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The map label for this gene is hisI [H]

Identifier: 37679541

GI number: 37679541

Start: 1382373

End: 1383008

Strand: Direct

Name: hisI [H]

Synonym: VV1357

Alternate gene names: 37679541

Gene position: 1382373-1383008 (Clockwise)

Preceding gene: 37679540

Following gene: 37679546

Centisome position: 41.21

GC content: 49.53

Gene sequence:

>636_bases
ATGAGTGTGAAAGCCGCCGAAGTAAGTTCGCTCGCTGAGCGAATCAACTGGGAAAAGGTGGATGGTCTGGTACCTGCCAT
CGTACAAGATTTCCAATCAAGCCAAGTGTTGATGATGGGTTACATGAACCAAGATGCGTTGGCAAAAACGGGCGAAACTG
GTCAAGTGACGTTTTTCTCTCGTACCAAAGAGCGTCTTTGGACCAAAGGGGAAACGTCCGGTAACGTGCTGCAATTGGTG
AACATGTCGTTGGATTGTGATAACGACACACTGCTAGTGAAAGTCAACCCAATTGGGCCAACGTGTCATACGGGCACCAC
CACTTGCTGGGATGGTGATCCACAGGAAGAGTCACAAATGGTGTGGCTTCATCAACTTGAGCAGCTACTGGCTGCCCGCA
AGAGTGCCGACCCAGATTCCTCTTATACTGCCAGTCTTTATGCTCGTGGTACCAAGCGTATTTCGCAGAAAGTGGGCGAA
GAAGGCGTTGAAGTCGCGCTTGCGGCGACGTCGGGCGATAAGGCGGAGTTAGTGTGTGAATCGGCAGACTTGATTTACCA
CTTGCTGGTATTGCTGCAAGATCAAGGCCTATCGATGAATGATGTGATCAATAAGCTTAAAGAGCGTCATAAGTAA

Upstream 100 bases:

>100_bases
ATGTAGATGGCGCGCTTGCCGCATCGGTATTCCACAAGCAAGTCATCAATATTGGTGAACTAAAGCAGTATTTGAAACAA
CAAGGCATTGAGGTACGACT

Downstream 100 bases:

>100_bases
GATAGAGACAAGGTCAAGGTTGATAGGGACTAGGGCCCTAGTAGAGAGTGCGCAGGGAGTCTGCGCACTTTGTTTTTTAG
AAAGAGTTATGGAACTCAGG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSVKAAEVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSGNVLQLV
NMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQLEQLLAARKSADPDSSYTASLYARGTKRISQKVGE
EGVEVALAATSGDKAELVCESADLIYHLLVLLQDQGLSMNDVINKLKERHK

Sequences:

>Translated_211_residues
MSVKAAEVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSGNVLQLV
NMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQLEQLLAARKSADPDSSYTASLYARGTKRISQKVGE
EGVEVALAATSGDKAELVCESADLIYHLLVLLQDQGLSMNDVINKLKERHK
>Mature_210_residues
SVKAAEVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSGNVLQLVN
MSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQLEQLLAARKSADPDSSYTASLYARGTKRISQKVGEE
GVEVALAATSGDKAELVCESADLIYHLLVLLQDQGLSMNDVINKLKERHK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=197, Percent_Identity=66.497461928934, Blast_Score=270, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=198, Percent_Identity=33.8383838383838, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23221; Mature: 23089

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKAAEVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFS
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCEEEEEE
RTKERLWTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQM
HHHHHHHCCCCCCCCEEEEEECEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
VWLHQLEQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHEEEC
SADLIYHLLVLLQDQGLSMNDVINKLKERHK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SVKAAEVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFS
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCEEEEEE
RTKERLWTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQM
HHHHHHHCCCCCCCCEEEEEECEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
VWLHQLEQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHEEEC
SADLIYHLLVLLQDQGLSMNDVINKLKERHK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]