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The map label for this gene is coaBC [H]

Identifier: 45357767

GI number: 45357767

Start: 211471

End: 212001

Strand: Direct

Name: coaBC [H]

Synonym: MMP0204

Alternate gene names: 45357767

Gene position: 211471-212001 (Clockwise)

Preceding gene: 45357766

Following gene: 45357768

Centisome position: 12.73

GC content: 37.85

Gene sequence:

>531_bases
ATGTTTAAAGACAAAAATATTGTGGTAGGTATCTGTGCATGCAGTCCTGCAATAAAAACTCTGGATTTGATTGGACAATT
GCGCGAAAGGGGTGCAGAAGTCGATGTTATCATGACACCGAATTCTGTCAACTTTGTGTCACCCTTGATGGTTCAAAGGG
AAGCTAAAAGACCGGTTCAAATCGAAGCTTTTGAACTTCCAAAAATGTATGATCCAAATCATAAATCATTATCACAAAAG
GCAGATTTGCTGATTTTAGCACCGGTTTCAGCTAATACATTAGGGAAAGCTGCAAATGGTATAGCAGATAACTTGTTGGC
AACAACAATCATGTCTACAAAAGCTCCTATCATTGCTGCAATGCACATAAACCCAATGATGTACAGCAATCCTGCCGTTC
AGAGAAACATAAAACAATTAAAAGAAGACGGATTTATCTTTGTTGACAATGGAAATGAAGAAACCCCTAGCAAGTTCCCT
GAAATTTCCCAGATCATGTCAACAGTTGAACAAGCGCTAAATCAAAAATAA

Upstream 100 bases:

>100_bases
AGAAATTAAAAATGAATTATCTAAACTTTAATATTGGAATATACTAATATGTCTGATATAGAATAATTGAGATTTAAAAA
GACATATAGGTAGATCGCCC

Downstream 100 bases:

>100_bases
GTTTTCTATATAAATATACTACTTTTTTTTATTTTTAAACGATTAATATTGGCAAAACCGGACAATGCGGTTAATAAGAG
ATATAATTTTAAAAAATTAG

Product: hypothetical protein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MFKDKNIVVGICACSPAIKTLDLIGQLRERGAEVDVIMTPNSVNFVSPLMVQREAKRPVQIEAFELPKMYDPNHKSLSQK
ADLLILAPVSANTLGKAANGIADNLLATTIMSTKAPIIAAMHINPMMYSNPAVQRNIKQLKEDGFIFVDNGNEETPSKFP
EISQIMSTVEQALNQK

Sequences:

>Translated_176_residues
MFKDKNIVVGICACSPAIKTLDLIGQLRERGAEVDVIMTPNSVNFVSPLMVQREAKRPVQIEAFELPKMYDPNHKSLSQK
ADLLILAPVSANTLGKAANGIADNLLATTIMSTKAPIIAAMHINPMMYSNPAVQRNIKQLKEDGFIFVDNGNEETPSKFP
EISQIMSTVEQALNQK
>Mature_176_residues
MFKDKNIVVGICACSPAIKTLDLIGQLRERGAEVDVIMTPNSVNFVSPLMVQREAKRPVQIEAFELPKMYDPNHKSLSQK
ADLLILAPVSANTLGKAANGIADNLLATTIMSTKAPIIAAMHINPMMYSNPAVQRNIKQLKEDGFIFVDNGNEETPSKFP
EISQIMSTVEQALNQK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=190, Percent_Identity=29.4736842105263, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082301, Length=151, Percent_Identity=33.7748344370861, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 19309; Mature: 19309

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKDKNIVVGICACSPAIKTLDLIGQLRERGAEVDVIMTPNSVNFVSPLMVQREAKRPVQ
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCEE
IEAFELPKMYDPNHKSLSQKADLLILAPVSANTLGKAANGIADNLLATTIMSTKAPIIAA
EEEECCCCCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
MHINPMMYSNPAVQRNIKQLKEDGFIFVDNGNEETPSKFPEISQIMSTVEQALNQK
EEECCCEECCHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKDKNIVVGICACSPAIKTLDLIGQLRERGAEVDVIMTPNSVNFVSPLMVQREAKRPVQ
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCEE
IEAFELPKMYDPNHKSLSQKADLLILAPVSANTLGKAANGIADNLLATTIMSTKAPIIAA
EEEECCCCCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
MHINPMMYSNPAVQRNIKQLKEDGFIFVDNGNEETPSKFPEISQIMSTVEQALNQK
EEECCCEECCHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]