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The map label for this gene is mtaA [H]

Identifier: 45358393

GI number: 45358393

Start: 823802

End: 824893

Strand: Direct

Name: mtaA [H]

Synonym: MMP0830

Alternate gene names: 45358393

Gene position: 823802-824893 (Clockwise)

Preceding gene: 45358392

Following gene: 45358394

Centisome position: 49.59

GC content: 37.27

Gene sequence:

>1092_bases
ATGGATTACCCAGACAAAATGACACCTGCTCAAAGAGCTGCTGCTAAAGCTAAGGGCGAACCCGCTGACCGGGTTGCATG
CAACCCAAACATTGCAAATGGAATGGCAAGAATTGCCGGCTACAAAATTTCACAGTTCAATGACGACCCTGAAGCGCTTG
CTGATGCAATTATTAAAACATACAGAAGATTTGGGGCAGATGGTGCAAGAATTTTCACAGATTTATTTTTAGTTTCAGAA
GCAATGGGCGCAAAAGTTAGAAAACCAGAAGATAATACTGCAGATTTAGAAGAACCTGCAATAAATGACATGTCAGAATT
TGATAAATTAAAAGTAATTGATCCATACACACAAGGTAGAATTCCAGTTCACTTAAGGGCAATTGAAATCGTAAGGGATG
AAATTGCAAGCGAAGTTGGAGTTACTGCTTCAGTTGTAGGTCCATTTACAAACGCTTTCTTTTTAATTGGCGTAGAAAAA
ATGACAAAAATGCTTTTAAAAGATCCTGAATCAGTTCATAAACTCTGTGAAATTTCATTACAAAGTTGCATTGCACTAAC
CGATGCAGTTTTGGAAAAAGGCGTTGGAGTTACTATTTCAGAACCTCTTTCATCATGTACGGTTGTAAGTCCAAAACACT
TTAGGGAATTTTCAGCACCGTACTTAAAAAGACTTATCGACCACATAAAAGCAAGAACTGGAAAATTGGTTATACACATT
TGTGGAATAACAGATCCAATTTGGGATGATCTTGTAGAAATGGGCGTAGATGTTTTAAGCATTGATAACGTTGCAGATAT
GGAAAAATGTGCAGAAACCGTTGGAGATAAAATGGTTATTGCAGGAAATGTTGACCCTTCAGCGATTATGTATGCAGGAT
CAAGAGAAGACGTTAGAAAAGCTACAATTAAATGTGCAAAACAGGGATTGAAAGCTAAAAAAGGATTCATGATCATGTCA
GGATGCAGTCTTCCAGTAGAAGTTCCTATTGAAAACATTGATGCAATGATGGATACTGCAAGGGAAATGGGATGGCCGGT
TACTGAGGAAAAATTAGACTATTTACTTAGTTTTGATAAATACAAAGACTAA

Upstream 100 bases:

>100_bases
TGCAGATGGCTACGCACCAGAAGCTTCAAAATCTGCAAGAATTGCAAAAGAATTGGTTACAACATTAAAAGGTTAATTTA
AACGGTATGGAGAGATTATT

Downstream 100 bases:

>100_bases
GTATCCAAATTATCAAGTTATTCACCCAGATTTTATAATTTTTAAATTTTTAGTTTGATTTTTTTAAATTTTAGTTTAAA
TTAATACATTATATTTGACA

Product: uroporphyrinogen decarboxylase

Products: CO2; Coproporphyrinogen III [C]

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MDYPDKMTPAQRAAAKAKGEPADRVACNPNIANGMARIAGYKISQFNDDPEALADAIIKTYRRFGADGARIFTDLFLVSE
AMGAKVRKPEDNTADLEEPAINDMSEFDKLKVIDPYTQGRIPVHLRAIEIVRDEIASEVGVTASVVGPFTNAFFLIGVEK
MTKMLLKDPESVHKLCEISLQSCIALTDAVLEKGVGVTISEPLSSCTVVSPKHFREFSAPYLKRLIDHIKARTGKLVIHI
CGITDPIWDDLVEMGVDVLSIDNVADMEKCAETVGDKMVIAGNVDPSAIMYAGSREDVRKATIKCAKQGLKAKKGFMIMS
GCSLPVEVPIENIDAMMDTAREMGWPVTEEKLDYLLSFDKYKD

Sequences:

>Translated_363_residues
MDYPDKMTPAQRAAAKAKGEPADRVACNPNIANGMARIAGYKISQFNDDPEALADAIIKTYRRFGADGARIFTDLFLVSE
AMGAKVRKPEDNTADLEEPAINDMSEFDKLKVIDPYTQGRIPVHLRAIEIVRDEIASEVGVTASVVGPFTNAFFLIGVEK
MTKMLLKDPESVHKLCEISLQSCIALTDAVLEKGVGVTISEPLSSCTVVSPKHFREFSAPYLKRLIDHIKARTGKLVIHI
CGITDPIWDDLVEMGVDVLSIDNVADMEKCAETVGDKMVIAGNVDPSAIMYAGSREDVRKATIKCAKQGLKAKKGFMIMS
GCSLPVEVPIENIDAMMDTAREMGWPVTEEKLDYLLSFDKYKD
>Mature_363_residues
MDYPDKMTPAQRAAAKAKGEPADRVACNPNIANGMARIAGYKISQFNDDPEALADAIIKTYRRFGADGARIFTDLFLVSE
AMGAKVRKPEDNTADLEEPAINDMSEFDKLKVIDPYTQGRIPVHLRAIEIVRDEIASEVGVTASVVGPFTNAFFLIGVEK
MTKMLLKDPESVHKLCEISLQSCIALTDAVLEKGVGVTISEPLSSCTVVSPKHFREFSAPYLKRLIDHIKARTGKLVIHI
CGITDPIWDDLVEMGVDVLSIDNVADMEKCAETVGDKMVIAGNVDPSAIMYAGSREDVRKATIKCAKQGLKAKKGFMIMS
GCSLPVEVPIENIDAMMDTAREMGWPVTEEKLDYLLSFDKYKD

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=267, Percent_Identity=25.4681647940075, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI2367337, Length=305, Percent_Identity=22.9508196721311, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: 4.1.1.37 [C]

Molecular weight: Translated: 39841; Mature: 39841

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYPDKMTPAQRAAAKAKGEPADRVACNPNIANGMARIAGYKISQFNDDPEALADAIIKT
CCCCCCCCHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHCCCHHCCCCCHHHHHHHHHHH
YRRFGADGARIFTDLFLVSEAMGAKVRKPEDNTADLEEPAINDMSEFDKLKVIDPYTQGR
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEECCCCCCC
IPVHLRAIEIVRDEIASEVGVTASVVGPFTNAFFLIGVEKMTKMLLKDPESVHKLCEISL
CCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEHHHHHHHHHCCHHHHHHHHHHHH
QSCIALTDAVLEKGVGVTISEPLSSCTVVSPKHFREFSAPYLKRLIDHIKARTGKLVIHI
HHHHHHHHHHHHCCCCCEECCCCCCCEECCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEE
CGITDPIWDDLVEMGVDVLSIDNVADMEKCAETVGDKMVIAGNVDPSAIMYAGSREDVRK
ECCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCEEEECCCCCCCEEECCCHHHHHH
ATIKCAKQGLKAKKGFMIMSGCSLPVEVPIENIDAMMDTAREMGWPVTEEKLDYLLSFDK
HHHHHHHHCCHHHCCEEEEECCCCCEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
YKD
CCC
>Mature Secondary Structure
MDYPDKMTPAQRAAAKAKGEPADRVACNPNIANGMARIAGYKISQFNDDPEALADAIIKT
CCCCCCCCHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHCCCHHCCCCCHHHHHHHHHHH
YRRFGADGARIFTDLFLVSEAMGAKVRKPEDNTADLEEPAINDMSEFDKLKVIDPYTQGR
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEECCCCCCC
IPVHLRAIEIVRDEIASEVGVTASVVGPFTNAFFLIGVEKMTKMLLKDPESVHKLCEISL
CCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEHHHHHHHHHCCHHHHHHHHHHHH
QSCIALTDAVLEKGVGVTISEPLSSCTVVSPKHFREFSAPYLKRLIDHIKARTGKLVIHI
HHHHHHHHHHHHCCCCCEECCCCCCCEECCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEE
CGITDPIWDDLVEMGVDVLSIDNVADMEKCAETVGDKMVIAGNVDPSAIMYAGSREDVRK
ECCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCEEEECCCCCCCEEECCCHHHHHH
ATIKCAKQGLKAKKGFMIMSGCSLPVEVPIENIDAMMDTAREMGWPVTEEKLDYLLSFDK
HHHHHHHHCCHHHCCEEEEECCCCCEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
YKD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Reducing agents [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.00231 {7-COOH,} 0.00053 {8-COOH-porphyrinogen} 0.00025 {8-COOH-porphyrinogen} 0.00533 {uroporphyrinogen} 0.00256 {uroporphyrinogen} 0.00133 {uroporphyrinogen} 0.001 {uroporphyrinogen} 0.0008 {uroporphyrinogen} 0.0004 {uroporphyrino

Substrates: H+; Uroporphyrinogen III [C]

Specific reaction: (4) H+ + Uroporphyrinogen III --> (4) CO2 + Coproporphyrinogen III [C]

General reaction: Decarboxylation [C]

Inhibitor: 5, 5'-Dithiobis (2-nitrobenzoate); 7-COOH-porphyrinogenI; 7-COOH-porphyrinogen III; Butanedione; Diethyl dicarbonate; Fe2+; Iodoacetamide; p-Hydroxy mercuribenzoate; Phenyl glyoxal; Pt2+; Sn2+; UroporphyrinogenI uroporphyrinogen III; Uroporphyrinogen III;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]