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The map label for this gene is fabF [H]

Identifier: 37679461

GI number: 37679461

Start: 1297096

End: 1298337

Strand: Direct

Name: fabF [H]

Synonym: VV1277

Alternate gene names: 37679461

Gene position: 1297096-1298337 (Clockwise)

Preceding gene: 37679460

Following gene: 161486633

Centisome position: 38.67

GC content: 47.58

Gene sequence:

>1242_bases
GTGTCCAAGCGTCGTGTAGTTGTCACTGGCATGGGTATGTTGTCACCGGTTGGCAACACCGTAGCAGAATCCTGGAAATC
CCTGCTTGAAGGCAAAAGTGGTATCGTCAATATCGAACATTTCGATGCAACTAACTTCTCTACCCGTTTCGCCGGTTTGG
TAAAAGACTTCAACTGCGAAGAATACATGTCTAAAAAAGATGCACGTAAAATGGATCTCTTCATCCAGTACGGCATTGCA
GCAGGTATTCAGGCTTTAGACGATTCAGGTCTTGAAATTACGGATGAAAACGCACACCGCGTTGGTGTTGCGATCGGCTC
TGGTATCGGCGGTCTTGATCTTATTGAAGCTGGCCACACCGCTTTAGTTGAAAAAGGCCCACGTAAAGTTAGCCCATTCT
TCGTTCCTTCAACTATTGTAAACATGGTTGCAGGTAATCTATCTATCATGCGTGGCATGCGCGGTCCGAACATCGCGATT
TCTACTGCATGTACTACTGGTCTGCATAACATCGGCCATGCAGCGCGAATGATCGCTTACGGCGATGCTGATGCTATGGT
TGCTGGTGGTGCTGAGAAAGCATCAACACCGCTTGGTATGGCTGGCTTTGGTGCGGCGAAAGCTCTTTCTACTCGTAACG
ATGAACCACAAAAAGCGTCTCGTCCTTGGGATAAAGATCGCGATGGTTTCGTATTAGGCGATGGTGCTGGCATCATGGTA
CTTGAAGAGTACGAACATGCAAAAGCACGTGGCGCAAAAATTTACGCTGAGCTGGTTGGCTTTGGTATGTCGGGTGATGC
TTATCACATGACTTCACCAAGCGAAGACGGCTCTGGTGGCGCTCTAGCGATGGAAGCGGCAATGCGTGACGCAGGTATTG
TTGGTACACAAGTGGGTTATGTGAACGCTCACGGTACATCAACACCAGCAGGCGATGTGGCTGAAATTAAAGGCGTAAAA
CGTGCTCTTGGTGAAGAGGGCGCAAAACAAGTTAAAGTATCTTCAACAAAATCTATGACCGGCCACCTACTTGGTGCTGC
TGGCTCTGTTGAAGCGATCATTACCGTGTTGTCGTTGGTTGATCAGATCGTTCCACCAACCATTAACCTGGATAATCCAG
AAGAAGGTTTGGATATCGATCTTGTTCCACATACTGCGAAGAAAGTGGATATGGAATACGCGATCTGTAACTCATTCGGC
TTCGGTGGAACAAACGGCTCACTCGTATTTAAGAAAATCTAA

Upstream 100 bases:

>100_bases
GCTCAGTAATCATCTCCCCCAGGCGGTCACCTAGACCGCCTGTGTTTTTTCTAACTTCTTCTATCCTCTCATAGAAATTC
AATCCCCGGAGAATTATATC

Downstream 100 bases:

>100_bases
CACTCATTTAGGTTTCTGAAACTTGTATTTAAACGGCTTGATGCTTAGCATTAAGCCGTTTTGTTTTTATTGGGATATAG
ATAGCATGTATTGGGTCAAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSKRRVVVTGMGMLSPVGNTVAESWKSLLEGKSGIVNIEHFDATNFSTRFAGLVKDFNCEEYMSKKDARKMDLFIQYGIA
AGIQALDDSGLEITDENAHRVGVAIGSGIGGLDLIEAGHTALVEKGPRKVSPFFVPSTIVNMVAGNLSIMRGMRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMVAGGAEKASTPLGMAGFGAAKALSTRNDEPQKASRPWDKDRDGFVLGDGAGIMV
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGIVGTQVGYVNAHGTSTPAGDVAEIKGVK
RALGEEGAKQVKVSSTKSMTGHLLGAAGSVEAIITVLSLVDQIVPPTINLDNPEEGLDIDLVPHTAKKVDMEYAICNSFG
FGGTNGSLVFKKI

Sequences:

>Translated_413_residues
MSKRRVVVTGMGMLSPVGNTVAESWKSLLEGKSGIVNIEHFDATNFSTRFAGLVKDFNCEEYMSKKDARKMDLFIQYGIA
AGIQALDDSGLEITDENAHRVGVAIGSGIGGLDLIEAGHTALVEKGPRKVSPFFVPSTIVNMVAGNLSIMRGMRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMVAGGAEKASTPLGMAGFGAAKALSTRNDEPQKASRPWDKDRDGFVLGDGAGIMV
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGIVGTQVGYVNAHGTSTPAGDVAEIKGVK
RALGEEGAKQVKVSSTKSMTGHLLGAAGSVEAIITVLSLVDQIVPPTINLDNPEEGLDIDLVPHTAKKVDMEYAICNSFG
FGGTNGSLVFKKI
>Mature_412_residues
SKRRVVVTGMGMLSPVGNTVAESWKSLLEGKSGIVNIEHFDATNFSTRFAGLVKDFNCEEYMSKKDARKMDLFIQYGIAA
GIQALDDSGLEITDENAHRVGVAIGSGIGGLDLIEAGHTALVEKGPRKVSPFFVPSTIVNMVAGNLSIMRGMRGPNIAIS
TACTTGLHNIGHAARMIAYGDADAMVAGGAEKASTPLGMAGFGAAKALSTRNDEPQKASRPWDKDRDGFVLGDGAGIMVL
EEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGIVGTQVGYVNAHGTSTPAGDVAEIKGVKR
ALGEEGAKQVKVSSTKSMTGHLLGAAGSVEAIITVLSLVDQIVPPTINLDNPEEGLDIDLVPHTAKKVDMEYAICNSFGF
GGTNGSLVFKKI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=46.1538461538462, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=45.7831325301205, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI41872631, Length=421, Percent_Identity=24.9406175771971, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=75.1207729468599, Blast_Score=607, Evalue=1e-175,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=38.9423076923077, Blast_Score=247, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=40.3381642512077, Blast_Score=280, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=45.1127819548872, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI212642053, Length=359, Percent_Identity=25.3481894150418, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=417, Percent_Identity=23.2613908872902, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=40.1805869074492, Blast_Score=292, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24644341, Length=428, Percent_Identity=44.6261682242991, Blast_Score=340, Evalue=8e-94,
Organism=Drosophila melanogaster, GI19920632, Length=427, Percent_Identity=23.1850117096019, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI221330659, Length=427, Percent_Identity=23.1850117096019, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24581345, Length=425, Percent_Identity=22.8235294117647, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43097; Mature: 42965

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVVTGMGMLSPVGNTVAESWKSLLEGKSGIVNIEHFDATNFSTRFAGLVKDFNCE
CCCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHH
EYMSKKDARKMDLFIQYGIAAGIQALDDSGLEITDENAHRVGVAIGSGIGGLDLIEAGHT
HHHHHHCCHHHHHHEEHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCCHHHHHCCCH
ALVEKGPRKVSPFFVPSTIVNMVAGNLSIMRGMRGPNIAISTACTTGLHNIGHAARMIAY
HHHCCCCCCCCCEECHHHHHHHHHCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHEEEE
GDADAMVAGGAEKASTPLGMAGFGAAKALSTRNDEPQKASRPWDKDRDGFVLGDGAGIMV
CCCCCEEECCCHHCCCCCCCCCCCHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGIVGTQVGY
EECCHHHHHCCHHEEEHHHCCCCCCCEEECCCCCCCCCCCEEEHHHHHHCCCCEEEEEEE
VNAHGTSTPAGDVAEIKGVKRALGEEGAKQVKVSSTKSMTGHLLGAAGSVEAIITVLSLV
EECCCCCCCCCCHHHHHHHHHHHCCCCHHEEEECCCCCHHHHEECCCCHHHHHHHHHHHH
DQIVPPTINLDNPEEGLDIDLVPHTAKKVDMEYAICNSFGFGGTNGSLVFKKI
HHHCCCCCCCCCCCCCCEEEECCCCHHHHCHHEEEECCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SKRRVVVTGMGMLSPVGNTVAESWKSLLEGKSGIVNIEHFDATNFSTRFAGLVKDFNCE
CCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHH
EYMSKKDARKMDLFIQYGIAAGIQALDDSGLEITDENAHRVGVAIGSGIGGLDLIEAGHT
HHHHHHCCHHHHHHEEHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCCHHHHHCCCH
ALVEKGPRKVSPFFVPSTIVNMVAGNLSIMRGMRGPNIAISTACTTGLHNIGHAARMIAY
HHHCCCCCCCCCEECHHHHHHHHHCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHEEEE
GDADAMVAGGAEKASTPLGMAGFGAAKALSTRNDEPQKASRPWDKDRDGFVLGDGAGIMV
CCCCCEEECCCHHCCCCCCCCCCCHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGIVGTQVGY
EECCHHHHHCCHHEEEHHHCCCCCCCEEECCCCCCCCCCCEEEHHHHHHCCCCEEEEEEE
VNAHGTSTPAGDVAEIKGVKRALGEEGAKQVKVSSTKSMTGHLLGAAGSVEAIITVLSLV
EECCCCCCCCCCHHHHHHHHHHHCCCCHHEEEECCCCCHHHHEECCCCHHHHHHHHHHHH
DQIVPPTINLDNPEEGLDIDLVPHTAKKVDMEYAICNSFGFGGTNGSLVFKKI
HHHCCCCCCCCCCCCCCEEEECCCCHHHHCHHEEEECCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]