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The map label for this gene is ftsJ

Identifier: 42522939

GI number: 42522939

Start: 1344434

End: 1345024

Strand: Direct

Name: ftsJ

Synonym: Bd1423

Alternate gene names: 42522939

Gene position: 1344434-1345024 (Clockwise)

Preceding gene: 42522938

Following gene: 42522940

Centisome position: 35.54

GC content: 49.75

Gene sequence:

>591_bases
ATGACTTACAATCCCCGTGATCACTACTTCAGAAAAGCAAAGCAGGAAAACTTTGCGGCTCGTTCCGTCTTCAAACTTGA
AGAGATCGACCAGAAATTTAAAATGTTCAAGCCCGGCCAGGTGGTGCTTGATCTGGGGGCTTCTCCGGGATCCTGGTCGC
AGTATGCTTCCAAGATGGCTGGTGAAAAGGGCCGTGTCCTGGGCGTGGATCTGAGCCCGGTCACCGTGAAGTTGAAGAAC
GCGGTTTTCATTCAGGCCGATCTTCGTGATTTGAATCTGGAAGACATCTTCAAAGAACATGGCTTCGTACCTCCGTTTGA
CATCGTGATGTCAGACATGGCACCAAAGACCACCGGCATTCGCATGACCGATCAGGCCAGATCCATGGAACTTTGTGAAC
TGGCTCTGGATGTCGCTCGTCGTTTCCTGAAAAAAGACGGGCATTTCGTGTGCAAGCTCTTCCACAGTGATGACTTCGGA
AAGCTTCGTGATGAGATGAAAAAGACCTTCGCCAAAGTGGAGGCGGTGAAGCCGGATTCCACCCGCAAGATTTCCAAAGA
AATCTTCCTCGTAGGCCTTAGTAAAAAATGA

Upstream 100 bases:

>100_bases
TGCTGGCGATGGTGAAAGAGCCTCGCGAAGCCTAATCCTTTTTACCGAGGCCCCAAAAAGGGGTGGACTTTGACGGGGGT
TCGCTGGATAACCCTCCGAT

Downstream 100 bases:

>100_bases
TTCAGATCGTATTTGAGAATACTCACTTTATCATCTGTGACAAACCCGCGGGTGTGCTTTCCACACCCAGCCGCTTTGAA
GAGGATGACGCCCGTCTGTG

Product: cell division protein FtsJ

Products: NA

Alternate protein names: 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTYNPRDHYFRKAKQENFAARSVFKLEEIDQKFKMFKPGQVVLDLGASPGSWSQYASKMAGEKGRVLGVDLSPVTVKLKN
AVFIQADLRDLNLEDIFKEHGFVPPFDIVMSDMAPKTTGIRMTDQARSMELCELALDVARRFLKKDGHFVCKLFHSDDFG
KLRDEMKKTFAKVEAVKPDSTRKISKEIFLVGLSKK

Sequences:

>Translated_196_residues
MTYNPRDHYFRKAKQENFAARSVFKLEEIDQKFKMFKPGQVVLDLGASPGSWSQYASKMAGEKGRVLGVDLSPVTVKLKN
AVFIQADLRDLNLEDIFKEHGFVPPFDIVMSDMAPKTTGIRMTDQARSMELCELALDVARRFLKKDGHFVCKLFHSDDFG
KLRDEMKKTFAKVEAVKPDSTRKISKEIFLVGLSKK
>Mature_195_residues
TYNPRDHYFRKAKQENFAARSVFKLEEIDQKFKMFKPGQVVLDLGASPGSWSQYASKMAGEKGRVLGVDLSPVTVKLKNA
VFIQADLRDLNLEDIFKEHGFVPPFDIVMSDMAPKTTGIRMTDQARSMELCELALDVARRFLKKDGHFVCKLFHSDDFGK
LRDEMKKTFAKVEAVKPDSTRKISKEIFLVGLSKK

Specific function: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit

COG id: COG0293

COG function: function code J; 23S rRNA methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family

Homologues:

Organism=Homo sapiens, GI29029591, Length=188, Percent_Identity=37.2340425531915, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI29029589, Length=188, Percent_Identity=37.2340425531915, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI7110661, Length=188, Percent_Identity=37.2340425531915, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI7019377, Length=201, Percent_Identity=33.8308457711443, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI194097365, Length=186, Percent_Identity=32.258064516129, Blast_Score=106, Evalue=1e-23,
Organism=Escherichia coli, GI1789569, Length=190, Percent_Identity=40, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17554650, Length=191, Percent_Identity=36.1256544502618, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17553474, Length=191, Percent_Identity=35.0785340314136, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71987550, Length=187, Percent_Identity=32.620320855615, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71987561, Length=187, Percent_Identity=32.620320855615, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17553860, Length=187, Percent_Identity=32.620320855615, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6319796, Length=186, Percent_Identity=34.9462365591398, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6321302, Length=272, Percent_Identity=27.2058823529412, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319535, Length=199, Percent_Identity=35.1758793969849, Blast_Score=99, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21356387, Length=200, Percent_Identity=34, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859957, Length=186, Percent_Identity=32.258064516129, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24647580, Length=196, Percent_Identity=32.6530612244898, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648639, Length=195, Percent_Identity=31.2820512820513, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RLME_BDEBA (Q6MN40)

Other databases:

- EMBL:   BX842649
- RefSeq:   NP_968319.1
- ProteinModelPortal:   Q6MN40
- SMR:   Q6MN40
- GeneID:   2735616
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1423
- NMPDR:   fig|264462.1.peg.1289
- HOGENOM:   HBG398270
- OMA:   SDMAANT
- PhylomeDB:   Q6MN40
- BioCyc:   BBAC264462:BD1423-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01547
- InterPro:   IPR015507
- InterPro:   IPR002877
- PANTHER:   PTHR10920
- PIRSF:   PIRSF005461

Pfam domain/function: PF01728 FtsJ

EC number: =2.1.1.166

Molecular weight: Translated: 22342; Mature: 22211

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: ACT_SITE 152-152 BINDING 50-50 BINDING 52-52 BINDING 70-70 BINDING 87-87 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYNPRDHYFRKAKQENFAARSVFKLEEIDQKFKMFKPGQVVLDLGASPGSWSQYASKMA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHC
GEKGRVLGVDLSPVTVKLKNAVFIQADLRDLNLEDIFKEHGFVPPFDIVMSDMAPKTTGI
CCCCCEEEECCCCEEEEECCEEEEEECCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCE
RMTDQARSMELCELALDVARRFLKKDGHFVCKLFHSDDFGKLRDEMKKTFAKVEAVKPDS
EECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
TRKISKEIFLVGLSKK
HHHHHHEEEEEEECCC
>Mature Secondary Structure 
TYNPRDHYFRKAKQENFAARSVFKLEEIDQKFKMFKPGQVVLDLGASPGSWSQYASKMA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHC
GEKGRVLGVDLSPVTVKLKNAVFIQADLRDLNLEDIFKEHGFVPPFDIVMSDMAPKTTGI
CCCCCEEEECCCCEEEEECCEEEEEECCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCE
RMTDQARSMELCELALDVARRFLKKDGHFVCKLFHSDDFGKLRDEMKKTFAKVEAVKPDS
EECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
TRKISKEIFLVGLSKK
HHHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA