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The map label for this gene is uvrY [H]

Identifier: 37679417

GI number: 37679417

Start: 1246448

End: 1247092

Strand: Direct

Name: uvrY [H]

Synonym: VV1233

Alternate gene names: 37679417

Gene position: 1246448-1247092 (Clockwise)

Preceding gene: 37679415

Following gene: 37679418

Centisome position: 37.16

GC content: 43.88

Gene sequence:

>645_bases
TTGATCAATGTTTTCCTTGTAGATGATCACGAGCTGGTTCGCACAGGGATACGACGTATTATTGAAGACGTCCGTGGAAT
GAACGTAGCAGGAGAAGCTGATAGCGGTGAAAATGCGGTAAAATGGTGTCGTAGCAATCATGCAGACGTCGTTTTAATGG
ATATGAACATGCCTGGTATTGGCGGCTTGGAAGCTACCAAGAAAATTTTGCGTGTTAATCCAGATGTAAAAATCATCGTC
TTAACTGTTCATACGGAAAATCCGTTTCCAACTAAAGTGATGCAAGCGGGGGCTTCTGGTTATTTGACCAAAGGCGCTGG
CCCAGATGAAATGGTGAATGCAATTCGTATTGTCCATAGTGGGCAACGTTATATTTCACCAGAAATTGCGCAGCAAATGG
CGTTAAGCCAGTTTTCGCCTGCGTCCGAAAACCCTTTCAAGGATCTGTCTGAGCGTGAGCTTCAGATCATGATGATGATC
ACGAAAGGTCAGAAAGTGACAGATATTTCTGAGCAGTTAAATCTCAGTCCTAAAACTGTCAACAGCTATCGTTATCGTTT
GTTTAGCAAGCTATCGATTAATGGTGACGTAGAGTTGACCCATTTGGCGATTCGCCACGGAATGTTAGATACCGAGACTC
TCTAG

Upstream 100 bases:

>100_bases
ATAGAAGGCATTTTCAGAGTAAATGCGGTAATATAGGCAACTGTACTGATATCCACACTTGATGTGGAACAGAGCCAATT
AATAGTGTGGAGATACAAGT

Downstream 100 bases:

>100_bases
TGTGACTCAAATTTTTGATTCGGTATCTTTCCTCAAGACAGTAACTCATCAGCCTGGCGTTTATCGTATGTATAACGCCG
AGGCTGTTGTTATTTATGTC

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEADSGENAVKWCRSNHADVVLMDMNMPGIGGLEATKKILRVNPDVKIIV
LTVHTENPFPTKVMQAGASGYLTKGAGPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFKDLSERELQIMMMI
TKGQKVTDISEQLNLSPKTVNSYRYRLFSKLSINGDVELTHLAIRHGMLDTETL

Sequences:

>Translated_214_residues
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEADSGENAVKWCRSNHADVVLMDMNMPGIGGLEATKKILRVNPDVKIIV
LTVHTENPFPTKVMQAGASGYLTKGAGPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFKDLSERELQIMMMI
TKGQKVTDISEQLNLSPKTVNSYRYRLFSKLSINGDVELTHLAIRHGMLDTETL
>Mature_214_residues
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEADSGENAVKWCRSNHADVVLMDMNMPGIGGLEATKKILRVNPDVKIIV
LTVHTENPFPTKVMQAGASGYLTKGAGPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFKDLSERELQIMMMI
TKGQKVTDISEQLNLSPKTVNSYRYRLFSKLSINGDVELTHLAIRHGMLDTETL

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=75.8139534883721, Blast_Score=347, Evalue=2e-97,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=33.5, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=32.6829268292683, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=24.8756218905473, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=25, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788546, Length=201, Percent_Identity=28.8557213930348, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23792; Mature: 23792

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEADSGENAVKWCRSNHADVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCC
GGLEATKKILRVNPDVKIIVLTVHTENPFPTKVMQAGASGYLTKGAGPDEMVNAIRIVHS
CCHHHHHHHHEECCCCEEEEEEEECCCCCCHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GQRYISPEIAQQMALSQFSPASENPFKDLSERELQIMMMITKGQKVTDISEQLNLSPKTV
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEEEEECCCEEECHHHHHCCCCCHH
NSYRYRLFSKLSINGDVELTHLAIRHGMLDTETL
HHHHHHHHHEEECCCCEEEEHHHHHHCCCCCCCC
>Mature Secondary Structure
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEADSGENAVKWCRSNHADVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCC
GGLEATKKILRVNPDVKIIVLTVHTENPFPTKVMQAGASGYLTKGAGPDEMVNAIRIVHS
CCHHHHHHHHEECCCCEEEEEEEECCCCCCHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GQRYISPEIAQQMALSQFSPASENPFKDLSERELQIMMMITKGQKVTDISEQLNLSPKTV
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEEEEECCCEEECHHHHHCCCCCHH
NSYRYRLFSKLSINGDVELTHLAIRHGMLDTETL
HHHHHHHHHEEECCCCEEEEHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]