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The map label for this gene is ndk [H]

Identifier: 45357846

GI number: 45357846

Start: 284066

End: 284485

Strand: Direct

Name: ndk [H]

Synonym: MMP0283

Alternate gene names: 45357846

Gene position: 284066-284485 (Clockwise)

Preceding gene: 45357844

Following gene: 45357847

Centisome position: 17.1

GC content: 37.62

Gene sequence:

>420_bases
GTGGCGTGTGAAAACGAATTGGAAAGAACATTTGTGGCACTAAAGCCTGATACTGTTGAAAGAAAGCTTGTTGGACGGGT
AATCCAAAGATTTGAAGATAGAGGTTTTGAAATCGTTGAAATGAGAATGTTAACCCTTACAATGGAAATGGCGGAAGAAT
ATTATGGTGAACACAAAGGAAAAGAGTTTTACGAAAGATTGATAAAGTTCATGACTTCGGGTAGAATAGTTGCAATGGTT
ATTAAAGGAGAGCGCGCAATTTCAACCGTTAGGAAAATGCTTGGAAATACGTGTCCTTGCGATGCAGAACCTGGAACTAT
TCGCGGAGATTTTGGACTATACACTCCAGCAAATATAATTCATGCATCAGATAGCTTAGAAAGTGCAGAACGTGAAATAG
ATTTATTTTTTGGAAGATAA

Upstream 100 bases:

>100_bases
AATCTTAAATTTTAGTCTTTATGAACAATTAGTATACTTTAACTACAACCAAAATAAATAATACTTTAAGAAAATTAAAA
TTAAAAATCTGGGGGATAAT

Downstream 100 bases:

>100_bases
TTTTTAAATAACCTCATTTGGCCATTTTTTATTTTCAAGTTTGTTAGTAAACTATATAATATTTAGATTACTAACTTCTG
TTTCGGATTTTTATCAACTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MACENELERTFVALKPDTVERKLVGRVIQRFEDRGFEIVEMRMLTLTMEMAEEYYGEHKGKEFYERLIKFMTSGRIVAMV
IKGERAISTVRKMLGNTCPCDAEPGTIRGDFGLYTPANIIHASDSLESAEREIDLFFGR

Sequences:

>Translated_139_residues
MACENELERTFVALKPDTVERKLVGRVIQRFEDRGFEIVEMRMLTLTMEMAEEYYGEHKGKEFYERLIKFMTSGRIVAMV
IKGERAISTVRKMLGNTCPCDAEPGTIRGDFGLYTPANIIHASDSLESAEREIDLFFGR
>Mature_138_residues
ACENELERTFVALKPDTVERKLVGRVIQRFEDRGFEIVEMRMLTLTMEMAEEYYGEHKGKEFYERLIKFMTSGRIVAMVI
KGERAISTVRKMLGNTCPCDAEPGTIRGDFGLYTPANIIHASDSLESAEREIDLFFGR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=49.2647058823529, Blast_Score=146, Evalue=5e-36,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=52.3076923076923, Blast_Score=144, Evalue=3e-35,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=51.1450381679389, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=51.1450381679389, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=51.1450381679389, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=51.1450381679389, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI66392203, Length=132, Percent_Identity=50.7575757575758, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI38045913, Length=130, Percent_Identity=50, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI4557797, Length=130, Percent_Identity=50, Blast_Score=139, Evalue=5e-34,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=40, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=33.5820895522388, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=33.5820895522388, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=34.0740740740741, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=32.1167883211679, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=28.8888888888889, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=132, Percent_Identity=47.7272727272727, Blast_Score=131, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=47.6923076923077, Blast_Score=132, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71995094, Length=140, Percent_Identity=33.5714285714286, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=43.7037037037037, Blast_Score=137, Evalue=9e-34,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=46.9230769230769, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=35.0746268656716, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15952; Mature: 15820

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACENELERTFVALKPDTVERKLVGRVIQRFEDRGFEIVEMRMLTLTMEMAEEYYGEHKG
CCCHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
KEFYERLIKFMTSGRIVAMVIKGERAISTVRKMLGNTCPCDAEPGTIRGDFGLYTPANII
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHE
HASDSLESAEREIDLFFGR
ECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ACENELERTFVALKPDTVERKLVGRVIQRFEDRGFEIVEMRMLTLTMEMAEEYYGEHKG
CCHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
KEFYERLIKFMTSGRIVAMVIKGERAISTVRKMLGNTCPCDAEPGTIRGDFGLYTPANII
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHE
HASDSLESAEREIDLFFGR
ECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA