Click here to switch to the map view.

The map label for this gene is hpaG [H]

Identifier: 37679768

GI number: 37679768

Start: 1626242

End: 1627021

Strand: Direct

Name: hpaG [H]

Synonym: VV1584

Alternate gene names: 37679768

Gene position: 1626242-1627021 (Clockwise)

Preceding gene: 37679767

Following gene: 37679769

Centisome position: 48.48

GC content: 48.72

Gene sequence:

>780_bases
ATGAAACGCGCACGTATTGAATATTTGGGAGATGTGCTGTCCGTTACAATTGGCGATGGTGACAATGCGATAACTGCAGA
TGGTCGCTCGCTTCCGGCAGGTCAATTTACTTGGCTATCACCAATCGAAAACCCAGGCACCATCTTTGCCCTTGGCTTGA
ATTACGCGGATCACGCCTCTGAGTTGGCGTTTGAGCCACCAAAAGAGCCGCTTGTGTTCTTAAAAGGTGCCAATACGCTG
ACCGCGCATCAACAACCGTCATACCGCCCGAATGATATCGAGTTCATGCACTACGAGTGTGAATTGGTCGCGGTTGTGGG
TAAAGAAGCACGCAACGTCAAACGTGAAGATGCGATGGACTACATCCAAGGCTTCACCATCTGTAATGACTACGCGATTC
GCGATTACCTAGAAAACTACTACCGTCCAAATCTACGTGTGAAGAGCCGTGATTCTTTGTGCCCAATCGGCCCTTGGATT
GTCGATTGCGACGACATCGAAGACGTTAACAACCTTGCGCTCACCACTCATGTAAACGGCGAGTTGACGCAGCAGGGTAA
CACTTCAGACATGATTTTCGATGTGCCGTTTTTGATTGAATACCTCAGCAGCTTTATGACCTTAAAACCGGGCGATTTGA
TTGCGACTGGTACACCAAAAGGTCTTAAAGACATCCAACCGGGTGATGTTGTGCGCTGCACCATCGAAGGTGTTGGCAGC
CTTGAAAACCCAGTTTTATCGGAAGATGACTTTTACGCGCGCCGTACAGTAGAACAGTAA

Upstream 100 bases:

>100_bases
GCTTTGCAGGAGAAAGAACCAAGCTTTCACCGGGTTATGTGGTGCGCTCAGCGTTGGGCGAGTCAGTCGAGTTGGAGAAT
CAAGTAAAAGGAGAGGCAGC

Downstream 100 bases:

>100_bases
GGAAGTGACATGACTCAACAGCTTGAACAAAATTTAGCGACCGCGCAGAAATACCTCGCGCGTTTTCGTGACAACACACT
TGGCCACTTTATTAATGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; HHDD isomerase; 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase; 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase; OPET decarboxylase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKRARIEYLGDVLSVTIGDGDNAITADGRSLPAGQFTWLSPIENPGTIFALGLNYADHASELAFEPPKEPLVFLKGANTL
TAHQQPSYRPNDIEFMHYECELVAVVGKEARNVKREDAMDYIQGFTICNDYAIRDYLENYYRPNLRVKSRDSLCPIGPWI
VDCDDIEDVNNLALTTHVNGELTQQGNTSDMIFDVPFLIEYLSSFMTLKPGDLIATGTPKGLKDIQPGDVVRCTIEGVGS
LENPVLSEDDFYARRTVEQ

Sequences:

>Translated_259_residues
MKRARIEYLGDVLSVTIGDGDNAITADGRSLPAGQFTWLSPIENPGTIFALGLNYADHASELAFEPPKEPLVFLKGANTL
TAHQQPSYRPNDIEFMHYECELVAVVGKEARNVKREDAMDYIQGFTICNDYAIRDYLENYYRPNLRVKSRDSLCPIGPWI
VDCDDIEDVNNLALTTHVNGELTQQGNTSDMIFDVPFLIEYLSSFMTLKPGDLIATGTPKGLKDIQPGDVVRCTIEGVGS
LENPVLSEDDFYARRTVEQ
>Mature_259_residues
MKRARIEYLGDVLSVTIGDGDNAITADGRSLPAGQFTWLSPIENPGTIFALGLNYADHASELAFEPPKEPLVFLKGANTL
TAHQQPSYRPNDIEFMHYECELVAVVGKEARNVKREDAMDYIQGFTICNDYAIRDYLENYYRPNLRVKSRDSLCPIGPWI
VDCDDIEDVNNLALTTHVNGELTQQGNTSDMIFDVPFLIEYLSSFMTLKPGDLIATGTPKGLKDIQPGDVVRCTIEGVGS
LENPVLSEDDFYARRTVEQ

Specific function: Decarboxylates OPET (5-oxo-pent-3-ene-1,2,5- tricarboxylic acid) into HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) and isomerizes it to OHED (2-oxo-hept-3-ene-1,7-dioate) [H]

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=239, Percent_Identity=35.1464435146443, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI40786394, Length=239, Percent_Identity=35.1464435146443, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI13654274, Length=197, Percent_Identity=37.0558375634518, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI215422413, Length=202, Percent_Identity=36.1386138613861, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI66348062, Length=194, Percent_Identity=37.1134020618557, Blast_Score=134, Evalue=8e-32,
Organism=Escherichia coli, GI1787428, Length=193, Percent_Identity=35.2331606217617, Blast_Score=128, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17557057, Length=187, Percent_Identity=38.5026737967914, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324161, Length=224, Percent_Identity=28.125, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28572127, Length=219, Percent_Identity=41.5525114155251, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24663695, Length=217, Percent_Identity=34.5622119815668, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI28571789, Length=210, Percent_Identity=36.1904761904762, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234
- InterPro:   IPR012684
- InterPro:   IPR012686 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: =5.3.3.10; =4.1.1.68 [H]

Molecular weight: Translated: 28874; Mature: 28874

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRARIEYLGDVLSVTIGDGDNAITADGRSLPAGQFTWLSPIENPGTIFALGLNYADHAS
CCCCHHHHHCCEEEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCHHHH
ELAFEPPKEPLVFLKGANTLTAHQQPSYRPNDIEFMHYECELVAVVGKEARNVKREDAMD
HCCCCCCCCCEEEEECCCEEECCCCCCCCCCCEEEEEEEEEEEEEECHHHHCCCHHHHHH
YIQGFTICNDYAIRDYLENYYRPNLRVKSRDSLCPIGPWIVDCDDIEDVNNLALTTHVNG
HHHHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCCCCCCCEEEEEECCC
ELTQQGNTSDMIFDVPFLIEYLSSFMTLKPGDLIATGTPKGLKDIQPGDVVRCTIEGVGS
EEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCC
LENPVLSEDDFYARRTVEQ
CCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MKRARIEYLGDVLSVTIGDGDNAITADGRSLPAGQFTWLSPIENPGTIFALGLNYADHAS
CCCCHHHHHCCEEEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCHHHH
ELAFEPPKEPLVFLKGANTLTAHQQPSYRPNDIEFMHYECELVAVVGKEARNVKREDAMD
HCCCCCCCCCEEEEECCCEEECCCCCCCCCCCEEEEEEEEEEEEEECHHHHCCCHHHHHH
YIQGFTICNDYAIRDYLENYYRPNLRVKSRDSLCPIGPWIVDCDDIEDVNNLALTTHVNG
HHHHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCCCCCCCEEEEEECCC
ELTQQGNTSDMIFDVPFLIEYLSSFMTLKPGDLIATGTPKGLKDIQPGDVVRCTIEGVGS
EEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCC
LENPVLSEDDFYARRTVEQ
CCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA