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The map label for this gene is atoB [H]

Identifier: 42522018

GI number: 42522018

Start: 380675

End: 381856

Strand: Direct

Name: atoB [H]

Synonym: Bd0404

Alternate gene names: 42522018

Gene position: 380675-381856 (Clockwise)

Preceding gene: 42522017

Following gene: 42522019

Centisome position: 10.06

GC content: 53.81

Gene sequence:

>1182_bases
ATGGAAAAAATCGTATTTATCTCTGGAAAAAGAACTCCCTTCGGAGCCTTCGGCGGTTCATTGAAGGATGTATCAGCAAC
GGATCTGGGTGTCGCTGCCGCTAAAGCGACCCTGGAGCAAGCCGGTCTGTCTGCAGACAAGATTGATCACGTGGTGTTTG
GCAACGTGGTTCAGTCCGGTGCGGATGCAGCCTATCTTCCAAGACATATTGGTTTGAAAACCGGAGTGCCGGTCGCGGTG
GGCGCTTTTGCGGTCAACCGTCTGTGTGGCAGTGGTTTCCAGTCCTGGGTGAATGCCGTGCAGATGATCCAGTGTGGGGA
AGCCACCGCGGTTCTTGCCGGTGGTGTCGAGCAAATGTCCCAGATTCCTTATGTGGCCCGCAAAGTCCGCTTTGATGGCA
TGCGCATGGGGAACTTCGAACTGGAAGATCTGATGACCTCGGCGCTGACGGACGCTTATGCCAAGATGCCTATGGCGATC
ACGGCTGAAAATCTGGCGGTGAAATACGGTATCACGCGCGAAGAATCTGACAAGTATTCCATCCAGTCCCAGCAGCGCTT
CCAGGCCGCGGTTGAAAAAGGTTTCATGAAACAGGAAATCTGCCTGGTCACAGTTGAGGGTCGCAAGGGCACCGTGGTGA
TTGAAAAAGACGAACATCCAAAACCGGATTCCACTCTGGAAAAACTGGCGACGCTAAAGCCTGTCTTCAAAAAAGACGGG
ATTGTAACGGCGGCGGCGGCTTCCGGTATTGTCGACGGGGCGGCTTGTTCTTTGTTGATGAGCGAATCCAAAGCCAAGGA
ACTGGGCATGAAACCAATGGCGCGTATCGTGAGCTACGCTTCTGTGGGTTGTGACCCGACGATCATGGGTATTGGTCCAG
CGGGCGCAGCTCGTCTGGCATTACAGAAAGCCGGACTGACTCTGGATCAGATGGATCTGGTGGAAGTGAACGAAGCTTTT
GCGGCCCAGTACCTGGCGGTGGAAAAAGAATTGAAACTGGATCCGGCAAAAACCAATGTGAACGGTGGTGCGATTGCTGT
CGGTCACCCCTTGGGTGCCTCCGGCACCCGCATTATGAATCACCTGGTGTATGAGCTTCATCGCCGCAACGCCAAGTACG
CTCTGGGTTCTGCTTGTATTGGCGGCGGTCAGGGTATTGCGATCATCATCGAAAGAATCTAA

Upstream 100 bases:

>100_bases
GAACAACAAAGATCTGGTTGTCAGTCACAAAGCCAACAAAGAACAGGGCCTGTCGATGATTGGCCTTGCCTGGTCCTGGT
AAGCGTCCTACCCTTAGGAC

Downstream 100 bases:

>100_bases
CAGCGAGGGGCCGCCAAGGACTGCGGCCTCTGGAACAGGGACTCATGGAATTTAATTTGAGAGAACGAACGGCGCTCATT
GTTGGACCTTTTACTTCAAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MEKIVFISGKRTPFGAFGGSLKDVSATDLGVAAAKATLEQAGLSADKIDHVVFGNVVQSGADAAYLPRHIGLKTGVPVAV
GAFAVNRLCGSGFQSWVNAVQMIQCGEATAVLAGGVEQMSQIPYVARKVRFDGMRMGNFELEDLMTSALTDAYAKMPMAI
TAENLAVKYGITREESDKYSIQSQQRFQAAVEKGFMKQEICLVTVEGRKGTVVIEKDEHPKPDSTLEKLATLKPVFKKDG
IVTAAAASGIVDGAACSLLMSESKAKELGMKPMARIVSYASVGCDPTIMGIGPAGAARLALQKAGLTLDQMDLVEVNEAF
AAQYLAVEKELKLDPAKTNVNGGAIAVGHPLGASGTRIMNHLVYELHRRNAKYALGSACIGGGQGIAIIIERI

Sequences:

>Translated_393_residues
MEKIVFISGKRTPFGAFGGSLKDVSATDLGVAAAKATLEQAGLSADKIDHVVFGNVVQSGADAAYLPRHIGLKTGVPVAV
GAFAVNRLCGSGFQSWVNAVQMIQCGEATAVLAGGVEQMSQIPYVARKVRFDGMRMGNFELEDLMTSALTDAYAKMPMAI
TAENLAVKYGITREESDKYSIQSQQRFQAAVEKGFMKQEICLVTVEGRKGTVVIEKDEHPKPDSTLEKLATLKPVFKKDG
IVTAAAASGIVDGAACSLLMSESKAKELGMKPMARIVSYASVGCDPTIMGIGPAGAARLALQKAGLTLDQMDLVEVNEAF
AAQYLAVEKELKLDPAKTNVNGGAIAVGHPLGASGTRIMNHLVYELHRRNAKYALGSACIGGGQGIAIIIERI
>Mature_393_residues
MEKIVFISGKRTPFGAFGGSLKDVSATDLGVAAAKATLEQAGLSADKIDHVVFGNVVQSGADAAYLPRHIGLKTGVPVAV
GAFAVNRLCGSGFQSWVNAVQMIQCGEATAVLAGGVEQMSQIPYVARKVRFDGMRMGNFELEDLMTSALTDAYAKMPMAI
TAENLAVKYGITREESDKYSIQSQQRFQAAVEKGFMKQEICLVTVEGRKGTVVIEKDEHPKPDSTLEKLATLKPVFKKDG
IVTAAAASGIVDGAACSLLMSESKAKELGMKPMARIVSYASVGCDPTIMGIGPAGAARLALQKAGLTLDQMDLVEVNEAF
AAQYLAVEKELKLDPAKTNVNGGAIAVGHPLGASGTRIMNHLVYELHRRNAKYALGSACIGGGQGIAIIIERI

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=56.8877551020408, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=42.3857868020305, Blast_Score=308, Evalue=5e-84,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=39.5465994962217, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=39.4936708860759, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=32.0093457943925, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=27.4358974358974, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=46.0559796437659, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=47.4619289340102, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1787663, Length=406, Percent_Identity=41.871921182266, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=41.5422885572139, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=35.2078239608802, Blast_Score=211, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=56.6326530612245, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=37.8787878787879, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI25147385, Length=395, Percent_Identity=35.1898734177215, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=32.7868852459016, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=28.030303030303, Blast_Score=151, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=38, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=33.0808080808081, Blast_Score=185, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=50.8951406649616, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=43.1472081218274, Blast_Score=317, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=37.3096446700508, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=31.2206572769953, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41453; Mature: 41453

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIVFISGKRTPFGAFGGSLKDVSATDLGVAAAKATLEQAGLSADKIDHVVFGNVVQSG
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
ADAAYLPRHIGLKTGVPVAVGAFAVNRLCGSGFQSWVNAVQMIQCGEATAVLAGGVEQMS
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHCCHHHHH
QIPYVARKVRFDGMRMGNFELEDLMTSALTDAYAKMPMAITAENLAVKYGITREESDKYS
HCHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCCC
IQSQQRFQAAVEKGFMKQEICLVTVEGRKGTVVIEKDEHPKPDSTLEKLATLKPVFKKDG
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
IVTAAAASGIVDGAACSLLMSESKAKELGMKPMARIVSYASVGCDPTIMGIGPAGAARLA
EEEEHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
LQKAGLTLDQMDLVEVNEAFAAQYLAVEKELKLDPAKTNVNGGAIAVGHPLGASGTRIMN
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHH
HLVYELHRRNAKYALGSACIGGGQGIAIIIERI
HHHHHHHHCCCCHHHCHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MEKIVFISGKRTPFGAFGGSLKDVSATDLGVAAAKATLEQAGLSADKIDHVVFGNVVQSG
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
ADAAYLPRHIGLKTGVPVAVGAFAVNRLCGSGFQSWVNAVQMIQCGEATAVLAGGVEQMS
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHCCHHHHH
QIPYVARKVRFDGMRMGNFELEDLMTSALTDAYAKMPMAITAENLAVKYGITREESDKYS
HCHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCCC
IQSQQRFQAAVEKGFMKQEICLVTVEGRKGTVVIEKDEHPKPDSTLEKLATLKPVFKKDG
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
IVTAAAASGIVDGAACSLLMSESKAKELGMKPMARIVSYASVGCDPTIMGIGPAGAARLA
EEEEHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
LQKAGLTLDQMDLVEVNEAFAAQYLAVEKELKLDPAKTNVNGGAIAVGHPLGASGTRIMN
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHH
HLVYELHRRNAKYALGSACIGGGQGIAIIIERI
HHHHHHHHCCCCHHHCHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]