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The map label for this gene is dppA [H]

Identifier: 42521975

GI number: 42521975

Start: 334166

End: 335788

Strand: Direct

Name: dppA [H]

Synonym: Bd0357

Alternate gene names: 42521975

Gene position: 334166-335788 (Clockwise)

Preceding gene: 42521971

Following gene: 42521976

Centisome position: 8.83

GC content: 46.09

Gene sequence:

>1623_bases
ATGAATATGAAGGGACTCCTGGCTCTTGCACTGAGCTCAGCTTTGACAGCTCCCGCTTTCGCAGCAGCACCAAATGCTAA
TGCACCAAAAGGCGGAAATTTCGTAAACAACCTTGGCGGTGAACCACCAACAGTTCATCCGATCACAAGCACAGACGTGT
ACGGTTCCAACGTGCAAGCGATGGTGTGTGAAGGTCTTTTGTCTCGTGATTCTGAGACTTATGACTGGAAACCTCGTTTG
GCTGAAAAGTGGGAAGTCTCCAAAGACAACAAAACTTTCACTTTCTTCCTTCGTAAAAATGCAGTCTTCCATGACGGCAA
GCCGGTAACAGCTGAAGACGTTAAGTTCTCCTTCGACGCGATCTTCGAGCCAAAATATGAAGCGGCTCACCTTCGTCCCT
ACTACGAAGGTCTTTCCAAAGTTGAAGTGGTTGATTCTCACACTGTGAAATTCACCGCTAAAGACATGTACTTCAAAAAC
TTCGAATCCGCTGCGGGTCTGACCATCATCCCTAAGCACATCTATGGCGATGTTGAGAAATCCAAAAAAATGAACCGTCA
GTTGATCTGCACCGGTGCATACTCCATGTCCAAATTCGACCGTGGTCAAATGATCCAGTTGAAGAAATTCGACAAATGGT
GGGGTTTGAACGAGCCATTGTACAAAGGCGCGTACAACTTCGACACTGTGACTCTTCGTTTCTACAAAGACGAGAACGTT
CAACTTGAGCGCGCTAAAAAAGGTGAGCTTGATTACCTTGACCTGCGTATTGAATCCTTCATGAAAAAAACTGAAGGGGC
TCCTTGGGGCAAAACTGTTCTTAAGCACAAAGTTGCCAACAGCGCTCCTAAGTCTTACGGCTTCGTGGGTTGGAACTTCC
GCAAAGAATTGTTCCAGGACAAAAACGTACGTGTGGCTTTGGCTCACCTGTTGAACCGCGAAGAGATGAACAAAAAGTTC
CGTTACGGCATGTCTGATCTTGCTAACGGCGCTGTTTACATCAAATCCGAATACAACCCAGGCAACAAAGCTTTGGAATT
CAATCCGAAGAAAGCTCAGGAATTGCTGGCTAAAGCCGGTTGGAATGACGCTGACAAAAACGGTGTTCTTGAGAAAACCG
TGAACGGCAAGAAATCTGAGTTCAAGTTCACTTTGATCTACCCTAATAAAGACGTAGAGAAATACTGGACTATGTACCGC
GAGGACCTGAAAAAAGCCGGTATCGACATGGAACTTAAGTATCTTGAGTGGAACTCCTTCCTGAAGCTGGTTGACGAAGG
TAACTTCGACGCTGTGACCATGGCTTGGGGTGGTGGTTCTGTTGATCCAGATCCAAAACAAATCTGGCACTCTTCCGGTG
CGATCCCAGGTGGTTCTAACTTCATCGGTTACAAAAACCCTGAAGTGGACAAACTTATCGACGAAGCCCGCGTTGAGCCG
AATAAAGCAAAACGTGTTGCTAAGTTGAAAGAAGTTTACAGAAGAATCGCTGAAGACGCTCCATACGCGTTCTTGTTCAA
CGACAAGTACGTATTCTATGCAAATTCTTCACGCATGGGCACTCCTGCAGAGACATTTAAGTACGAAATTGGTACAGACT
ACTGGTGGATGAAGCCTCAATAG

Upstream 100 bases:

>100_bases
TCAATCGAGCAATAACTTGATTATTTTTGTCGCATAACCCATTTTAACCCAACTTTGGGAACCACTTAAATTCCCAGCGA
AATTCTTTGGAGGAAACACA

Downstream 100 bases:

>100_bases
GCTTCTTCCTCTGGAATTGTTCATCTGTCTCTTATTAGTTTGGGAGTAGGGCTTTGATCGTCTACCTGATTCGCCGATTA
CTACTGATGATCCCGACATT

Product: peptide ABC transporter periplasmic protein

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MNMKGLLALALSSALTAPAFAAAPNANAPKGGNFVNNLGGEPPTVHPITSTDVYGSNVQAMVCEGLLSRDSETYDWKPRL
AEKWEVSKDNKTFTFFLRKNAVFHDGKPVTAEDVKFSFDAIFEPKYEAAHLRPYYEGLSKVEVVDSHTVKFTAKDMYFKN
FESAAGLTIIPKHIYGDVEKSKKMNRQLICTGAYSMSKFDRGQMIQLKKFDKWWGLNEPLYKGAYNFDTVTLRFYKDENV
QLERAKKGELDYLDLRIESFMKKTEGAPWGKTVLKHKVANSAPKSYGFVGWNFRKELFQDKNVRVALAHLLNREEMNKKF
RYGMSDLANGAVYIKSEYNPGNKALEFNPKKAQELLAKAGWNDADKNGVLEKTVNGKKSEFKFTLIYPNKDVEKYWTMYR
EDLKKAGIDMELKYLEWNSFLKLVDEGNFDAVTMAWGGGSVDPDPKQIWHSSGAIPGGSNFIGYKNPEVDKLIDEARVEP
NKAKRVAKLKEVYRRIAEDAPYAFLFNDKYVFYANSSRMGTPAETFKYEIGTDYWWMKPQ

Sequences:

>Translated_540_residues
MNMKGLLALALSSALTAPAFAAAPNANAPKGGNFVNNLGGEPPTVHPITSTDVYGSNVQAMVCEGLLSRDSETYDWKPRL
AEKWEVSKDNKTFTFFLRKNAVFHDGKPVTAEDVKFSFDAIFEPKYEAAHLRPYYEGLSKVEVVDSHTVKFTAKDMYFKN
FESAAGLTIIPKHIYGDVEKSKKMNRQLICTGAYSMSKFDRGQMIQLKKFDKWWGLNEPLYKGAYNFDTVTLRFYKDENV
QLERAKKGELDYLDLRIESFMKKTEGAPWGKTVLKHKVANSAPKSYGFVGWNFRKELFQDKNVRVALAHLLNREEMNKKF
RYGMSDLANGAVYIKSEYNPGNKALEFNPKKAQELLAKAGWNDADKNGVLEKTVNGKKSEFKFTLIYPNKDVEKYWTMYR
EDLKKAGIDMELKYLEWNSFLKLVDEGNFDAVTMAWGGGSVDPDPKQIWHSSGAIPGGSNFIGYKNPEVDKLIDEARVEP
NKAKRVAKLKEVYRRIAEDAPYAFLFNDKYVFYANSSRMGTPAETFKYEIGTDYWWMKPQ
>Mature_540_residues
MNMKGLLALALSSALTAPAFAAAPNANAPKGGNFVNNLGGEPPTVHPITSTDVYGSNVQAMVCEGLLSRDSETYDWKPRL
AEKWEVSKDNKTFTFFLRKNAVFHDGKPVTAEDVKFSFDAIFEPKYEAAHLRPYYEGLSKVEVVDSHTVKFTAKDMYFKN
FESAAGLTIIPKHIYGDVEKSKKMNRQLICTGAYSMSKFDRGQMIQLKKFDKWWGLNEPLYKGAYNFDTVTLRFYKDENV
QLERAKKGELDYLDLRIESFMKKTEGAPWGKTVLKHKVANSAPKSYGFVGWNFRKELFQDKNVRVALAHLLNREEMNKKF
RYGMSDLANGAVYIKSEYNPGNKALEFNPKKAQELLAKAGWNDADKNGVLEKTVNGKKSEFKFTLIYPNKDVEKYWTMYR
EDLKKAGIDMELKYLEWNSFLKLVDEGNFDAVTMAWGGGSVDPDPKQIWHSSGAIPGGSNFIGYKNPEVDKLIDEARVEP
NKAKRVAKLKEVYRRIAEDAPYAFLFNDKYVFYANSSRMGTPAETFKYEIGTDYWWMKPQ

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence. AppA can bind and transport tetra- and pentapep

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI87082063, Length=558, Percent_Identity=22.5806451612903, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1789966, Length=533, Percent_Identity=26.078799249531, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1787052, Length=525, Percent_Identity=24.5714285714286, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787551, Length=524, Percent_Identity=23.4732824427481, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787495, Length=547, Percent_Identity=23.9488117001828, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789887, Length=462, Percent_Identity=22.5108225108225, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787762, Length=530, Percent_Identity=23.9622641509434, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081878, Length=537, Percent_Identity=22.7188081936685, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1789397, Length=530, Percent_Identity=21.8867924528302, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 61606; Mature: 61606

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKGLLALALSSALTAPAFAAAPNANAPKGGNFVNNLGGEPPTVHPITSTDVYGSNVQA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCEECCCCCCCCCCCCHHH
MVCEGLLSRDSETYDWKPRLAEKWEVSKDNKTFTFFLRKNAVFHDGKPVTAEDVKFSFDA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCCHHHCEEEEHE
IFEPKYEAAHLRPYYEGLSKVEVVDSHTVKFTAKDMYFKNFESAAGLTIIPKHIYGDVEK
EECCCCCHHCCCHHHHCCCEEEEECCCEEEEEEHHHHHHHHCCCCCCEEECHHHHCCHHH
SKKMNRQLICTGAYSMSKFDRGQMIQLKKFDKWWGLNEPLYKGAYNFDTVTLRFYKDENV
HHCCCCEEEEECCCHHHHCCCCCEEEEEHHHHHCCCCCHHHCCCCCCCEEEEEEEECCCC
QLERAKKGELDYLDLRIESFMKKTEGAPWGKTVLKHKVANSAPKSYGFVGWNFRKELFQD
EEEECCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
KNVRVALAHLLNREEMNKKFRYGMSDLANGAVYIKSEYNPGNKALEFNPKKAQELLAKAG
CCCEEHHHHHHCHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCEEEECHHHHHHHHHHCC
WNDADKNGVLEKTVNGKKSEFKFTLIYPNKDVEKYWTMYREDLKKAGIDMELKYLEWNSF
CCCCCCCCCEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHH
LKLVDEGNFDAVTMAWGGGSVDPDPKQIWHSSGAIPGGSNFIGYKNPEVDKLIDEARVEP
HHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
NKAKRVAKLKEVYRRIAEDAPYAFLFNDKYVFYANSSRMGTPAETFKYEIGTDYWWMKPQ
HHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCCCHHHEEEECCCCEEEECCC
>Mature Secondary Structure
MNMKGLLALALSSALTAPAFAAAPNANAPKGGNFVNNLGGEPPTVHPITSTDVYGSNVQA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCEECCCCCCCCCCCCHHH
MVCEGLLSRDSETYDWKPRLAEKWEVSKDNKTFTFFLRKNAVFHDGKPVTAEDVKFSFDA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCCHHHCEEEEHE
IFEPKYEAAHLRPYYEGLSKVEVVDSHTVKFTAKDMYFKNFESAAGLTIIPKHIYGDVEK
EECCCCCHHCCCHHHHCCCEEEEECCCEEEEEEHHHHHHHHCCCCCCEEECHHHHCCHHH
SKKMNRQLICTGAYSMSKFDRGQMIQLKKFDKWWGLNEPLYKGAYNFDTVTLRFYKDENV
HHCCCCEEEEECCCHHHHCCCCCEEEEEHHHHHCCCCCHHHCCCCCCCEEEEEEEECCCC
QLERAKKGELDYLDLRIESFMKKTEGAPWGKTVLKHKVANSAPKSYGFVGWNFRKELFQD
EEEECCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
KNVRVALAHLLNREEMNKKFRYGMSDLANGAVYIKSEYNPGNKALEFNPKKAQELLAKAG
CCCEEHHHHHHCHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCEEEECHHHHHHHHHHCC
WNDADKNGVLEKTVNGKKSEFKFTLIYPNKDVEKYWTMYREDLKKAGIDMELKYLEWNSF
CCCCCCCCCEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHH
LKLVDEGNFDAVTMAWGGGSVDPDPKQIWHSSGAIPGGSNFIGYKNPEVDKLIDEARVEP
HHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
NKAKRVAKLKEVYRRIAEDAPYAFLFNDKYVFYANSSRMGTPAETFKYEIGTDYWWMKPQ
HHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCCCHHHEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]