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The map label for this gene is napA-2 [H]

Identifier: 45358427

GI number: 45358427

Start: 854998

End: 856164

Strand: Direct

Name: napA-2 [H]

Synonym: MMP0864

Alternate gene names: 45358427

Gene position: 854998-856164 (Clockwise)

Preceding gene: 45358426

Following gene: 45358432

Centisome position: 51.47

GC content: 33.68

Gene sequence:

>1167_bases
GTGGATATTTCATGGGTGTTGTTTACTGTTGGAGTATGCCTTATATTTGGAAAAATTGGAAACGAAATAATGTGGCGATT
TGGCTTTCCAAGTGTATTTGGAGAGATCCTAATCGGAATAATATTTGGAAACCTGTTATTTTTTGGAATAGTTGATTCCT
CTCACCTAACGCTCCATGAAAACGATATTTTTGACTTTTTATCCACTGTTGGGATCATGTTTTTACTGTTTATAAGTGGC
CTTGAAATAGACATACACAGGCTTAAAAAGACCGAAAATATCTCTATAGTTGCAGCGGTACTTGGAGCGGTGTTTCCTTT
AATTTTTGGATATATTTCATTATCTTATTTTGGTTACACGGCCAAAGAATCTATTGTTGGTGGGGTAATTCTTACAGCAA
CGAGTATTGGAATTACTGCAAGGCTTTTGATGGATTTAAAAGTTTTAAAAACTGATGTGGGGGCAGCTGCAATTAGTGCG
AGTATTCTTGACGACTTTTTGGGCCTTATTCTTCTTATCCTCGCTGTCGGATCGGGCAGTTTACTCGGGCTAATTTCGGA
AATTACTGTATTTTTTATTATTACTGGATACTTTGGATGGAAATTGATTAAAAAATACTTAATTTTCGCAGAAAAGTTTC
ATATTGAAAAAACCGTTCTTTCATTTACAATTGCGTTGATGTTTTTATTTTCATTTTTATCAGAAAGCTGGTTTGAAGTT
GCAATTGAAGGCGCATTTATGGCAGGATTAATCCTTTCAAAAACTTCAGAAGGTAAAACACTCGCAAAAGAGATAAAATC
AATTGGAAATTCATTTTTAATTCCATTATTTTTTATATACACTGGAGCAAGGTTGAATTTAACTGCATTTTTAAATCATG
AAGCTCTGATACTTGCTACAATTTTTATAATTGTAGGCGTTTTTACTAAATTTGTGGGTTGGGGACTTGGTGCAAAAATA
ATGGGTAAATGGGATCTTAAAAAATCGATACAGCTTGCTTCAGCATCCGTTCCAAGGGCAGAAATAGCACTGATAAATTT
AATGATTGCAGTTTCTGCAGGAGTAATTTTAGAAGAAAATATTTCAAAATTCATTGCAGCAACGCTGATATTTGTTACAT
TTTCGATAGTTATAACTCCACCACTCTTAAAAAAAGTTTTTGAGTGA

Upstream 100 bases:

>100_bases
AACTTTTAGCCGTGGTTGATGATGAAAATAGGTTAATTGGTGAAATTAGTCTCAGGATATTGATAAATAAGTTTCTTGAT
CTCTGCTTTTAGGTGTTTTC

Downstream 100 bases:

>100_bases
TATAATATATTGAATTTTTAAAAAGAAAATAAAAAATAAAAAAAGCAAAATTTATTTTTAGAGTACTTTTTCATCTAAAA
GTTCAGAAATCGATTCATAA

Product: Na+/H+ exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDISWVLFTVGVCLIFGKIGNEIMWRFGFPSVFGEILIGIIFGNLLFFGIVDSSHLTLHENDIFDFLSTVGIMFLLFISG
LEIDIHRLKKTENISIVAAVLGAVFPLIFGYISLSYFGYTAKESIVGGVILTATSIGITARLLMDLKVLKTDVGAAAISA
SILDDFLGLILLILAVGSGSLLGLISEITVFFIITGYFGWKLIKKYLIFAEKFHIEKTVLSFTIALMFLFSFLSESWFEV
AIEGAFMAGLILSKTSEGKTLAKEIKSIGNSFLIPLFFIYTGARLNLTAFLNHEALILATIFIIVGVFTKFVGWGLGAKI
MGKWDLKKSIQLASASVPRAEIALINLMIAVSAGVILEENISKFIAATLIFVTFSIVITPPLLKKVFE

Sequences:

>Translated_388_residues
MDISWVLFTVGVCLIFGKIGNEIMWRFGFPSVFGEILIGIIFGNLLFFGIVDSSHLTLHENDIFDFLSTVGIMFLLFISG
LEIDIHRLKKTENISIVAAVLGAVFPLIFGYISLSYFGYTAKESIVGGVILTATSIGITARLLMDLKVLKTDVGAAAISA
SILDDFLGLILLILAVGSGSLLGLISEITVFFIITGYFGWKLIKKYLIFAEKFHIEKTVLSFTIALMFLFSFLSESWFEV
AIEGAFMAGLILSKTSEGKTLAKEIKSIGNSFLIPLFFIYTGARLNLTAFLNHEALILATIFIIVGVFTKFVGWGLGAKI
MGKWDLKKSIQLASASVPRAEIALINLMIAVSAGVILEENISKFIAATLIFVTFSIVITPPLLKKVFE
>Mature_388_residues
MDISWVLFTVGVCLIFGKIGNEIMWRFGFPSVFGEILIGIIFGNLLFFGIVDSSHLTLHENDIFDFLSTVGIMFLLFISG
LEIDIHRLKKTENISIVAAVLGAVFPLIFGYISLSYFGYTAKESIVGGVILTATSIGITARLLMDLKVLKTDVGAAAISA
SILDDFLGLILLILAVGSGSLLGLISEITVFFIITGYFGWKLIKKYLIFAEKFHIEKTVLSFTIALMFLFSFLSESWFEV
AIEGAFMAGLILSKTSEGKTLAKEIKSIGNSFLIPLFFIYTGARLNLTAFLNHEALILATIFIIVGVFTKFVGWGLGAKI
MGKWDLKKSIQLASASVPRAEIALINLMIAVSAGVILEENISKFIAATLIFVTFSIVITPPLLKKVFE

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=416, Percent_Identity=25.2403846153846, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 42437; Mature: 42437

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISWVLFTVGVCLIFGKIGNEIMWRFGFPSVFGEILIGIIFGNLLFFGIVDSSHLTLHE
CCCHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
NDIFDFLSTVGIMFLLFISGLEIDIHRLKKTENISIVAAVLGAVFPLIFGYISLSYFGYT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
AKESIVGGVILTATSIGITARLLMDLKVLKTDVGAAAISASILDDFLGLILLILAVGSGS
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLGLISEITVFFIITGYFGWKLIKKYLIFAEKFHIEKTVLSFTIALMFLFSFLSESWFEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEGAFMAGLILSKTSEGKTLAKEIKSIGNSFLIPLFFIYTGARLNLTAFLNHEALILAT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
IFIIVGVFTKFVGWGLGAKIMGKWDLKKSIQLASASVPRAEIALINLMIAVSAGVILEEN
HHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
ISKFIAATLIFVTFSIVITPPLLKKVFE
HHHHHHHHHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MDISWVLFTVGVCLIFGKIGNEIMWRFGFPSVFGEILIGIIFGNLLFFGIVDSSHLTLHE
CCCHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
NDIFDFLSTVGIMFLLFISGLEIDIHRLKKTENISIVAAVLGAVFPLIFGYISLSYFGYT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
AKESIVGGVILTATSIGITARLLMDLKVLKTDVGAAAISASILDDFLGLILLILAVGSGS
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLGLISEITVFFIITGYFGWKLIKKYLIFAEKFHIEKTVLSFTIALMFLFSFLSESWFEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEGAFMAGLILSKTSEGKTLAKEIKSIGNSFLIPLFFIYTGARLNLTAFLNHEALILAT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
IFIIVGVFTKFVGWGLGAKIMGKWDLKKSIQLASASVPRAEIALINLMIAVSAGVILEEN
HHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
ISKFIAATLIFVTFSIVITPPLLKKVFE
HHHHHHHHHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]