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The map label for this gene is gyrA [H]

Identifier: 37679431

GI number: 37679431

Start: 1264566

End: 1267268

Strand: Direct

Name: gyrA [H]

Synonym: VV1247

Alternate gene names: 37679431

Gene position: 1264566-1267268 (Clockwise)

Preceding gene: 37679429

Following gene: 37679432

Centisome position: 37.7

GC content: 48.8

Gene sequence:

>2703_bases
ATGAGCGATCTAGCTAAAGAGATCACGCCCGTAAACATTGAAGATGAGCTAAGAGGTTCATACCTTGACTACGCGATGTC
CGTTATCGTGGGTCGTGCTCTTCCGGATGTGCGTGATGGCCTAAAACCAGTACACCGCCGCGTGCTTTACGCGATGAATG
TACTAGGCAACGACTGGAATAAACCATATAAAAAATCTGCCCGTGTCGTCGGCGACGTAATCGGTAAATATCACCCTCAT
GGTGACAGTGCGGTATACGACACCATCGTGCGTATGGCACAACCGTTCTCGCTACGTTACATGCTGGTCGATGGCCAAGG
TAACTTTGGTTCGATCGATGGTGACTCCGCGGCAGCAATGCGTTATACCGAAGTTCGCATGGCGAAAATCGCCCACGAGC
TTTTGGCTGACCTAGATAAAGAAACCGTGGATTACGTGCCGAACTATGACGGTACAGAACAGATCCCAGCGGTTCTTCCT
ACGAAAATTCCAAACCTGCTGGTCAACGGTTCTTCCGGTATCGCAGTAGGTATGGCAACCAACATTCCTCCGCACAACTT
GACGGAAGTGATTGATGGCTGCCTTGCATACATCAATAACGAAGCCATCACGATTGATGAGCTGATGGATTACATTCCTG
GTCCAGATTTCCCTACGGCTGCTTTGATTAGCGGACGTAAAGGCATTATTGACGCGTACAAAACTGGTCGCGGCAAAATC
TACATGCGTTCAAAAGCGGAAATCGAAGTCGAGAAGAATGGCAAAGAAACCATCATCGTTACTGAGATCCCATATCAAGT
GAACAAAGCTCGTTTGATCGAAAAGATCGCTGAGCTAGTGAAAGATAAGAAAGTAGAAGGCATCAGTGCACTGCGCGACG
AGTCGGACAAAGACGGTATGCGTATTGTTATTGAATGTAAGCGCGACGCAGTGGGTGAAGTGGTTCTAAACAACCTTTAC
GCCCAAACTCAGCTGCAAACGACTTTCGGCATCAACATGGTTGCGCTTGATAATGGCCAGCCAAAGTTATTCAACTTGAA
AGAGATGTTGAAGTGCTTCGTTGATCACCGTCGTGAAGTGGTCACTCGTCGTACTATCTTCGAACTGAAGAAAGCACGCG
ATCGTGCCCATATCCTTGAAGCGTTGGCTCTGGCTCTTGCGAACATCGATGAAATCATCGAATTGATCCGTAACGCCGCG
ACTCCAGCAGAAGCGAAAGCAGGCTTAGTGGCTCGTGGCTGGGATCTGGGCAACGTGGCTGCTATGCTTGAAAGCGCCGG
AACTGACGCTGCTCGTCCAGATTGGCTTGAACCTCAATATGGCATCCGTGATGGTCAGTACTTCCTAACGGAAACCCAAG
CGCAAGCGATCCTTGATCTACGCCTACATAAACTGACAGGCCTAGAGCACGAGAAGATCCTAGACGAGTACAAAGCGCTA
TTAGACGAAATCAAAGAGTTGATGCATATCCTTGCAAGCACTGAACGTTTGATGGAAGTGATTCGTGAAGAACTTGAAAT
GGTCCGTGATGCATTCGGCGATGTACGTCGTACTGAAATCACCGCTGCGAGCCATGACATTGATCTTGAAGAGCTGATCG
CTCGTGAAGACGTTGTTGTGACGCTTTCTCACGAAGGTTACGTTAAGTACCAAATTCTAAGCGACTACGAAGCACAACGT
CGTGGTGGTAAGGGTAAGAGCGCAACCAAGATGAAAGATGAAGATTACATCGAACGTCTATTGGTCGCGAACACGCACGA
CAACATTTTGTTGTTCTCAACGCGTGGTAAGACTTACCGCATGAAAGTATACCAATTGCCTCTCGCAAGCCGCACGGCTC
GTGGTAAGCCAATTGTGAACCTACTACCGCTGGAAGAAAACGAACGTATTACGGCTATTCTACCGGTAACAGAGTTCAGT
GCTGACAAGTTTATCTTCATGGCAACTGGCGATGGTACGGTGAAGAAGACCTCACTTGATCAATTCTCCAACGTTCGTGC
AAATGGTCTTATCGCTGTGAACCTACGTGATGAAGATTCGCTGATTGGTGTTGATATCACTGACGGCGAAAGCGAAATCA
TGCTGTTCTCTAAATTTGGTAAAGTGGTGCGCTTCAAAGAAGCAGAAGAGAGCCCAGTACTGGATGAAAACGGTAACCCA
GTTCTTGATGAGAACGGTCAGCCAGAGATCAAGTTCAAAGGCGTGCGACCTATGGGCCGTACCGCGGCAGGTGTTCGTGG
TATGAAACTCGCTGATGGCGATCAAGTTGTGTCACTGATCGTACCGAAGAATGACGGCGATGTCCTTACTGTGACTGAAA
ACGGTTACGGCAAACGTACTGTGCTTTCAGAGTACCCAACCAAAGGCCGCGGCACTCAGGGTGTTGTGTCTATTAAGGTT
TCTGAGCGTAACGGTAGTGTTGTTGGCGCGGTTCAAGTTGAAGACGGTGACGAATTCATGATGATCACGGACGCTGGTAC
ACTAGTACGTACTCGTGTGGCGGAAGTGAGCCAAGTGGGTCGTAACACTCAAGGTGTCACCCTGATCCGTACTGCAGAAG
ACGAATCGGTTGTGGGCTTACAGCGCATTGATGAAGTTGAAGAAACTGAGTTGCCAGAAGGCGAAGAAGCGGACGCAACT
GAGCAAGTACCTCAGGCACAAGATCCTCAAGCAGACAACGATGACGCAGCCGAGCAAGAGTAA

Upstream 100 bases:

>100_bases
AGGACAGGGAAAGTGATGCCGAACTAGGGAATTGTGTGTTATATTTTTGCACCTTACACGTATTGTACATACGATCAGAA
AATAGAGGGATAATGGCTCT

Downstream 100 bases:

>100_bases
TCTTGCTTAGCAACGACATAACAAAGCCAGATAGTGCAAACTATCTGGCTTTTTTTCATTTTTGTCGATAGGAAGTTGGC
AATGGGTCAAAGCAGTTGCT

Product: DNA gyrase, subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 900; Mature: 899

Protein sequence:

>900_residues
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLP
TKIPNLLVNGSSGIAVGMATNIPPHNLTEVIDGCLAYINNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKI
YMRSKAEIEVEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLY
AQTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELKKARDRAHILEALALALANIDEIIELIRNAA
TPAEAKAGLVARGWDLGNVAAMLESAGTDAARPDWLEPQYGIRDGQYFLTETQAQAILDLRLHKLTGLEHEKILDEYKAL
LDEIKELMHILASTERLMEVIREELEMVRDAFGDVRRTEITAASHDIDLEELIAREDVVVTLSHEGYVKYQILSDYEAQR
RGGKGKSATKMKDEDYIERLLVANTHDNILLFSTRGKTYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFS
ADKFIFMATGDGTVKKTSLDQFSNVRANGLIAVNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKEAEESPVLDENGNP
VLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKNDGDVLTVTENGYGKRTVLSEYPTKGRGTQGVVSIKV
SERNGSVVGAVQVEDGDEFMMITDAGTLVRTRVAEVSQVGRNTQGVTLIRTAEDESVVGLQRIDEVEETELPEGEEADAT
EQVPQAQDPQADNDDAAEQE

Sequences:

>Translated_900_residues
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLP
TKIPNLLVNGSSGIAVGMATNIPPHNLTEVIDGCLAYINNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKI
YMRSKAEIEVEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLY
AQTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELKKARDRAHILEALALALANIDEIIELIRNAA
TPAEAKAGLVARGWDLGNVAAMLESAGTDAARPDWLEPQYGIRDGQYFLTETQAQAILDLRLHKLTGLEHEKILDEYKAL
LDEIKELMHILASTERLMEVIREELEMVRDAFGDVRRTEITAASHDIDLEELIAREDVVVTLSHEGYVKYQILSDYEAQR
RGGKGKSATKMKDEDYIERLLVANTHDNILLFSTRGKTYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFS
ADKFIFMATGDGTVKKTSLDQFSNVRANGLIAVNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKEAEESPVLDENGNP
VLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKNDGDVLTVTENGYGKRTVLSEYPTKGRGTQGVVSIKV
SERNGSVVGAVQVEDGDEFMMITDAGTLVRTRVAEVSQVGRNTQGVTLIRTAEDESVVGLQRIDEVEETELPEGEEADAT
EQVPQAQDPQADNDDAAEQE
>Mature_899_residues
SDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKPYKKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLPT
KIPNLLVNGSSGIAVGMATNIPPHNLTEVIDGCLAYINNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKIY
MRSKAEIEVEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLYA
QTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELKKARDRAHILEALALALANIDEIIELIRNAAT
PAEAKAGLVARGWDLGNVAAMLESAGTDAARPDWLEPQYGIRDGQYFLTETQAQAILDLRLHKLTGLEHEKILDEYKALL
DEIKELMHILASTERLMEVIREELEMVRDAFGDVRRTEITAASHDIDLEELIAREDVVVTLSHEGYVKYQILSDYEAQRR
GGKGKSATKMKDEDYIERLLVANTHDNILLFSTRGKTYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSA
DKFIFMATGDGTVKKTSLDQFSNVRANGLIAVNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKEAEESPVLDENGNPV
LDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKNDGDVLTVTENGYGKRTVLSEYPTKGRGTQGVVSIKVS
ERNGSVVGAVQVEDGDEFMMITDAGTLVRTRVAEVSQVGRNTQGVTLIRTAEDESVVGLQRIDEVEETELPEGEEADATE
QVPQAQDPQADNDDAAEQE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=547, Percent_Identity=26.1425959780622, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=330, Percent_Identity=25.1515151515152, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788562, Length=904, Percent_Identity=74.1150442477876, Blast_Score=1353, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=737, Percent_Identity=36.6350067842605, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI212645845, Length=408, Percent_Identity=25.9803921568627, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=283, Percent_Identity=28.2685512367491, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=282, Percent_Identity=28.0141843971631, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=27.0893371757925, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136538, Length=354, Percent_Identity=28.2485875706215, Blast_Score=77, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 99636; Mature: 99504

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVIDGCLAYINNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKI
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCHHHHHCCCCCCHHHHCCCCCEE
YMRSKAEIEVEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGM
EEECCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
RIVIECKRDAVGEVVLNNLYAQTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREV
EEEEEECCCHHHHHHHHHHHHHHEEEHHHCEEEEEECCCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELKKARDRAHILEALALALANIDEIIELIRNAATPAEAKAGLVARGWDLGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHCCCEEEECCCHHHHH
AMLESAGTDAARPDWLEPQYGIRDGQYFLTETQAQAILDLRLHKLTGLEHEKILDEYKAL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LDEIKELMHILASTERLMEVIREELEMVRDAFGDVRRTEITAASHDIDLEELIAREDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHCCCCEEE
TLSHEGYVKYQILSDYEAQRRGGKGKSATKMKDEDYIERLLVANTHDNILLFSTRGKTYR
EEECCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEE
MKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSADKFIFMATGDGTVKKTSLD
EEEEECCCCCCCCCCCCCEEEECCCCCCCEEEEEEEEECCCCCEEEEEECCCCEEECCHH
QFSNVRANGLIAVNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKEAEESPVLDENGNP
HHHCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEHHCCCEEECCCCCCCCCCCCCCC
VLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKNDGDVLTVTENGYGKRT
CCCCCCCCCEEEECCCCCCCHHHCCCCCEECCCCEEEEEEEECCCCCEEEEECCCCCCCC
VLSEYPTKGRGTQGVVSIKVSERNGSVVGAVQVEDGDEFMMITDAGTLVRTRVAEVSQVG
CHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHC
RNTQGVTLIRTAEDESVVGLQRIDEVEETELPEGEEADATEQVPQAQDPQADNDDAAEQE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVIDGCLAYINNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKI
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCHHHHHCCCCCCHHHHCCCCCEE
YMRSKAEIEVEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGM
EEECCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
RIVIECKRDAVGEVVLNNLYAQTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREV
EEEEEECCCHHHHHHHHHHHHHHEEEHHHCEEEEEECCCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELKKARDRAHILEALALALANIDEIIELIRNAATPAEAKAGLVARGWDLGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHCCCEEEECCCHHHHH
AMLESAGTDAARPDWLEPQYGIRDGQYFLTETQAQAILDLRLHKLTGLEHEKILDEYKAL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LDEIKELMHILASTERLMEVIREELEMVRDAFGDVRRTEITAASHDIDLEELIAREDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHCCCCEEE
TLSHEGYVKYQILSDYEAQRRGGKGKSATKMKDEDYIERLLVANTHDNILLFSTRGKTYR
EEECCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEE
MKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSADKFIFMATGDGTVKKTSLD
EEEEECCCCCCCCCCCCCEEEECCCCCCCEEEEEEEEECCCCCEEEEEECCCCEEECCHH
QFSNVRANGLIAVNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKEAEESPVLDENGNP
HHHCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEHHCCCEEECCCCCCCCCCCCCCC
VLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKNDGDVLTVTENGYGKRT
CCCCCCCCCEEEECCCCCCCHHHCCCCCEECCCCEEEEEEEECCCCCEEEEECCCCCCCC
VLSEYPTKGRGTQGVVSIKVSERNGSVVGAVQVEDGDEFMMITDAGTLVRTRVAEVSQVG
CHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHC
RNTQGVTLIRTAEDESVVGLQRIDEVEETELPEGEEADATEQVPQAQDPQADNDDAAEQE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]