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The map label for this gene is 42521677

Identifier: 42521677

GI number: 42521677

Start: 25900

End: 27543

Strand: Direct

Name: 42521677

Synonym: Bd0029

Alternate gene names: NA

Gene position: 25900-27543 (Clockwise)

Preceding gene: 42521676

Following gene: 42521680

Centisome position: 0.68

GC content: 49.76

Gene sequence:

>1644_bases
ATGAAAGGGCTTATCGGAAGAGCCTCCAAGGCAGCCATCTTCGGTTTGCTGATCACAGGATTGAACGCGTTTGCAGCAAC
GCCGGAATCCGTACCTGGTGAATTCATCGTAAAATTCAAGGACGAAGCCGTCGCAGTTTCTTCCATGAAAGAGCTGAGCC
AGGATCTGGGTTCTTACATTAAAGATGTAATCCCTGGTCAAAACATCGTCGTGATCAAACGCCCGGTGTTTGAAATCCAA
TCCAACGTGATGAAATCCCTGGCGATGAATCCCAACGTGGACATCGTTGAGCCGAACTTCATCTATAGAATCAATAAAAC
TCCCAACGATCCAATGCTGGGTCAATTGTGGGGCATGATCAACACTGGTCAGGCTGATTCCCAAAAACGTGAGGGCATTG
CCGGCATCGACATTGGTGCGGAACAAGCTTGGGATATCACGACGGGTTCCAAAGATGTTGTTGTTGCCGTAATCGACACG
GGTATCAACTACAACCATCCGGATCTGAAATCCAATCTTTGGACGAACGATGCAGAACTAAATGGTAAAGCGGGTGTTGA
TGACGACGGCAACGGCATCATCGATGACATTTACGGTGCAAACTTTGTAACAGCGGCGAAACCAACCGGCAATCCATTGG
ATGATCACGGTCACGGTTCTCACTGCTCTGGTACCATCGGTGCTTCCGGTGACGATGGCAAAGGTCTTGTGGGCGTGGCT
TGGAATGTTCGCATCATGGGTGTGAAATTCCTTTCTGCGAGCGGTTCCGGTTCTTTGGACGGCGCTTTGAAAGCCATTGA
TTACGCAACTTCCAAGGGTGCAAAAATCCTTTCCAACTCCTGGGGTGGCGGTGGTTACTCTGAGACTTTGAAACAAGCGA
TCGAAAGATCCAACGCTGCAGGTACTTTGTTTGTGGCGGCTGCGGGGAATGAATCCAACAACAACGATTCCAACCCGACT
TACCCTGCAACTTACGATGTGCCAAACGTGTTGTCTGTCGCAGCTATCGACAACCGCGGTCAGATCGCCTCCTTCTCGAA
CTATGGTAAAACCAAAGTTCACGTGGGCGCTCCGGGTGTGAACATCGTTTCCTCCATCACAGGTGCGGGTTACGATTCCT
GGTCTGGTACTTCCATGGCGACACCTCACGTGTCTGGTATGGCCGTTCTTCTGGCAACAGCAGAGCCGAATCTGACAGGT
ATCGAGATGAAAGAAAGAATTATCGCGACTTCCAAGCCTCTGGCGGGTCTTCGTGGTAAATCCAAAGGTGGTTTGGCAAA
TGCTTACACCATGCTGACAAACACCCTGCCACAGCCGGATCCAAACGATCCCGTAAACTGGCAGACTGTGGATGTGGCTC
ACTCCACTCCGCACCCTTACACCAACAAATCCAACCTGGTGTATGAAGTTTCTGTACCGGGCGCAAAGCAGATCTCTGTC
TATTTCTCCAAGTTCGACACTGAGAGAGACTATGACAAAGTGGAGCTTTACGATGCCAATGGCAAACTTGTCGGCACCAT
GAGCGGCAAGAACGATGAAACATTCTCTCCGGTGATTGATGGTGAGTATGTGAAGATCGTCTTCACTTCCGATGATTCAG
TTAACAGATACGGTTTCGATATCACTAAAGCGGCGTGGAGATAA

Upstream 100 bases:

>100_bases
AGCCCCCTTTCACATTGGTACCATTTTGGAACTAGGAAACGTCTGGGAAAATTTTTCCCCTTCGCTTTCTGGAAAATCAC
CCAATGAAGGAGAGGATCAT

Downstream 100 bases:

>100_bases
TAAGCCCCACTGGTGATTGAAAAAGCAAAAGCCACTCTGGAAATGAGTGGCTTTTTTATTTTCTAAGATTCAGATCTTAT
TTTCTTTCACATCCAGCAGG

Product: subtilase

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MKGLIGRASKAAIFGLLITGLNAFAATPESVPGEFIVKFKDEAVAVSSMKELSQDLGSYIKDVIPGQNIVVIKRPVFEIQ
SNVMKSLAMNPNVDIVEPNFIYRINKTPNDPMLGQLWGMINTGQADSQKREGIAGIDIGAEQAWDITTGSKDVVVAVIDT
GINYNHPDLKSNLWTNDAELNGKAGVDDDGNGIIDDIYGANFVTAAKPTGNPLDDHGHGSHCSGTIGASGDDGKGLVGVA
WNVRIMGVKFLSASGSGSLDGALKAIDYATSKGAKILSNSWGGGGYSETLKQAIERSNAAGTLFVAAAGNESNNNDSNPT
YPATYDVPNVLSVAAIDNRGQIASFSNYGKTKVHVGAPGVNIVSSITGAGYDSWSGTSMATPHVSGMAVLLATAEPNLTG
IEMKERIIATSKPLAGLRGKSKGGLANAYTMLTNTLPQPDPNDPVNWQTVDVAHSTPHPYTNKSNLVYEVSVPGAKQISV
YFSKFDTERDYDKVELYDANGKLVGTMSGKNDETFSPVIDGEYVKIVFTSDDSVNRYGFDITKAAWR

Sequences:

>Translated_547_residues
MKGLIGRASKAAIFGLLITGLNAFAATPESVPGEFIVKFKDEAVAVSSMKELSQDLGSYIKDVIPGQNIVVIKRPVFEIQ
SNVMKSLAMNPNVDIVEPNFIYRINKTPNDPMLGQLWGMINTGQADSQKREGIAGIDIGAEQAWDITTGSKDVVVAVIDT
GINYNHPDLKSNLWTNDAELNGKAGVDDDGNGIIDDIYGANFVTAAKPTGNPLDDHGHGSHCSGTIGASGDDGKGLVGVA
WNVRIMGVKFLSASGSGSLDGALKAIDYATSKGAKILSNSWGGGGYSETLKQAIERSNAAGTLFVAAAGNESNNNDSNPT
YPATYDVPNVLSVAAIDNRGQIASFSNYGKTKVHVGAPGVNIVSSITGAGYDSWSGTSMATPHVSGMAVLLATAEPNLTG
IEMKERIIATSKPLAGLRGKSKGGLANAYTMLTNTLPQPDPNDPVNWQTVDVAHSTPHPYTNKSNLVYEVSVPGAKQISV
YFSKFDTERDYDKVELYDANGKLVGTMSGKNDETFSPVIDGEYVKIVFTSDDSVNRYGFDITKAAWR
>Mature_547_residues
MKGLIGRASKAAIFGLLITGLNAFAATPESVPGEFIVKFKDEAVAVSSMKELSQDLGSYIKDVIPGQNIVVIKRPVFEIQ
SNVMKSLAMNPNVDIVEPNFIYRINKTPNDPMLGQLWGMINTGQADSQKREGIAGIDIGAEQAWDITTGSKDVVVAVIDT
GINYNHPDLKSNLWTNDAELNGKAGVDDDGNGIIDDIYGANFVTAAKPTGNPLDDHGHGSHCSGTIGASGDDGKGLVGVA
WNVRIMGVKFLSASGSGSLDGALKAIDYATSKGAKILSNSWGGGGYSETLKQAIERSNAAGTLFVAAAGNESNNNDSNPT
YPATYDVPNVLSVAAIDNRGQIASFSNYGKTKVHVGAPGVNIVSSITGAGYDSWSGTSMATPHVSGMAVLLATAEPNLTG
IEMKERIIATSKPLAGLRGKSKGGLANAYTMLTNTLPQPDPNDPVNWQTVDVAHSTPHPYTNKSNLVYEVSVPGAKQISV
YFSKFDTERDYDKVELYDANGKLVGTMSGKNDETFSPVIDGEYVKIVFTSDDSVNRYGFDITKAAWR

