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The map label for this gene is ldh [H]

Identifier: 42523503

GI number: 42523503

Start: 1937302

End: 1938432

Strand: Direct

Name: ldh [H]

Synonym: Bd2028

Alternate gene names: 42523503

Gene position: 1937302-1938432 (Clockwise)

Preceding gene: 42523502

Following gene: 42523504

Centisome position: 51.21

GC content: 50.04

Gene sequence:

>1131_bases
ATGAAGGAGCCTACATTGGGAACTTTTGAGATTATCTCTAAGCATGGTGATCATGAGCAGGTTGTTTTCTGTAACGACCC
TCATGTTGGTTTGAAAGCGATCATCGCTATTCATAACACCTCTTTGGGGCCTGCACTTGGCGGCACCCGTATGTGGAACT
ACAAGAACGAAGACGAGGCTCTTGTTGACGTTCTTCGTTTGTCCAAAGGTATGACTTACAAAGCTGCTGCTTCCGGCCTG
AATCTGGGTGGTGGTAAAGCAGTTATCATCGGCGATCCTAAGACTCAAAAGTCTGAAGGTTTGTTCCGCGCTTTCGGTCA
GTTCGTGAACTCTCTGAATGGTAAATACATCACTGCTGAAGACGTTGGTACGTCTGTCCAGGACATGGAGCACATCTACA
TGGAGACTCCTTGGGTGACTGGTATCCCTAAGGATTTCGGTGGTTCCGGCGATCCATCTCCATACACTGCACACGGTGTA
TTGATGGGTATTAAAGCTTCCGCTAAAGAAAAATTCGGCACAGACTCTTTGAAAGGCATCCATATCGCCGTTCAAGGTCT
GGGTAACGTGGGTTCCAACCTGGTGAAATACCTGGTTGAAGAAGGCGCTGTGATCACAGTGGCTGATATCGACATGAACC
GCACCAAAAGCGTGGCTGACAAGTTCGGCGCAAAAGCGGTGAGCTCTGACGACATCCTTTTCACTGAGTGCGACATTTTG
GCTCCTTGCGCCCTGGGCGCCATCGTGAACGATCAGACGATCACGAAGCTTAAAACCAAAGTTATCGCTGGTGGCGCGAA
CAACGTATTGGCTGAAGCCCGCCACGGTGACCAGTTGAAAGAACTGGGCATCTTGTATGCTCCAGACTATGTCATCAACG
CTGGTGGTTTGATGAACGTCTTCGTTGAGCTTGAGGGCTACTCTCCAGAGCGCGCCTTCGAAAAGACAAAACGCGTTTAC
GACAACATCCTTAAAGTTTACGAAATCGCAAAACGTGACGGTATCGGTACCCACACTGCTGCGGACCGTCTGGCTGAAGA
GCGTATCAACACAATTGGTCGCCTGAAACAGCGCCACCCGGGCAAATCTTCCCGCGCGTTCACCACACTGCGTGAAGTGC
ACAACAGATAG

Upstream 100 bases:

>100_bases
AACAGGCCTCCAAATGAAAATCTGGAGGCCTCCGCTTATACCCCGCATTAACGCTAGTCTTTTTACTCAATTGGACCCAT
GATCGTCCGGCAATTCAAAA

Downstream 100 bases:

>100_bases
TTTTAAAGGGGTCGAAAGACCCCTTTTTTTATGCGCCGAGTGATAGCATTCATTACGGCCCGTTTTCTTGACATCCCCTC
GGGACCAAAGAACAATCTTT

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKEPTLGTFEIISKHGDHEQVVFCNDPHVGLKAIIAIHNTSLGPALGGTRMWNYKNEDEALVDVLRLSKGMTYKAAASGL
NLGGGKAVIIGDPKTQKSEGLFRAFGQFVNSLNGKYITAEDVGTSVQDMEHIYMETPWVTGIPKDFGGSGDPSPYTAHGV
LMGIKASAKEKFGTDSLKGIHIAVQGLGNVGSNLVKYLVEEGAVITVADIDMNRTKSVADKFGAKAVSSDDILFTECDIL
APCALGAIVNDQTITKLKTKVIAGGANNVLAEARHGDQLKELGILYAPDYVINAGGLMNVFVELEGYSPERAFEKTKRVY
DNILKVYEIAKRDGIGTHTAADRLAEERINTIGRLKQRHPGKSSRAFTTLREVHNR

Sequences:

