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The map label for this gene is cysG [H]

Identifier: 37679742

GI number: 37679742

Start: 1604468

End: 1605388

Strand: Direct

Name: cysG [H]

Synonym: VV1558

Alternate gene names: 37679742

Gene position: 1604468-1605388 (Clockwise)

Preceding gene: 37679736

Following gene: 37679743

Centisome position: 47.83

GC content: 45.93

Gene sequence:

>921_bases
ATGCGATATTTTCCTCTTTTCATGGATCTAGAAAACAAACCCGTACTTGTTGTCGGAGGAGGGGAAGTTGCCAGTCGTAA
AATTGAAGCGCTGTTAAATGTCGGGGCGAAAGTAACGATCGTCTCGCCGACATTGGTGGATGAGCTTCACCGTTGGGTGG
AGGAAAACCGCTGTTACTGGGTGAAAAATTTCTATTCATCTGAGTTGATGGATGGGGCCTATGTTCAAGTCTGGGCGACA
ACCAACAATCCGTCTCTCAACCATCAAGTATACCGTGACGCTAAACAGCGCAATCTGTTGGTGAACGTCGTGGATGATAA
ACCGTATTGTGACTTCATTACGCCTTCAATGATCTCGCGTGGGCGAGTGCAAATTGCCATATCCAGTGGTGGTGCTTCCC
CTGTGTTGATTCGTAATCTCAGAGAATCATTAGAAGCGGTTTTGCCACAAAATCTGAGTTTGCTGGCGGAGTTCGCCGAG
TCAAAACGTGTAGCGGTTAAAGAGCGATTCCCGACAGTCGAAGAACGTCGCATGTTTTGGGAGCTGTTTTTTGACTTACC
AGAGGTCAAATCGTCACAAAATCATAGAGAGCTTGAAACCTTGTTTGCACAGGCAATCAAAGGGGAGGTTCAACGAACTG
CGCAATGCACATGGATTGGTTGCACAGAAGATGTTGAGCTGTTACCTATTAAAGCCCTTCGTTATATGCAAAAAGCGGAG
CTTGTGTTGGCACCAGAGCAGATTCATCCTGCTTTTCTAGAAATGGTGCGTCGAGATGCCCAACGTTTGAGTTATGAAAC
TCCGGCACAACTCTCGGAAAAGATTCACCAAGCGAAGCTCGAGCCGATTAAAATCTGCGTGTTATTTGCTAAAAACAGCC
AAGAATTCAGCTTTCTTCAACAAGGTGATCTGATTATCTGA

Upstream 100 bases:

>100_bases
TTCGAACAAAAATTATTTGTTACATCGGTTTGTGATGATATTTATGCACCAAATCTGCTACGATGAGCGCTTTAGTCATA
AAGAACAGACAGGGATTTAA

Downstream 100 bases:

>100_bases
TCGCAATACTTTTGCTCTTGCTGGTTCCTTCCTTCAATCCACGGCGACGACACCATGACGGAATGCCTTACGGTGTTGCT
CTAGTGGATTGATTGCAACA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRYFPLFMDLENKPVLVVGGGEVASRKIEALLNVGAKVTIVSPTLVDELHRWVEENRCYWVKNFYSSELMDGAYVQVWAT
TNNPSLNHQVYRDAKQRNLLVNVVDDKPYCDFITPSMISRGRVQIAISSGGASPVLIRNLRESLEAVLPQNLSLLAEFAE
SKRVAVKERFPTVEERRMFWELFFDLPEVKSSQNHRELETLFAQAIKGEVQRTAQCTWIGCTEDVELLPIKALRYMQKAE
LVLAPEQIHPAFLEMVRRDAQRLSYETPAQLSEKIHQAKLEPIKICVLFAKNSQEFSFLQQGDLII

Sequences:

>Translated_306_residues
MRYFPLFMDLENKPVLVVGGGEVASRKIEALLNVGAKVTIVSPTLVDELHRWVEENRCYWVKNFYSSELMDGAYVQVWAT
TNNPSLNHQVYRDAKQRNLLVNVVDDKPYCDFITPSMISRGRVQIAISSGGASPVLIRNLRESLEAVLPQNLSLLAEFAE
SKRVAVKERFPTVEERRMFWELFFDLPEVKSSQNHRELETLFAQAIKGEVQRTAQCTWIGCTEDVELLPIKALRYMQKAE
LVLAPEQIHPAFLEMVRRDAQRLSYETPAQLSEKIHQAKLEPIKICVLFAKNSQEFSFLQQGDLII
>Mature_306_residues
MRYFPLFMDLENKPVLVVGGGEVASRKIEALLNVGAKVTIVSPTLVDELHRWVEENRCYWVKNFYSSELMDGAYVQVWAT
TNNPSLNHQVYRDAKQRNLLVNVVDDKPYCDFITPSMISRGRVQIAISSGGASPVLIRNLRESLEAVLPQNLSLLAEFAE
SKRVAVKERFPTVEERRMFWELFFDLPEVKSSQNHRELETLFAQAIKGEVQRTAQCTWIGCTEDVELLPIKALRYMQKAE
LVLAPEQIHPAFLEMVRRDAQRLSYETPAQLSEKIHQAKLEPIKICVLFAKNSQEFSFLQQGDLII

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=267, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 35072; Mature: 35072

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFPLFMDLENKPVLVVGGGEVASRKIEALLNVGAKVTIVSPTLVDELHRWVEENRCYW
CCEEEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCEEE
VKNFYSSELMDGAYVQVWATTNNPSLNHQVYRDAKQRNLLVNVVDDKPYCDFITPSMISR
EECHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHCC
GRVQIAISSGGASPVLIRNLRESLEAVLPQNLSLLAEFAESKRVAVKERFPTVEERRMFW
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEHHHHCCCHHHHHHHH
ELFFDLPEVKSSQNHRELETLFAQAIKGEVQRTAQCTWIGCTEDVELLPIKALRYMQKAE
HHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEHHHHHHHHHHHH
LVLAPEQIHPAFLEMVRRDAQRLSYETPAQLSEKIHQAKLEPIKICVLFAKNSQEFSFLQ
EEECCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHC
QGDLII
CCCCCC
>Mature Secondary Structure
MRYFPLFMDLENKPVLVVGGGEVASRKIEALLNVGAKVTIVSPTLVDELHRWVEENRCYW
CCEEEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCEEE
VKNFYSSELMDGAYVQVWATTNNPSLNHQVYRDAKQRNLLVNVVDDKPYCDFITPSMISR
EECHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHCC
GRVQIAISSGGASPVLIRNLRESLEAVLPQNLSLLAEFAESKRVAVKERFPTVEERRMFW
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEHHHHCCCHHHHHHHH
ELFFDLPEVKSSQNHRELETLFAQAIKGEVQRTAQCTWIGCTEDVELLPIKALRYMQKAE
HHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEHHHHHHHHHHHH
LVLAPEQIHPAFLEMVRRDAQRLSYETPAQLSEKIHQAKLEPIKICVLFAKNSQEFSFLQ
EEECCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHC
QGDLII
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA