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The map label for this gene is adhA [H]

Identifier: 38637893

GI number: 38637893

Start: 245601

End: 246626

Strand: Direct

Name: adhA [H]

Synonym: PHG229

Alternate gene names: 38637893

Gene position: 245601-246626 (Clockwise)

Preceding gene: 38637892

Following gene: 38637894

Centisome position: 54.32

GC content: 68.03

Gene sequence:

>1026_bases
ATGGCCCAGACCATGCGAGCCATGATCTTCGAGGGCGCAGGACTGCCGCTGCGCCTGCAGGACGTGCCGGTTCCCGACCC
GGGGCCCGGCGAGGTGTGCATCGCCGCGGCTGCATGCGAGGTGTGCCACACCGACCTGCATATCGCCGACGGCGACCTCT
CCCACCCCAAGCCGGCGCTGATCCCGGGGCATGAAGCCGTCGGCCAGGTCGAATCGTGCGGCACCGGTGTCACGGCATTC
TCGCCCGGCGAGCGCGTAGGCGTGCCGTGGCTGGGAAATACCTGCGGTGATTGCCGCTACTGCATGCATCTTCACGGGAA
CCTCTGCGATGCGCCGCAGCTCACCGGATACACGCGCGATGGCGGCTACGCGGAATACGTGGTCGCCGACAGCAGCTACT
ACTTCAGGATTCCGCCCGCCTACGACGACGAACATGCTGAGCCGCTGCTCTGCGCCGGCCTGATCGACTACCGGACGTTG
CGAATGGCGGGCGAGGCCCAGCGCATCGGCATCTACGGCTTCGGCGCCGCGGCCCACCTAGTGACACAAATTGCCGCCGC
ACAAGGCCGTGAGGTCTATGGCTTCACTCGCGCGGGCGACACCGGCGCCCAGCAACTGGCCTACGAGACCGGCGCGTGCT
GGGCCGGCTCCAGCGACCTCCAGTCGCCCGTGGCGCTGGATGCGGCGCTTATCTTCGCCCCGGTGGGTGCGCTGGTTCCC
TGCGCGCTGCGCGCCGTGGACAAGGGGGAGCGCTGTCGTCTGCGCCGGCATCCACATGAGCGACATCCCGCGCATGCCCT
ACCAGCTGCTATGGGAAGAGCGTCGCCTGTGTTCGGTCGCCAACCTCACGCGCGCCGACGGAATTGCGTTGATGCAGATC
GCCGTCCGGACGCCGCTGCAGACGCACACGACCGCCTACCCGCTCGAGCAGGCCAATGCGGCACTGGCCGATCTGCGCGA
GGGGCGTCTGTCCGGTGCCGCCGTCCTGAGAATCCGTCACTAAGGCTTCGGCAGATATCCCCATGA

Upstream 100 bases:

>100_bases
GTCCGAAGGCGTGATCGCCAGGACCAGCAAGCCGGTGCTGCTGGTTCGCAGCGAAACCGAAGGCTAGCGTGGCGCCCGCA
CAATGACGGAGCATCGCGCT

Downstream 100 bases:

>100_bases
GCCGTTACCAGACACGTTTCCAGACGCGGGAGCAGGCCGGCACGGAGCTGGCGTTGGCATTGCGTCCGTACCAGGGGACC
GGCGCCCTGGTCCTGGCGAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MAQTMRAMIFEGAGLPLRLQDVPVPDPGPGEVCIAAAACEVCHTDLHIADGDLSHPKPALIPGHEAVGQVESCGTGVTAF
SPGERVGVPWLGNTCGDCRYCMHLHGNLCDAPQLTGYTRDGGYAEYVVADSSYYFRIPPAYDDEHAEPLLCAGLIDYRTL
RMAGEAQRIGIYGFGAAAHLVTQIAAAQGREVYGFTRAGDTGAQQLAYETGACWAGSSDLQSPVALDAALIFAPVGALVP
CALRAVDKGERCRLRRHPHERHPAHALPAAMGRASPVFGRQPHARRRNCVDADRRPDAAADAHDRLPARAGQCGTGRSAR
GASVRCRRPENPSLRLRQISP

Sequences:

>Translated_341_residues
MAQTMRAMIFEGAGLPLRLQDVPVPDPGPGEVCIAAAACEVCHTDLHIADGDLSHPKPALIPGHEAVGQVESCGTGVTAF
SPGERVGVPWLGNTCGDCRYCMHLHGNLCDAPQLTGYTRDGGYAEYVVADSSYYFRIPPAYDDEHAEPLLCAGLIDYRTL
RMAGEAQRIGIYGFGAAAHLVTQIAAAQGREVYGFTRAGDTGAQQLAYETGACWAGSSDLQSPVALDAALIFAPVGALVP
CALRAVDKGERCRLRRHPHERHPAHALPAAMGRASPVFGRQPHARRRNCVDADRRPDAAADAHDRLPARAGQCGTGRSAR
GASVRCRRPENPSLRLRQISP
>Mature_340_residues
AQTMRAMIFEGAGLPLRLQDVPVPDPGPGEVCIAAAACEVCHTDLHIADGDLSHPKPALIPGHEAVGQVESCGTGVTAFS
PGERVGVPWLGNTCGDCRYCMHLHGNLCDAPQLTGYTRDGGYAEYVVADSSYYFRIPPAYDDEHAEPLLCAGLIDYRTLR
MAGEAQRIGIYGFGAAAHLVTQIAAAQGREVYGFTRAGDTGAQQLAYETGACWAGSSDLQSPVALDAALIFAPVGALVPC
ALRAVDKGERCRLRRHPHERHPAHALPAAMGRASPVFGRQPHARRRNCVDADRRPDAAADAHDRLPARAGQCGTGRSARG
ASVRCRRPENPSLRLRQISP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=104, Percent_Identity=40.3846153846154, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4501933, Length=94, Percent_Identity=40.4255319148936, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI262073058, Length=145, Percent_Identity=31.0344827586207, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71743840, Length=145, Percent_Identity=31.0344827586207, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4501929, Length=109, Percent_Identity=38.5321100917431, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI71565152, Length=104, Percent_Identity=39.4230769230769, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI71565154, Length=110, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=145, Percent_Identity=37.2413793103448, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786518, Length=198, Percent_Identity=34.8484848484849, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082401, Length=142, Percent_Identity=31.6901408450704, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790045, Length=136, Percent_Identity=35.2941176470588, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787863, Length=228, Percent_Identity=28.5087719298246, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786825, Length=169, Percent_Identity=28.9940828402367, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788407, Length=208, Percent_Identity=28.8461538461538, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=194, Percent_Identity=30.9278350515464, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=159, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=167, Percent_Identity=32.3353293413174, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=212, Percent_Identity=29.2452830188679, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=214, Percent_Identity=28.9719626168224, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=213, Percent_Identity=35.6807511737089, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323729, Length=197, Percent_Identity=34.5177664974619, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=215, Percent_Identity=34.8837209302326, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=199, Percent_Identity=36.1809045226131, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319949, Length=185, Percent_Identity=32.972972972973, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=186, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36344; Mature: 36213

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTMRAMIFEGAGLPLRLQDVPVPDPGPGEVCIAAAACEVCHTDLHIADGDLSHPKPAL
CCHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHCCCEEECCCCCCCCCCC
IPGHEAVGQVESCGTGVTAFSPGERVGVPWLGNTCGDCRYCMHLHGNLCDAPQLTGYTRD
CCCHHHHCCHHHCCCCCEECCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEECC
GGYAEYVVADSSYYFRIPPAYDDEHAEPLLCAGLIDYRTLRMAGEAQRIGIYGFGAAAHL
CCEEEEEEECCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCHHHHH
VTQIAAAQGREVYGFTRAGDTGAQQLAYETGACWAGSSDLQSPVALDAALIFAPVGALVP
HHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
CALRAVDKGERCRLRRHPHERHPAHALPAAMGRASPVFGRQPHARRRNCVDADRRPDAAA
HHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
DAHDRLPARAGQCGTGRSARGASVRCRRPENPSLRLRQISP
CHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCC
>Mature Secondary Structure 
AQTMRAMIFEGAGLPLRLQDVPVPDPGPGEVCIAAAACEVCHTDLHIADGDLSHPKPAL
CHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHCCCEEECCCCCCCCCCC
IPGHEAVGQVESCGTGVTAFSPGERVGVPWLGNTCGDCRYCMHLHGNLCDAPQLTGYTRD
CCCHHHHCCHHHCCCCCEECCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEECC
GGYAEYVVADSSYYFRIPPAYDDEHAEPLLCAGLIDYRTLRMAGEAQRIGIYGFGAAAHL
CCEEEEEEECCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCHHHHH
VTQIAAAQGREVYGFTRAGDTGAQQLAYETGACWAGSSDLQSPVALDAALIFAPVGALVP
HHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
CALRAVDKGERCRLRRHPHERHPAHALPAAMGRASPVFGRQPHARRRNCVDADRRPDAAA
HHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
DAHDRLPARAGQCGTGRSARGASVRCRRPENPSLRLRQISP
CHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]