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The map label for this gene is uvrC

Identifier: 37679418

GI number: 37679418

Start: 1247094

End: 1248926

Strand: Direct

Name: uvrC

Synonym: VV1234

Alternate gene names: 37679418

Gene position: 1247094-1248926 (Clockwise)

Preceding gene: 37679417

Following gene: 37679419

Centisome position: 37.18

GC content: 46.37

Gene sequence:

>1833_bases
GTGACTCAAATTTTTGATTCGGTATCTTTCCTCAAGACAGTAACTCATCAGCCTGGCGTTTATCGTATGTATAACGCCGA
GGCTGTTGTTATTTATGTCGGTAAAGCCAAAGATCTCAAAAAACGCCTCTCAAGCTATTTCCGCAAAAAAGTTGACAGCG
AAAAAACCAAAGCATTGGTGAGTAATATTGCCAAAATTGATGTGACCGTGACGCACACCGAAACGGAAGCGCTGATTCTT
GAGCATAATTACATTAAGCAATATTTGCCGAAGTATAATGTCCTGCTGCGAGACGATAAGTCTTATCCCTATATTTTCCT
TAGTGCCCATCGCCATCCTAGGGTCTCTCTGCATCGTGGTGCTAAGAAGAGAAAAGGCGAGTATTTCGGACCTTATCCGG
ACTCAGGTGCAGTACGTGAAACCTTGCACTTGATCCAGAAAATTTTCCCGGTGAGACAGTGTGAAGACACCGTTTATGCT
AACCGAACGCGTCCTTGTTTGATGTACCAGATTGGTCGCTGTGCGGGCCCTTGTGTCAGCAGTGTCATTTCTGATGTCGA
TTATGCAGAGCTGGTGGGTTACTTACGTCTATTTTTACAAGGTAAAGATAACCAAGTTCTAGAGCTCCTAGTGCAAAAAA
TGGAGATTGCGAGCCAGCAACTTAAGTTTGAGGATGCGGCAAAATTTCGTGATCAGATCCAAGCGATTCGTCGCGTTCAG
GAACAACAATATGTTTCGGAAGATAGCCAAGAAGATATGGATGTGCTCGGTTTTGCACAAGAAAATGGCATTGCATGCAT
CCATATCTTGATGATTCGCCAAGGTAAGGTACTGGGAAGTCGCAGTCATTTTCCCAAGATTCCTCAAAACACCAATGCGC
AAGAAGTGTTTGACAGCTTTTTGACGCAATACTATTTGAGCCACAACGAAGCTCGGACGATTCCATCGCGCATCATTCTC
AATCAGGAACTGGCTGCGGATGTCGAGGCGATTCAGCTGGCGCTCAGTGATGTCGCTGGGCGGAAAGTACAATTTCATAC
CTCGCCATCAGGGTCACGTGGTCGTTACCTCAAATTGTCCAATACCAATGCTCTGACGGCAATGACGACCAAAATCAATC
ATAAGATGACGATTAATCAACGCTTTAAGGCGTTACGTGACGTTCTTGCGATGGACTCGATTGCTCGCATGGAGTGTTTC
GATATTTCTCATACCATGGGCGAAAGCACGATTGCCTCATGCGTGGTGTTCAACAGTGAAGGTCCGGTAAAGCAAGAGTA
TCGTCGTTACAACATTACCGGAATCACTGGTGGTGACGACTATGCAGCCATGGGGCAAGCTTTAGAGCGTCGTTACGCCA
AACAACTGGATGTCGAGAAAATTCCAGACGTTATTTTTATTGATGGTGGTAAAGGGCAACTCAATCGAGCGCACGAAATC
ATCGCGCAATACTGGGGAGATTGGCCGAAGCGGCCCGTGATGATCGGAATCGCAAAAGGAGTCACTCGTAAACCAGGTTT
GGAAACTTTGATTACGGTTGATGGCGATGAGTTTCATCTACCAAGTGATGATCCGGCTCTACATTTAATCCAGCACATCC
GTGATGAGAGCCATAATCATGCCATCGCAGGGCACAGAGCGAAGCGCGGAAAAACGCGTAAAACGAGTGCGTTAGAGGGC
ATTGAAGGCGTAGGACCCAAACGCCGTCAAGCGCTGTTGAAATACACGGGGGGCTTACAAGAGCTCAAGCGTGCAAGTGT
TGAAGAAATCGCCAAAGTGCCGGGCATCAGTCACTCTTTGGCAGAAATTATCTATCAAGCATTGAAACAATAG

Upstream 100 bases:

>100_bases
TATCGTTATCGTTTGTTTAGCAAGCTATCGATTAATGGTGACGTAGAGTTGACCCATTTGGCGATTCGCCACGGAATGTT
AGATACCGAGACTCTCTAGT

Downstream 100 bases:

>100_bases
TGAAAATCCAGCACCATTAGCGCGCAAAGTGTAAGAGAATAATAATATGCGTTTGAACATCCCCAACATATTGTCACTAA
TGAGATTATTTCTCATCCCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTQIFDSVSFLKTVTHQPGVYRMYNAEAVVIYVGKAKDLKKRLSSYFRKKVDSEKTKALVSNIAKIDVTVTHTETEALIL
EHNYIKQYLPKYNVLLRDDKSYPYIFLSAHRHPRVSLHRGAKKRKGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYA
NRTRPCLMYQIGRCAGPCVSSVISDVDYAELVGYLRLFLQGKDNQVLELLVQKMEIASQQLKFEDAAKFRDQIQAIRRVQ
EQQYVSEDSQEDMDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPQNTNAQEVFDSFLTQYYLSHNEARTIPSRIIL
NQELAADVEAIQLALSDVAGRKVQFHTSPSGSRGRYLKLSNTNALTAMTTKINHKMTINQRFKALRDVLAMDSIARMECF
DISHTMGESTIASCVVFNSEGPVKQEYRRYNITGITGGDDYAAMGQALERRYAKQLDVEKIPDVIFIDGGKGQLNRAHEI
IAQYWGDWPKRPVMIGIAKGVTRKPGLETLITVDGDEFHLPSDDPALHLIQHIRDESHNHAIAGHRAKRGKTRKTSALEG
IEGVGPKRRQALLKYTGGLQELKRASVEEIAKVPGISHSLAEIIYQALKQ

Sequences:

>Translated_610_residues
MTQIFDSVSFLKTVTHQPGVYRMYNAEAVVIYVGKAKDLKKRLSSYFRKKVDSEKTKALVSNIAKIDVTVTHTETEALIL
EHNYIKQYLPKYNVLLRDDKSYPYIFLSAHRHPRVSLHRGAKKRKGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYA
NRTRPCLMYQIGRCAGPCVSSVISDVDYAELVGYLRLFLQGKDNQVLELLVQKMEIASQQLKFEDAAKFRDQIQAIRRVQ
EQQYVSEDSQEDMDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPQNTNAQEVFDSFLTQYYLSHNEARTIPSRIIL
NQELAADVEAIQLALSDVAGRKVQFHTSPSGSRGRYLKLSNTNALTAMTTKINHKMTINQRFKALRDVLAMDSIARMECF
DISHTMGESTIASCVVFNSEGPVKQEYRRYNITGITGGDDYAAMGQALERRYAKQLDVEKIPDVIFIDGGKGQLNRAHEI
IAQYWGDWPKRPVMIGIAKGVTRKPGLETLITVDGDEFHLPSDDPALHLIQHIRDESHNHAIAGHRAKRGKTRKTSALEG
IEGVGPKRRQALLKYTGGLQELKRASVEEIAKVPGISHSLAEIIYQALKQ
>Mature_609_residues
TQIFDSVSFLKTVTHQPGVYRMYNAEAVVIYVGKAKDLKKRLSSYFRKKVDSEKTKALVSNIAKIDVTVTHTETEALILE
HNYIKQYLPKYNVLLRDDKSYPYIFLSAHRHPRVSLHRGAKKRKGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYAN
RTRPCLMYQIGRCAGPCVSSVISDVDYAELVGYLRLFLQGKDNQVLELLVQKMEIASQQLKFEDAAKFRDQIQAIRRVQE
QQYVSEDSQEDMDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPQNTNAQEVFDSFLTQYYLSHNEARTIPSRIILN
QELAADVEAIQLALSDVAGRKVQFHTSPSGSRGRYLKLSNTNALTAMTTKINHKMTINQRFKALRDVLAMDSIARMECFD
ISHTMGESTIASCVVFNSEGPVKQEYRRYNITGITGGDDYAAMGQALERRYAKQLDVEKIPDVIFIDGGKGQLNRAHEII
AQYWGDWPKRPVMIGIAKGVTRKPGLETLITVDGDEFHLPSDDPALHLIQHIRDESHNHAIAGHRAKRGKTRKTSALEGI
EGVGPKRRQALLKYTGGLQELKRASVEEIAKVPGISHSLAEIIYQALKQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=611, Percent_Identity=63.0114566284779, Blast_Score=809, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68949; Mature: 68818

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2 ; PS00034 PAIRED_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIFDSVSFLKTVTHQPGVYRMYNAEAVVIYVGKAKDLKKRLSSYFRKKVDSEKTKALV
CCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHH
SNIAKIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFLSAHRHPRVSLHRG
HHHHHEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHCC
AKKRKGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYANRTRPCLMYQIGRCAGPCVS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHH
SVISDVDYAELVGYLRLFLQGKDNQVLELLVQKMEIASQQLKFEDAAKFRDQIQAIRRVQ
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQQYVSEDSQEDMDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPQNTNAQEVFDSF
HHHHHCCCCCCCHHHHEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
LTQYYLSHNEARTIPSRIILNQELAADVEAIQLALSDVAGRKVQFHTSPSGSRGRYLKLS
HHHHHHHCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEC
NTNALTAMTTKINHKMTINQRFKALRDVLAMDSIARMECFDISHTMGESTIASCVVFNSE
CCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCC
GPVKQEYRRYNITGITGGDDYAAMGQALERRYAKQLDVEKIPDVIFIDGGKGQLNRAHEI
CCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCCHHHHHHH
IAQYWGDWPKRPVMIGIAKGVTRKPGLETLITVDGDEFHLPSDDPALHLIQHIRDESHNH
HHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHCCCCCC
AIAGHRAKRGKTRKTSALEGIEGVGPKRRQALLKYTGGLQELKRASVEEIAKVPGISHSL
CCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHH
AEIIYQALKQ
HHHHHHHHCC
>Mature Secondary Structure 
TQIFDSVSFLKTVTHQPGVYRMYNAEAVVIYVGKAKDLKKRLSSYFRKKVDSEKTKALV
CHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHH
SNIAKIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFLSAHRHPRVSLHRG
HHHHHEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHCC
AKKRKGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYANRTRPCLMYQIGRCAGPCVS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHH
SVISDVDYAELVGYLRLFLQGKDNQVLELLVQKMEIASQQLKFEDAAKFRDQIQAIRRVQ
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQQYVSEDSQEDMDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPQNTNAQEVFDSF
HHHHHCCCCCCCHHHHEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
LTQYYLSHNEARTIPSRIILNQELAADVEAIQLALSDVAGRKVQFHTSPSGSRGRYLKLS
HHHHHHHCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEC
NTNALTAMTTKINHKMTINQRFKALRDVLAMDSIARMECFDISHTMGESTIASCVVFNSE
CCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCC
GPVKQEYRRYNITGITGGDDYAAMGQALERRYAKQLDVEKIPDVIFIDGGKGQLNRAHEI
CCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCCHHHHHHH
IAQYWGDWPKRPVMIGIAKGVTRKPGLETLITVDGDEFHLPSDDPALHLIQHIRDESHNH
HHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHCCCCCC
AIAGHRAKRGKTRKTSALEGIEGVGPKRRQALLKYTGGLQELKRASVEEIAKVPGISHSL
CCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHH
AEIIYQALKQ
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]