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The map label for this gene is slyD [H]

Identifier: 42521958

GI number: 42521958

Start: 321102

End: 321575

Strand: Direct

Name: slyD [H]

Synonym: Bd0336

Alternate gene names: 42521958

Gene position: 321102-321575 (Clockwise)

Preceding gene: 42521951

Following gene: 42521959

Centisome position: 8.49

GC content: 50.21

Gene sequence:

>474_bases
ATGAAAAGAGTCTTGGCATTTAACTACGTTTTAAAAGGACCTGACGGCAACGTATTGGACGCTTCTGAGCGCAACCAGCC
GCTTCCATTCCTGGAAGGTGCGGGCCAGATCATTCCTAAACTTGAAGAAGAAATCAAAGACCTGCAAGAGGGCGATAAAA
AAACTGTGAAGCTGGCAGCGAAAGACGCTTACGGCGAAGTGAAAGACAATATGTTCATGGACGTTCCTAAAGCGGAGCTT
GCGCACCTTCCACAATTGGAAGTCGGTGCTCACCTGCGTTTGGAATTGGGTCAGGGTGCACACATCGTGCGCGTGACTAA
AATCACTGACGAAGCAGTTACTTTGGATGGCAACCACCCATTGGCAGGTCAGGATCTTGAATTTGCAATTGAGATGGTTT
TGATTCGTGAGGCGACGGCGGAAGAAGTTCTGCATGGACACCCGCACGGCCTCCACGGCAACAGTGGCCACTAG

Upstream 100 bases:

>100_bases
AAGTGTCTCGTTAAATATTCAAAAGAACTGGGTCTTTTCGGTTGCCTGAATAGGTCCAAAATGGGATACCGTCGGCATTA
AGCGCACAGGAGGCATATAA

Downstream 100 bases:

>100_bases
TCGGCCGATGAAAAGGGCCCATCCGACTGCGTTGTCGGGGGACCCTTTTCGCTTCGACGTGCTTGGAGCACGCCTCCGCT
TCAAGGGGACCCCTCCGCCT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Metallochaperone slyD [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKRVLAFNYVLKGPDGNVLDASERNQPLPFLEGAGQIIPKLEEEIKDLQEGDKKTVKLAAKDAYGEVKDNMFMDVPKAEL
AHLPQLEVGAHLRLELGQGAHIVRVTKITDEAVTLDGNHPLAGQDLEFAIEMVLIREATAEEVLHGHPHGLHGNSGH

Sequences:

>Translated_157_residues
MKRVLAFNYVLKGPDGNVLDASERNQPLPFLEGAGQIIPKLEEEIKDLQEGDKKTVKLAAKDAYGEVKDNMFMDVPKAEL
AHLPQLEVGAHLRLELGQGAHIVRVTKITDEAVTLDGNHPLAGQDLEFAIEMVLIREATAEEVLHGHPHGLHGNSGH
>Mature_157_residues
MKRVLAFNYVLKGPDGNVLDASERNQPLPFLEGAGQIIPKLEEEIKDLQEGDKKTVKLAAKDAYGEVKDNMFMDVPKAEL
AHLPQLEVGAHLRLELGQGAHIVRVTKITDEAVTLDGNHPLAGQDLEFAIEMVLIREATAEEVLHGHPHGLHGNSGH

Specific function: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789748, Length=140, Percent_Identity=40, Blast_Score=101, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17177; Mature: 17177

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVLAFNYVLKGPDGNVLDASERNQPLPFLEGAGQIIPKLEEEIKDLQEGDKKTVKLAA
CCCEEEEEEEEECCCCCEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
KDAYGEVKDNMFMDVPKAELAHLPQLEVGAHLRLELGQGAHIVRVTKITDEAVTLDGNHP
CCCCCCCCCCEEEECCHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEECCCCC
LAGQDLEFAIEMVLIREATAEEVLHGHPHGLHGNSGH
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKRVLAFNYVLKGPDGNVLDASERNQPLPFLEGAGQIIPKLEEEIKDLQEGDKKTVKLAA
CCCEEEEEEEEECCCCCEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
KDAYGEVKDNMFMDVPKAELAHLPQLEVGAHLRLELGQGAHIVRVTKITDEAVTLDGNHP
CCCCCCCCCCEEEECCHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEECCCCC
LAGQDLEFAIEMVLIREATAEEVLHGHPHGLHGNSGH
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]