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The map label for this gene is 45357751

Identifier: 45357751

GI number: 45357751

Start: 196599

End: 197528

Strand: Direct

Name: 45357751

Synonym: MMP0188

Alternate gene names: NA

Gene position: 196599-197528 (Clockwise)

Preceding gene: 45357749

Following gene: 45357752

Centisome position: 11.84

GC content: 31.61

Gene sequence:

>930_bases
ATGTGGGATTTAGAGACAGATAGGGTCTTAAACGAGATAAAAACAAGAAATGCGAGAAAAGTATTGTTTCAAGCACCCGA
AGGACTTAAACGAGCTGTTGAAAAGGAAATAGAATTTTTAAAAACAAAAATTGACGCAGAACTCATGATATGGGGCGAAA
CATGTTTTGGTGCGTGCGATCTATGTGACGAAGAAGTTACAATTTTAGGAATAGATTTAATTATCCATTACGGGCACGAA
GAACTTTCATACGTTCATTCAGAAATTCCAGTAGTATTCGTTCATGCTTATTTTAAAGAAAACGAGTATTTTTTAAAAGA
TGTTGAAAATATCCTTGAAAAAATGGAAAATCCAACAGTTACAACAACAATTCAATTTAAAAAAGCACTTTCAAAGTTTA
ATCCTGTTGTAATTTTGGGATGCAGGGCTCCAGTTGATAATGCAGAAAATATCCTTTTTGTTGGAACTGGAAGGTTTCAC
CCTTTAATGATGGCATATAAACTTAAAAAAACCGTTAAAATTTATAATCCTATTACGAGAGAGATTTCTGAAATAAGCGA
CCAAGAGATAAAAAAACTGATAAAATTAAGAATCGGCCGAGTTTCAAAGTTATTATTAAATCCTCCTAAAAAAATCGGTG
TAGTTTTATCGACAAAAAAAGGACAGTGCAGATTAAAGTCGTTTGAAAACGTAATTGAACTTTTAAAGAAAAATAACATT
GAATATATTCCAATAATTTTAAATAATCTATCGCAGAGCTATTTATTTTACAAAGTCGATGCATACGTGATCTGCGCATG
TCCGAGAATTGTAATGGACGACTACCAAAATTATGAAAGCACGTTACTTACTCCAGAAGAGCTCAGAATGTACCTTTCAA
ATGATTTTGAATACAAATTCGATGAAATTTTGGAAAATAATTTCTACTAA

Upstream 100 bases:

>100_bases
ATCTGGGTCATAATATCACTTTTATAACTTTAATTAAATAGTATACAAGCATCTGTATTAGTATGTAGTGATTATTTAAA
TAAATATTCGAAGTGGTATT

Downstream 100 bases:

>100_bases
ATTTTTTAATTTTAAATTCACCGATAAACGAAAAGTATATATATCAGATCAGTATAGGTATAGATGCGAAGTAATGTGCT
CATTGGAGGGATTGCCAAGC

Product: diphthamide biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MWDLETDRVLNEIKTRNARKVLFQAPEGLKRAVEKEIEFLKTKIDAELMIWGETCFGACDLCDEEVTILGIDLIIHYGHE
ELSYVHSEIPVVFVHAYFKENEYFLKDVENILEKMENPTVTTTIQFKKALSKFNPVVILGCRAPVDNAENILFVGTGRFH
PLMMAYKLKKTVKIYNPITREISEISDQEIKKLIKLRIGRVSKLLLNPPKKIGVVLSTKKGQCRLKSFENVIELLKKNNI
EYIPIILNNLSQSYLFYKVDAYVICACPRIVMDDYQNYESTLLTPEELRMYLSNDFEYKFDEILENNFY

Sequences:

