHCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
KNLTGKKGLFIVPLKALANEKFDEFKEKYEKYGIKVGLSIGDFDTKENLSKFHIIITTSE
CCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEECHH
KLDSLMRHEVEWINDVSLAVIDEIHLIGDNDRGGTLEVILTKLKNLNAQIVGLSATIGNP
HHHHHHHHHHHHHCCCHHHEEHEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCH
EELSNWLNAKLIVDEWRPVELKKGIYFENELEFVKSPAKKIKQVSKNNITDLIVDSVEEK
HHHHHHHCCEEEEECCCCEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GSCLIFCNSKRNAVGEAKKHNLTKYLTRTEQHELNKLSEEILSILDTPTETCKALSECIK
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGIAFHHAGLTYQHRKIVEDGFRNRLIKVICCTPTLSAGLNLPCRRAIVRDIKRYSQNGL
HCHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
VDIPRMEIQQCIGRAGRPGLDPYGEGIIYIKNEKEIEKAYEILTGSVENIYSKLANQKVL
EECCHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCCEE
RIHILGLISTGEIKDGQNLVNFMKNTFYAYQFGNIGAVLLNVSEVVKFLEKNKFLETSVL
EEEEEEEEECCCCCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHH
KKTENTVRELSFDSSNNLVLDSKETSFDLANPDSKVEFRSTKLGKRISELYIDPMSSEII
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHH
IEELYELKKKCAQLDRSKIDQSLFYLISKTNEMRPLLRVRANEELDLILKMDKMGLKDYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCC
AENIEAFKNSKMFCDWVSEIPEEIILEKYGVEPGILRYKVEQAKWMIYSTKEIAKLINLD
CHHHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCEEEEEEHHHHHHHHCCC
SSAIYRALMEMELRIEYGAKEELIELLKVKNIGRSRSRKLYNAGIRSKIEINNNPEKIFE
HHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCHHHHHH
LFGEKIGKKILGELGMKYGQQTLLNFN
HHHHHHHHHHHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA