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The map label for this gene is yrhP [H]

Identifier: 45358412

GI number: 45358412

Start: 840626

End: 841249

Strand: Direct

Name: yrhP [H]

Synonym: MMP0849

Alternate gene names: 45358412

Gene position: 840626-841249 (Clockwise)

Preceding gene: 45358409

Following gene: 45358413

Centisome position: 50.61

GC content: 35.58

Gene sequence:

>624_bases
ATGATTGAATCTACACAAGTTTTTTATTTTGTGATTGCATCGGCCGCACTTACAATTCTTCCAGGGCCCGACATAATATT
TGTAACGGTTCAAAGTATATCTCAGGGAAAATGGGCAGGGATTTCAACAGCGTTAGGGCTTTGTACCGGACTTATAGTCC
ACACTACTGCAGCAGCACTTGGAATTTCTGCGATAATCTACAATTCTGCGTTTGCATTTACGATTGTAAAATATCTTGGA
GCTTTGTATCTGCTTTACCTTGCAGTTCTCGCATTATTTGATAAAAATGTAGTAATAACTGAATCAGTAGTTAAATCGGA
AAACACTGCACTTTATAAAAAAGGAATATTTATGAATTTATTAAACCCGAAAGTTTCGTTATTTTTCCTCGCATTTCTTC
CCCAGTTTGTAAATCCAAATTCTGGAAGCGTTCCGATTCAGATGATACTATTGGGAGTTATTTTCATGATTCAGGCAATC
TTAATTTTTTCAGCGGTTGCAGTATTCTCAAGCATTTTTGGAGAAAAAATATTAAACAGCCAAAAATGTGGAAAATATAT
CAATCTGGCTAAAGCAGGAATATTTGGTGCAATTGGGATTCAGCTGGCACTTTTGAGTAAATAA

Upstream 100 bases:

>100_bases
TATTTTTAAAAGATTGATTAATCGAAATACGTTAAAATTGCCCGCAGGGGTTAAATATCATGAATACATAACTAAATACC
TAAAAAATTATGGTGTTAGC

Downstream 100 bases:

>100_bases
TAAATTTAAATTAATTTAAAAATGAAAAACGTGAAAATTAAACGGAATATACAGGAATATTTATGAGTTCTAAAAAATTG
GGGCCTTATACATTAAGTGG

Product: L-lysine/ homoserine-homoserine lactone exporter family protein

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MIESTQVFYFVIASAALTILPGPDIIFVTVQSISQGKWAGISTALGLCTGLIVHTTAAALGISAIIYNSAFAFTIVKYLG
ALYLLYLAVLALFDKNVVITESVVKSENTALYKKGIFMNLLNPKVSLFFLAFLPQFVNPNSGSVPIQMILLGVIFMIQAI
LIFSAVAVFSSIFGEKILNSQKCGKYINLAKAGIFGAIGIQLALLSK

Sequences:

>Translated_207_residues
MIESTQVFYFVIASAALTILPGPDIIFVTVQSISQGKWAGISTALGLCTGLIVHTTAAALGISAIIYNSAFAFTIVKYLG
ALYLLYLAVLALFDKNVVITESVVKSENTALYKKGIFMNLLNPKVSLFFLAFLPQFVNPNSGSVPIQMILLGVIFMIQAI
LIFSAVAVFSSIFGEKILNSQKCGKYINLAKAGIFGAIGIQLALLSK
>Mature_207_residues
MIESTQVFYFVIASAALTILPGPDIIFVTVQSISQGKWAGISTALGLCTGLIVHTTAAALGISAIIYNSAFAFTIVKYLG
ALYLLYLAVLALFDKNVVITESVVKSENTALYKKGIFMNLLNPKVSLFFLAFLPQFVNPNSGSVPIQMILLGVIFMIQAI
LIFSAVAVFSSIFGEKILNSQKCGKYINLAKAGIFGAIGIQLALLSK

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=156, Percent_Identity=28.2051282051282, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1788099, Length=179, Percent_Identity=27.9329608938547, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI48994978, Length=189, Percent_Identity=26.984126984127, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22154; Mature: 22154

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESTQVFYFVIASAALTILPGPDIIFVTVQSISQGKWAGISTALGLCTGLIVHTTAAAL
CCCCHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISAIIYNSAFAFTIVKYLGALYLLYLAVLALFDKNVVITESVVKSENTALYKKGIFMNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCHHHHHHHHHHHH
LNPKVSLFFLAFLPQFVNPNSGSVPIQMILLGVIFMIQAILIFSAVAVFSSIFGEKILNS
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
QKCGKYINLAKAGIFGAIGIQLALLSK
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIESTQVFYFVIASAALTILPGPDIIFVTVQSISQGKWAGISTALGLCTGLIVHTTAAAL
CCCCHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISAIIYNSAFAFTIVKYLGALYLLYLAVLALFDKNVVITESVVKSENTALYKKGIFMNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCHHHHHHHHHHHH
LNPKVSLFFLAFLPQFVNPNSGSVPIQMILLGVIFMIQAILIFSAVAVFSSIFGEKILNS
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
QKCGKYINLAKAGIFGAIGIQLALLSK
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]