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The map label for this gene is hutU [H]

Identifier: 37680135

GI number: 37680135

Start: 1939528

End: 1941225

Strand: Direct

Name: hutU [H]

Synonym: VV1951

Alternate gene names: 37680135

Gene position: 1939528-1941225 (Clockwise)

Preceding gene: 37680134

Following gene: 37680136

Centisome position: 57.82

GC content: 53.36

Gene sequence:

>1698_bases
ATGACACAGAGCCAAGGACAAGATCCTCGCCTAGACACCAGCCGAACCATTCGCGCCCCTCATGGCACCACGCTAAGAGC
CAAGTCATGGTTGACCGAAGCGCCATTGCGCATGCTGATGAACAATTTGGATCCTGATGTGGCTGAGCATCCGCACGCCT
TAGTGGTGTATGGCGGCATTGGGCGTGCTGCACGCAATTGGGCATGCTTCGACAAGATTGTTGAAGTGCTTGAGCGCCTG
GAAGACGACCAAACTTTGTTGGTTCAATCAGGTAAACCTGTGGGTGTCTTCCCTACGCATAAAAATGCACCACGCGTGCT
GATCGCCAACTCTAACCTGGTTCCACACTGGGCAAACTGGGAACACTTCAATGAGCTCGATAAACAAGGCTTGATGATGT
ATGGCCAAATGACCGCGGGCAGTTGGATCTACATCGGCTCTCAAGGCATCGTACAGGGTACCTACGAAACCTTCGTCGCT
GTTGCAAAAAAACACTTCGCCGGTGAAGCAAAAGGTCGTTGGGTACTCACTGGTGGTCTTGGTGGCATGGGCGGCGCACA
GCCACTGGCTGCAACCATGGCGGGCTTCTCGATGATTGCCGTTGAATGTGATGAATCGCGTATCGATTATCGCCTACGTA
CGGGTTATGTCGATAAGAAAGCGACCACCCTAGACGAAGCGCTGGCCATCGTCAAAGAATCCGACACGCCTGTCTCTGTT
GGCTTACTGGGTAACGCCGCCGATGTGTTCGCAGAATTGGTGGAGCGCAACATCACGCCCGATATCGTCACCGATCAAAC
CTCGGCACATGACCCGTTGAATGGCTACTTACCGCAAGGCTGGAGTATGGCCTACGCAGCGGAAATGCGTCAGCAAGATG
AAAGCGCTGTCGTCAAAGCCGCAAAACAGTCCATGGCGGTTCAAGTCAAAGCCATGCTTGCACTGCAAACTCGTGGAGCC
GCCACGCTCGATTACGGCAACAACATTCGTCAAATGGCGCTAGAAGAAGGGGTCGAGAATGCATTTGATTTCCCGGGCTT
CGTGCCAGCCTATATTCGACCTTTGTTCTGCGAAGGCATTGGCCCTTTCCGCTGGGCGGCGCTGTCGGGCGATCCTGAGG
ACATTTACAAAACAGACCAAAAAGTGAAAGAGCTGATTCCTGACAATCCTCATTTGCACAATTGGTTGGACATGGCACGC
GAGCGTATTCAATTCCAAGGTTTACCCGCACGCATTTGCTGGGTGGGTCTGAAAGATCGCGAGCGCCTAGGTCAGGCATT
TAATGAAATGGTGAAAAATGGCGAATTAAAAGCGCCGATCGTGATTGGCCGAGATCATCTAGATTCGGGTTCCGTCGCCA
GCCCAAACCGTGAAACGGAAGGCATGATGGACGGTTCAGACGCGGTTTCTGACTGGCCACTGCTCAATGCCCTCCTCAAT
ACCGCCGGTGGTGCGACTTGGGTATCACTCCATCATGGTGGTGGTGTAGGCATGGGTTTCTCACAGCACTCTGGAATGGT
AATTTGCTGTGACGGAACAGAAGATGCGTCCGCACGTATTGCCCGAGTGCTGCATAACGATCCCGCAACGGGGGTAATGC
GCCACGCCGATGCGGGTTACGACATCGCCAAACAGTGCGCAGCGCAACAAGGTCTTGACCTACCGATGCTGAACGAAGAA
TTGAGCAAGTTGAAGTAA

Upstream 100 bases:

>100_bases
TTGCCAACGCCATGAACGACAAACTCGAACATCAATAAACAGAACAACAATCAGGTGAACCGATGAGTTCACCGCTACGT
GAAATTAAAGGAGTCTTACA

Downstream 100 bases:

>100_bases
GGAATATGGATATGTTAAATCTCACGCTAAAGCCCGGTTGTCTTAGCTTAAATCAACTGCGTCAAGTCAGTCGTTCGCCC
ATCAACCTTTCCCTTGATGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MTQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARNWACFDKIVEVLERL
EDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVA
VAKKHFAGEAKGRWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLDEALAIVKESDTPVSV
GLLGNAADVFAELVERNITPDIVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESAVVKAAKQSMAVQVKAMLALQTRGA
ATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMAR
ERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGYDIAKQCAAQQGLDLPMLNEE
LSKLK

Sequences:

>Translated_565_residues
MTQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARNWACFDKIVEVLERL
EDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVA
VAKKHFAGEAKGRWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLDEALAIVKESDTPVSV
GLLGNAADVFAELVERNITPDIVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESAVVKAAKQSMAVQVKAMLALQTRGA
ATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMAR
ERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGYDIAKQCAAQQGLDLPMLNEE
LSKLK
>Mature_564_residues
TQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARNWACFDKIVEVLERLE
DDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAV
AKKHFAGEAKGRWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLDEALAIVKESDTPVSVG
LLGNAADVFAELVERNITPDIVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESAVVKAAKQSMAVQVKAMLALQTRGAA
TLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARE
RIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLNT
AGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGYDIAKQCAAQQGLDLPMLNEEL
SKLK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=548, Percent_Identity=34.4890510948905, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI260306182, Length=196, Percent_Identity=40.8163265306122, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71997891, Length=583, Percent_Identity=34.3053173241852, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61603; Mature: 61471

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCC
GRAARNWACFDKIVEVLERLEDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANW
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCC
EHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAVAKKHFAGEAKGRWVLTGGL
HHHHHHHHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLDEALAIVKESDTPVSV
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
GLLGNAADVFAELVERNITPDIVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESAVVKA
EECCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKQSMAVQVKAMLALQTRGAATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGI
HHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
GPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDR
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCH
ERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGY
CCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHCCCCH
DIAKQCAAQQGLDLPMLNEELSKLK
HHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGI
CCCCCCCCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCC
GRAARNWACFDKIVEVLERLEDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANW
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCC
EHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAVAKKHFAGEAKGRWVLTGGL
HHHHHHHHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLDEALAIVKESDTPVSV
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
GLLGNAADVFAELVERNITPDIVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESAVVKA
EECCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKQSMAVQVKAMLALQTRGAATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGI
HHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
GPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDR
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCH
ERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGY
CCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHCCCCH
DIAKQCAAQQGLDLPMLNEELSKLK
HHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA