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The map label for this gene is ccmE

Identifier: 38637881

GI number: 38637881

Start: 234091

End: 234558

Strand: Direct

Name: ccmE

Synonym: PHG217

Alternate gene names: 38637881

Gene position: 234091-234558 (Clockwise)

Preceding gene: 38637880

Following gene: 38637882

Centisome position: 51.77

GC content: 69.66

Gene sequence:

>468_bases
ATGACACCACGCAGGCGCCGCCTGGGTCTGTTGCTCGCCGCGCTGATCTGCGTCGGCATCGCCACGACGCTGGTGCTCAA
TGCGTTCCGCTCCAACCTGGTGTTCTTCTTCAGCCCAAGCCAGGTCGCGGCGCACGAGGCGCCGGTGGCGCGCAGCTTCC
GCCTGGGCGGGCTGGTGGCGCCCGGGTCGATCCGGCGCGAGGGCGACGGCATGACCATCCGCTTCATCGTCACCGATACC
GCGCGGCAGGTGCTGGTGGTCTATCGCGGCCTGCTGCCCGACCTGTTCCGCGAGGGCAAAGGCGTGGTGGCGCGCGGCAA
GCTGGAAGCGGACGGCACTTTCGTCGCCAGCGAGGTGCTGGCCAAGCATGATGAGAACTACATGCCGCCCGAGGCCGCCG
ACGCGCTGAAGCAGGCCGAGCAGGTCAACCGCCGCATGGCCGGGACCCCGCAAGGAGCGCGGCAATGA

Upstream 100 bases:

>100_bases
CAGCATATATCGTGGGCGCCTTCGGCATGGCTTTCGCCCTGCTCGCCATCGAACTGTTCTTGCTTGCGCGGCGCGCCCGT
GCCGGCGCAGGTCCTCGCCG

Downstream 100 bases:

>100_bases
ATGCCGAACTCGGCCATTTCGCGCTGATCGTGGCCCTGCTGGTCGCGATAGTGCAGGCCGCATTGCCGCTGGCCGGCGCC
GCGCACGGCAACATCGCGTG

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MTPRRRRLGLLLAALICVGIATTLVLNAFRSNLVFFFSPSQVAAHEAPVARSFRLGGLVAPGSIRREGDGMTIRFIVTDT
ARQVLVVYRGLLPDLFREGKGVVARGKLEADGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMAGTPQGARQ

Sequences:

>Translated_155_residues
MTPRRRRLGLLLAALICVGIATTLVLNAFRSNLVFFFSPSQVAAHEAPVARSFRLGGLVAPGSIRREGDGMTIRFIVTDT
ARQVLVVYRGLLPDLFREGKGVVARGKLEADGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMAGTPQGARQ
>Mature_154_residues
TPRRRRLGLLLAALICVGIATTLVLNAFRSNLVFFFSPSQVAAHEAPVARSFRLGGLVAPGSIRREGDGMTIRFIVTDTA
RQVLVVYRGLLPDLFREGKGVVARGKLEADGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMAGTPQGARQ

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=140, Percent_Identity=42.1428571428571, Blast_Score=120, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_CUPNH (Q7WXB8)

Other databases:

- EMBL:   AY305378
- RefSeq:   NP_942855.1
- ProteinModelPortal:   Q7WXB8
- SMR:   Q7WXB8
- GeneID:   2656659
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG217
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q7WXB8
- ProtClustDB:   PRK13254
- BioCyc:   REUT381666:PHG217-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 16846; Mature: 16715

Theoretical pI: Translated: 11.07; Mature: 11.07

Prosite motif: NA

Important sites: BINDING 123-123

Signals:

None

Transmembrane regions:

HASH(0xaef3bd8)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRRRRLGLLLAALICVGIATTLVLNAFRSNLVFFFSPSQVAAHEAPVARSFRLGGLVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCCHHHHHCCCCEEC
PGSIRREGDGMTIRFIVTDTARQVLVVYRGLLPDLFREGKGVVARGKLEADGTFVASEVL
CCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
AKHDENYMPPEAADALKQAEQVNRRMAGTPQGARQ
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure 
TPRRRRLGLLLAALICVGIATTLVLNAFRSNLVFFFSPSQVAAHEAPVARSFRLGGLVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCCHHHHHCCCCEEC
PGSIRREGDGMTIRFIVTDTARQVLVVYRGLLPDLFREGKGVVARGKLEADGTFVASEVL
CCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
AKHDENYMPPEAADALKQAEQVNRRMAGTPQGARQ
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12948488