>Translated_376_residues
MKEPTLGTFEIISKHGDHEQVVFCNDPHVGLKAIIAIHNTSLGPALGGTRMWNYKNEDEALVDVLRLSKGMTYKAAASGL
NLGGGKAVIIGDPKTQKSEGLFRAFGQFVNSLNGKYITAEDVGTSVQDMEHIYMETPWVTGIPKDFGGSGDPSPYTAHGV
LMGIKASAKEKFGTDSLKGIHIAVQGLGNVGSNLVKYLVEEGAVITVADIDMNRTKSVADKFGAKAVSSDDILFTECDIL
APCALGAIVNDQTITKLKTKVIAGGANNVLAEARHGDQLKELGILYAPDYVINAGGLMNVFVELEGYSPERAFEKTKRVY
DNILKVYEIAKRDGIGTHTAADRLAEERINTIGRLKQRHPGKSSRAFTTLREVHNR
>Mature_376_residues
MKEPTLGTFEIISKHGDHEQVVFCNDPHVGLKAIIAIHNTSLGPALGGTRMWNYKNEDEALVDVLRLSKGMTYKAAASGL
NLGGGKAVIIGDPKTQKSEGLFRAFGQFVNSLNGKYITAEDVGTSVQDMEHIYMETPWVTGIPKDFGGSGDPSPYTAHGV
LMGIKASAKEKFGTDSLKGIHIAVQGLGNVGSNLVKYLVEEGAVITVADIDMNRTKSVADKFGAKAVSSDDILFTECDIL
APCALGAIVNDQTITKLKTKVIAGGANNVLAEARHGDQLKELGILYAPDYVINAGGLMNVFVELEGYSPERAFEKTKRVY
DNILKVYEIAKRDGIGTHTAADRLAEERINTIGRLKQRHPGKSSRAFTTLREVHNR

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Drosophila melanogaster, GI45553475, Length=312, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45549226, Length=312, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24649283, Length=338, Percent_Identity=28.4023668639053, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24649460, Length=277, Percent_Identity=28.158844765343, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 40601; Mature: 40601

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEPTLGTFEIISKHGDHEQVVFCNDPHVGLKAIIAIHNTSLGPALGGTRMWNYKNEDEA
CCCCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCEECCCCCHHHH
LVDVLRLSKGMTYKAAASGLNLGGGKAVIIGDPKTQKSEGLFRAFGQFVNSLNGKYITAE
HHHHHHHHCCCEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHH
DVGTSVQDMEHIYMETPWVTGIPKDFGGSGDPSPYTAHGVLMGIKASAKEKFGTDSLKGI
HCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCEEECCEEEEECHHHHHHCCCCCCCEE
HIAVQGLGNVGSNLVKYLVEEGAVITVADIDMNRTKSVADKFGAKAVSSDDILFTECDIL
EEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCHH
APCALGAIVNDQTITKLKTKVIAGGANNVLAEARHGDQLKELGILYAPDYVINAGGLMNV
HHHHHHHHCCCHHHHHHHHHHEECCCCHHHHHHHCCCHHHHCCCEECCCEEEECCCEEEE
FVELEGYSPERAFEKTKRVYDNILKVYEIAKRDGIGTHTAADRLAEERINTIGRLKQRHP
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GKSSRAFTTLREVHNR
CCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKEPTLGTFEIISKHGDHEQVVFCNDPHVGLKAIIAIHNTSLGPALGGTRMWNYKNEDEA
CCCCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCEECCCCCHHHH
LVDVLRLSKGMTYKAAASGLNLGGGKAVIIGDPKTQKSEGLFRAFGQFVNSLNGKYITAE
HHHHHHHHCCCEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHH
DVGTSVQDMEHIYMETPWVTGIPKDFGGSGDPSPYTAHGVLMGIKASAKEKFGTDSLKGI
HCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCEEECCEEEEECHHHHHHCCCCCCCEE
HIAVQGLGNVGSNLVKYLVEEGAVITVADIDMNRTKSVADKFGAKAVSSDDILFTECDIL
EEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCHH
APCALGAIVNDQTITKLKTKVIAGGANNVLAEARHGDQLKELGILYAPDYVINAGGLMNV
HHHHHHHHCCCHHHHHHHHHHEECCCCHHHHHHHCCCHHHHCCCEECCCEEEECCCEEEE
FVELEGYSPERAFEKTKRVYDNILKVYEIAKRDGIGTHTAADRLAEERINTIGRLKQRHP
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GKSSRAFTTLREVHNR
CCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]