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI76443679, Length=350, Percent_Identity=27.1428571428571, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI20336244, Length=342, Percent_Identity=27.4853801169591, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI20336190, Length=359, Percent_Identity=24.2339832869081, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI27894285, Length=359, Percent_Identity=24.2339832869081, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI20336188, Length=359, Percent_Identity=24.2339832869081, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI20336180, Length=359, Percent_Identity=24.2339832869081, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4505577, Length=359, Percent_Identity=24.2339832869081, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI20336186, Length=359, Percent_Identity=24.2339832869081, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4505579, Length=351, Percent_Identity=25.0712250712251, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI20336182, Length=359, Percent_Identity=24.2339832869081, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI20336184, Length=359, Percent_Identity=24.2339832869081, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI295424143, Length=371, Percent_Identity=25.0673854447439, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI20336242, Length=371, Percent_Identity=25.0673854447439, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI299523015, Length=383, Percent_Identity=23.4986945169713, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI20336246, Length=386, Percent_Identity=23.5751295336788, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI31317307, Length=274, Percent_Identity=29.9270072992701, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71987206, Length=375, Percent_Identity=26.1333333333333, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71983555, Length=506, Percent_Identity=24.703557312253, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25141268, Length=415, Percent_Identity=23.855421686747, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320775, Length=357, Percent_Identity=30.5322128851541, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324576, Length=328, Percent_Identity=28.3536585365854, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319893, Length=268, Percent_Identity=30.2238805970149, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324091, Length=308, Percent_Identity=27.9220779220779, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136192, Length=332, Percent_Identity=27.4096385542169, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281360987, Length=331, Percent_Identity=25.3776435045317, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642494, Length=331, Percent_Identity=25.3776435045317, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642490, Length=331, Percent_Identity=25.3776435045317, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45555723, Length=331, Percent_Identity=25.3776435045317, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642492, Length=331, Percent_Identity=25.3776435045317, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642488, Length=333, Percent_Identity=25.2252252252252, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642484, Length=333, Percent_Identity=25.2252252252252, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642486, Length=333, Percent_Identity=25.2252252252252, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650056, Length=324, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45553515, Length=324, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17864552, Length=324, Percent_Identity=24.0740740740741, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 57873; Mature: 57873

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS01180 CUB ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLIGRASKAAIFGLLITGLNAFAATPESVPGEFIVKFKDEAVAVSSMKELSQDLGSYI
CCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
KDVIPGQNIVVIKRPVFEIQSNVMKSLAMNPNVDIVEPNFIYRINKTPNDPMLGQLWGMI
HHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCCCCHHHHHHCCC
NTGQADSQKREGIAGIDIGAEQAWDITTGSKDVVVAVIDTGINYNHPDLKSNLWTNDAEL
CCCCCCCHHHCCCEEEECCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
NGKAGVDDDGNGIIDDIYGANFVTAAKPTGNPLDDHGHGSHCSGTIGASGDDGKGLVGVA
CCCCCCCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
WNVRIMGVKFLSASGSGSLDGALKAIDYATSKGAKILSNSWGGGGYSETLKQAIERSNAA
EEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCC
GTLFVAAAGNESNNNDSNPTYPATYDVPNVLSVAAIDNRGQIASFSNYGKTKVHVGAPGV
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCEEEEECCCCC
NIVSSITGAGYDSWSGTSMATPHVSGMAVLLATAEPNLTGIEMKERIIATSKPLAGLRGK
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCC
SKGGLANAYTMLTNTLPQPDPNDPVNWQTVDVAHSTPHPYTNKSNLVYEVSVPGAKQISV
CCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEE
YFSKFDTERDYDKVELYDANGKLVGTMSGKNDETFSPVIDGEYVKIVFTSDDSVNRYGFD
EEECCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEECCCEEEEEEECCCCCCCCCCC
ITKAAWR
HHHHHCC
>Mature Secondary Structure
MKGLIGRASKAAIFGLLITGLNAFAATPESVPGEFIVKFKDEAVAVSSMKELSQDLGSYI
CCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
KDVIPGQNIVVIKRPVFEIQSNVMKSLAMNPNVDIVEPNFIYRINKTPNDPMLGQLWGMI
HHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCCCCHHHHHHCCC
NTGQADSQKREGIAGIDIGAEQAWDITTGSKDVVVAVIDTGINYNHPDLKSNLWTNDAEL
CCCCCCCHHHCCCEEEECCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
NGKAGVDDDGNGIIDDIYGANFVTAAKPTGNPLDDHGHGSHCSGTIGASGDDGKGLVGVA
CCCCCCCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
WNVRIMGVKFLSASGSGSLDGALKAIDYATSKGAKILSNSWGGGGYSETLKQAIERSNAA
EEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCC
GTLFVAAAGNESNNNDSNPTYPATYDVPNVLSVAAIDNRGQIASFSNYGKTKVHVGAPGV
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCEEEEECCCCC
NIVSSITGAGYDSWSGTSMATPHVSGMAVLLATAEPNLTGIEMKERIIATSKPLAGLRGK
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCC
SKGGLANAYTMLTNTLPQPDPNDPVNWQTVDVAHSTPHPYTNKSNLVYEVSVPGAKQISV
CCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEE
YFSKFDTERDYDKVELYDANGKLVGTMSGKNDETFSPVIDGEYVKIVFTSDDSVNRYGFD
EEECCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEECCCEEEEEEECCCCCCCCCCC
ITKAAWR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]