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The map label for this gene is lysC [H]

Identifier: 42521771

GI number: 42521771

Start: 118476

End: 119858

Strand: Direct

Name: lysC [H]

Synonym: Bd0134

Alternate gene names: 42521771

Gene position: 118476-119858 (Clockwise)

Preceding gene: 42521769

Following gene: 42521772

Centisome position: 3.13

GC content: 50.4

Gene sequence:

>1383_bases
GTGGCAAAACTGGTAGTTTCTAAATTTGGCGGCACCTCCATGGGAGATGCAGACTGTATGCTTCGCAGTGCGGAAGTCAG
CTTCCGCCAGGGTTCGGGTCTGGTGGTTGTTTCTGCCACCTCCGGCACCACCAACGATCTGATTGCTCTTGGCAAAACCG
CCGAATCCCAAGCTTGGTCGGAATCTGAAAAAATCCTTTCCAAGATTCAGGACAAACACAATAAGATCGCCCAGGATCTG
AAACTGCCAGCCGATGCCAAAGCCAAACTGGAAACTTTGTTTGAAGAAATGAGTTCATTGGCAAAAGGTATGCACCTTCT
GAAAGACTGCTCGGTCAAAGCCATGGACACCCTGATGAGTCTGGGGGAAAGAATGTCCTCCGTTCTTTTCACCGAAGCGA
TGTCTCAGGTTCTAAAAAAGCACGGCTCTGCAAAATCCGCTGAACTTTTGGACGTGCGCACAGTTTTGCGCACGGATGAT
CAGTTCGGTAAAGCCAAACCACTCACCAATGATGTGGCTAACCTGTGCCAGAAGAACCTGTCTTTCCTGCGTGAGGGAAA
GAAAGTCATGTGCACGCAAGGTTACATTGGCATGACTGAAGAAGGCATCACAACCACTTTAGGGCGCGGGGGCAGTGACT
ATTCCGCCGCGATTTTGGCCGAAGGTGTGTCTGCGGATGTGCTGGAGATCTGGACAGATGTGGCGGGGATTGCAACGACG
GATCCGCGTCTGTGCCCGAAGGCACAACCTATCAGCGAAATTTCCTTCAAAGAAGCTTCCGAACTTGCCACTTTTGGTGC
GAAAGTTCTGCATCCGGCGACATTGCTTCCAGCCATTCGCAAGAACATTCCTGTCTTTGTGGGTTCCAGTTTTGATGTTG
AAGCCCGCGGCACCTGGGTGCGCATGGATGTGGAAGATCATCCGCTGATTCGTGCGATGGCGCTTCGAAAAAAACAGGTG
CTTGTGACCCTTTCCACTCCGGAAATGCTTTACGCGCATGGCTTTTTGTTCCAGATCTTCAAAATCTTCAACGATCACAA
AGTCAGTATCGACGCGATCACCACCTCTGAAATTTCAGTCAGTGTGACCCTGGATGACTCAACTTTATTGAATAAAAATC
TGATCAAGGATCTTTCTCAGATCGCGGATGTGCAGGTGGAAGAAAACCTGGCACTGATTTCTTTGATCGGAAACAACATC
AACCACACGCCGGGCTTGGGAAAAAGAATCTTCGAGACCATTCCGGACATCAATGTGCGCATGATCTGTCTGGGTGCCAG
CAAACACAACTTCTGTTTCCTGGTGGCCGATGAACAGGGCCCCGAGGTCATCAAACGCCTGCACGCCTGCTTCATCGAAG
CCGGCATCGAAGAAATGGCCTAA

Upstream 100 bases:

>100_bases
AGGTGGTCGCGTTCATAGGGAAAGTCTGCCATAAAAGTCGTTGAATGAAAAAGCATAACCGCATTAGGATATTCCCTGGC
CCAAGGGCCAAGGAGTGCAT

Downstream 100 bases:

>100_bases
AAGGTACCTGCTTACTTTTTCCGAAGCGTCGCGTAAGGAGATTTACAAATGGAAAAGAATGAATTTTACAAGTTGCTGGA
ATCCAGAAAGTCCATTCGTA

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAKLVVSKFGGTSMGDADCMLRSAEVSFRQGSGLVVVSATSGTTNDLIALGKTAESQAWSESEKILSKIQDKHNKIAQDL
KLPADAKAKLETLFEEMSSLAKGMHLLKDCSVKAMDTLMSLGERMSSVLFTEAMSQVLKKHGSAKSAELLDVRTVLRTDD
QFGKAKPLTNDVANLCQKNLSFLREGKKVMCTQGYIGMTEEGITTTLGRGGSDYSAAILAEGVSADVLEIWTDVAGIATT
DPRLCPKAQPISEISFKEASELATFGAKVLHPATLLPAIRKNIPVFVGSSFDVEARGTWVRMDVEDHPLIRAMALRKKQV
LVTLSTPEMLYAHGFLFQIFKIFNDHKVSIDAITTSEISVSVTLDDSTLLNKNLIKDLSQIADVQVEENLALISLIGNNI
NHTPGLGKRIFETIPDINVRMICLGASKHNFCFLVADEQGPEVIKRLHACFIEAGIEEMA

Sequences:

>Translated_460_residues
MAKLVVSKFGGTSMGDADCMLRSAEVSFRQGSGLVVVSATSGTTNDLIALGKTAESQAWSESEKILSKIQDKHNKIAQDL
KLPADAKAKLETLFEEMSSLAKGMHLLKDCSVKAMDTLMSLGERMSSVLFTEAMSQVLKKHGSAKSAELLDVRTVLRTDD
QFGKAKPLTNDVANLCQKNLSFLREGKKVMCTQGYIGMTEEGITTTLGRGGSDYSAAILAEGVSADVLEIWTDVAGIATT
DPRLCPKAQPISEISFKEASELATFGAKVLHPATLLPAIRKNIPVFVGSSFDVEARGTWVRMDVEDHPLIRAMALRKKQV
LVTLSTPEMLYAHGFLFQIFKIFNDHKVSIDAITTSEISVSVTLDDSTLLNKNLIKDLSQIADVQVEENLALISLIGNNI
NHTPGLGKRIFETIPDINVRMICLGASKHNFCFLVADEQGPEVIKRLHACFIEAGIEEMA
>Mature_459_residues
AKLVVSKFGGTSMGDADCMLRSAEVSFRQGSGLVVVSATSGTTNDLIALGKTAESQAWSESEKILSKIQDKHNKIAQDLK
LPADAKAKLETLFEEMSSLAKGMHLLKDCSVKAMDTLMSLGERMSSVLFTEAMSQVLKKHGSAKSAELLDVRTVLRTDDQ
FGKAKPLTNDVANLCQKNLSFLREGKKVMCTQGYIGMTEEGITTTLGRGGSDYSAAILAEGVSADVLEIWTDVAGIATTD
PRLCPKAQPISEISFKEASELATFGAKVLHPATLLPAIRKNIPVFVGSSFDVEARGTWVRMDVEDHPLIRAMALRKKQVL
VTLSTPEMLYAHGFLFQIFKIFNDHKVSIDAITTSEISVSVTLDDSTLLNKNLIKDLSQIADVQVEENLALISLIGNNIN
HTPGLGKRIFETIPDINVRMICLGASKHNFCFLVADEQGPEVIKRLHACFIEAGIEEMA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=45.6709956709957, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786183, Length=465, Percent_Identity=28.6021505376344, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790376, Length=429, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320893, Length=498, Percent_Identity=27.1084337349398, Blast_Score=153, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49994; Mature: 49863

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLVVSKFGGTSMGDADCMLRSAEVSFRQGSGLVVVSATSGTTNDLIALGKTAESQAWS
CCCEEEECCCCCCCCCHHHHEEHHHCCEECCCCEEEEEECCCCCCCCEEECCCCCHHHHH
ESEKILSKIQDKHNKIAQDLKLPADAKAKLETLFEEMSSLAKGMHLLKDCSVKAMDTLMS
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LGERMSSVLFTEAMSQVLKKHGSAKSAELLDVRTVLRTDDQFGKAKPLTNDVANLCQKNL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SFLREGKKVMCTQGYIGMTEEGITTTLGRGGSDYSAAILAEGVSADVLEIWTDVAGIATT
HHHHCCCEEEEECCCCCCCCCCCEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCC
DPRLCPKAQPISEISFKEASELATFGAKVLHPATLLPAIRKNIPVFVGSSFDVEARGTWV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEECCCCEE
RMDVEDHPLIRAMALRKKQVLVTLSTPEMLYAHGFLFQIFKIFNDHKVSIDAITTSEISV
EEECCCCHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECEEEE
SVTLDDSTLLNKNLIKDLSQIADVQVEENLALISLIGNNINHTPGLGKRIFETIPDINVR
EEEECCHHHHHHHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEE
MICLGASKHNFCFLVADEQGPEVIKRLHACFIEAGIEEMA
EEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKLVVSKFGGTSMGDADCMLRSAEVSFRQGSGLVVVSATSGTTNDLIALGKTAESQAWS
CCEEEECCCCCCCCCHHHHEEHHHCCEECCCCEEEEEECCCCCCCCEEECCCCCHHHHH
ESEKILSKIQDKHNKIAQDLKLPADAKAKLETLFEEMSSLAKGMHLLKDCSVKAMDTLMS
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LGERMSSVLFTEAMSQVLKKHGSAKSAELLDVRTVLRTDDQFGKAKPLTNDVANLCQKNL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SFLREGKKVMCTQGYIGMTEEGITTTLGRGGSDYSAAILAEGVSADVLEIWTDVAGIATT
HHHHCCCEEEEECCCCCCCCCCCEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCC
DPRLCPKAQPISEISFKEASELATFGAKVLHPATLLPAIRKNIPVFVGSSFDVEARGTWV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEECCCCEE
RMDVEDHPLIRAMALRKKQVLVTLSTPEMLYAHGFLFQIFKIFNDHKVSIDAITTSEISV
EEECCCCHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECEEEE
SVTLDDSTLLNKNLIKDLSQIADVQVEENLALISLIGNNINHTPGLGKRIFETIPDINVR
EEEECCHHHHHHHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEE
MICLGASKHNFCFLVADEQGPEVIKRLHACFIEAGIEEMA
EEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]