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The map label for this gene is pepR [C]

Identifier: 42523059

GI number: 42523059

Start: 1478703

End: 1479971

Strand: Direct

Name: pepR [C]

Synonym: Bd1552

Alternate gene names: 42523059

Gene position: 1478703-1479971 (Clockwise)

Preceding gene: 42523058

Following gene: 42523060

Centisome position: 39.09

GC content: 51.14

Gene sequence:

>1269_bases
ATGAATACAAAGTTCAAAAAATCTGAACTTTCTAACGGGATCCGGGTGGTGAGTGAACTCCATCCAGGGTCCCGTGCCGT
TTCTATGGGTATTTGGGTTTTGACGGGCACTCGGGATGAAACTCCTGACGTGGCCGGGATCTCTCACTTGCTTGAGCACC
TTGTGTTCAAGGGCACCAAAACCCGTTCAGCCTATCAAATTGCCAAATCCTTGGAAGCTCTGGGCGGAGAGCTGAATGCT
TACACCACCCGCGAGTACACTTGTTATCATGCTCTGGTTCTGAAGGATCACTGGGAAAAAGCCCTGGATGTTCTGGCAGA
CCTGGTTTCGAACATGAAGCTGACCCAGAAGGAGTTCGACCTTGAAAAAGGCGTGATCCTTCAGGAAATCGCCATGTCCG
AAGACAGCCATGAAGACATGGTCTATGACGTGTTCTATGAACAGGTCTATGGCGCACATCCATTGGGTCGTCCTATTCTG
GGTACGCCGGTATCGGTGGCGCGCATGAAGCAGACCCAAGTGATGAACTATTATAAAAAAACCTACACCGGCAAAAATAT
CATCGTCAGCGCCTCCGGGTGCATTGATCATGATGATCTGATGGCCGGGATCCAAAAGCGCCTGGGCGCAAAAAAGAAAA
GCGAACTGAAGAACACCCGTCGCGTGCCACGCTGGTTGAACCGTCGTCACGTCGTTGAAAAACAGGCGGAGCAGGTTCAC
ATGCTGTTGGGTCTTCCGACAGCCAGCTTCCAGGACAAACACCGTTTTGAGGCGGTGGTCACCAACACTTTGCTGGGCGG
GGGGATGACCTCGAAGCTGTATCAAAGTGTGCGTGAAAAAAGAGGTCTGGTTTATTCCATTCACTCCAGTCTGAACACCA
ACATTGATTCCGGCATGCTGACAATTTATGCCGGCACCGAGGCGAAAAACGCGCGCAAGGTGGGGGATCTGATTTCGAAA
GAGTTCGCCAAGATCCGCAAAGCGGGTGTGACCAAGGCGGATGTTGAGATGTGTAAAACTCAAGTCATCGGCAGTATCCT
GCTGGGATCTGACGACATTGAAAACCGCATGACCTCACTGGCCGTGAACGAGATGGTCTTTGGCCGTTATCGCGCGGTAG
AGTCCGTCATTGATGAAATCAAAGCAGTGACAGTGGATTCAGTGAATGAGTATATTCGCAACGTCCTGGATCTGGACAAA
GCCGCAGGCGTTCTGCTGGGACCTGAAGTGACCAAGCTTCAGGACTGGTGGCAAGATCTAAAACTGTAA

Upstream 100 bases:

>100_bases
TGACGTACTAAAAGAAGGTGAAATCATCGATGTGAAAGTTCTTGAAGTGGACCGTTCTGGTCGCGTCAAGCTTTCCCGCA
AGGCTTTGCTACAGTAATAG

Downstream 100 bases:

>100_bases
ATTTTGGGAAGGGCATCATATGCAAAAACTGGCTGTAAAAATCAAAAAACTCGAAAACTTCCATGGCGATCTGCCTCAGT
ATCAGTCTTTGGGCGCCAGT

Product: zinc proteinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNTKFKKSELSNGIRVVSELHPGSRAVSMGIWVLTGTRDETPDVAGISHLLEHLVFKGTKTRSAYQIAKSLEALGGELNA
YTTREYTCYHALVLKDHWEKALDVLADLVSNMKLTQKEFDLEKGVILQEIAMSEDSHEDMVYDVFYEQVYGAHPLGRPIL
GTPVSVARMKQTQVMNYYKKTYTGKNIIVSASGCIDHDDLMAGIQKRLGAKKKSELKNTRRVPRWLNRRHVVEKQAEQVH
MLLGLPTASFQDKHRFEAVVTNTLLGGGMTSKLYQSVREKRGLVYSIHSSLNTNIDSGMLTIYAGTEAKNARKVGDLISK
EFAKIRKAGVTKADVEMCKTQVIGSILLGSDDIENRMTSLAVNEMVFGRYRAVESVIDEIKAVTVDSVNEYIRNVLDLDK
AAGVLLGPEVTKLQDWWQDLKL

Sequences:

>Translated_422_residues
MNTKFKKSELSNGIRVVSELHPGSRAVSMGIWVLTGTRDETPDVAGISHLLEHLVFKGTKTRSAYQIAKSLEALGGELNA
YTTREYTCYHALVLKDHWEKALDVLADLVSNMKLTQKEFDLEKGVILQEIAMSEDSHEDMVYDVFYEQVYGAHPLGRPIL
GTPVSVARMKQTQVMNYYKKTYTGKNIIVSASGCIDHDDLMAGIQKRLGAKKKSELKNTRRVPRWLNRRHVVEKQAEQVH
MLLGLPTASFQDKHRFEAVVTNTLLGGGMTSKLYQSVREKRGLVYSIHSSLNTNIDSGMLTIYAGTEAKNARKVGDLISK
EFAKIRKAGVTKADVEMCKTQVIGSILLGSDDIENRMTSLAVNEMVFGRYRAVESVIDEIKAVTVDSVNEYIRNVLDLDK
AAGVLLGPEVTKLQDWWQDLKL
>Mature_422_residues
MNTKFKKSELSNGIRVVSELHPGSRAVSMGIWVLTGTRDETPDVAGISHLLEHLVFKGTKTRSAYQIAKSLEALGGELNA
YTTREYTCYHALVLKDHWEKALDVLADLVSNMKLTQKEFDLEKGVILQEIAMSEDSHEDMVYDVFYEQVYGAHPLGRPIL
GTPVSVARMKQTQVMNYYKKTYTGKNIIVSASGCIDHDDLMAGIQKRLGAKKKSELKNTRRVPRWLNRRHVVEKQAEQVH
MLLGLPTASFQDKHRFEAVVTNTLLGGGMTSKLYQSVREKRGLVYSIHSSLNTNIDSGMLTIYAGTEAKNARKVGDLISK
EFAKIRKAGVTKADVEMCKTQVIGSILLGSDDIENRMTSLAVNEMVFGRYRAVESVIDEIKAVTVDSVNEYIRNVLDLDK
AAGVLLGPEVTKLQDWWQDLKL

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=421, Percent_Identity=26.3657957244656, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI46593007, Length=202, Percent_Identity=33.1683168316832, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI24308013, Length=384, Percent_Identity=24.21875, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787770, Length=223, Percent_Identity=24.6636771300448, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71999683, Length=420, Percent_Identity=24.047619047619, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17553678, Length=417, Percent_Identity=25.1798561151079, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323192, Length=400, Percent_Identity=28, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321813, Length=406, Percent_Identity=22.6600985221675, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319426, Length=204, Percent_Identity=24.5098039215686, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325449, Length=189, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357875, Length=419, Percent_Identity=27.9236276849642, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24646943, Length=419, Percent_Identity=27.9236276849642, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI19921772, Length=430, Percent_Identity=21.6279069767442, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47225; Mature: 47225

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKFKKSELSNGIRVVSELHPGSRAVSMGIWVLTGTRDETPDVAGISHLLEHLVFKGTK
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
TRSAYQIAKSLEALGGELNAYTTREYTCYHALVLKDHWEKALDVLADLVSNMKLTQKEFD
CHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEKGVILQEIAMSEDSHEDMVYDVFYEQVYGAHPLGRPILGTPVSVARMKQTQVMNYYKK
HHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TYTGKNIIVSASGCIDHDDLMAGIQKRLGAKKKSELKNTRRVPRWLNRRHVVEKQAEQVH
HCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLGLPTASFQDKHRFEAVVTNTLLGGGMTSKLYQSVREKRGLVYSIHSSLNTNIDSGML
HHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECHHHCCCCCCCEE
TIYAGTEAKNARKVGDLISKEFAKIRKAGVTKADVEMCKTQVIGSILLGSDDIENRMTSL
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AVNEMVFGRYRAVESVIDEIKAVTVDSVNEYIRNVLDLDKAAGVLLGPEVTKLQDWWQDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHH
KL
CC
>Mature Secondary Structure
MNTKFKKSELSNGIRVVSELHPGSRAVSMGIWVLTGTRDETPDVAGISHLLEHLVFKGTK
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
TRSAYQIAKSLEALGGELNAYTTREYTCYHALVLKDHWEKALDVLADLVSNMKLTQKEFD
CHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEKGVILQEIAMSEDSHEDMVYDVFYEQVYGAHPLGRPILGTPVSVARMKQTQVMNYYKK
HHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TYTGKNIIVSASGCIDHDDLMAGIQKRLGAKKKSELKNTRRVPRWLNRRHVVEKQAEQVH
HCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLGLPTASFQDKHRFEAVVTNTLLGGGMTSKLYQSVREKRGLVYSIHSSLNTNIDSGML
HHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECHHHCCCCCCCEE
TIYAGTEAKNARKVGDLISKEFAKIRKAGVTKADVEMCKTQVIGSILLGSDDIENRMTSL
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AVNEMVFGRYRAVESVIDEIKAVTVDSVNEYIRNVLDLDKAAGVLLGPEVTKLQDWWQDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHH
KL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]