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The map label for this gene is hisA

Identifier: 45357980

GI number: 45357980

Start: 418670

End: 419395

Strand: Direct

Name: hisA

Synonym: MMP0417

Alternate gene names: 45357980

Gene position: 418670-419395 (Clockwise)

Preceding gene: 45357979

Following gene: 45357981

Centisome position: 25.2

GC content: 33.88

Gene sequence:

>726_bases
GTGCTAGTTATTCCTGCAGTTGATATGAAAAATAAAAAATGTGTACAGCTTATCCAGGGAAATCCTGATAAAAAACACGT
TGAATTAGATAATCCTCCTGAAATTGCAAAAAAATGGGTAAATGAAGGTGCAGAAATGCTTCACCTCGTGGACCTTGATG
GTGCACTTGACGGAAAACGGGTAAACGATGAATTTATCGAAGAAATAATTAAAAAATCTGGGGTACCTGTTCAAATTGGT
GGCGGAATTCGATCAATCGAAGATGCAGAATACCTCGTTGAAAAAGGGGCTAAAAAAGTAATTATTGGAACTATTGCTGT
AGAAAATCCAGAAATAATAAAAGAACTTTCTAAACGTATCGGCAGTGAAAAAATAATGGTTTCACTTGATGCAAAAGACG
GCAAAGTTGTAATAAAAGGCTGGAAAGAAAAAACAAAATACACTCCTGTTCAAATTGGAAAAATACTCGAAGAAATGGGC
GCTGGAAGTATTTTATTTACAAATGTAGATAGTGAAGGTCTTTTGAATGGAATAAATATCGAACCAACAAAAGAACTTGT
CGACAACTTGAAAATACCTATTGTAGCATCAGGCGGCGTTACAACAATCGATGATCTTTTAAAATTAAAAGAAATCGGGG
TATATGGGGTAGTTGTAGGTTCTGCAATTTACAAAAATATGATAAATTTAAAAGATGCGATTGAAGCAGTAAATAAAAGT
AATTAA

Upstream 100 bases:

>100_bases
TTTAGATATTCATATATAGCTTGAAATTTAATGTAAAATAGATTTTTAGCATACGTAAATTTTCTATTTTTTAAGACGTA
TTTACAGTAAGGTGAATATT

Downstream 100 bases:

>100_bases
TAATGATTTTGGTGGTTTGATGGACAAAATTGGTAAAATAACAGCGGTAGGCCATATTGCACTTGATTACATATTCAATG
TGGATAAATTTCCAGAATTA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MLVIPAVDMKNKKCVQLIQGNPDKKHVELDNPPEIAKKWVNEGAEMLHLVDLDGALDGKRVNDEFIEEIIKKSGVPVQIG
GGIRSIEDAEYLVEKGAKKVIIGTIAVENPEIIKELSKRIGSEKIMVSLDAKDGKVVIKGWKEKTKYTPVQIGKILEEMG
AGSILFTNVDSEGLLNGINIEPTKELVDNLKIPIVASGGVTTIDDLLKLKEIGVYGVVVGSAIYKNMINLKDAIEAVNKS
N

Sequences:

>Translated_241_residues
MLVIPAVDMKNKKCVQLIQGNPDKKHVELDNPPEIAKKWVNEGAEMLHLVDLDGALDGKRVNDEFIEEIIKKSGVPVQIG
GGIRSIEDAEYLVEKGAKKVIIGTIAVENPEIIKELSKRIGSEKIMVSLDAKDGKVVIKGWKEKTKYTPVQIGKILEEMG
AGSILFTNVDSEGLLNGINIEPTKELVDNLKIPIVASGGVTTIDDLLKLKEIGVYGVVVGSAIYKNMINLKDAIEAVNKS
N
>Mature_241_residues
MLVIPAVDMKNKKCVQLIQGNPDKKHVELDNPPEIAKKWVNEGAEMLHLVDLDGALDGKRVNDEFIEEIIKKSGVPVQIG
GGIRSIEDAEYLVEKGAKKVIIGTIAVENPEIIKELSKRIGSEKIMVSLDAKDGKVVIKGWKEKTKYTPVQIGKILEEMG
AGSILFTNVDSEGLLNGINIEPTKELVDNLKIPIVASGGVTTIDDLLKLKEIGVYGVVVGSAIYKNMINLKDAIEAVNKS
N

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=239, Percent_Identity=31.7991631799163, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1788336, Length=239, Percent_Identity=27.1966527196653, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_METMP (P62357)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_987537.1
- ProteinModelPortal:   P62357
- SMR:   P62357
- GeneID:   2762631
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0417
- NMPDR:   fig|267377.1.peg.417
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK13585
- BioCyc:   MMAR267377:MMP0417-MONOMER
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26205; Mature: 26205

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIPAVDMKNKKCVQLIQGNPDKKHVELDNPPEIAKKWVNEGAEMLHLVDLDGALDGKR
CEEECCCCCCCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCHHEEEEEECCCCCCCCC
VNDEFIEEIIKKSGVPVQIGGGIRSIEDAEYLVEKGAKKVIIGTIAVENPEIIKELSKRI
CCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHC
GSEKIMVSLDAKDGKVVIKGWKEKTKYTPVQIGKILEEMGAGSILFTNVDSEGLLNGINI
CCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
EPTKELVDNLKIPIVASGGVTTIDDLLKLKEIGVYGVVVGSAIYKNMINLKDAIEAVNKS
CCHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
N
C
>Mature Secondary Structure
MLVIPAVDMKNKKCVQLIQGNPDKKHVELDNPPEIAKKWVNEGAEMLHLVDLDGALDGKR
CEEECCCCCCCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCHHEEEEEECCCCCCCCC
VNDEFIEEIIKKSGVPVQIGGGIRSIEDAEYLVEKGAKKVIIGTIAVENPEIIKELSKRI
CCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHC
GSEKIMVSLDAKDGKVVIKGWKEKTKYTPVQIGKILEEMGAGSILFTNVDSEGLLNGINI
CCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
EPTKELVDNLKIPIVASGGVTTIDDLLKLKEIGVYGVVVGSAIYKNMINLKDAIEAVNKS
CCHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA