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The map label for this gene is mdtA [H]

Identifier: 37679312

GI number: 37679312

Start: 1135407

End: 1136474

Strand: Direct

Name: mdtA [H]

Synonym: VV1128

Alternate gene names: 37679312

Gene position: 1135407-1136474 (Clockwise)

Preceding gene: 37679309

Following gene: 37679313

Centisome position: 33.85

GC content: 49.16

Gene sequence:

>1068_bases
ATGAAAAAACGCATTCTTATCTCATTTATTACTCTGGCTCTTATGGGGACTTCCTCTCTATCCCATGCTGCTCCAAGAGG
GCCATCTGCTGTTACTGTGGTTGCCGAAGAAGTGCAAACACACCAAATTAGCCAATCTTTAGCTCTGGTCGGTAAATTGG
AAGCGGTGCAGTCAGTGGTGATTGCGTCCGAAGTGTCCGGCAAAGTCGAAAGCATTCAAGTGAAAGCCAACCAGAATGTC
ACTAAAGGGCAACTGTTGGTCAAGCTTGAGGACGATAAAGCCTTAGCAGCGGTATCTGAAGCAAAAGCTTATCTAAAAGA
TGAGCAGAGAAAGCTGAAAGAGTTTGAGCGACTGGTCAGCCGCAATGCGATTACGCAAACAGAAATTGACGCGCAAAAAG
CCAGTGTCGAGATTGCACAAGCGCGTTTGACCGCTGCCAATGCCAACTTGAATGATCTTCATATCACCGCGCCTTTTGCC
GGAACGGTGGGTTTCGTCGATTTTAGCCGCGGCAAGTTGGTGAACTCAGGCACTGAATTACTGACGCTCGACGATCTGTC
GTTGATGCAACTGGATCTGAGAATTCCGGAACGTTATCTGTCGATGTTGTCGATAGGTATGCCTGTGACAGCAACATCCA
GCGCTTGGGGCAAACAAGTGTTCACTGGCAAGGTGGTGGGCATTGACTCACGGATTAACGCCGAAACGTTGAACCTACGC
GTGCGCATTCAGTTTGAAAATCCGGAAAATCAGTTGAAACCAGGGATGTTGCTCAATACCGCCTTAGCGTTCCCTGCGAT
TGAAGCGCCGATCATTCCGGTGCAGGCATTAGAGTATTCTGGGACCAAACGTTACGTCTATGTCATCGGCAGCGACAACA
AAGCGAAACGCACAGAAGTTCTGCTTGGTGCGCGAGTAGAGAACCAAGTGGTGATCGAGTCGGGTGTCAACATCGGCGAT
AAAATCGTCGTGCAAGGTATCGTGAACATGCGTGACGGTGTGTTAGTCAAAGAAATTGGCGGCGCAGCGACAGGGCAAAA
GACCGTAGCGAAGAAGGATGAGCAATAA

Upstream 100 bases:

>100_bases
AATCCTTCACTTCTCACCATAATTTACACAACTTGACGTTACAGTACGCTAGAGCTGATAAACTTATAATCTCAACTATG
GCTTTATTGATTGACGGAAC

Downstream 100 bases:

>100_bases
TGTTACTCTCTGATGTCTCGGTGAAAAGGCCAGTTGCTGCGCTGGTATTGAGTTTGTTGCTGTGTGTGTTTGGTTTTGTC
TCGTTCAGCAAATTGGCGGT

Product: membrane-fusion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKKRILISFITLALMGTSSLSHAAPRGPSAVTVVAEEVQTHQISQSLALVGKLEAVQSVVIASEVSGKVESIQVKANQNV
TKGQLLVKLEDDKALAAVSEAKAYLKDEQRKLKEFERLVSRNAITQTEIDAQKASVEIAQARLTAANANLNDLHITAPFA
GTVGFVDFSRGKLVNSGTELLTLDDLSLMQLDLRIPERYLSMLSIGMPVTATSSAWGKQVFTGKVVGIDSRINAETLNLR
VRIQFENPENQLKPGMLLNTALAFPAIEAPIIPVQALEYSGTKRYVYVIGSDNKAKRTEVLLGARVENQVVIESGVNIGD
KIVVQGIVNMRDGVLVKEIGGAATGQKTVAKKDEQ

Sequences:

>Translated_355_residues
MKKRILISFITLALMGTSSLSHAAPRGPSAVTVVAEEVQTHQISQSLALVGKLEAVQSVVIASEVSGKVESIQVKANQNV
TKGQLLVKLEDDKALAAVSEAKAYLKDEQRKLKEFERLVSRNAITQTEIDAQKASVEIAQARLTAANANLNDLHITAPFA
GTVGFVDFSRGKLVNSGTELLTLDDLSLMQLDLRIPERYLSMLSIGMPVTATSSAWGKQVFTGKVVGIDSRINAETLNLR
VRIQFENPENQLKPGMLLNTALAFPAIEAPIIPVQALEYSGTKRYVYVIGSDNKAKRTEVLLGARVENQVVIESGVNIGD
KIVVQGIVNMRDGVLVKEIGGAATGQKTVAKKDEQ
>Mature_355_residues
MKKRILISFITLALMGTSSLSHAAPRGPSAVTVVAEEVQTHQISQSLALVGKLEAVQSVVIASEVSGKVESIQVKANQNV
TKGQLLVKLEDDKALAAVSEAKAYLKDEQRKLKEFERLVSRNAITQTEIDAQKASVEIAQARLTAANANLNDLHITAPFA
GTVGFVDFSRGKLVNSGTELLTLDDLSLMQLDLRIPERYLSMLSIGMPVTATSSAWGKQVFTGKVVGIDSRINAETLNLR
VRIQFENPENQLKPGMLLNTALAFPAIEAPIIPVQALEYSGTKRYVYVIGSDNKAKRTEVLLGARVENQVVIESGVNIGD
KIVVQGIVNMRDGVLVKEIGGAATGQKTVAKKDEQ

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=336, Percent_Identity=25.8928571428571, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI87081796, Length=364, Percent_Identity=25.5494505494505, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789929, Length=304, Percent_Identity=24.0131578947368, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38270; Mature: 38270

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRILISFITLALMGTSSLSHAAPRGPSAVTVVAEEVQTHQISQSLALVGKLEAVQSVV
CCCEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IASEVSGKVESIQVKANQNVTKGQLLVKLEDDKALAAVSEAKAYLKDEQRKLKEFERLVS
HHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNAITQTEIDAQKASVEIAQARLTAANANLNDLHITAPFAGTVGFVDFSRGKLVNSGTEL
CCCCCHHHCCHHHHHHHHHHHEEEECCCCCCEEEEECCCCCCEEEEECCCCEEECCCCCE
LTLDDLSLMQLDLRIPERYLSMLSIGMPVTATSSAWGKQVFTGKVVGIDSRINAETLNLR
EEECCCEEEEEECCCCHHHHHHHHCCCCEEECCCCCCCCEEEEEEEEECCCCCCEEEEEE
VRIQFENPENQLKPGMLLNTALAFPAIEAPIIPVQALEYSGTKRYVYVIGSDNKAKRTEV
EEEEECCCHHHCCCCEEEHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCEEE
LLGARVENQVVIESGVNIGDKIVVQGIVNMRDGVLVKEIGGAATGQKTVAKKDEQ
EEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MKKRILISFITLALMGTSSLSHAAPRGPSAVTVVAEEVQTHQISQSLALVGKLEAVQSVV
CCCEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IASEVSGKVESIQVKANQNVTKGQLLVKLEDDKALAAVSEAKAYLKDEQRKLKEFERLVS
HHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNAITQTEIDAQKASVEIAQARLTAANANLNDLHITAPFAGTVGFVDFSRGKLVNSGTEL
CCCCCHHHCCHHHHHHHHHHHEEEECCCCCCEEEEECCCCCCEEEEECCCCEEECCCCCE
LTLDDLSLMQLDLRIPERYLSMLSIGMPVTATSSAWGKQVFTGKVVGIDSRINAETLNLR
EEECCCEEEEEECCCCHHHHHHHHCCCCEEECCCCCCCCEEEEEEEEECCCCCCEEEEEE
VRIQFENPENQLKPGMLLNTALAFPAIEAPIIPVQALEYSGTKRYVYVIGSDNKAKRTEV
EEEEECCCHHHCCCCEEEHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCEEE
LLGARVENQVVIESGVNIGDKIVVQGIVNMRDGVLVKEIGGAATGQKTVAKKDEQ
EEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]