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The map label for this gene is htrA [H]

Identifier: 42522491

GI number: 42522491

Start: 873473

End: 874903

Strand: Direct

Name: htrA [H]

Synonym: Bd0922

Alternate gene names: 42522491

Gene position: 873473-874903 (Clockwise)

Preceding gene: 42522488

Following gene: 42522492

Centisome position: 23.09

GC content: 52.83

Gene sequence:

>1431_bases
ATGGCAAAAAAGGCCCACGAGGCCACGCGAGCTGTCGTTCGTATCCTTGTACAAGGATTTAGCGAAACGGATCCTCGTTC
TATTTTGGACCCGCGCTTTGCTGCTCCGGAACAGTGGAGCGCCTCCGGATTTTTCATCCAGCTTCACGGGGAGTCCGGAT
ACATTCTGACCAATTCACATGTTGTTCGAAACTCTGTGCGTATTGAAGTGCGATCGACACTGACCAGTGACGAGACCTTT
CGTGCCGAAGTGCTGGGAATGGTGGAGGATCTGGAGCCCGACGTGGCTCTTTTAAGGTTGGGCCGGGAGGACATTAAACG
TTTTCTGAAACTGACAGGTTTAAAAAAGATCCCGGCATTAAAGCTGGGCTTTGACGTGAAGGTGTATCGTGGGGAGGAGG
TCAAAACAATCGGATTTCCCTTGGGTGTGGATGAACCTCATTTCTCTGGCGGGGAGATCTCGAACTTTATTGCCGGCTCG
GGCGACACCACTGAGCGCATGGTTACCGATGCGGCCATTAATTTTGGGAACAGTGGCGGGCCGGCTCTGGTGGAGGGAGG
CTGGGTTGTCGGCATTAACACCGCCGTCATTGAGGGCGCAGAAAATTTCAGCTTTATCACCCCGATTCATCTCGCGAAGC
ATGTTCTGGAAACCTTTCTAAAAAAAGACAAGGCCTCACTTTCACGCTTGGGATTGTTGATTCAGAAGAATTCAGATTGG
AACAGCCGGGTGTTGGGGGTTCCAGCGGATGCCGGCGTGATCGTGCGCAAGGTATTTCCAGGGAGTCCTGCGGCGTCCAT
GGGACTGCAAAGCCGGGATGTGATTTTGGCGATTGCCGGAGAGGCGCTGGATCGACATGGCAATGTGCTGCCGATGGCAA
GTGACCGTAAAAGAAATATTTATGACGCTATTCACGATGTCCCTGAGGGCGGTGTGTTGGATGTCGCCATCCTTCGGCGG
AAAAAACATCTGAATTTACGAGGCAGAATGTTTGCGTGGGAGTCAGGCGAGATTTCGCGCAGGCCTGTTTTGGTCGACAG
GGCTTATTTGTCCTTTGGTGGGATGATCTTACAGGATATCTGTACGGATGTTGTGTCCGCCTTGATTGCATTTGGATACA
GCCGGGATCAGATTCTTCGTGATTTCTATCTAGGGGGATCCAAGCTGGTGGTCTCTTATGTGGTCCCGGGCAGTCCGGCC
GATGAAATGGGCATTTCAGTGGCTGACTTCGTAACATCGGTGCAGGGGGCGCCGGTGGGGGATGTGCCTTCATTTGCCAA
AGAACTCACCTTGGCAAGGGGGCGGAAACCCGCCAGTATTTTGGTTGAAATGGTCTCTGGGGCCTTTGGAAACTTCATGA
CCTCCAGGCTGGCAGCGGAGGATCTTGAAATTCAGATGATGCGAATACCGGGATCCGCCACTTTGGGGTAG

Upstream 100 bases:

>100_bases
ATGAACTGGCCCTTGCTCTTTGACACCCGCATGGCCAGGAGATGGCGTTGCCATCAACCCAAGTCTAAGATTTTGGGCTA
TGTCCCCAAAGATTTCCAGC

Downstream 100 bases:

>100_bases
GAAAACATTCAATACAAGCCCCTGTAATTAATAAAAATTTCGCATTTTAAGGGGGCGCCGGGATTCTGCTTGCGGAAATC
CCTGGGGACTGGCTTATTAG

Product: periplasmic serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MAKKAHEATRAVVRILVQGFSETDPRSILDPRFAAPEQWSASGFFIQLHGESGYILTNSHVVRNSVRIEVRSTLTSDETF
RAEVLGMVEDLEPDVALLRLGREDIKRFLKLTGLKKIPALKLGFDVKVYRGEEVKTIGFPLGVDEPHFSGGEISNFIAGS
GDTTERMVTDAAINFGNSGGPALVEGGWVVGINTAVIEGAENFSFITPIHLAKHVLETFLKKDKASLSRLGLLIQKNSDW
NSRVLGVPADAGVIVRKVFPGSPAASMGLQSRDVILAIAGEALDRHGNVLPMASDRKRNIYDAIHDVPEGGVLDVAILRR
KKHLNLRGRMFAWESGEISRRPVLVDRAYLSFGGMILQDICTDVVSALIAFGYSRDQILRDFYLGGSKLVVSYVVPGSPA
DEMGISVADFVTSVQGAPVGDVPSFAKELTLARGRKPASILVEMVSGAFGNFMTSRLAAEDLEIQMMRIPGSATLG

Sequences:

>Translated_476_residues
MAKKAHEATRAVVRILVQGFSETDPRSILDPRFAAPEQWSASGFFIQLHGESGYILTNSHVVRNSVRIEVRSTLTSDETF
RAEVLGMVEDLEPDVALLRLGREDIKRFLKLTGLKKIPALKLGFDVKVYRGEEVKTIGFPLGVDEPHFSGGEISNFIAGS
GDTTERMVTDAAINFGNSGGPALVEGGWVVGINTAVIEGAENFSFITPIHLAKHVLETFLKKDKASLSRLGLLIQKNSDW
NSRVLGVPADAGVIVRKVFPGSPAASMGLQSRDVILAIAGEALDRHGNVLPMASDRKRNIYDAIHDVPEGGVLDVAILRR
KKHLNLRGRMFAWESGEISRRPVLVDRAYLSFGGMILQDICTDVVSALIAFGYSRDQILRDFYLGGSKLVVSYVVPGSPA
DEMGISVADFVTSVQGAPVGDVPSFAKELTLARGRKPASILVEMVSGAFGNFMTSRLAAEDLEIQMMRIPGSATLG
>Mature_475_residues
AKKAHEATRAVVRILVQGFSETDPRSILDPRFAAPEQWSASGFFIQLHGESGYILTNSHVVRNSVRIEVRSTLTSDETFR
AEVLGMVEDLEPDVALLRLGREDIKRFLKLTGLKKIPALKLGFDVKVYRGEEVKTIGFPLGVDEPHFSGGEISNFIAGSG
DTTERMVTDAAINFGNSGGPALVEGGWVVGINTAVIEGAENFSFITPIHLAKHVLETFLKKDKASLSRLGLLIQKNSDWN
SRVLGVPADAGVIVRKVFPGSPAASMGLQSRDVILAIAGEALDRHGNVLPMASDRKRNIYDAIHDVPEGGVLDVAILRRK
KHLNLRGRMFAWESGEISRRPVLVDRAYLSFGGMILQDICTDVVSALIAFGYSRDQILRDFYLGGSKLVVSYVVPGSPAD
EMGISVADFVTSVQGAPVGDVPSFAKELTLARGRKPASILVEMVSGAFGNFMTSRLAAEDLEIQMMRIPGSATLG

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI24308541, Length=267, Percent_Identity=28.4644194756554, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI22129776, Length=274, Percent_Identity=26.6423357664234, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI7019477, Length=305, Percent_Identity=29.5081967213115, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786356, Length=402, Percent_Identity=24.6268656716418, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789629, Length=424, Percent_Identity=26.1792452830189, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789630, Length=290, Percent_Identity=25.1724137931034, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646839, Length=309, Percent_Identity=29.4498381877023, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51546; Mature: 51415

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKAHEATRAVVRILVQGFSETDPRSILDPRFAAPEQWSASGFFIQLHGESGYILTNSH
CCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEECCC
VVRNSVRIEVRSTLTSDETFRAEVLGMVEDLEPDVALLRLGREDIKRFLKLTGLKKIPAL
EEECEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCCCCEE
KLGFDVKVYRGEEVKTIGFPLGVDEPHFSGGEISNFIAGSGDTTERMVTDAAINFGNSGG
EECCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCC
PALVEGGWVVGINTAVIEGAENFSFITPIHLAKHVLETFLKKDKASLSRLGLLIQKNSDW
CEEEECCEEEEECHHEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCC
NSRVLGVPADAGVIVRKVFPGSPAASMGLQSRDVILAIAGEALDRHGNVLPMASDRKRNI
CCEEEECCCCCCEEEEEECCCCCHHHCCCCCCCEEEEEECHHHHCCCCEECCCCCCCHHH
YDAIHDVPEGGVLDVAILRRKKHLNLRGRMFAWESGEISRRPVLVDRAYLSFGGMILQDI
HHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCHHHHHHH
CTDVVSALIAFGYSRDQILRDFYLGGSKLVVSYVVPGSPADEMGISVADFVTSVQGAPVG
HHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHCCCHHHHHHHCCCCCCC
DVPSFAKELTLARGRKPASILVEMVSGAFGNFMTSRLAAEDLEIQMMRIPGSATLG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
AKKAHEATRAVVRILVQGFSETDPRSILDPRFAAPEQWSASGFFIQLHGESGYILTNSH
CCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEECCC
VVRNSVRIEVRSTLTSDETFRAEVLGMVEDLEPDVALLRLGREDIKRFLKLTGLKKIPAL
EEECEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCCCCEE
KLGFDVKVYRGEEVKTIGFPLGVDEPHFSGGEISNFIAGSGDTTERMVTDAAINFGNSGG
EECCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCC
PALVEGGWVVGINTAVIEGAENFSFITPIHLAKHVLETFLKKDKASLSRLGLLIQKNSDW
CEEEECCEEEEECHHEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCC
NSRVLGVPADAGVIVRKVFPGSPAASMGLQSRDVILAIAGEALDRHGNVLPMASDRKRNI
CCEEEECCCCCCEEEEEECCCCCHHHCCCCCCCEEEEEECHHHHCCCCEECCCCCCCHHH
YDAIHDVPEGGVLDVAILRRKKHLNLRGRMFAWESGEISRRPVLVDRAYLSFGGMILQDI
HHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCHHHHHHH
CTDVVSALIAFGYSRDQILRDFYLGGSKLVVSYVVPGSPADEMGISVADFVTSVQGAPVG
HHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHCCCHHHHHHHCCCCCCC
DVPSFAKELTLARGRKPASILVEMVSGAFGNFMTSRLAAEDLEIQMMRIPGSATLG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]