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The map label for this gene is hpcH [H]

Identifier: 37679766

GI number: 37679766

Start: 1624758

End: 1625567

Strand: Direct

Name: hpcH [H]

Synonym: VV1582

Alternate gene names: 37679766

Gene position: 1624758-1625567 (Clockwise)

Preceding gene: 37679765

Following gene: 37679767

Centisome position: 48.44

GC content: 51.6

Gene sequence:

>810_bases
GTGGCTATGTTACCGATTAACCAATTTAAGCAGCAATTGCATGAGCCTCAGACTCTTTGGGGATTATGGCTTGGTCTGCC
AGATACCAGCTGCGCGGAAATCTGCGGTAGCGCGGGTTTTGACTGGGTGTTGATTGATGGTGAACACGCTTCTTTCGACT
TAACCAGCATCAAGCTGCATTTACAGGCGCTTGCACCACATTCGGCGTCACCGATTGTGCGTGCTGAAGAAGCGAATCCA
ACTTTGATCAAACGCCTATTAGATATTGGTGCTCAAACCTTGCTATTGCCGATGATCAACACCAAGCAACAGGCAGAGCA
GGCAGTACGTGCGTCTTACTACCCGCCAATGGGTGAACGCGGTATTGGTGCAGCCTTGGCGCGTGCGTCTCAGTGGAATC
GAATTCCGAATTACCTGCACCAAGCAAACGAGCAAATTAGCGTGCTGTTGCAAGTCGAAACGCAGCAAGCGATCGATAAC
ATCGAAGAGATCGCAGCGGTGGAAGGGGTAGACGGCATCTTTATTGGCCCGTCTGACTTATCCGGCTCAATGGGGCATAT
CGGCAATCCGTCGCACCCTGAAGTGGTCGCTGCGATTGACCAAGCAATTGAAGTGATTCAAGCCCACGGTAAAGCGGTCG
GCATTCTGAGCTTAGACCCAGCGCAAGCGCAGCAATACGCCAAACGTGGGGTGAAATTTATTGGCGCGGGTGTCGATACC
TTGCTGCTAAGAGCTGGCGCAGAATCACTCGCGCAGTCGCTGAAACAGCCGTTATCTGAATCGAACAAGCTCGTCGACAA
CGTTTATTAA

Upstream 100 bases:

>100_bases
TAGCGGGTTCATTTACTAGACCCGTCGCGGTTAAAGCAGGCGACACGATCCACGCTGATTTTGGTCCGCTTGGCGGCATT
TCAGTGAAGTTTGTGTAGAG

Downstream 100 bases:

>100_bases
TTCGTAGAGTCAGAAACTAGAGAACAAATAATGAATACACAACTACAAGGAAAAGTGGTGTGCGTGGCGCTAAATGACGC
TGAGCAACTGCAATCAATGA

Product: 2;4-dihydroxyhept-2-ene-1;7-dioic acid aldolase

Products: NA

Alternate protein names: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MAMLPINQFKQQLHEPQTLWGLWLGLPDTSCAEICGSAGFDWVLIDGEHASFDLTSIKLHLQALAPHSASPIVRAEEANP
TLIKRLLDIGAQTLLLPMINTKQQAEQAVRASYYPPMGERGIGAALARASQWNRIPNYLHQANEQISVLLQVETQQAIDN
IEEIAAVEGVDGIFIGPSDLSGSMGHIGNPSHPEVVAAIDQAIEVIQAHGKAVGILSLDPAQAQQYAKRGVKFIGAGVDT
LLLRAGAESLAQSLKQPLSESNKLVDNVY

Sequences:

>Translated_269_residues
MAMLPINQFKQQLHEPQTLWGLWLGLPDTSCAEICGSAGFDWVLIDGEHASFDLTSIKLHLQALAPHSASPIVRAEEANP
TLIKRLLDIGAQTLLLPMINTKQQAEQAVRASYYPPMGERGIGAALARASQWNRIPNYLHQANEQISVLLQVETQQAIDN
IEEIAAVEGVDGIFIGPSDLSGSMGHIGNPSHPEVVAAIDQAIEVIQAHGKAVGILSLDPAQAQQYAKRGVKFIGAGVDT
LLLRAGAESLAQSLKQPLSESNKLVDNVY
>Mature_268_residues
AMLPINQFKQQLHEPQTLWGLWLGLPDTSCAEICGSAGFDWVLIDGEHASFDLTSIKLHLQALAPHSASPIVRAEEANPT
LIKRLLDIGAQTLLLPMINTKQQAEQAVRASYYPPMGERGIGAALARASQWNRIPNYLHQANEQISVLLQVETQQAIDNI
EEIAAVEGVDGIFIGPSDLSGSMGHIGNPSHPEVVAAIDQAIEVIQAHGKAVGILSLDPAQAQQYAKRGVKFIGAGVDTL
LLRAGAESLAQSLKQPLSESNKLVDNVY

Specific function: Catalyzes the reversible retro-aldol cleavage of 4- hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde [H]

COG id: COG3836

COG function: function code G; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1788578, Length=262, Percent_Identity=46.9465648854962, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI1789514, Length=250, Percent_Identity=42.4, Blast_Score=222, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR012689
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: 4.1.2.-

Molecular weight: Translated: 28945; Mature: 28814

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMLPINQFKQQLHEPQTLWGLWLGLPDTSCAEICGSAGFDWVLIDGEHASFDLTSIKLH
CCCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCCCCEEHHHHEEE
LQALAPHSASPIVRAEEANPTLIKRLLDIGAQTLLLPMINTKQQAEQAVRASYYPPMGER
HHHHCCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
GIGAALARASQWNRIPNYLHQANEQISVLLQVETQQAIDNIEEIAAVEGVDGIFIGPSDL
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCCC
SGSMGHIGNPSHPEVVAAIDQAIEVIQAHGKAVGILSLDPAQAQQYAKRGVKFIGAGVDT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCHHHHHCCHHH
LLLRAGAESLAQSLKQPLSESNKLVDNVY
HHHHHCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AMLPINQFKQQLHEPQTLWGLWLGLPDTSCAEICGSAGFDWVLIDGEHASFDLTSIKLH
CCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCCCCEEHHHHEEE
LQALAPHSASPIVRAEEANPTLIKRLLDIGAQTLLLPMINTKQQAEQAVRASYYPPMGER
HHHHCCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
GIGAALARASQWNRIPNYLHQANEQISVLLQVETQQAIDNIEEIAAVEGVDGIFIGPSDL
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCCC
SGSMGHIGNPSHPEVVAAIDQAIEVIQAHGKAVGILSLDPAQAQQYAKRGVKFIGAGVDT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCHHHHHCCHHH
LLLRAGAESLAQSLKQPLSESNKLVDNVY
HHHHHCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA