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The map label for this gene is ilvC [H]

Identifier: 45358217

GI number: 45358217

Start: 645729

End: 646721

Strand: Direct

Name: ilvC [H]

Synonym: MMP0654

Alternate gene names: 45358217

Gene position: 645729-646721 (Clockwise)

Preceding gene: 45358215

Following gene: 45358218

Centisome position: 38.87

GC content: 37.26

Gene sequence:

>993_bases
ATGAAGGTATTCTATGACTCAGATTTTAAATTAGATGCTTTAAAAGAAAAAACAATTGCAGTAATCGGTTATGGAAGTCA
AGGTAGGGCACAGTCCTTAAACATGAAAGACAGCGGATTAAACGTTGTTGTTGGTTTAAGAAAAAACGGTGCTTCATGGA
ACAACGCTAAAGCAGACGGTCACAATGTAATGACCATTGAAGAAGCTGCTGAAAAAGCGGACATCATCCACATCTTAATA
CCTGATGAATTACAGGCAGAAGTTTATGAAAGCCAGATAAAACCATACCTAAAAGAAGGAAAAACACTAAGCTTTTCACA
TGGTTTTAACATCCACTATGGATTCATTGTTCCACCAAAAGGAGTTAACGTGGTTTTAGTTGCTCCAAAATCACCTGGAA
AAATGGTTAGAAGAACATACGAAGAAGGTTTCGGTGTTCCAGGTTTAATCTGTATTGAAATTGATGCAACAAACAACGCA
TTTGATATTGTTTCAGCAATGGCAAAAGGAATCGGTTTATCAAGAGCTGGAGTTATCCAGACAACTTTCAAAGAAGAAAC
AGAAACTGACCTTTTCGGTGAACAAGCTGTTTTATGCGGTGGAGTTACCGAATTAATCAAGGCAGGATTTGAAACACTCG
TTGAAGCAGGATACGCACCAGAAATGGCATACTTTGAAACCTGCCACGAATTGAAATTAATCGTTGACTTAATCTACCAA
AAAGGATTCAAAAACATGTGGAACGATGTAAGTAACACTGCAGAATACGGCGGACTTACAAGAAGAAGCAGAATCGTTAC
AGCTGATTCAAAAGCTGCAATGAAAGAAATCTTAAGAGAAATCCAAGATGGAAGATTCACAAAAGAATTCCTTCTCGAAA
AACAGGTAAGCTATGCTCATTTAAAATCAATGAGAAGACTCGAAGGAGACTTACAAATCGAAGAAGTCGGCGCAAAATTA
AGAAAAATGTGCGGTCTTGAAAAAGAAGAATAA

Upstream 100 bases:

>100_bases
AGTTCGTGTTTTGCCGTAATTTATTATAGTTTATGCCTAATTTTAGATATCATTATATATGATTATACTATAAAAGATTG
TGAGATTAGAGGTGAAGACA

Downstream 100 bases:

>100_bases
TTTATTTATTTTTCATTTTTAACTATTTTTTTATTATTTTAAAATCAGGTGGTTCTTTTGAAAGTTTTTATAAAGAATGC
TGGAGAATTGTCCGAAATTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKVFYDSDFKLDALKEKTIAVIGYGSQGRAQSLNMKDSGLNVVVGLRKNGASWNNAKADGHNVMTIEEAAEKADIIHILI
PDELQAEVYESQIKPYLKEGKTLSFSHGFNIHYGFIVPPKGVNVVLVAPKSPGKMVRRTYEEGFGVPGLICIEIDATNNA
FDIVSAMAKGIGLSRAGVIQTTFKEETETDLFGEQAVLCGGVTELIKAGFETLVEAGYAPEMAYFETCHELKLIVDLIYQ
KGFKNMWNDVSNTAEYGGLTRRSRIVTADSKAAMKEILREIQDGRFTKEFLLEKQVSYAHLKSMRRLEGDLQIEEVGAKL
RKMCGLEKEE

Sequences:

>Translated_330_residues
MKVFYDSDFKLDALKEKTIAVIGYGSQGRAQSLNMKDSGLNVVVGLRKNGASWNNAKADGHNVMTIEEAAEKADIIHILI
PDELQAEVYESQIKPYLKEGKTLSFSHGFNIHYGFIVPPKGVNVVLVAPKSPGKMVRRTYEEGFGVPGLICIEIDATNNA
FDIVSAMAKGIGLSRAGVIQTTFKEETETDLFGEQAVLCGGVTELIKAGFETLVEAGYAPEMAYFETCHELKLIVDLIYQ
KGFKNMWNDVSNTAEYGGLTRRSRIVTADSKAAMKEILREIQDGRFTKEFLLEKQVSYAHLKSMRRLEGDLQIEEVGAKL
RKMCGLEKEE
>Mature_330_residues
MKVFYDSDFKLDALKEKTIAVIGYGSQGRAQSLNMKDSGLNVVVGLRKNGASWNNAKADGHNVMTIEEAAEKADIIHILI
PDELQAEVYESQIKPYLKEGKTLSFSHGFNIHYGFIVPPKGVNVVLVAPKSPGKMVRRTYEEGFGVPGLICIEIDATNNA
FDIVSAMAKGIGLSRAGVIQTTFKEETETDLFGEQAVLCGGVTELIKAGFETLVEAGYAPEMAYFETCHELKLIVDLIYQ
KGFKNMWNDVSNTAEYGGLTRRSRIVTADSKAAMKEILREIQDGRFTKEFLLEKQVSYAHLKSMRRLEGDLQIEEVGAKL
RKMCGLEKEE

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=290, Percent_Identity=36.2068965517241, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=327, Percent_Identity=36.697247706422, Blast_Score=170, Evalue=4e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36604; Mature: 36604

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFYDSDFKLDALKEKTIAVIGYGSQGRAQSLNMKDSGLNVVVGLRKNGASWNNAKADG
CEEEECCCCCCHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
HNVMTIEEAAEKADIIHILIPDELQAEVYESQIKPYLKEGKTLSFSHGFNIHYGFIVPPK
CCEEEHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCC
GVNVVLVAPKSPGKMVRRTYEEGFGVPGLICIEIDATNNAFDIVSAMAKGIGLSRAGVIQ
CCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEE
TTFKEETETDLFGEQAVLCGGVTELIKAGFETLVEAGYAPEMAYFETCHELKLIVDLIYQ
EHHHCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KGFKNMWNDVSNTAEYGGLTRRSRIVTADSKAAMKEILREIQDGRFTKEFLLEKQVSYAH
HHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LKSMRRLEGDLQIEEVGAKLRKMCGLEKEE
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKVFYDSDFKLDALKEKTIAVIGYGSQGRAQSLNMKDSGLNVVVGLRKNGASWNNAKADG
CEEEECCCCCCHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
HNVMTIEEAAEKADIIHILIPDELQAEVYESQIKPYLKEGKTLSFSHGFNIHYGFIVPPK
CCEEEHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCC
GVNVVLVAPKSPGKMVRRTYEEGFGVPGLICIEIDATNNAFDIVSAMAKGIGLSRAGVIQ
CCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEE
TTFKEETETDLFGEQAVLCGGVTELIKAGFETLVEAGYAPEMAYFETCHELKLIVDLIYQ
EHHHCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KGFKNMWNDVSNTAEYGGLTRRSRIVTADSKAAMKEILREIQDGRFTKEFLLEKQVSYAH
HHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LKSMRRLEGDLQIEEVGAKLRKMCGLEKEE
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA