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The map label for this gene is ycdW [C]

Identifier: 37681332

GI number: 37681332

Start: 3231691

End: 3232617

Strand: Direct

Name: ycdW [C]

Synonym: VV3148

Alternate gene names: 37681332

Gene position: 3231691-3232617 (Clockwise)

Preceding gene: 37681330

Following gene: 37681333

Centisome position: 96.34

GC content: 50.27

Gene sequence:

>927_bases
ATGCATCAGTCAAAACACAAGATTTTCATTGTTACCGAAGACAACGAGACCTATCGCCAACTGCTTGCTGATCACGCGTT
ACCCGATTTAGCACTCACTGAGAACATCGAGCAAGCCAATATCATCCTCGCGGCGCCACCTCACATTGCCCCACGCTTGT
CTGAGTGCCATCAGCTCGAATGGCTACAATCGACTTACGCTGGCGTGAACGCGCTCATGCAACCTGAGTTACGACGAGAT
TACAAGCTAACCAATGTCCGTGGGATTTTTGGCCCCTTGATTGCGGAATACGTCATCGGCTACACCATTCAACACTATCG
CCACTTGGCCCGCTATGCGGAGCAGCAACAGCAACGTCTCTGGCAACCGCATCCCTACTCTTCCCTAGAGGGCAAAACGA
TCACCATCTTAGGCACTGGGAGCATAGGTAATCATCTTGCGCATGCCTGCTCGGCGATGGGGTTACACACCATTGGCGTC
AATCGCACAGGCATTCCGCCAAACGGTAGCCATTTTCAGCAAACCTATCACATCAATGAGCTGGCAGCGGCCTTGAAGCA
AGCGCACATCGTGGTCAACACTCTGCCTAGCACAGAACACACTCACCACTTGTTGAACCAAGCGAGCCTCAGCCATTGTC
GTCATGCTCTATTATTTAATGTTGGACGTGGGGACGTTATTGACAATGCGGCACTACTTTTGGCGATTAAAAATCACTGG
GTTGAACATGCGTTCTTAGATGTATTTGAACAAGAACCCCTCGTCACGGATCATCCATTTTGGGGGCTCAAACAAATCAC
TATCACGCCGCATATTGCCGCGCTGAGCTTTCCTGAGAAAGTGATGGCGCTGTTTGCAGAAAATTACCATCGTTGGCTTG
AAGGGTACCCGCTCAACCATCAAGTCAGCTTCACCAAAGGGTATTGA

Upstream 100 bases:

>100_bases
TTTCTAAACGGACCTGTAGGGGATTCTGTAGCATAATCACTCAATCATTGCGGAAAAAGACAGCGGAAGTGTACTTGATT
CGCCACAGGGAAAAAAGTTA

Downstream 100 bases:

>100_bases
TGCATGCCACTTGAGCCGCTGTTAACTCAAATCCGGGCTTGCCAAGTGTGTGCCTCCGCCTTGCCGCTAGGTGCTAACCC
TGTGGTTCAAGCTCACTCAG

Product: phosphoglycerate dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: ORF5 [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MHQSKHKIFIVTEDNETYRQLLADHALPDLALTENIEQANIILAAPPHIAPRLSECHQLEWLQSTYAGVNALMQPELRRD
YKLTNVRGIFGPLIAEYVIGYTIQHYRHLARYAEQQQQRLWQPHPYSSLEGKTITILGTGSIGNHLAHACSAMGLHTIGV
NRTGIPPNGSHFQQTYHINELAAALKQAHIVVNTLPSTEHTHHLLNQASLSHCRHALLFNVGRGDVIDNAALLLAIKNHW
VEHAFLDVFEQEPLVTDHPFWGLKQITITPHIAALSFPEKVMALFAENYHRWLEGYPLNHQVSFTKGY

Sequences:

>Translated_308_residues
MHQSKHKIFIVTEDNETYRQLLADHALPDLALTENIEQANIILAAPPHIAPRLSECHQLEWLQSTYAGVNALMQPELRRD
YKLTNVRGIFGPLIAEYVIGYTIQHYRHLARYAEQQQQRLWQPHPYSSLEGKTITILGTGSIGNHLAHACSAMGLHTIGV
NRTGIPPNGSHFQQTYHINELAAALKQAHIVVNTLPSTEHTHHLLNQASLSHCRHALLFNVGRGDVIDNAALLLAIKNHW
VEHAFLDVFEQEPLVTDHPFWGLKQITITPHIAALSFPEKVMALFAENYHRWLEGYPLNHQVSFTKGY
>Mature_308_residues
MHQSKHKIFIVTEDNETYRQLLADHALPDLALTENIEQANIILAAPPHIAPRLSECHQLEWLQSTYAGVNALMQPELRRD
YKLTNVRGIFGPLIAEYVIGYTIQHYRHLARYAEQQQQRLWQPHPYSSLEGKTITILGTGSIGNHLAHACSAMGLHTIGV
NRTGIPPNGSHFQQTYHINELAAALKQAHIVVNTLPSTEHTHHLLNQASLSHCRHALLFNVGRGDVIDNAALLLAIKNHW
VEHAFLDVFEQEPLVTDHPFWGLKQITITPHIAALSFPEKVMALFAENYHRWLEGYPLNHQVSFTKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=296, Percent_Identity=24.3243243243243, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI87081824, Length=220, Percent_Identity=31.3636363636364, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082289, Length=188, Percent_Identity=29.2553191489362, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789279, Length=188, Percent_Identity=26.5957446808511, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=216, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=151, Percent_Identity=33.112582781457, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=163, Percent_Identity=30.6748466257669, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322116, Length=196, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=196, Percent_Identity=28.0612244897959, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 34877; Mature: 34877

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQSKHKIFIVTEDNETYRQLLADHALPDLALTENIEQANIILAAPPHIAPRLSECHQLE
CCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHH
WLQSTYAGVNALMQPELRRDYKLTNVRGIFGPLIAEYVIGYTIQHYRHLARYAEQQQQRL
HHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WQPHPYSSLEGKTITILGTGSIGNHLAHACSAMGLHTIGVNRTGIPPNGSHFQQTYHINE
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHH
LAAALKQAHIVVNTLPSTEHTHHLLNQASLSHCRHALLFNVGRGDVIDNAALLLAIKNHW
HHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHEEHHHHHH
VEHAFLDVFEQEPLVTDHPFWGLKQITITPHIAALSFPEKVMALFAENYHRWLEGYPLNH
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
QVSFTKGY
EEEEECCC
>Mature Secondary Structure
MHQSKHKIFIVTEDNETYRQLLADHALPDLALTENIEQANIILAAPPHIAPRLSECHQLE
CCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHH
WLQSTYAGVNALMQPELRRDYKLTNVRGIFGPLIAEYVIGYTIQHYRHLARYAEQQQQRL
HHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WQPHPYSSLEGKTITILGTGSIGNHLAHACSAMGLHTIGVNRTGIPPNGSHFQQTYHINE
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHH
LAAALKQAHIVVNTLPSTEHTHHLLNQASLSHCRHALLFNVGRGDVIDNAALLLAIKNHW
HHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHEEHHHHHH
VEHAFLDVFEQEPLVTDHPFWGLKQITITPHIAALSFPEKVMALFAENYHRWLEGYPLNH
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
QVSFTKGY
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406267 [H]