>Translated_309_residues
MWDLETDRVLNEIKTRNARKVLFQAPEGLKRAVEKEIEFLKTKIDAELMIWGETCFGACDLCDEEVTILGIDLIIHYGHE
ELSYVHSEIPVVFVHAYFKENEYFLKDVENILEKMENPTVTTTIQFKKALSKFNPVVILGCRAPVDNAENILFVGTGRFH
PLMMAYKLKKTVKIYNPITREISEISDQEIKKLIKLRIGRVSKLLLNPPKKIGVVLSTKKGQCRLKSFENVIELLKKNNI
EYIPIILNNLSQSYLFYKVDAYVICACPRIVMDDYQNYESTLLTPEELRMYLSNDFEYKFDEILENNFY
>Mature_309_residues
MWDLETDRVLNEIKTRNARKVLFQAPEGLKRAVEKEIEFLKTKIDAELMIWGETCFGACDLCDEEVTILGIDLIIHYGHE
ELSYVHSEIPVVFVHAYFKENEYFLKDVENILEKMENPTVTTTIQFKKALSKFNPVVILGCRAPVDNAENILFVGTGRFH
PLMMAYKLKKTVKIYNPITREISEISDQEIKKLIKLRIGRVSKLLLNPPKKIGVVLSTKKGQCRLKSFENVIELLKKNNI
EYIPIILNNLSQSYLFYKVDAYVICACPRIVMDDYQNYESTLLTPEELRMYLSNDFEYKFDEILENNFY

Specific function: Unknown

COG id: COG1736

COG function: function code J; Diphthamide synthase subunit DPH2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI116686106, Length=327, Percent_Identity=23.8532110091743, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552166, Length=323, Percent_Identity=23.8390092879257, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322088, Length=332, Percent_Identity=24.3975903614458, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24662841, Length=347, Percent_Identity=26.5129682997118, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356957, Length=347, Percent_Identity=26.5129682997118, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016435
- InterPro:   IPR002728
- InterPro:   IPR022428 [H]

Pfam domain/function: PF01866 Diphthamide_syn [H]

EC number: NA

Molecular weight: Translated: 36031; Mature: 36031

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWDLETDRVLNEIKTRNARKVLFQAPEGLKRAVEKEIEFLKTKIDAELMIWGETCFGACD
CCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
LCDEEVTILGIDLIIHYGHEELSYVHSEIPVVFVHAYFKENEYFLKDVENILEKMENPTV
CCCCCEEEEEEEEEEECCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
TTTIQFKKALSKFNPVVILGCRAPVDNAENILFVGTGRFHPLMMAYKLKKTVKIYNPITR
EEEEHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHH
EISEISDQEIKKLIKLRIGRVSKLLLNPPKKIGVVLSTKKGQCRLKSFENVIELLKKNNI
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHCCC
EYIPIILNNLSQSYLFYKVDAYVICACPRIVMDDYQNYESTLLTPEELRMYLSNDFEYKF
CEEEHEECCCCCCEEEEEECEEEEECCCHHHHHHHCCHHHHCCCHHHHHHHHCCCCCCHH
DEILENNFY
HHHHCCCCC
>Mature Secondary Structure
MWDLETDRVLNEIKTRNARKVLFQAPEGLKRAVEKEIEFLKTKIDAELMIWGETCFGACD
CCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
LCDEEVTILGIDLIIHYGHEELSYVHSEIPVVFVHAYFKENEYFLKDVENILEKMENPTV
CCCCCEEEEEEEEEEECCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
TTTIQFKKALSKFNPVVILGCRAPVDNAENILFVGTGRFHPLMMAYKLKKTVKIYNPITR
EEEEHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHH
EISEISDQEIKKLIKLRIGRVSKLLLNPPKKIGVVLSTKKGQCRLKSFENVIELLKKNNI
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHCCC
EYIPIILNNLSQSYLFYKVDAYVICACPRIVMDDYQNYESTLLTPEELRMYLSNDFEYKF
CEEEHEECCCCCCEEEEEECEEEEECCCHHHHHHHCCHHHHCCCHHHHHHHHCCCCCCHH
DEILENNFY
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]