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The map label for this gene is 42521703

Identifier: 42521703

GI number: 42521703

Start: 49662

End: 50582

Strand: Direct

Name: 42521703

Synonym: Bd0056

Alternate gene names: NA

Gene position: 49662-50582 (Clockwise)

Preceding gene: 42521702

Following gene: 42521705

Centisome position: 1.31

GC content: 53.85

Gene sequence:

>921_bases
ATGATTAAAAAAGCCCTGCCCGTCTTACTTGTTCTTGGCGCCGTCATCAGCTATCTGCTGTGGCCCCGGTCTTCCGAAAA
TTCAGAAGTCCCTCATCCGACGTCCACTATTGAAAAGCAAGAGCCTCAAGATGCACAAACTCCCTCCGACTCTGAGCCTG
GGGCAGTTTTCTCGGCTTTTGAAATTAAGACCGTGCAAACTGTCAGCGAAAGTGTTCCCTTTGAAGAACCATCATCGCCG
CACGACGAGCCCGCCGCGAAAAGTGAAGTGACCTATGTGGTGGAAGACGGCGTGGCGGTCGTTAACGAAGACATCGTGAT
CGGAGTTCCCCGCAGCGCCAAGGCCCGCGGCAGCGTGGTCCTGGAAAGCGTGCAGCTGTGGGAGGGCGGTGTGGTGCCTT
TTCATATCCAGGGAGATGTCCCCAACAAATCTGAGATCATTCAGGCCATTGCTGAGTTCGTTGAAACTCCCATCAAGTTT
GTTCCCTACACAAATCAGGAAGATGTCCTGGTGTTTGAAGCCGGAGCGGGCTGTAAATCCTATCTGGGGAAAGTCGGCGG
CAAGCAGCCGCTGTGGATCTCCGGGGGCTGCGGGGTGACCGAGATCACCCATGAGATCATGCATGCATTGGGGTTTATCC
ACGAACAAAATCGCACGGACCGGGACCGGTTTGTTGAAGTGGTGTGGGACAATATCCACGAGAAGTACAAACACAACTTT
GAGCTGTTTCCCGCCTCTTTGATGGTGCTCAGCGGGGCCGCGGCGTTTGATTTTGAATCTGTCATGCTTTATCAGCCGAC
CGCGTTTAGCAAAAACGGCGAGGTCACCATAAGATCAAAAACAGAATCCCTGCTGGCTCCGAGCGCGGCTCTGAGCGCCG
GAGACATCCAGCGACTTGTGCATGTCTATGGCAGAAACTAA

Upstream 100 bases:

>100_bases
CGAACGAAAATTCGTTCAGCATTGGTTCAATTTTAAAACCCACGGCCCTGAAACCGTGGGTTTTGCATTTTTTAGCACTG
AAAATTCCGTCGGAGTTTGA

Downstream 100 bases:

>100_bases
ATCATGGCCTGAAGCTCTTCCCAAGAGATGATCTTCACACCCAAGCCCTGGGCTTTTTCCACTTTAGAGCCCGGATCATC
ACCCACCACCAGATAATTCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIKKALPVLLVLGAVISYLLWPRSSENSEVPHPTSTIEKQEPQDAQTPSDSEPGAVFSAFEIKTVQTVSESVPFEEPSSP
HDEPAAKSEVTYVVEDGVAVVNEDIVIGVPRSAKARGSVVLESVQLWEGGVVPFHIQGDVPNKSEIIQAIAEFVETPIKF
VPYTNQEDVLVFEAGAGCKSYLGKVGGKQPLWISGGCGVTEITHEIMHALGFIHEQNRTDRDRFVEVVWDNIHEKYKHNF
ELFPASLMVLSGAAAFDFESVMLYQPTAFSKNGEVTIRSKTESLLAPSAALSAGDIQRLVHVYGRN

Sequences:

>Translated_306_residues
MIKKALPVLLVLGAVISYLLWPRSSENSEVPHPTSTIEKQEPQDAQTPSDSEPGAVFSAFEIKTVQTVSESVPFEEPSSP
HDEPAAKSEVTYVVEDGVAVVNEDIVIGVPRSAKARGSVVLESVQLWEGGVVPFHIQGDVPNKSEIIQAIAEFVETPIKF
VPYTNQEDVLVFEAGAGCKSYLGKVGGKQPLWISGGCGVTEITHEIMHALGFIHEQNRTDRDRFVEVVWDNIHEKYKHNF
ELFPASLMVLSGAAAFDFESVMLYQPTAFSKNGEVTIRSKTESLLAPSAALSAGDIQRLVHVYGRN
>Mature_306_residues
MIKKALPVLLVLGAVISYLLWPRSSENSEVPHPTSTIEKQEPQDAQTPSDSEPGAVFSAFEIKTVQTVSESVPFEEPSSP
HDEPAAKSEVTYVVEDGVAVVNEDIVIGVPRSAKARGSVVLESVQLWEGGVVPFHIQGDVPNKSEIIQAIAEFVETPIKF
VPYTNQEDVLVFEAGAGCKSYLGKVGGKQPLWISGGCGVTEITHEIMHALGFIHEQNRTDRDRFVEVVWDNIHEKYKHNF
ELFPASLMVLSGAAAFDFESVMLYQPTAFSKNGEVTIRSKTESLLAPSAALSAGDIQRLVHVYGRN

Specific function: Zinc metallendopeptidase that cleaves preferentially on amino-terminal side of aspartate-containing substrates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ricin B-type lectin domain [H]

Homologues:

Organism=Homo sapiens, GI153070262, Length=167, Percent_Identity=38.3233532934132, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI157502169, Length=185, Percent_Identity=37.8378378378378, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI153070264, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI22547221, Length=210, Percent_Identity=30, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI6912724, Length=204, Percent_Identity=30.3921568627451, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4502421, Length=192, Percent_Identity=32.2916666666667, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5453579, Length=192, Percent_Identity=32.2916666666667, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115532764, Length=191, Percent_Identity=36.6492146596859, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71986189, Length=226, Percent_Identity=33.1858407079646, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71989620, Length=206, Percent_Identity=34.4660194174757, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71981168, Length=215, Percent_Identity=30.6976744186047, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71995692, Length=195, Percent_Identity=32.8205128205128, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71981193, Length=214, Percent_Identity=33.1775700934579, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71986142, Length=214, Percent_Identity=26.6355140186916, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71983097, Length=196, Percent_Identity=33.1632653061224, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25149641, Length=200, Percent_Identity=30.5, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17568533, Length=185, Percent_Identity=34.0540540540541, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71996833, Length=203, Percent_Identity=31.5270935960591, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71983640, Length=196, Percent_Identity=29.5918367346939, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17562122, Length=191, Percent_Identity=29.8429319371728, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71983649, Length=196, Percent_Identity=29.5918367346939, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193210526, Length=131, Percent_Identity=37.4045801526718, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71993705, Length=157, Percent_Identity=36.9426751592357, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17509235, Length=186, Percent_Identity=27.4193548387097, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71996558, Length=110, Percent_Identity=35.4545454545455, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534131, Length=175, Percent_Identity=30.2857142857143, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71996566, Length=110, Percent_Identity=35.4545454545455, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI72000269, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25150905, Length=143, Percent_Identity=36.3636363636364, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71989946, Length=148, Percent_Identity=33.7837837837838, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71989942, Length=148, Percent_Identity=33.7837837837838, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25152806, Length=207, Percent_Identity=29.4685990338164, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86562912, Length=168, Percent_Identity=29.7619047619048, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71991562, Length=167, Percent_Identity=28.7425149700599, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532766, Length=100, Percent_Identity=37, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212645453, Length=153, Percent_Identity=37.2549019607843, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24649626, Length=286, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355491, Length=187, Percent_Identity=35.8288770053476, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24644493, Length=166, Percent_Identity=39.7590361445783, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921388, Length=242, Percent_Identity=30.9917355371901, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643089, Length=193, Percent_Identity=33.160621761658, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20129545, Length=191, Percent_Identity=32.9842931937173, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921382, Length=202, Percent_Identity=30.1980198019802, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921390, Length=198, Percent_Identity=30.8080808080808, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921384, Length=209, Percent_Identity=31.1004784688995, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921386, Length=192, Percent_Identity=31.25, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136740, Length=211, Percent_Identity=28.436018957346, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24649765, Length=211, Percent_Identity=28.436018957346, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549230, Length=199, Percent_Identity=30.6532663316583, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001506
- InterPro:   IPR006026
- InterPro:   IPR008997
- InterPro:   IPR000772 [H]

Pfam domain/function: PF01400 Astacin; PF00652 Ricin_B_lectin [H]

EC number: =3.4.24.76 [H]

Molecular weight: Translated: 33431; Mature: 33431

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKALPVLLVLGAVISYLLWPRSSENSEVPHPTSTIEKQEPQDAQTPSDSEPGAVFSAF
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
EIKTVQTVSESVPFEEPSSPHDEPAAKSEVTYVVEDGVAVVNEDIVIGVPRSAKARGSVV
EHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCEEEECCCCCCCCCHHH
LESVQLWEGGVVPFHIQGDVPNKSEIIQAIAEFVETPIKFVPYTNQEDVLVFEAGAGCKS
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCHHH
YLGKVGGKQPLWISGGCGVTEITHEIMHALGFIHEQNRTDRDRFVEVVWDNIHEKYKHNF
HHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
ELFPASLMVLSGAAAFDFESVMLYQPTAFSKNGEVTIRSKTESLLAPSAALSAGDIQRLV
EECHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEECCHHHHCCHHHCCHHHHHHHH
HVYGRN
HHHCCC
>Mature Secondary Structure
MIKKALPVLLVLGAVISYLLWPRSSENSEVPHPTSTIEKQEPQDAQTPSDSEPGAVFSAF
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
EIKTVQTVSESVPFEEPSSPHDEPAAKSEVTYVVEDGVAVVNEDIVIGVPRSAKARGSVV
EHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCEEEECCCCCCCCCHHH
LESVQLWEGGVVPFHIQGDVPNKSEIIQAIAEFVETPIKFVPYTNQEDVLVFEAGAGCKS
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCHHH
YLGKVGGKQPLWISGGCGVTEITHEIMHALGFIHEQNRTDRDRFVEVVWDNIHEKYKHNF
HHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
ELFPASLMVLSGAAAFDFESVMLYQPTAFSKNGEVTIRSKTESLLAPSAALSAGDIQRLV
EECHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEECCHHHHCCHHHCCHHHHHHHH
HVYGRN
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7771796; 7768917 [H]