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The map label for this gene is serS

Identifier: 42521723

GI number: 42521723

Start: 71677

End: 72972

Strand: Direct

Name: serS

Synonym: Bd0077

Alternate gene names: 42521723

Gene position: 71677-72972 (Clockwise)

Preceding gene: 42521722

Following gene: 42521724

Centisome position: 1.89

GC content: 50.15

Gene sequence:

>1296_bases
ATGATTGATATTAAACTTCTTGAGAAAAAAGCTGAAACCGGAACTTCTTACTATGATGAATACAAGCAGGGTCTTGTGAA
TCGTGGTGCTTCGACCGAAGTTCTTGAGCAGATCATGGAGCTTAATAAAAAGCGTAAAGAACTGATCACTCAGGCGGAAA
CGGCCAAAGCCAGTCAGAACAAACTCAGCGGTGAGATCGGTAAAATCAAACGCGAAGGCGGCGACGCTTCTGCCATTTTG
GCTGAAGTCGACGTTTTGAAAACCCAGGTGAAAGAGCTTGAAGCCAAGGCTGCGGAAGCCGACCAGCAGGTGACAAACCT
GGCGTTGGTGATTCCGAACAAGCCGCACTCTTCTGTGCCTGTGGGTTCTTCTGAAAAAGACAATAAAGAGATCAAAGTTG
TTGGCACTCCGACCCAGTTTTCTTTTAAAGCCAAAGAACACTGGGAACTGGGTGAAGCGCTGAACATCATTGATTTCGAG
CGTGCAGGTAAAACCACCGGCACTCGTTTTGCCTTCCTGAAAGGGGCGGCGGCGCAAATGGAGCGCGCGTTGATCCAGTT
CATGATGGACAAACACTCCATGAAACATGGTTACACCGAAATGATTCCTCCGTTCATGGTGAACAGCAACAGTTTGTTGG
GCACCGGGAACTTCCCGAAATTCAAAGAAGACGTGTTCCATCTGGAAGGCTCTGACTTGTATCTGATTCCAACCGCGGAA
GTGCCGGTGACGAATTACTACAACAACGAGATCCTGGATGAAAAAGATCTGCCACAAAGCTTCTGTGCGTATTCTCCGTG
CTTCCGTTCTGAAGCGGGCTCAGCGGGTCGCGACACCAAAGGTCTGATTCGTCAGCACCAGTTCGACAAGGTTGAATTGA
TGGTGTTTGCTCATCCGGACAAGTCCCATGAAGTTCACGAGGCATTGACCTCCCACGCTGAACAGATCCTGATGGATCTG
GAGCTTCCGTTCCGTCGTGTGCTTCTGTGCACCGGGGACATGGGCTTTGGATCTGCGAAAACTTATGATCTGGAAGTATG
GTTGCCGGGTCAGAATGCGTATCGTGAGATCAGCTCTTGCTCTAACTTCGAAGATTTCCAGGCTCGTCGCGCGAACATTC
GTTTCCGCAGTGCGGGTGGTAAACCTCAGTTCGTTCACACCCTGAACGGCTCTGCTTTGGCGGTGGGAAGAACCTTGGTG
GCCATCCTGGAAAACTACCAGCGTGAAGACGGTTCCGTGGGCATTCCAAAGGCTTTACAGCCTTATATGGGCGGCCGTAC
GGAGATTCGTAAGTAA

Upstream 100 bases:

>100_bases
TAATTTTTGATCTGATCTGTGTGCTTGTGGTGATGCTTCTTAGAATGTATATACTGGTCGCGCCTTAGTAGAGGCGCTAG
TTGGTTAAAAGGACGTTGAG

Downstream 100 bases:

>100_bases
GTCCTTTAAATCCAGGCAGCATGAGGCGGCGACCTCGTGCTGCGTCATGGAAACAACTGCTTGAATACTCTCGTCAAAAC
CCATAAAACGGTCGACGGAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MIDIKLLEKKAETGTSYYDEYKQGLVNRGASTEVLEQIMELNKKRKELITQAETAKASQNKLSGEIGKIKREGGDASAIL
AEVDVLKTQVKELEAKAAEADQQVTNLALVIPNKPHSSVPVGSSEKDNKEIKVVGTPTQFSFKAKEHWELGEALNIIDFE
RAGKTTGTRFAFLKGAAAQMERALIQFMMDKHSMKHGYTEMIPPFMVNSNSLLGTGNFPKFKEDVFHLEGSDLYLIPTAE
VPVTNYYNNEILDEKDLPQSFCAYSPCFRSEAGSAGRDTKGLIRQHQFDKVELMVFAHPDKSHEVHEALTSHAEQILMDL
ELPFRRVLLCTGDMGFGSAKTYDLEVWLPGQNAYREISSCSNFEDFQARRANIRFRSAGGKPQFVHTLNGSALAVGRTLV
AILENYQREDGSVGIPKALQPYMGGRTEIRK

Sequences:

>Translated_431_residues
MIDIKLLEKKAETGTSYYDEYKQGLVNRGASTEVLEQIMELNKKRKELITQAETAKASQNKLSGEIGKIKREGGDASAIL
AEVDVLKTQVKELEAKAAEADQQVTNLALVIPNKPHSSVPVGSSEKDNKEIKVVGTPTQFSFKAKEHWELGEALNIIDFE
RAGKTTGTRFAFLKGAAAQMERALIQFMMDKHSMKHGYTEMIPPFMVNSNSLLGTGNFPKFKEDVFHLEGSDLYLIPTAE
VPVTNYYNNEILDEKDLPQSFCAYSPCFRSEAGSAGRDTKGLIRQHQFDKVELMVFAHPDKSHEVHEALTSHAEQILMDL
ELPFRRVLLCTGDMGFGSAKTYDLEVWLPGQNAYREISSCSNFEDFQARRANIRFRSAGGKPQFVHTLNGSALAVGRTLV
AILENYQREDGSVGIPKALQPYMGGRTEIRK
>Mature_431_residues
MIDIKLLEKKAETGTSYYDEYKQGLVNRGASTEVLEQIMELNKKRKELITQAETAKASQNKLSGEIGKIKREGGDASAIL
AEVDVLKTQVKELEAKAAEADQQVTNLALVIPNKPHSSVPVGSSEKDNKEIKVVGTPTQFSFKAKEHWELGEALNIIDFE
RAGKTTGTRFAFLKGAAAQMERALIQFMMDKHSMKHGYTEMIPPFMVNSNSLLGTGNFPKFKEDVFHLEGSDLYLIPTAE
VPVTNYYNNEILDEKDLPQSFCAYSPCFRSEAGSAGRDTKGLIRQHQFDKVELMVFAHPDKSHEVHEALTSHAEQILMDL
ELPFRRVLLCTGDMGFGSAKTYDLEVWLPGQNAYREISSCSNFEDFQARRANIRFRSAGGKPQFVHTLNGSALAVGRTLV
AILENYQREDGSVGIPKALQPYMGGRTEIRK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI225579074, Length=398, Percent_Identity=33.6683417085427, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI8923421, Length=398, Percent_Identity=33.4170854271357, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI16306548, Length=389, Percent_Identity=33.4190231362468, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=48.8532110091743, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539260, Length=440, Percent_Identity=31.8181818181818, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=370, Percent_Identity=26.7567567567568, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=430, Percent_Identity=33.2558139534884, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321799, Length=372, Percent_Identity=30.1075268817204, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24581334, Length=349, Percent_Identity=33.810888252149, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17737985, Length=355, Percent_Identity=30.9859154929577, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BDEBA (Q6MRK1)

Other databases:

- EMBL:   BX842646
- RefSeq:   NP_967103.1
- ProteinModelPortal:   Q6MRK1
- SMR:   Q6MRK1
- GeneID:   2734234
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0077
- NMPDR:   fig|264462.1.peg.73
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q6MRK1
- ProtClustDB:   PRK05431
- BioCyc:   BBAC264462:BD0077-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48047; Mature: 48047

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 292-292 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIKLLEKKAETGTSYYDEYKQGLVNRGASTEVLEQIMELNKKRKELITQAETAKASQN
CCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLSGEIGKIKREGGDASAILAEVDVLKTQVKELEAKAAEADQQVTNLALVIPNKPHSSVP
HHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
VGSSEKDNKEIKVVGTPTQFSFKAKEHWELGEALNIIDFERAGKTTGTRFAFLKGAAAQM
CCCCCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCEEHHHCCCCCCCEEHHHHCHHHHH
ERALIQFMMDKHSMKHGYTEMIPPFMVNSNSLLGTGNFPKFKEDVFHLEGSDLYLIPTAE
HHHHHHHHHHHHHHHCCHHHHCCCEEECCCCEEECCCCCCHHHHHEEECCCCEEEEECCC
VPVTNYYNNEILDEKDLPQSFCAYSPCFRSEAGSAGRDTKGLIRQHQFDKVELMVFAHPD
CCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEEEECCC
KSHEVHEALTSHAEQILMDLELPFRRVLLCTGDMGFGSAKTYDLEVWLPGQNAYREISSC
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHC
SNFEDFQARRANIRFRSAGGKPQFVHTLNGSALAVGRTLVAILENYQREDGSVGIPKALQ
CCCHHHHHHHHCEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
PYMGGRTEIRK
HHCCCCCCCCC
>Mature Secondary Structure
MIDIKLLEKKAETGTSYYDEYKQGLVNRGASTEVLEQIMELNKKRKELITQAETAKASQN
CCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLSGEIGKIKREGGDASAILAEVDVLKTQVKELEAKAAEADQQVTNLALVIPNKPHSSVP
HHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
VGSSEKDNKEIKVVGTPTQFSFKAKEHWELGEALNIIDFERAGKTTGTRFAFLKGAAAQM
CCCCCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCEEHHHCCCCCCCEEHHHHCHHHHH
ERALIQFMMDKHSMKHGYTEMIPPFMVNSNSLLGTGNFPKFKEDVFHLEGSDLYLIPTAE
HHHHHHHHHHHHHHHCCHHHHCCCEEECCCCEEECCCCCCHHHHHEEECCCCEEEEECCC
VPVTNYYNNEILDEKDLPQSFCAYSPCFRSEAGSAGRDTKGLIRQHQFDKVELMVFAHPD
CCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEEEECCC
KSHEVHEALTSHAEQILMDLELPFRRVLLCTGDMGFGSAKTYDLEVWLPGQNAYREISSC
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHC
SNFEDFQARRANIRFRSAGGKPQFVHTLNGSALAVGRTLVAILENYQREDGSVGIPKALQ
CCCHHHHHHHHCEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
PYMGGRTEIRK
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA