Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 37679901

GI number: 37679901

Start: 1772705

End: 1774483

Strand: Direct

Name: moeA [H]

Synonym: VV1717

Alternate gene names: 37679901

Gene position: 1772705-1774483 (Clockwise)

Preceding gene: 37679900

Following gene: 37679902

Centisome position: 52.85

GC content: 49.47

Gene sequence:

>1779_bases
ATGAGAAACACCATCACTTTGCCTTTACTTGGCTTTGCTGCTTATTCAGGAACAGGAAAAACCACCCTACTGGAAGCCTT
GTTGCCCAAATTGACCGCAGCAGGTCTGCGAATTGGTTTACTGAAACACGCTCATCATGATTTTGACGTCGATAAACCAG
GTAAAGACAGCTACCGCTTACGCAAAGCGGGTGCCTCACAAATGCTGATTGCTTCGAGAAATCGTTTTGCCTTGATGACA
GAGACCCCTGAGGCTGAATCGGAATTTGATTACCTGCTTAGCCGCTTTGATCAGCAAACGATTGACGTCATTTTGGTCGA
AGGCTGCAAGAACATTGCGTTTCCCAAAATCGAATTGCATCGTGAAGAAGTCGGAAAACCGTGGTTGTACCCTAATGATG
AGAACATTATCGCCATCGCTTCAGACAGTGGCCCGTTAGAAAGCGCACTGCCCCAACTCAACATCAATGATTTGGATGCG
ATTTGCCAATTTGTCCTAGATTATGTCCACCAACATCAGCAAGTGGCCACGCAAAATGCACCTGCCGCATGTTGCGATAC
GCTTTCTCCGGCGTTTCTTTCTGTTGCCCAAGGGCAAGAGAAAATTCTCTCCCTTGTCTCTACTGTGGGTGATATTGAAT
CGTGTCCGATACAACACGCCTATGGGCGTGTGCTGGCTCACGACGTGATTTCTCCGGTGAATGTACCGCAATACACCAAC
TCAGCGATGGATGGATACGCCATTCGAAGTGATGACTTACAGCGAGAAAGTTACCAGATCGTGGCTGAAGTGCTGGCCGG
TTACCACTACGAACACCCGTTAGAATTGGGGCAAGCGGTCAAAATCATGACCGGTGCGCCAACGCCCATCAACGGAGATA
CGGTGGTCATGCGTGAGCAAGCGCATCAAGACGGTGACAAGGTCACTTTCAATGGTGCCAACATCAAAGCCGGACAAAAC
GTACGCCAAGCGGGTGAAGACTTAACCATCGGCAGTAGCGTGTTTACCGCAGGGACTCGCCTCGCCTCACCTGAAATGGG
CATGATGGCTTCTCTTGGTTTTGCACAAGCCAATGTATTACGTAAGTTGAAAGTGGCAGTCTTCTCCACCGGCGACGAAG
TTCAAGCGCCTGGTACAGAACAGAAAGCGAACTCTATCTACGATTCAAACCGTTTTACCATTATGGGCATGCTTGAGAAG
CTCGGCTGTGACATCTTGGATTTCGGCATTCTAGAAGACAACGAGCAATCGATGATCGACGCACTAGAAAGCGCAGCGCA
GCAAGCGGATGTGGTCATTACTTCGGGTGGCGTGTCCGTTGGCGATGCCGACTACATCAAACTGGCTCTCGACAAGCTCG
GACAAATTGATTTCTGGCGCATCAATATGCGTCCTGGGCGCCCATTAGCATTTGGTCAGATCAATGAAAAACCGTTTTTT
GGCCTGCCGGGCAACCCTGTTGCCGTGATGGTGTCATTCATCAACTTTGTTGAGCCTGCGGTGCGTAAAATGCAAGGCGA
GCTAGGCTGGAAACCATTGAAAGTCAGTGCGATTGCCAAAGAAGATTTGCGTTCTCGCCAAGGCCGCACGGAGTTTAGCC
GTGGTATCTATGAATTGGATGAAACTGGCCGCCTAACCGCTCGTACGACTGGGAAACAAGGCTCTGGCATTTTGCGCTCG
ATGAGTGAAGCGAATTGTTTGATTGAAATTTCTCCCGCGGTGGATAGCGTAAAAACAGGAGAAAGCGTGACAATTATTCC
ACTTCAAGGCAGAATCTAG

Upstream 100 bases:

>100_bases
AAGAGTGTCACACACAGTATGTGGATTTTAGTGATTCTCCAGACTGTTTCGTCAACCTCAACACGCCTGAAGAACTCACC
CAATTTGGACAACTAGAATC

Downstream 100 bases:

>100_bases
CCCTGTTGTTGTTAGAAACAGATACAAGGTCAGCGCGTCTGGCCTTTTATTTTGAGAGATTTCATGATTCGTACCATTAT
TTACACCTATAAGGGTGTTG

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MRNTITLPLLGFAAYSGTGKTTLLEALLPKLTAAGLRIGLLKHAHHDFDVDKPGKDSYRLRKAGASQMLIASRNRFALMT
ETPEAESEFDYLLSRFDQQTIDVILVEGCKNIAFPKIELHREEVGKPWLYPNDENIIAIASDSGPLESALPQLNINDLDA
ICQFVLDYVHQHQQVATQNAPAACCDTLSPAFLSVAQGQEKILSLVSTVGDIESCPIQHAYGRVLAHDVISPVNVPQYTN
SAMDGYAIRSDDLQRESYQIVAEVLAGYHYEHPLELGQAVKIMTGAPTPINGDTVVMREQAHQDGDKVTFNGANIKAGQN
VRQAGEDLTIGSSVFTAGTRLASPEMGMMASLGFAQANVLRKLKVAVFSTGDEVQAPGTEQKANSIYDSNRFTIMGMLEK
LGCDILDFGILEDNEQSMIDALESAAQQADVVITSGGVSVGDADYIKLALDKLGQIDFWRINMRPGRPLAFGQINEKPFF
GLPGNPVAVMVSFINFVEPAVRKMQGELGWKPLKVSAIAKEDLRSRQGRTEFSRGIYELDETGRLTARTTGKQGSGILRS
MSEANCLIEISPAVDSVKTGESVTIIPLQGRI

Sequences:

>Translated_592_residues
MRNTITLPLLGFAAYSGTGKTTLLEALLPKLTAAGLRIGLLKHAHHDFDVDKPGKDSYRLRKAGASQMLIASRNRFALMT
ETPEAESEFDYLLSRFDQQTIDVILVEGCKNIAFPKIELHREEVGKPWLYPNDENIIAIASDSGPLESALPQLNINDLDA
ICQFVLDYVHQHQQVATQNAPAACCDTLSPAFLSVAQGQEKILSLVSTVGDIESCPIQHAYGRVLAHDVISPVNVPQYTN
SAMDGYAIRSDDLQRESYQIVAEVLAGYHYEHPLELGQAVKIMTGAPTPINGDTVVMREQAHQDGDKVTFNGANIKAGQN
VRQAGEDLTIGSSVFTAGTRLASPEMGMMASLGFAQANVLRKLKVAVFSTGDEVQAPGTEQKANSIYDSNRFTIMGMLEK
LGCDILDFGILEDNEQSMIDALESAAQQADVVITSGGVSVGDADYIKLALDKLGQIDFWRINMRPGRPLAFGQINEKPFF
GLPGNPVAVMVSFINFVEPAVRKMQGELGWKPLKVSAIAKEDLRSRQGRTEFSRGIYELDETGRLTARTTGKQGSGILRS
MSEANCLIEISPAVDSVKTGESVTIIPLQGRI
>Mature_592_residues
MRNTITLPLLGFAAYSGTGKTTLLEALLPKLTAAGLRIGLLKHAHHDFDVDKPGKDSYRLRKAGASQMLIASRNRFALMT
ETPEAESEFDYLLSRFDQQTIDVILVEGCKNIAFPKIELHREEVGKPWLYPNDENIIAIASDSGPLESALPQLNINDLDA
ICQFVLDYVHQHQQVATQNAPAACCDTLSPAFLSVAQGQEKILSLVSTVGDIESCPIQHAYGRVLAHDVISPVNVPQYTN
SAMDGYAIRSDDLQRESYQIVAEVLAGYHYEHPLELGQAVKIMTGAPTPINGDTVVMREQAHQDGDKVTFNGANIKAGQN
VRQAGEDLTIGSSVFTAGTRLASPEMGMMASLGFAQANVLRKLKVAVFSTGDEVQAPGTEQKANSIYDSNRFTIMGMLEK
LGCDILDFGILEDNEQSMIDALESAAQQADVVITSGGVSVGDADYIKLALDKLGQIDFWRINMRPGRPLAFGQINEKPFF
GLPGNPVAVMVSFINFVEPAVRKMQGELGWKPLKVSAIAKEDLRSRQGRTEFSRGIYELDETGRLTARTTGKQGSGILRS
MSEANCLIEISPAVDSVKTGESVTIIPLQGRI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=382, Percent_Identity=35.6020942408377, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI66932975, Length=382, Percent_Identity=35.6020942408377, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=41.77545691906, Blast_Score=319, Evalue=4e-88,
Organism=Escherichia coli, GI145693204, Length=173, Percent_Identity=51.4450867052023, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=374, Percent_Identity=29.6791443850267, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=342, Percent_Identity=25.4385964912281, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136978, Length=352, Percent_Identity=33.2386363636364, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24638841, Length=352, Percent_Identity=33.2386363636364, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 64372; Mature: 64372

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTITLPLLGFAAYSGTGKTTLLEALLPKLTAAGLRIGLLKHAHHDFDVDKPGKDSYRL
CCCEEEEEHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
RKAGASQMLIASRNRFALMTETPEAESEFDYLLSRFDQQTIDVILVEGCKNIAFPKIELH
HHCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCHHEEEEEEECCCCCCCCHHEEC
REEVGKPWLYPNDENIIAIASDSGPLESALPQLNINDLDAICQFVLDYVHQHQQVATQNA
HHHCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PAACCDTLSPAFLSVAQGQEKILSLVSTVGDIESCPIQHAYGRVLAHDVISPVNVPQYTN
CHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
SAMDGYAIRSDDLQRESYQIVAEVLAGYHYEHPLELGQAVKIMTGAPTPINGDTVVMREQ
CCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHCCEEEEEECCCCCCCCCEEEEEHH
AHQDGDKVTFNGANIKAGQNVRQAGEDLTIGSSVFTAGTRLASPEMGMMASLGFAQANVL
HCCCCCEEEECCCCCCCCCHHHHCCCCCEECCHHHHCCCCCCCCCCCHHHHCCHHHHHHH
RKLKVAVFSTGDEVQAPGTEQKANSIYDSNRFTIMGMLEKLGCDILDFGILEDNEQSMID
HHHHHEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHCCCEEECCCCCCCHHHHHH
ALESAAQQADVVITSGGVSVGDADYIKLALDKLGQIDFWRINMRPGRPLAFGQINEKPFF
HHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCC
GLPGNPVAVMVSFINFVEPAVRKMQGELGWKPLKVSAIAKEDLRSRQGRTEFSRGIYELD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCHHHCCCEEEC
ETGRLTARTTGKQGSGILRSMSEANCLIEISPAVDSVKTGESVTIIPLQGRI
CCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MRNTITLPLLGFAAYSGTGKTTLLEALLPKLTAAGLRIGLLKHAHHDFDVDKPGKDSYRL
CCCEEEEEHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
RKAGASQMLIASRNRFALMTETPEAESEFDYLLSRFDQQTIDVILVEGCKNIAFPKIELH
HHCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCHHEEEEEEECCCCCCCCHHEEC
REEVGKPWLYPNDENIIAIASDSGPLESALPQLNINDLDAICQFVLDYVHQHQQVATQNA
HHHCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PAACCDTLSPAFLSVAQGQEKILSLVSTVGDIESCPIQHAYGRVLAHDVISPVNVPQYTN
CHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
SAMDGYAIRSDDLQRESYQIVAEVLAGYHYEHPLELGQAVKIMTGAPTPINGDTVVMREQ
CCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHCCEEEEEECCCCCCCCCEEEEEHH
AHQDGDKVTFNGANIKAGQNVRQAGEDLTIGSSVFTAGTRLASPEMGMMASLGFAQANVL
HCCCCCEEEECCCCCCCCCHHHHCCCCCEECCHHHHCCCCCCCCCCCHHHHCCHHHHHHH
RKLKVAVFSTGDEVQAPGTEQKANSIYDSNRFTIMGMLEKLGCDILDFGILEDNEQSMID
HHHHHEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHCCCEEECCCCCCCHHHHHH
ALESAAQQADVVITSGGVSVGDADYIKLALDKLGQIDFWRINMRPGRPLAFGQINEKPFF
HHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCC
GLPGNPVAVMVSFINFVEPAVRKMQGELGWKPLKVSAIAKEDLRSRQGRTEFSRGIYELD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCHHHCCCEEEC
ETGRLTARTTGKQGSGILRSMSEANCLIEISPAVDSVKTGESVTIIPLQGRI
CCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]