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The map label for this gene is ligA [H]

Identifier: 37679818

GI number: 37679818

Start: 1680173

End: 1681015

Strand: Direct

Name: ligA [H]

Synonym: VV1634

Alternate gene names: 37679818

Gene position: 1680173-1681015 (Clockwise)

Preceding gene: 37679798

Following gene: 37679819

Centisome position: 50.09

GC content: 48.75

Gene sequence:

>843_bases
ATGCGTTTGACTATATTATCGATGGCGATTCTCGTCGCCATCCCTGCGATGGCTGAGGAAGAGCCATTGCCAATACCAGA
GGTGATGCTTGCACAAACTTATGGGCATGGCGTGAAGATCAACGATTATTGGTATAGCGAAAAATTGGATGGTATTCGGG
CGTATTGGACTGGCACTCAATTGCTTACTCGCAATGGCAATCGAATTTATGCTCCGACGTGGTTTATTGAAGCATTACCA
CCGATGGCGCTCGATGGTGAGTTATGGGCCGGACGAGGTAATTTTCACATTGTGCAGCAGACAGTGCTGGACGCCACGCC
CGATGAGCATGCTTGGAAGCAGATTGACTTTATGGTTTTTGACCTGCCAGAGTCAGCGGGTGATTACCAAAAGCGCTACT
ATACCCTGATCGATTTAGTGAAAAACATCGACGCGAGGCACATCAAATTTGTTGAGCACAAACCGATCGTCAGCGAAGCA
CAGCTTTTTGAAAAACTGGATGCCATTACGGGCATCAGTGGTGAAGGGGTGATGCTTAGGAATATCACCAGCCGCTACCA
AGCGGGGCGGGGCAGTGATCTACTGAAACTGAAGAAGTACAGTGATGCAGAAGCGACGGTCATTGGTTATAAGCCAGGGA
GTGGCCGTTTAATGGGTATGCTAGGCGCATTGTTGGTGCGGCTCGATGATGGTACCGAGTTCTATATCGGTAGTGGTTTC
ACCGACGAACAACGCAAAAATCCCCCTGCTATTGGTGCGACTGTTACTTATCGACACAATGGTTTCACTAACAGCGGCAA
ACCCAAATTTGCCCGATATCTGCGAGAGCGTCTTCCAGAATAA

Upstream 100 bases:

>100_bases
AGTGCTGTCGCACATCATTTATGAACCTTGATACTGGACGTGAACATGGCGGGGAAATGCGATAAAAAACGCTAGAAAGG
AAAGGATTAGGGGAAGCAGG

Downstream 100 bases:

>100_bases
AGGGCTTTATTAGCAGAACTTTTAACTGAAATGCATTGGTTGTGTGACGAATGTCTTGCGTTATAGAGTTGGAAATTATA
TATAACGCAATCACCATGTT

Product: DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MRLTILSMAILVAIPAMAEEEPLPIPEVMLAQTYGHGVKINDYWYSEKLDGIRAYWTGTQLLTRNGNRIYAPTWFIEALP
PMALDGELWAGRGNFHIVQQTVLDATPDEHAWKQIDFMVFDLPESAGDYQKRYYTLIDLVKNIDARHIKFVEHKPIVSEA
QLFEKLDAITGISGEGVMLRNITSRYQAGRGSDLLKLKKYSDAEATVIGYKPGSGRLMGMLGALLVRLDDGTEFYIGSGF
TDEQRKNPPAIGATVTYRHNGFTNSGKPKFARYLRERLPE

Sequences:

>Translated_280_residues
MRLTILSMAILVAIPAMAEEEPLPIPEVMLAQTYGHGVKINDYWYSEKLDGIRAYWTGTQLLTRNGNRIYAPTWFIEALP
PMALDGELWAGRGNFHIVQQTVLDATPDEHAWKQIDFMVFDLPESAGDYQKRYYTLIDLVKNIDARHIKFVEHKPIVSEA
QLFEKLDAITGISGEGVMLRNITSRYQAGRGSDLLKLKKYSDAEATVIGYKPGSGRLMGMLGALLVRLDDGTEFYIGSGF
TDEQRKNPPAIGATVTYRHNGFTNSGKPKFARYLRERLPE
>Mature_280_residues
MRLTILSMAILVAIPAMAEEEPLPIPEVMLAQTYGHGVKINDYWYSEKLDGIRAYWTGTQLLTRNGNRIYAPTWFIEALP
PMALDGELWAGRGNFHIVQQTVLDATPDEHAWKQIDFMVFDLPESAGDYQKRYYTLIDLVKNIDARHIKFVEHKPIVSEA
QLFEKLDAITGISGEGVMLRNITSRYQAGRGSDLLKLKKYSDAEATVIGYKPGSGRLMGMLGALLVRLDDGTEFYIGSGF
TDEQRKNPPAIGATVTYRHNGFTNSGKPKFARYLRERLPE

Specific function: Catalyzes efficient strand joining on a single nicked DNA [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF01068 DNA_ligase_A_M [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 31548; Mature: 31548

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00333 DNA_LIGASE_A2 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTILSMAILVAIPAMAEEEPLPIPEVMLAQTYGHGVKINDYWYSEKLDGIRAYWTGTQ
CEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECEECCCCCCCEEEEEECCE
LLTRNGNRIYAPTWFIEALPPMALDGELWAGRGNFHIVQQTVLDATPDEHAWKQIDFMVF
EEECCCCEEECCEEHHHCCCCCEECCCEEECCCCEEEEEEHHHCCCCCHHHHHEEEEEEE
DLPESAGDYQKRYYTLIDLVKNIDARHIKFVEHKPIVSEAQLFEKLDAITGISGEGVMLR
ECCCCCCHHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEH
NITSRYQAGRGSDLLKLKKYSDAEATVIGYKPGSGRLMGMLGALLVRLDDGTEFYIGSGF
HHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHEEEECCCCEEEEECCC
TDEQRKNPPAIGATVTYRHNGFTNSGKPKFARYLRERLPE
CCHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRLTILSMAILVAIPAMAEEEPLPIPEVMLAQTYGHGVKINDYWYSEKLDGIRAYWTGTQ
CEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECEECCCCCCCEEEEEECCE
LLTRNGNRIYAPTWFIEALPPMALDGELWAGRGNFHIVQQTVLDATPDEHAWKQIDFMVF
EEECCCCEEECCEEHHHCCCCCEECCCEEECCCCEEEEEEHHHCCCCCHHHHHEEEEEEE
DLPESAGDYQKRYYTLIDLVKNIDARHIKFVEHKPIVSEAQLFEKLDAITGISGEGVMLR
ECCCCCCHHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEH
NITSRYQAGRGSDLLKLKKYSDAEATVIGYKPGSGRLMGMLGALLVRLDDGTEFYIGSGF
HHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHEEEECCCCEEEEECCC
TDEQRKNPPAIGATVTYRHNGFTNSGKPKFARYLRERLPE
CCHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550458; 7542800; 9060431 [H]